Efthalia Moustakli

@oldsite.med.uoi.gr

Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece

Efthalia Moustakli


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https://researchid.co/thaleiaki
PhD-trained biologist with a solid background in medical genetics, molecular biology, and bioinformatics. Currently engaged in postdoctoral research focused on data-driven approaches to clinical and translational science, while also serving as an adjunct Professor in the Nursing department. Experienced in both wet-lab and computational techniques, clinical research, and data analysis. Demonstrated ability to mentor, collaborate across disciplines, and contribute to impactful, real-world outcomes. Adept at navigating regulatory standards and committed to bridging scientific discovery with practical healthcare applications.

EDUCATION

PhD in Medical Genetics
Laboratory of Medical Genetics in Clinical Practice, School of Medicine, University of Ioannina, Greece
April 2021 – May 2024
• Dissertation: “Exploring telomere and mitochondrial genomic recombinations in spermatozoa: a comprehensive examination and detection” (graded "EXCELLENT").

Integrated Master’s in Biological Applications and Technology
University of Ioannina, Greece
September 2014 – April 2020
• Thesis: “Genetic abnormalities in preimplantation and endometrial embryos, neonates and gametes” (graded 10/10).

RESEARCH, TEACHING, or OTHER INTERESTS

Molecular Biology, Genetics, Aging, Artificial Intelligence
70

Scopus Publications

964

Scholar Citations

16

Scholar h-index

23

Scholar i10-index

Scopus Publications

  • The AHEPA EEG benchmark: setting the standard for machine learning in dementia diagnosis, a scoping review
    Andreas Miltiadous, Aimilia Ntetska, Vasileios Aspiotis, Efthalia Moustakli, Markos G. Tsipouras, Alexandros T. Tzallas, Nikolaos Giannakeas, Euripidis Glavas, Pantelis Angelidis, Katerina D. Tzimourta
    Cognitive Neurodynamics, 2026
    Accurate and reproducible electroencephalography (EEG)-based classification of dementia remains a key challenge in computational neurodiagnostics. The open-access AHEPA dataset has become the most commonly used benchmark for Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) classification, yet reported results vary widely due to methodological inconsistencies. This study presents the first systematic and quantitative benchmark review of all published machine learning approaches applied to the AHEPA dataset. Forty-six studies were reviewed and stratified into three validity tiers, with Validity 1 representing the highest methodological rigor and Validity 3 the lowest.According to their evaluation rigor: (1) subject-level validation (e.g., Leave-One-Subject-Out cross-validation, LOSO-CV), (2) subject-level train/test splits, and (3) epoch-level k-fold cross-validation. Performance metrics were normalized across classification problems. The analysis revealed that methodological rigor is inversely correlated with reported accuracy: for AD versus Cognitively Normal controls, mean accuracy decreased from 90.81% overall to 82.11% in Validity-1 studies; for FTD versus controls, accuracy dropped from 86.53% to 75.18%. Linear regression analyses demonstrated that weaker validation protocols were associated with systematic increases of 7–10% points in reported accuracy, explaining more than half of the observed performance variance. Deep and hybrid models reported the highest nominal accuracies, but under proper validation, traditional algorithms performed comparably, indicating that data leakage often drives apparent improvements. The review also highlights the lack of cross-configuration generalization and the urgent need for adaptive, montage-independent methodologies. Overall, this benchmark establishes the first reproducible reference framework for EEG-based dementia classification on the AHEPA dataset, providing quantitative baselines and validity criteria against which all future studies should be evaluated.
  • The Influence of Sexually Transmitted Bacteria and Human Papillomavirus on Sperm Parameters: Data from a Preliminary Study
    Maria Samara, Eleni Thodou, Christina Messini, Efthalia Moustakli, Maria Anagnostou, Athanasios Zikopoulos, Alexandros Daponte, Ioannis Georgiou, George Anifandis
    Medicina Lithuania, 2026
    Background and Objectives: The microbiome plays a pivotal role in male infertility, with distinct microbial species exerting both beneficial and deleterious effects on reproductive function. Sexually transmitted bacteria and several viruses, including human papillomavirus (HPV), have been identified in semen. This cross-sectional study aimed to examine the prevalence of single and co-infections of sexually transmitted bacteria (STB)—such as Chlamydia trachomatis, Mycoplasma spp., and Ureaplasma spp.—with various HPV subtypes in Greek male partners of infertile couples and to evaluate their potential impact on sperm parameters. In addition, the possible effect of cryopreservation on the maintenance of these pathogens was assessed. Materials and Methods: Eighty-two semen samples were initially collected from 82 individuals undergoing routine sperm analysis. In total, 80/82 (97.6%) participants proceeded to further analysis, as 2/82 (2.4%) were excluded due to poor DNA quality. Results: A total of 18/80 (22.5%) sperm samples tested positive for STB, with Ureaplasma spp. representing the most frequently detected pathogen. Co-infection of Ureaplasma spp. and Mycoplasma hominis was observed in 4/80 (5%) samples. Twelve samples (12/80, 15%) were positive for HPV, including low-risk (LR) and high-risk (HR) types, and HPV 16 was the predominant HR genotype. Notably, a co-infection of STB and HPV was not found in our specimens. STB-positive samples demonstrated significantly higher sperm concentration and improved progressive motility compared with STB-negative samples. HPV-positive samples exhibited lower sperm volume and concentration and increased non-progressive motility compared with HPV-negative samples. Following three months of cryopreservation, LR HPV and STB were no longer detectable, whereas HR HPV types remained detectable. Conclusions: These preliminary findings are interesting, as they could be useful for routine screening of HPV and STB in sperm samples preserved in sperm banks and highlight the need for future research.
  • Extracellular Vesicles in Human Reproduction: Integrating Redox–Mitochondrial Signaling with Multi-Omics and AI-Driven Biomarker Discovery
    Sofoklis Stavros, Angeliki Gerede, Efthalia Moustakli, Athanasios Zikopoulos, Ioannis Tsakiridis, Christina Messini, Anastasios Potiris, Ismini Anagnostaki, Ioannis Arkoulis, Spyridon Topis, Themistoklis Dagklis, Dimitrios Loutradis
    Cells, 2026
