Dr. Manik Chandra Shill has completed his PhD from Tokushima University, Japan. He worked in the development of anti-allergic lead(s) from Ayurvedic plants through the suppression of PKCδ dependent signaling pathway. Dr. Shill is expert in molecular pharmacology, toxicology and natural product chemistry. Before joining at North South University, Dr. Shill worked in pharmaceutical industry, market research and hospital to different capacities. Dr. Shill is highly experienced in hospital pharmacy with international training. Dr. Manik Chandra Shill is now working as Assistant Professor in the Department of Pharmaceutical Sciences. His research interests are pharmacology, toxicology, natural product chemistry, hospital and clinical pharmacy practices. Dr. Shill has published 65 pear reviewed journals.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Immunology and Allergy
54
Scopus Publications
Scopus Publications
Rice bran oil ameliorates the symptoms of benign prostatic hyperplasia in male Wistar rats Md Ashik Miah, Mafuja Akter Sathi, Md Golam Hasib, Muktadiur Rahman, Nabila Mahmud, et al. Avicenna Journal of Phytomedicine, 2026 Objective: Benign prostatic hyperplasia (BPH) is the proliferation of prostatic cells and the growth of the prostate gland in elderly men. Oils that are rich in free fatty acids have been reported to be potentially effective in treating BPH. In the present study, we investigated the effect of rice bran oil (RO) on the treatment of testosterone enanthate (TE)-induced experimental BPH in male Wistar rats. Materials and Methods: An animal model of BPH was established by subcutaneous administration of TE to Wistar rats for 28 days. RO was administered by oral gavage daily before TE/corn oil injection at a dose of 400 and 800 mg/kg body weight. All the rats were sacrificed at the end of the experiment and we measured prostate index (PI), histological changes, and activities of antioxidant enzymes. Moreover, we assessed the level of prostate-specific antigen (PSA) in the serum. Results: Our findings indicate that RO significantly inhibited the development of BPH in experimental rats, reduced PI (p<0.0001), decreased PSA in serum (p<0.01), increased antioxidant enzyme activities (Glutatione (GSH), super oxide dismutase (SOD), and catalase (CAT); p<0.0001), and decreased concentration of oxidative stress biomarkers advanced oxidation protein products (AOPP), and nitric oxide (NO) (p<0.0001) compared to positive controls. Hematoxylin & Eosin staining demonstrated that RO decreased pathological changes in the prostate of experimental animals. The treatment effect of RO was better exhibited in rats receiving RO at high dose. Conclusion: These results suggest that RO may be used as a therapeutic agent for BPH as oral administration of RO significantly halted the disease progression via anti-proliferative, antioxidant, and anti-inflammatory activity.
Optimized Lipid Nanoparticles for Pioglitazone Delivery: Molecular Docking Insights and In Vivo Efficacy in Nonalcoholic Steatohepatitis Shimul Halder, Tanveer Hossain, Najibah Nasrin, Rumman Reza, Md. Nazmus Samdani, Manik Chandra Shill, Jakir Ahmed Chowdhury, Md. Selim Reza Nano Life, 2026 Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with limited therapeutic options, where pioglitazone (PGZ), a PPAR-[Formula: see text] agonist, has shown promise but suffers from poor solubility and systemic side effects. In this study, we developed and optimized lipid nanoparticles (LNP-PGZ) to enhance the targeted delivery and therapeutic efficacy of PGZ for the treatment of NASH. The formulation was designed to improve solubility and stability, and was characterized through detailed physicochemical analyses, including particle size distribution and in vitro dissolution studies. The optimized LNP-PGZ exhibited a particle size of 56.7 nm, a PDI of 0.113, an EE% of 85% and a DL% of 8.5%. Moreover, the optimized LNP-PGZ exhibited a controlled drug-release profile compared with free PGZ, suggesting improved therapeutic potential. Molecular docking studies further supported the formulation’s effectiveness by demonstrating strong binding affinity of PGZ for key NASH-related targets, including PPAR-[Formula: see text] and STK25, highlighting its potential to modulate metabolic and inflammatory pathways. In vivo efficacy was evaluated in a rat model of NASH induced by a high-fat diet (HFD). Furthermore, LNP-PGZ significantly reduced liver damage in rats with HFD-induced hepatic injury, with 91.7% ([Formula: see text]) reduction in ALT and 86.8% ([Formula: see text]) in AST (Group IV) compared to the disease control (Group II). These findings collectively suggest that LNP-PGZ not only enhances its solubility and bioavailability but also amplifies its therapeutic benefits in NASH, potentially reducing off-target effects. This integrated approach, combining molecular modelling and in vivo validation, offers a promising platform for advancing safer, more effective treatments for liver diseases, such as NASH.