    In the human reproductive system, extracellular vesicles (EVs) have been recognized as playing a vital role in mediating cell–cell communication. They are considered critical for embryo development, implantation, gamete interaction, and fertilization. The various cargoes carried by EVs, depending on the physiological and pathological state of the cell, include proteins, lipids, nucleic acids, and mitochondrial components. EVs are recognized as critical carriers of redox-related signals and mitochondrial components, linking oxidative stress (OS) to reproductive failure and influencing gamete quality and embryo competence. Although considerable progress has been made, research remains poorly integrated, despite individual omics technologies providing valuable molecular insights. The use of multi-omics technologies, including transcriptomics, proteomics, metabolomics, and microbiome analysis, has been proposed as a global approach to understanding the complexities associated with EVs and discovering new biomarkers associated with infertility. ML and AI have been proposed to identify predictive signatures linked to ART effectiveness and reproductive outcomes, with a strong capacity to handle high-dimensional data. The review aims to provide an overview of current knowledge on EV-mediated redox–mitochondrial signaling in human reproduction, while highlighting the importance of emerging multi-omics and AI technologies for EV-mediated biomarker development. The review discusses the promise of EVs in the development of minimally invasive diagnostic approaches and therapeutic interventions, as well as the challenges in the standardization, integration, and clinical translation of EV-mediated research. In addition, the review proposes integrating computational approaches to better understand molecular pathways involved in the development of next-generation precision medicine in human reproduction.
  • The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review
    Sofoklis Stavros, Angeliki Gerede, Nektaria Zagorianakou, Efthalia Moustakli, Anastasios Potiris, Ismini Anagnostaki, Alexios Kozonis, Maria Tzeli, Aikaterini Lydia Vogiatzoglou, Pavlos Machairoudias, Konstantinos Zacharis, Athanasios Zikopoulos, Dimitrios Loutradis, Ekaterini Domali
    Microorganisms, 2026
    Endocrine-disrupting chemicals (EDCs) are a diverse group of environmental pollutants capable of interfering with hormonal and immune system regulation. In recent years, increasing concern has been raised about the effects of chemicals, including bisphenols, phthalates, per- and polyfluoroalkyl substances (PFAS), insecticides, and parabens, on maternal and fetal health, primarily due to their widespread exposure in human populations. Pregnancy represents a critical window characterized by tightly regulated hormonal and immunological adaptations. Emerging evidence suggests that EDC exposure during this period may alter maternal microbiota, disrupt immune responses, and interfere with endocrine signaling. These changes may increase susceptibility to bacterial and viral infections, including bacterial vaginosis, urinary tract infections, and intrauterine infections, all of which are associated with adverse pregnancy outcomes. This review summarizes the current evidence on the sources and mechanisms of exposure to endocrine disruptors during pregnancy and examines the potential biological pathways linking endocrine disruption to the development of infections. Particular emphasis is placed on the interactions between immune regulation, hormonal signaling, and changes in the microbiome, which may contribute to increased susceptibility to infections. A deeper understanding of these complex mechanisms is critical to improve risk assessment, develop effective public health strategies, and ultimately protect maternal and fetal health in an environment of increasing chemical exposure. A literature search was conducted using PubMed/MEDLINE, Scopus, and Web of Science, including studies published up to January 2026.
  • Extracellular Matrix Remodeling and Matrix Metalloproteinases in Ovarian Function and Infertility
    Efthalia Moustakli, Athanasios Zikopoulos, Periklis Katopodis, Vasilios Sebastian Paraschos, Ioannis Messinis, Christina Messini
    International Journal of Molecular Sciences, 2026
    Ovarian function relies on a network of well-coordinated molecular mechanisms that regulate follicular development, oocyte maturation, ovulation, and corpus luteum function. When these processes are disrupted, infertility can result. Extracellular matrix (ECM) remodeling represents a central regulatory component in these processes and is essential for follicle rupture and oocyte release. This mechanism involves metalloproteinases (MMPs), mainly MMP-2 and MMP-9, which degrade the ECM and allow the necessary structural changes. Other ECM-modulating proteases, such as ADAM and ADAMTS families, also contribute to this process. Their activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs), ensuring that tissue remodeling occurs in a controlled manner. Disruption of the balance between MMPs and TIMPs increases the risk of infertility-related conditions such as polycystic ovary syndrome (PCOS), endometriosis, luteinizing hormone (LH) deficiency syndrome, and ovarian aging. In addition to the ECM, other factors, including intracellular signaling pathways, oxidative stress (OS), and mitochondrial function, contribute to ovarian physiology and directly affect oocyte quality and viability. This narrative review focuses on the molecular mechanisms governing ovarian function, with particular emphasis on the remodeling of the ECM by MMPs during ovulation, and examines how their disorders contribute to infertility. A deeper understanding of these mechanisms may lead to the identification of new therapeutic targets and the improvement of assisted reproduction outcomes.
  • Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure
    Athanasios Zikopoulos, Efthalia Moustakli, Anastasios Potiris, Vasilis Sebastian Paraschos, Periklis Katopodis, Pavlos Machairoudias, Panagiotis Antsaklis, Nikolaos Kathopoulis, Ismini Anagnostaki, Sofoklis Stavros
    Biomedicines, 2026
    Several reproductive issues in both men and women are caused by changes in the pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). For males to sustain spermatogenesis and Leydig cell function, and for females to ensure orderly folliculogenesis, ovulation, and ovarian steroidogenesis, precise coordination of LH and FSH secretion is necessary. Pituitary responsiveness, the frequency or amplitude of gonadotropin-releasing hormone pulses, or the dysregulation of feedback signals mediated by sex steroids and inhibins all disrupt the balance between LH and FSH secretion. Oligozoospermia, luteal-phase abnormalities, anovulation, or complete spermatogenic failure are possible clinical signs of these alterations. In addition to functional neuroendocrine disturbances, emerging genetic and epigenetic evidence, including pathogenic variants in genes such as gonadotropin-releasing hormone receptor, kisspeptin, kisspeptin receptor, luteinizing hormone beta subunit, follicle-stimulating hormone beta subunit, follicle-stimulating hormone receptor, and luteinizing hormone/choriogonadotropin receptor, has highlighted the role of inherited and acquired molecular defects in disrupting gonadotropin regulation. This narrative review synthesizes contemporary mechanistic, clinical, translational, and genetic evidence elucidating how dysregulated secretion of LH and FSH contributes to reproductive dysfunction. The molecular processes that regulate gonadotropin synthesis and release, as well as neuroendocrine regulation, gene-level determinants of hypothalamic–pituitary–gonadal (HPG) axis dysfunction, and the clinical phenotypes that result from their disruption, are all given special attention. We conclude with a discussion of new treatment strategies that target local intragonadal regulators to enhance gametogenic capacity, modulate gonadotropin signaling, or restore physiological gonadotropin-releasing hormone (GnRH) pulsatility, with consideration of how genetic insights may inform personalized therapeutic approaches.
  • Miscarriage and the Microbiome: Host Genetics, Immunity, and the Reproductive Tract Ecosystem
    Nektaria Zagorianakou, Stylianos Makrydimas, Efthalia Moustakli, Ioannis Mitrogiannis, George Makrydimas
    Genes, 2026
    Background/Objectives: Pregnancy loss is a common and multifactorial complication of human reproduction, traditionally attributed to fetal chromosomal abnormalities, maternal anatomical and endocrine disorders, and immune dysfunction. Growing evidence now indicates that the maternal microbiome, particularly within the reproductive tract, plays a critical role in implantation, placental development, and the maintenance of immune tolerance during early pregnancy. Importantly, the influence of the microbiome on miscarriage appears to be strongly modulated by host genetic background and immune regulation. Methods: This narrative review summarizes current evidence linking alterations in the vaginal, endometrial, placental, and gut microbiomes to miscarriage, with a specific focus on host genetics and immune–microbial interactions. Results: We discuss how genetic variation in innate and adaptive immune pathways, inflammatory signaling, and mucosal barrier function may shape host responses to microbial communities, thereby influencing susceptibility to PL. In addition, we highlight emerging data on microbiome-driven regulation of gene expression and epigenetic modifications in the endometrium and decidua, emphasizing the role of microbial metabolites in immune tolerance and placental function. Conclusions: By integrating findings from microbiome research, host genomics, immunology, and epigenetics, this review proposes a framework in which miscarriage is viewed as a consequence of disrupted host–microbe crosstalk rather than isolated pathology. Finally, we address key methodological challenges and outline future research directions aimed at advancing mechanistic understanding and translational applications.
  • Linking Oxidative Stress to Placental Dysfunction: The Key Role of Mitochondria in Trophoblast Function
    Ioanna Vasilaki, Anastasios Potiris, Efthalia Moustakli, Despoina Mavrogianni, Nikoletta Daponte, Theodoros Karampitsakos, Alexios Kozonis, Konstantinos Louis, Christina Messini, Themos Grigoriadis, Ekaterini Domali, Sofoklis Stavros
    Medical Sciences, 2026
    Oxidative stress (OS) is a critical regulator of placental development; however, its specific effects on trophoblast biology remain incompletely elucidated. This narrative review synthesizes evidence derived from studies using human placental tissues and trophoblast cell models to delineate how excessive reactive oxygen species (ROS) disrupt molecular and cellular pathways essential for normal placentation. The literature search was restricted to human-based and in vitro investigations. Across these studies, OS was consistently shown to impair mitochondrial function in trophoblasts, resulting in increased mitochondrial ROS generation, loss of mitochondrial membrane potential, and activation of apoptotic signaling cascades. These mitochondrial disturbances were associated with reduced trophoblast proliferation, migration, and invasion, as well as dysregulation of angiogenic balance. Furthermore, several studies reported alterations in mitophagy, involvement of redox-sensitive pathways such as CYP1A1 and KLF9, and the extracellular release of mitochondrial DNA, which was linked to reduced cell viability and increased necrotic cell death. Collectively, the available evidence indicates that OS interferes with key trophoblast-dependent developmental processes, providing mechanistic insight into the pathogenesis of placental dysfunction observed in pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR). Elucidation of these pathways may inform the development of targeted therapeutic strategies aimed at preserving placental function and improving adverse pregnancy outcomes.
  • Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis
    Athanasios Zikopoulos, Efthalia Moustakli, Periklis Katopodis, Vasilis Sebastian Paraschos, Anastasios Potiris, Ismini Anagnostaki, Aikaterini Lydia Vogiatzoglou, Konstantinos Zacharis, Theodoros Karampitsakos, Konstantinos Zikopoulos, Sofoklis Stavros
    International Journal of Molecular Sciences, 2026
    Adipocytes produce the hormone leptin, a hormone that links energy availability to reproductive function by permitting activation of the hypothalamic–pituitary–gonadal (HPG) axis. Loss-of-function mutations in the long leptin receptor isoform (LEPRb) disrupt intracellular signaling pathways, including the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3), phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways, resulting in central leptin resistance and impaired neuroendocrine control of reproduction. Evidence from human monogenic obesity syndromes, animal models, and neuroendocrine studies indicates that LEPRb mutations disrupt hypothalamic circuitry upstream of gonadotropin-releasing hormone (GnRH) neurons, impairing GnRH pulsatility and leading to hypogonadotropic hypogonadism (HH) and infertility. This review synthesizes molecular, translational, and clinical data highlighting the central role of kisspeptin-mediated signaling in leptin-dependent reproductive regulation. Current therapeutic limitations are discussed alongside emerging approaches, including kisspeptin-based therapies and receptor-targeted strategies. Elucidating how LEPRb dysfunction disrupts metabolic–reproductive integration may provide insights into both rare monogenic conditions and common obesity-associated reproductive dysfunction.
  • A Deep Learning Approach for Classifying Benign, Malignant, and Borderline Ovarian Tumors Using Convolutional Neural Networks and Generative Adversarial Networks
    Maria Giourga, Ioannis Petropoulos, Sofoklis Stavros, Anastasios Potiris, Kallirroi Goula, Efthalia Moustakli, Anthi-Maria Papahliou, Maria-Anastasia Daskalaki, Margarita Segou, Alexandros Rodolakis, George Daskalakis, Ekaterini Domali
    Medical Sciences, 2026
    Background/Objectives: Accurate preoperative characterization of ovarian masses is essential for appropriate clinical management, particularly for borderline ovarian tumors (BOTs), which are less common and often difficult to distinguish from benign or malignant lesions on ultrasound. Although expert subjective ultrasound assessment achieves high diagnostic accuracy, limited availability of highly trained sonologists restricts its widespread application. Artificial intelligence-based approaches offer a potential solution; however, the low prevalence of BOTs restricts the development of robust deep learning models due to severe class imbalance. This study aimed to develop a Convolutional Neural Network (CNN)-based classifier enhanced with Generative Adversarial Networks (GANs) to improve the discrimination of ovarian masses as benign, malignant, or BOT using ultrasound images. Methods: A total of 3816 ultrasound images from 636 ovarian masses were retrospectively analyzed, including 390 benign lesions, 202 malignant tumors, and 44 BOTs. To address class imbalance, a Deep Convolutional GAN (DCGAN) was used to generate 2000 synthetic BOT images for data augmentation. A three-class ensemble CNN model integrating VGG16, ResNet50, and InceptionNetV3 architectures was developed. Performance was assessed on an independent test set and compared with a baseline model trained without DCGAN augmentation. Results: The incorporation of DCGAN-generated BOT images significantly enhanced classification performance. The BOT F1-score increased from 68.4% to 86.5%, while overall accuracy improved from 84.7% to 91.5%. For BOT identification, the final model achieved a sensitivity of 88.2% and specificity of 85.1%. Class-specific AUCs were 0.96 for benign lesions, 0.94 for malignant tumors, and 0.91 for BOTs. Conclusions: DCGAN-based augmentation effectively expands limited ultrasound datasets and improves CNN performance, particularly for BOT detection. This approach demonstrates potential as a decision support tool for preoperative assessment of ovarian masses.
  • Thrombocytopenia in Pregnancy: Clinical Challenges, Maternal–Fetal Risks, and Management Strategies
    Sofoklis Stavros, Nikolaos Kathopoulis, Angeliki Gerede, Themos Grigoriadis, Efthalia Moustakli, Athanasios Zikopoulos, Nefeli Arkouli, Pavlos Machairoudias, Maria Tzeli, Ismini Anagnostaki, Dimos Sioutis, Konstantinos Louis, Anastasios Potiris
    Life, 2026
  • The Impact of Endocrine-Disrupting Chemicals on Embryonic Recurrent Implantation Failure: A Narrative Review
    Anastasios Potiris, Panagiotis Antsaklis, Panagiotis Christopoulos, Nikolaos Kathopoulis, Efthalia Moustakli, Ismini Anagnostaki, Eirini Drakaki, Nefeli Arkouli, Aikaterini-Lydia Vogiatzoglou, Athanasios Zikopoulos, Sofoklis Stavros, Charalampos Theofanakis
    Journal of Xenobiotics, 2026
  • Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration
    Athanasios Zikopoulos, Panagiotis Christopoulos, Theodoros Kalampokas, Angeliki Gerede, Efthalia Moustakli, Ioannis Arkoulis, Spyridon Topis, Anastasios Potiris, Chrysi Christodoulaki, Ioannis Tsakiridis, Themistoklis Dagklis, Sofoklis Stavros
    Diagnostics, 2026
  • The Gut–Extracellular Vesicle–Mitochondria Axis in Reproductive Aging: Antioxidant and Anti-Senescence Mechanisms
    Efthalia Moustakli, Christina Messini, Anastasios Potiris, Athanasios Zikopoulos, Ioannis Arkoulis, Alexios Kozonis, Theodoros Karampitsakos, Pavlos Machairoudias, Nikolaos Machairiotis, Panagiotis Antsaklis, Periklis Panagopoulos, Sofoklis Stavros, Ekaterini Domali
    Antioxidants, 2026
  • Artificial Intelligence in Recurrent Pregnancy Loss: Current Evidence, Limitations, and Future Directions
    Athanasios Zikopoulos, Efthalia Moustakli, Anastasios Potiris, Konstantinos Louis, Ioannis Arkoulis, Aikaterini Lydia Vogiatzoglou, Maria Tzeli, Nikolaos Kathopoulis, Panagiotis Christopoulos, Nikolaos Thomakos, Ekaterini Domali, Sofoklis Stavros
    Journal of Clinical Medicine, 2026
  • Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence
    Sofoklis Stavros, Nikolaos Thomakos, Efthalia Moustakli, Nikoleta Daponte, Dimos Sioutis, Nikolaos Kathopoulis, Athanasios Zikopoulos, Ismini Anagnostaki, Chrysi Christodoulaki, Themos Grigoriadis, Ekaterini Domali, Anastasios Potiris
    Cells, 2026
  • Endometrial Hyperplasia: Current Insights into Epidemiology, Risk Factors, and Clinical Management
    Apostolia Galani, Sofoklis Stavros, Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Ismini Anagnostaki, Konstantinos Zacharis, Maria Paraskevaidi, Deirdre Lyons, Stefania Maneta-Stavrakaki, Nikolaos Thomakos, Maria Kyrgiou, Ekaterini Domali
    Cancers, 2026
  • Beyond the Exome: The Role of Noncoding and Regulatory Variants in Monogenic Diseases
    Efthalia Moustakli, Nektaria Zagorianakou, Stylianos Makrydimas, Andreas Miltiadous, Alexandros T. Tzallas, George Makrydimas
    Current Issues in Molecular Biology, 2025
  • MicroRNAs Regulating Oxidative Stress in Human Fertility: A Narrative Review of Mechanistic Insights and Clinical Potential
    Ioanna Vassilaki, Anastasios Potiris, Ekaterini Domali, Theodoros Karampitsakos, Despoina Mavrogianni, Themos Grigoriadis, Athanasios Zikopoulos, Efthalia Moustakli, Argyro Papadopoulou, Ismini Anagnostaki, Eriketi Kokkosi, Nikolaos Thomakos, Sofoklis Stavros
    Medical Sciences, 2025
  • Reductive stress and the role of antioxidants in male infertility: a narrative review
    Efthalia Moustakli, Panagiotis Christopoulos, Anastasios Potiris, Athanasios Zikopoulos, Alkis Matsas, Ioannis Arkoulis, Despoina Mavrogianni, Eirini Drakaki, Athanasios Zachariou, Peter Drakakis, Sofoklis Stavros
    Archives of Gynecology and Obstetrics, 2025
  • Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men
    Athanasios Zachariou, Efthalia Moustakli, Athanasios Zikopoulos, Maria Filiponi, Anastasios Potiris, Nikolaos Kathopoulis, Themos Grigoriadis, Maria Tzeli, Nikolaos Machairiotis, Ekaterini Domali, Nikolaos Thomakos, Sofoklis Stavros
    Current Issues in Molecular Biology, 2025
  • Physical Activity During Pregnancy and Gestational Weight Gain: Implications for Maternal–Fetal Epigenetic Programming and Long-Term Health
    Nektaria Zagorianakou, Stylianos Makrydimas, Efthalia Moustakli, Ioannis Mitrogiannis, Ermanno Vitale, George Makrydimas
    Genes, 2025
  • Cervical Cancer Screening in the HPV-Vaccinated and Digital Era: Reassessing Strategies in Light of Artificial Intelligence and Evolving Risk
    Apostolia Galani, Athanasios Zikopoulos, Efthalia Moustakli, Anastasios Potiris, Maria Paraskevaidi, Ioannis Arkoulis, Pavlos Machairoudias, Stefania Maneta Stavrakaki, Maria Kyrgiou, Sofoklis Stavros
    Cancers, 2025
  • Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health
    Anastasios Potiris, Nikoletta Daponte, Efthalia Moustakli, Athanasios Zikopoulos, Eriketi Kokkosi, Nefeli Arkouli, Ismini Anagnostaki, Aikaterini Lydia Vogiatzoglou, Maria Tzeli, Angeliki Sarella, Ekaterini Domali, Sofoklis Stavros
    Toxics, 2025
  • Endocrine-Disrupting Chemicals and Male Infertility: Mechanisms, Risks, and Regulatory Challenges
    Sofoklis Stavros, Nikolaos Kathopoulis, Efthalia Moustakli, Anastasios Potiris, Ismini Anagnostaki, Spyridon Topis, Nefeli Arkouli, Konstantinos Louis, Charalampos Theofanakis, Themos Grigoriadis, Nikolaos Thomakos, Athanasios Zikopoulos
    Journal of Xenobiotics, 2025
  • Obesity and Pregnancy: Impact on Childbirth Timing, Delivery Mode, and Maternal Recovery: An Update
    Angeliki Gerede, Maria Danavasi, Sofoklis Stavros, Anastasios Potiris, Athanasios Zikopoulos, Efthalia Moustakli, Charikleia Skentou, Ekaterini Domali, Nikolaos Nikolettos, Makarios Eleftheriades
    Medical Sciences, 2025
  • Hyperemesis in Pregnancy: Complications and Treatment
    Angeliki Gerede, Sofoklis Stavros, Efthalia Moustakli, Anastasios Potiris, Ilias Orgianelis, et al.
    Medical Sciences, 2025
  • After the Shock: Impact of Ectopic Pregnancy on Subsequent Fertility and Parenthood
    Efthalia Moustakli, Ekaterini Domali, Anastasios Potiris, Angeliki Gerede, Ismini Anagnostaki, Athanasios Zikopoulos, Charalampos Theofanakis, Nikolaos Kathopoulis, Konstantinos Louis, Peter Drakakis, Sofoklis Stavros
    Biomedicines, 2025
  • The Gut–Endometriosis Axis: Genetic Mechanisms and Public Health Implications
    Efthalia Moustakli, Nektaria Zagorianakou, Stylianos Makrydimas, Emmanouil D. Oikonomou, Andreas Miltiadous, George Makrydimas
    Genes, 2025
  • Artificial Intelligence in Assessing Reproductive Aging: Role of Mitochondria, Oxidative Stress, and Telomere Biology
    Efthalia Moustakli, Themos Grigoriadis, Sofoklis Stavros, Anastasios Potiris, Athanasios Zikopoulos, Angeliki Gerede, Ioannis Tsimpoukis, Charikleia Papageorgiou, Konstantinos Louis, Ekaterini Domali
    Diagnostics, 2025
  • The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review
    Efthalia Moustakli, Themos Grigoriadis, Anastasios Potiris, Eirini Drakaki, Athanasios Zikopoulos, Ismini Anagnostaki, Athanasios Zachariou, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Life, 2025
  • Informed Consent in Perinatal Care: Challenges and Best Practices in Obstetric and Midwifery-Led Models
    Eriketi Kokkosi, Sofoklis Stavros, Efthalia Moustakli, Saraswathi Vedam, Anastasios Potiris, Despoina Mavrogianni, Nikolaos Antonakopoulos, Periklis Panagopoulos, Peter Drakakis, Kleanthi Gourounti, Maria Iliadou, Angeliki Sarella
    Nursing Reports, 2025
  • Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors
    Efthalia Moustakli, Anastasios Potiris, Themos Grigoriadis, Athanasios Zikopoulos, Eirini Drakaki, Ioanna Zouganeli, Charalampos Theofanakis, Angeliki Gerede, Athanasios Zachariou, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    International Journal of Molecular Sciences, 2025
  • Immunological Factors in Recurrent Pregnancy Loss: Mechanisms, Controversies, and Emerging Therapies
    Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Eirini Drakaki, Ioannis Arkoulis, Charikleia Skentou, Ioannis Tsakiridis, Themistoklis Dagklis, Peter Drakakis, Sofoklis Stavros
    Biology, 2025
  • Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders
    Efthalia Moustakli, Panagiotis Christopoulos, Anastasios Potiris, Athanasios Zikopoulos, Despoina Mavrogianni, Grigorios Karampas, Nikolaos Kathopoulis, Ismini Anagnostaki, Ekaterini Domali, Alexandros T. Tzallas, Peter Drakakis, Sofoklis Stavros
    Diagnostics, 2025
  • Scoping Review of Letrozole in Assisted Reproductive Cycles: Efficacy and Outcomes Across Infertility Causes
    Anastasios Potiris, Efthalia Moustakli, Fani Migka, Athanasios Zikopoulos, Chrysi Christodoulaki, Argyro Papadopoulou, Nikolaos Kathopoulis, Charalampos Theofanakis, Periklis Panagopoulos, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Healthcare Switzerland, 2025
  • Unraveling the Role of the microRNA-Mediated Regulation of Actin-Binding Proteins in Ovarian Cancer: A Narrative Review
    Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Apostolia Galani, Konstantinos Kechagias, Grigorios Karampas, Ismini Anagnostaki, Chrysi Christodoulaki, Angeliki Gerede, Panagiotis Christopoulos, Nikolaos Thomakos, Sofoklis Stavros
    Cancers, 2025
  • Sex Differences in Hypertension Risk: Insights from Placental Genomics and Pregnancy-Driven Vascular Programming
    Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Despoina Mavrogianni, Nikolaos Kathopoulis, Eirini Drakaki, Ismini Anagnostaki, Ioannis Tsakiridis, Themistoklis Dagklis, Charikleia Skentou, Peter Drakakis, Panagiotis Christopoulos, Sofoklis Stavros
    International Journal of Molecular Sciences, 2025
  • Reproductive Health and Assisted Conception in Celiac Disease and Non-Celiac Gluten Sensitivity: A Narrative Review
    Efthalia Moustakli, Panagiotis Christopoulos, Anastasios Potiris, Athanasios Zikopoulos, Eirini Drakaki, Theodoros Karampitsakos, Ismini Anagnostaki, Nikolaos Kathopoulis, Periklis Katopodis, Apostolia Galani, Chrysi Christodoulaki, Athanasios Zachariou, Peter Drakakis, Sofoklis Stavros
    Nutrients, 2025
  • Dietary and Lifestyle Interventions to Mitigate Oxidative Stress in Male and Female Fertility: Practical Insights for Infertility Management—A Narrative Review
    Efthalia Moustakli, Athanasios Zikopoulos, Periklis Katopodis, Stefanos Dafopoulos, Vasilis Sebastian Paraschos, Athanasios Zachariou, Konstantinos Dafopoulos
    Metabolites, 2025
  • Exploring the Impact of First Trimester Elevated Lipoprotein(a) Levels on Preeclampsia, Preterm Delivery, and Fetal Growth Restriction
    Apostolia Galani, Athanasios Zikopoulos, Anastasios Potiris, Efthalia Moustakli, Stefania Maneta-Stavrakaki, Maria Paraskevaidi, Charikleia Skentou, Konstantinos Zikopoulos, Peter Drakakis, Sofoklis Stavros
    Journal of Clinical Medicine, 2025
  • Gut Microbiome Dysbiosis and Its Impact on Reproductive Health: Mechanisms and Clinical Applications
    Efthalia Moustakli, Sofoklis Stavros, Periklis Katopodis, Anastasios Potiris, Peter Drakakis, Stefanos Dafopoulos, Athanasios Zachariou, Konstantinos Dafopoulos, Konstantinos Zikopoulos, Athanasios Zikopoulos
    Metabolites, 2025
  • Behind-the-Scenes Actors in Fertility: A Comprehensive Review of the Female Reproductive Tract Microbiome and Its Clinical Relevance
    Anthi Papakonstantinou, Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Ermioni Tsarna, Chrysi Christodoulaki, Ioannis Tsakiridis, Themistoklis Dagklis, Periklis Panagopoulos, Peter Drakakis, Sofoklis Stavros
    Life, 2025
  • Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency
    Efthalia Moustakli, Anastasios Potiris, Athanasios Zikopoulos, Athanasios Zachariou, Spyridon Topis, Periklis Panagopoulos, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Biomedicines, 2025
  • Long-Term Effects of COVID-19 on Women’s Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis
    Efthalia Moustakli, Sofoklis Stavros, Theologos M. Michaelidis, Anastasios Potiris, Chrysi Christodoulaki, Athanasios Zachariou, Peter Drakakis, Konstantinos Zikopoulos, Ekaterini Domali, Athanasios Zikopoulos
    Journal of Clinical Medicine, 2025
  • Exploring the Potential Impact of SERPINE Gene Expression in Cumulus Cells During Fertility Treatments: A Single Center Study
    Sofoklis Stavros, Anastasios Potiris, Despoina Mavrogianni, Efthalia Moustakli, Kyriaki Tsiorou, Athanasios Zikopoulos, Nikolaos Kathopoulis, Charalampos Theofanakis, Dimitrios Loutradis, Ekaterini Domali, Peter Drakakis
    Clinics and Practice, 2025
  • miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma
    Georgia Panagou, Anastasios Potiris, Dimitra Dedousi, Despoina Mavrogianni, Ioanna Vassilaki, Athanasios Zikopoulos, Efthalia Moustakli, Antonios Sfakianakis, Nikolaos Kathopoulis, Angeliki Gerede, Periklis Panagopoulos, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Current Issues in Molecular Biology, 2025
  • From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health
    Anastasios Potiris, Efthalia Moustakli, Eleni Trismpioti, Eirini Drakaki, Despoina Mavrogianni, Alkis Matsas, Athanasios Zikopoulos, Antonios Sfakianakis, Ioannis Tsakiridis, Themistoklis Dagklis, Athanasios Zachariou, Panagiotis Christopoulos, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Metabolites, 2025
  • Genetic Variations in Vascular Endothelial Growth Factor and Their Impact on Preeclampsia: Insights into Risk, Severity, and Pregnancy Outcomes
    Ioanna Zouganeli, Efthalia Moustakli, Anastasios Potiris, Chrysi Christodoulaki, Ioannis Arkoulis, Nikolaos Kathopoulis, Charalampos Theofanakis, Ekaterini Domali, Periklis Panagopoulos, Peter Drakakis, Sofoklis Stavros
    Current Issues in Molecular Biology, 2025
  • MicroRNAs in Preeclampsia: Bridging Diagnosis and Treatment
    Angeliki Gerede, Sofoklis Stavros, Maria Danavasi, Anastasios Potiris, Efthalia Moustakli, Nikolaos Machairiotis, Athanasios Zikopoulos, Konstantinos Nikolettos, Peter Drakakis, Nikolaos Nikolettos, Makarios Eleftheriades, Ekaterini Domali
    Journal of Clinical Medicine, 2025
  • Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review
    Anastasios Potiris, Sofoklis Stavros, Eleni Alyfanti, Nikolaos Machairiotis, Eirini Drakaki, Athanasios Zikopoulos, Efthalia Moustakli, Charikleia Skentou, Peter Drakakis, Ekaterini Domali
    Biomedicines, 2025
  • Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health
    Efthalia Moustakli, Sofoklis Stavros, Periklis Katopodis, Charikleia Skentou, Anastasios Potiris, Periklis Panagopoulos, Ekaterini Domali, Ioannis Arkoulis, Theodoros Karampitsakos, Eleftheria Sarafi, Theologos M. Michaelidis, Athanasios Zachariou, Athanasios Zikopoulos
    Cells, 2025
  • Reproductive Health in Women with Major β-Thalassemia: Evaluating Ovarian Reserve and Endocrine Complications
    Vasileios Tsilionis, Efthalia Moustakli, Stefanos Dafopoulos, Athanasios Zikopoulos, Sotirios Sotiriou, Athanasios Zachariou, Konstantinos Dafopoulos
    Metabolites, 2024
  • The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review
    Eirini Drakaki, Sofoklis Stavros, Dimitra Dedousi, Anastasios Potiris, Despoina Mavrogianni, Athanasios Zikopoulos, Efthalia Moustakli, Charikleia Skentou, Nikolaos Thomakos, Alexandros Rodolakis, Peter Drakakis, Ekaterini Domali
    Journal of Clinical Medicine, 2024
  • Impact of Reductive Stress on Human Infertility: Underlying Mechanisms and Perspectives
    Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou, Periklis Katopodis, Ekaterini Domali, Anastasios Potiris, Sofoklis Stavros, Athanasios Zachariou
    International Journal of Molecular Sciences, 2024
  • Comparative Analysis of Fluorescence In Situ Hybridization and Next-Generation Sequencing in Sperm Evaluation: Implications for Preimplantation Genetic Testing and Male Infertility
    Efthalia Moustakli, Antonios Gkountis, Stefanos Dafopoulos, Athanasios Zikopoulos, Sotirios Sotiriou, Athanasios Zachariou, Konstantinos Dafopoulos
    International Journal of Molecular Sciences, 2024
  • Oxidative Stress and Erectile Dysfunction: Pathophysiology, Impacts, and Potential Treatments
    Aris Kaltsas, Athanasios Zikopoulos, Fotios Dimitriadis, Danja Sheshi, Magdalena Politis, Efthalia Moustakli, Evangelos N. Symeonidis, Michael Chrisofos, Nikolaos Sofikitis, Athanasios Zachariou
    Current Issues in Molecular Biology, 2024
  • Bridging the Gap between Galectin-3 Expression and Hypertensive Pregnancy Disorders: A Narrative Review
    Anastasios Potiris, Alexandros Fotiou, Eirini Drakaki, Angeliki Potetsianaki, Athanasios Zikopoulos, Efthalia Moustakli, Theodoros Karampitsakos, Spyridon Topis, Pavlos Machairoudias, Stamatoula Ouzouni, Angeliki Gerede, Panagiotis Christopoulos, Charikleia Skentou, Ekaterini Domali, Peter Drakakis, Sofoklis Stavros
    Journal of Clinical Medicine, 2024
  • The Roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in Folliculogenesis and In Vitro Fertilization
    Serafeim Fountas, Efthymia Petinaki, Stamatis Bolaris, Magdalini Kargakou, Stefanos Dafopoulos, Athanasios Zikopoulos, Efthalia Moustakli, Sotirios Sotiriou, Konstantinos Dafopoulos
    Journal of Clinical Medicine, 2024
  • Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice
    Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou, Sofoklis Stavros, Nikolaos Sofikitis, Ioannis Georgiou, Athanasios Zachariou
    Journal of Clinical Medicine, 2024
  • The Expression of microRNAs and Their Involvement in Recurrent Pregnancy Loss
    Maria-Markella Patronia, Anastasios Potiris, Despoina Mavrogianni, Eirini Drakaki, Theodoros Karampitsakos, Pavlos Machairoudias, Spyridon Topis, Athanasios Zikopoulos, Dionysios Vrachnis, Efthalia Moustakli, Chara Skentou, Ekaterini Domali, Nikolaos Vrachnis, Peter Drakakis, Sofoklis Stavros
    Journal of Clinical Medicine, 2024
  • Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview
    Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou, Ioanna Bouba, Konstantinos Dafopoulos, Ioannis Georgiou
    Journal of Clinical Medicine, 2024
  • Association of Obesity with Telomere Length in Human Sperm
    Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou, Stefanos Dafopoulos, Sofoklis Stavros, Konstantinos Dafopoulos, Peter Drakakis, Ioannis Georgiou, Athanasios Zachariou
    Journal of Clinical Medicine, 2024
  • Exploring Hormone Therapy Effects on Reproduction and Health in Transgender Individuals
    Efthalia Moustakli, Orestis Tsonis
    Medicina Lithuania, 2023
  • Sperm Mitochondrial Content and Mitochondrial DNA to Nuclear DNA Ratio Are Associated with Body Mass Index and Progressive Motility
    Efthalia Moustakli, Athanasios Zikopoulos, Charikleia Skentou, Ioanna Bouba, Georgia Tsirka, Sofoklis Stavros, Dionysios Vrachnis, Nikolaos Vrachnis, Anastasios Potiris, Ioannis Georgiou, Athanasios Zachariou
    Biomedicines, 2023
  • The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress
    Aris Kaltsas, Athanasios Zikopoulos, Efthalia Moustakli, Athanasios Zachariou, Georgia Tsirka, Chara Tsiampali, Natalia Palapela, Nikolaos Sofikitis, Fotios Dimitriadis
    Antioxidants, 2023
  • COVID-19 and Male Infertility: Is There a Role for Antioxidants?
    Thomas Kalfas, Aris Kaltsas, Evangelos Symeonidis, Asterios Symeonidis, Athanasios Zikopoulos, Efthalia Moustakli, Chara Tsiampali, Georgios Tsampoukas, Natalia Palapela, Athanasios Zachariou, Nikolaos Sofikitis, Fotios Dimitriadis
    Antioxidants, 2023
  • The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age
    Georgia Tsirka, Athanasios Zikopoulos, Kyriaki Papageorgiou, Charilaos Kostoulas, Ioannis Tsigkas, Efthalia Moustakli, Aris Kaltsas, Eleftheria Sarafi, Theologos M. Michaelidis, Ioannis Georgiou
    Genes, 2023
  • Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring
    Aris Kaltsas, Efthalia Moustakli, Athanasios Zikopoulos, Ioannis Georgiou, Fotios Dimitriadis, Evangelos N. Symeonidis, Eleftheria Markou, Theologos M. Michaelidis, Dung Mai Ba Tien, Ioannis Giannakis, Eleni Maria Ioannidou, Athanasios Papatsoris, Panagiota Tsounapi, Atsushi Takenaka, Nikolaos Sofikitis, Athanasios Zachariou
    Genes, 2023
  • Functional association between telomeres, oxidation and mitochondria
    Efthalia Moustakli, Athanasios Zikopoulos, Prodromos Sakaloglou, Ioanna Bouba, Nikolaos Sofikitis, Ioannis Georgiou
    Frontiers in Reproductive Health, 2023

RECENT SCHOLAR PUBLICATIONS

  • The AHEPA EEG benchmark: setting the standard for machine learning in dementia diagnosis, a scoping review
    A Miltiadous, A Ntetska, V Aspiotis, E Moustakli, MG Tsipouras, AT Tzallas, ...
    Cognitive Neurodynamics 20 (1), 95 , 2026
    2026
  • Extracellular Vesicles in Human Reproduction: Integrating Redox–Mitochondrial Signaling with Multi-Omics and AI-Driven Biomarker Discovery
    S Stavros, A Gerede, E Moustakli, A Zikopoulos, I Tsakiridis, C Messini, ...
    Cells 15 (10), 955 , 2026
    2026
  • The Influence of Sexually Transmitted Bacteria and Human Papillomavirus on Sperm Parameters: Data from a Preliminary Study
    M Samara, E Thodou, C Messini, E Moustakli, M Anagnostou, ...
    Medicina 62 (5), 874 , 2026
    2026
  • The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review
    S Stavros, A Gerede, N Zagorianakou, E Moustakli, A Potiris, ...
    Microorganisms 14 (5), 1012 , 2026
    2026
  • Extracellular Matrix Remodeling and Matrix Metalloproteinases in Ovarian Function and Infertility
    E Moustakli, A Zikopoulos, P Katopodis, VS Paraschos, I Messinis, ...
    International journal of molecular sciences 27 (8), 3652 , 2026
    2026
  • Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure
    A Zikopoulos, E Moustakli, A Potiris, VS Paraschos, P Katopodis, ...
    Biomedicines 14 (4), 789 , 2026
    2026
  • Thrombocytopenia in Pregnancy: Clinical Challenges, Maternal–Fetal Risks, and Management Strategies
    S Stavros, N Kathopoulis, A Gerede, T Grigoriadis, E Moustakli, ...
    Life 16 (3), 462 , 2026
    2026
  • Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis
    A Zikopoulos, E Moustakli, P Katopodis, VS Paraschos, A Potiris, ...
    International journal of molecular sciences 27 (5), 2482 , 2026
    2026
  • Miscarriage and the Microbiome: Host Genetics, Immunity, and the Reproductive Tract Ecosystem
    N Zagorianakou, S Makrydimas, E Moustakli, I Mitrogiannis, ...
    Genes 17 (3), 259 , 2026
    2026
  • A deep learning approach for classifying benign, malignant, and borderline ovarian tumors using convolutional neural networks and generative adversarial networks
    M Giourga, I Petropoulos, S Stavros, A Potiris, K Goula, E Moustakli, ...
    Medical Sciences 14 (1), 89 , 2026
    2026
    Citations: 1
  • Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration
    A Zikopoulos, P Christopoulos, T Kalampokas, A Gerede, E Moustakli, ...
    Diagnostics 16 (4), 527 , 2026
    2026
    Citations: 2
  • The Impact of Endocrine-Disrupting Chemicals on Embryonic Recurrent Implantation Failure: A Narrative Review
    A Potiris, P Antsaklis, P Christopoulos, N Kathopoulis, E Moustakli, ...
    Journal of Xenobiotics 16 (1), 30 , 2026
    2026
    Citations: 1
  • The Gut–Extracellular Vesicle–Mitochondria Axis in Reproductive Aging: Antioxidant and Anti-Senescence Mechanisms
    E Moustakli, C Messini, A Potiris, A Zikopoulos, I Arkoulis, A Kozonis, ...
    Antioxidants 15 (2), 174 , 2026
    2026
    Citations: 2
  • Linking Oxidative Stress to Placental Dysfunction: The Key Role of Mitochondria in Trophoblast Function
    I Vasilaki, A Potiris, E Moustakli, D Mavrogianni, N Daponte, ...
    Medical Sciences 14 (1), 53 , 2026
    2026
    Citations: 1
  • Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence
    S Stavros, N Thomakos, E Moustakli, N Daponte, D Sioutis, N Kathopoulis, ...
    Cells 15 (2), 149 , 2026
    2026
  • Artificial Intelligence in Recurrent Pregnancy Loss: Current Evidence, Limitations, and Future Directions
    A Zikopoulos, E Moustakli, A Potiris, K Louis, I Arkoulis, AL Vogiatzoglou, ...
    Journal of Clinical Medicine 15 (2), 686 , 2026
    2026
    Citations: 1
  • A Preliminary Machine Learning Assessment of Oxidation-Reduction Potential and Classical Sperm Parameters as Predictors of Sperm DNA Fragmentation Index
    ED Oikonomou, E Moustakli, A Zikopoulos, S Dafopoulos, E Prapa, ...
    DNA 6 (1), 3 , 2026
    2026
    Citations: 1
  • Endometrial Hyperplasia: Current Insights into Epidemiology, Risk Factors, and Clinical Management
    A Galani, S Stavros, E Moustakli, A Potiris, A Zikopoulos, I Anagnostaki, ...
    Cancers 18 (1), 148 , 2025
    2025
    Citations: 2
  • Beyond the Exome: The Role of Noncoding and Regulatory Variants in Monogenic Diseases
    E Moustakli, N Zagorianakou, S Makrydimas, A Miltiadous, AT Tzallas, ...
    Current Issues in Molecular Biology 47 (12), 1038 , 2025
    2025
  • Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men
    A Zachariou, E Moustakli, A Zikopoulos, M Filiponi, A Potiris, ...
    Current Issues in Molecular Biology 47 (11), 930 , 2025
    2025
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Impact of advanced paternal age on fertility and risks of genetic disorders in offspring
    A Kaltsas, E Moustakli, A Zikopoulos, I Georgiou, F Dimitriadis, ...
    Genes 14 (2), 486 , 2023
    2023
    Citations: 157
  • The silent threat to women’s fertility: uncovering the devastating effects of oxidative stress
    A Kaltsas, A Zikopoulos, E Moustakli, A Zachariou, G Tsirka, C Tsiampali, ...
    Antioxidants 12 (8), 1490 , 2023
    2023
    Citations: 101
  • Oxidative stress and erectile dysfunction: pathophysiology, impacts, and potential treatments
    A Kaltsas, A Zikopoulos, F Dimitriadis, D Sheshi, M Politis, E Moustakli, ...
    Current Issues in Molecular Biology 46 (8), 8807-8834 , 2024
    2024
    Citations: 96
  • From inflammation to infertility: how oxidative stress and infections disrupt male reproductive health
    A Potiris, E Moustakli, E Trismpioti, E Drakaki, D Mavrogianni, A Matsas, ...
    Metabolites 15 (4), 267 , 2025
    2025
    Citations: 54
  • Oxidative stress and the NLRP3 inflammasome: focus on female fertility and reproductive health
    E Moustakli, S Stavros, P Katopodis, C Skentou, A Potiris, ...
    Cells 14 (1), 36 , 2025
    2025
    Citations: 42
  • The roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in folliculogenesis and in vitro fertilization
    S Fountas, E Petinaki, S Bolaris, M Kargakou, S Dafopoulos, A Zikopoulos, ...
    Journal of Clinical Medicine 13 (13), 3775 , 2024
    2024
    Citations: 40
  • Gut microbiome dysbiosis and its impact on reproductive health: mechanisms and clinical applications
    E Moustakli, S Stavros, P Katopodis, A Potiris, P Drakakis, S Dafopoulos, ...
    Metabolites 15 (6), 390 , 2025
    2025
    Citations: 36
  • Impact of reductive stress on human infertility: underlying mechanisms and perspectives
    E Moustakli, A Zikopoulos, C Skentou, P Katopodis, E Domali, A Potiris, ...
    International Journal of Molecular Sciences 25 (21), 11802 , 2024
    2024
    Citations: 32
  • Functional association between telomeres, oxidation and mitochondria
    E Moustakli, A Zikopoulos, P Sakaloglou, I Bouba, N Sofikitis, I Georgiou
    Frontiers in reproductive health 5, 1107215 , 2023
    2023
    Citations: 30
  • Exploring hormone therapy effects on reproduction and health in transgender individuals
    E Moustakli, O Tsonis
    Medicina 59 (12), 2094 , 2023
    2023
    Citations: 25
  • The expression of microRNAs and their involvement in recurrent pregnancy loss
    MM Patronia, A Potiris, D Mavrogianni, E Drakaki, T Karampitsakos, ...
    Journal of Clinical Medicine 13 (12), 3361 , 2024
    2024
    Citations: 23
  • Sperm mitochondrial content and mitochondrial DNA to nuclear DNA ratio are associated with body mass index and progressive motility
    E Moustakli, A Zikopoulos, C Skentou, I Bouba, G Tsirka, S Stavros, ...
    Biomedicines 11 (11), 3014 , 2023
    2023
    Citations: 22
  • Long-read sequencing and structural variant detection: unlocking the hidden genome in rare genetic disorders
    E Moustakli, P Christopoulos, A Potiris, A Zikopoulos, D Mavrogianni, ...
    Diagnostics 15 (14), 1803 , 2025
    2025
    Citations: 20
  • MicroRNAs in preeclampsia: bridging diagnosis and treatment
    A Gerede, S Stavros, M Danavasi, A Potiris, E Moustakli, N Machairiotis, ...
    Journal of Clinical Medicine 14 (6), 2003 , 2025
    2025
    Citations: 20
  • Evolution of minimally invasive and non-invasive preimplantation genetic testing: an overview
    E Moustakli, A Zikopoulos, C Skentou, I Bouba, K Dafopoulos, I Georgiou
    Journal of Clinical Medicine 13 (8), 2160 , 2024
    2024
    Citations: 19
  • Integrative assessment of seminal plasma biomarkers: A narrative review bridging the gap between infertility research and clinical practice
    E Moustakli, A Zikopoulos, C Skentou, S Stavros, N Sofikitis, I Georgiou, ...
    Journal of Clinical Medicine 13 (11), 3147 , 2024
    2024
    Citations: 17
  • Dietary and lifestyle interventions to mitigate oxidative stress in male and female fertility: practical insights for infertility management—a narrative review
    E Moustakli, A Zikopoulos, P Katopodis, S Dafopoulos, VS Paraschos, ...
    Metabolites 15 (6), 379 , 2025
    2025
    Citations: 16
  • Platelet-rich plasma (PRP) in reproductive medicine: a critical review of PRP therapy in low-reserve and premature ovarian insufficiency
    E Moustakli, A Potiris, A Zikopoulos, A Zachariou, S Topis, ...
    Biomedicines 13 (5), 1257 , 2025
    2025
    Citations: 15
  • Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health
    A Potiris, N Daponte, E Moustakli, A Zikopoulos, E Kokkosi, N Arkouli, ...
    Toxics 13 (10), 864 , 2025
    2025
    Citations: 13
  • Endocrine-Disrupting Chemicals and Male Infertility: Mechanisms, Risks, and Regulatory Challenges
    S Stavros, N Kathopoulis, E Moustakli, A Potiris, I Anagnostaki, S Topis, ...
    Journal of Xenobiotics 15 (5), 165 , 2025
    2025
    Citations: 12