Swertia chirayita Ameliorates Acrylamide-Induced Hepatorenal Toxicities and Oxidative Damage Through Modulating Biomarkers and Proinflammatory Genes Rumky Rahman, Zasia Hossain Tishe, Sudip Saha, Hemayet Hossain, Murad Hossain, Preeti Jain, Hasan Mahmud Reza, Manik Chandra Shill Journal of Food Biochemistry, 2026 Background Acrylamide (ACR), used in various food industries, leads to a number of harmful effects, including nephrotoxicity and hepatotoxicity in humans. In this study, we aimed to explore the protective potential of Swertia chirayita against ACR‐induced hepatorenal toxicities and the underlying mechanism in rats. Method Liver and kidney damage was induced using ACR in the male Wistar rats. The ethanolic extract of S. chirayita was used to evaluate the protective effects by analyzing oxidative stress markers, proinflammatory gene expression, and histological changes. Results Experimental results showed that treatment with S. chirayita extract (250 mg/kg and 500 mg/kg) reduced the serum level of liver function markers AST, ALT, ALP, and kidney function markers creatinine and BUN in the ACR rats. Further analysis showed that S. chirayita notably normalized the aberrant level of oxidative stress markers NO, AOPP, and antioxidant enzymes SOD and GSH in the liver and kidney. ACR administration also increased the level of TNF‐α and IL‐1β in the liver and kidney of the ACR rats, which was downregulated by S. chirayita treatment. Histological data revealed that the morphology of the liver and kidney in ACR rats was irregular, and there was a significant accumulation of collagen. Treatment with S. chirayita markedly regularized these changes. Conclusion Our study suggests that the ethanolic extract of S. chirayita has the potential against ACR‐induced hepatorenal damage in rats by balancing oxidative stress and inflammatory response.
Biopharmaceutical characterization of Ajwain (Carum copticum) seed extract-loaded self-microemulsifying drug delivery system for enhanced hepatoprotective and nephroprotective activity Shimul Halder, Fatema-Tuz-Zohora, Tania Ahmed Chowdhury, Leon Bhowmik, Madhabi Lata Shuma, Harinarayan Das, Sulobh Sarkar, Md. Abdul Muhit, Manik Chandra Shill Scientific Reports, 2025 The increasing demand for plant-based therapies has highlighted the need for innovative delivery technologies to enhance the bioavailability of phytoconstituents. Ajwain (Carum copticum) is a medicinal plant recognized for its antioxidant, anti-inflammatory, and hepatoprotective attributes. Nevertheless, its therapeutic application is greatly affected by insufficient aqueous solubility and low absorption. Targeting the biopharmaceutical performance improvement of Ajwain seed extract (ASE) by integrating it into a self-microemulsifying drug delivery system (SMEDDS) was considered, along with assessing its protective effects. ASE underwent GC-MS analysis for phytochemical profiling, followed by solubility assessment in several oils, surfactants, and co-surfactants. The improved SMEDDS-ASE was characterized physicochemically for micelle formation potential, dispersibility, gastrointestinal stability, and polymer miscibility with ASE. The hepatorenal protective effects were evaluated in a rat model of acute hepatorenal injury generated by cisplatin (7.5 mg/kg, i.p.) through the assessment of serum biomarkers and histological analysis. SMEDDS-ASE exhibited the formation of tiny micelles with an average droplet size of 183 ± 5.8 nm in water, resulting in a dispersibility enhancement of at least 2.4 times compared to ASE in water. The treatment of SMEDDS-ASE (75 mg/kg and 150 mg/kg, p.o.) significantly reduces different serum biomarker levels (decreased ALT, AST, ALP; p < 0.01; reduced creatinine, BUN; p < 0.05), which is ascribed to improved hepatorenal protection in a dose-dependent manner compared to ASE. Histological examinations suggest that SMEDDS-ASE may initiate the protection of hepatic and renal cells against damage and inflammation, thereby offering benefits in preventing diseases associated with free radicals. These findings suggest that the prospective implementation of the SMEDDS-based method may effectively enhance ASE's nutraceutical properties.
Nanoliposomal Formulation of Gynura procumbens Leaf Extract Potentiates Hepatorenal Protection in Cisplatin-Induced Rats Leon Bhowmik, Ashikur Rahaman, Madhobi Karmakar, S. M. M. Sharif Nowaz Antu, Zahidul Islam Zahid, Madhabi Lata Shuma, Shazid Md. Sharker, Hasan Mahmud Reza, Shimul Halder, Manik Chandra Shill Food Science and Nutrition, 2025 Gynura procumbens, commonly known as longevity spinach, is traditionally used in Southeast Asia for its hepatoprotective, anti‐inflammatory, antihypertensive, and antihyperglycemic properties. This study aimed to enhance the hepatorenal protective effects of G. procumbens leaf extract (GLE) by incorporating it into a nanoliposomal drug delivery system (LIP), thereby improving its dispersibility/solubility and therapeutic efficacy. The resulting nano‐formulation, LIP–GLE, produced micelles with an average size of 112 ± 2.6 nm, showing a 6.6‐fold and 4.6‐fold improvement in dispersibility in water and simulated gastric fluid, respectively, compared to GLE. In a rat model of cisplatin‐induced acute hepatorenal injury (7.5 mg/kg, i.p.), oral administration of LIP–GLE (75 mg GLE/kg) significantly improved liver and kidney function, as indicated by reduced serum levels of ALT, AST, ALP, BUN, and creatinine. Histopathological investigations further confirmed reduced tissue damage in the liver and kidneys. Additionally, LIP–GLE enhanced antioxidant enzyme activities (SOD, GSH) and reduced oxidative stress markers (NO, AOPP), indicating strong protective effects against cisplatin‐induced oxidative injury. These findings demonstrate that liposomal encapsulation significantly enhances the bioavailability and therapeutic potential of GLE, making it a promising approach for enhancing the nutraceutical potential of G. procumbens.
Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats Manik Chandra Shill, Md. Faisal Bin Jalal, Madhabi Lata Shuma, Patricia Prova Mollick, Md. Abdul Muhit, Shimul Halder Plos One, 2025 Gynura procumbens, known as longevity spinach, is a plant traditionally used in tropical Asian countries for its anti-inflammatory, hepatoprotective, anti-hypertensive, and anti-hyperglycemic properties. The current study aimed to enhance the hepatorenal protective activity of Gynura procumbens leaf extract (GLE) by developing a self-microemulsifying drug delivery system (SMEDDS). SMEDDS-GLE exhibited the formation of small micelles with a mean droplet size of 231 nm. This resulted in a significant enhancement in the dispersion of GLE in water, as evidenced by a dispersibility that was at least 4.8 times greater than that of GLE alone. In the rat model of hepatic injury induced by cisplatin (7.5 mg/kg, i.p.), the administration of SMEDDS-GLE (75 mg-GLE/kg, p.o.) significantly reduced liver damage, observed by histological examination and reduced levels of plasma biomarkers associated with hepatic injury. Furthermore, according to histological examination findings and plasma biomarkers assessment, SMEDDS-GLE enhanced the nephroprotective benefits of GLE in the rat model of acute kidney injury. Based on these findings, a strategic application of the SMEDDS-based approach could be a viable choice to enhance GLE’s nutraceutical properties.
Improved Biopharmaceutical Performance of Coenzyme Q10 Through Solid Lipid Nanoparticles for Enhanced Brain Delivery Shimul Halder, Faria Nasrin, Manik Chandra Shill, Madhabi Lata Shuma, Md. Zakir Sultan, Md. Selim Reza Scientifica, 2025 Coenzyme Q10 (CoQ) is a powerful antioxidant with neuroprotective characteristics; nevertheless, its clinical use is constrained by inadequate solubility, diminished bioavailability, and limited blood–brain barrier (BBB) penetration. Solid lipid nanoparticles (SLNs) offer a promising approach to improve the biopharmaceutical characteristics and targeted delivery of CoQ to the brain. This study focuses on the strategic formulation and optimization of SLN‐CoQ to improve solubility, oral absorption, and BBB permeability. The SLNs with drug loading of 2.5% (w/w) were prepared using a solvent injection technique and physicochemically characterized employing encapsulation efficiency, drug loading, particle size, zeta potential, surface morphology, crystallinity, in vitro drug release behavior, and mucus penetrating behavior. Pharmacokinetic studies were conducted in rats (100 mg‐CoQ/kg, p.o.) after oral administration to elucidate the possible enhancement in the oral absorption of CoQ. The SLN‐CoQ (F2) exhibited favorable physicochemical characteristics, including optimal particle size (91.6 ± 8.2 nm), zeta potential (−41.7 ± 1.03 mV), high encapsulation efficiency (85.2 ± 5.0), distinct surface morphology, reduced crystallinity, enhanced drug release, and better mucus penetration than crystalline CoQ. In the dissolution test, SLN‐CoQ demonstrated a significant enhancement in the dissolution profile of CoQ as exhibited by an 83.6‐fold higher dissolved amount of CoQ in 120 min in water in the F2 formulation ratio. Moreover, in the artificial mucus test, a 42‐fold increase in mucus permeation was observed for the F2 formulation compared to the crystalline drug. Orally administered CoQ exhibited a higher systemic exposure of CoQ (3.6‐fold higher) in SLLN‐CoQ compared to crystalline CoQ, with prolonged circulation time and improved tissue distribution (3‐fold higher) in rats. The findings suggest that SLN‐CoQ offers a feasible nanotechnological method for enhanced drug transport to the brain, potentially aiding therapeutic approaches for neurodegenerative diseases, including Parkinson’s and Alzheimer’s.
Gigantol, a promising natural drug for inflammation: a literature review and computational based study Raihan Chowdhury, Shimul Bhuia, Asraful Islam Rakib, Sakib Al Hasan, Manik Chandra Shill, Heba A. S. El-Nashar, Mohamed El-Shazly, Muhammad Torequl Islam Natural Product Research, 2025 Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown a number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol’s promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits potential anti-inflammatory properties in pre-clinical pharmacological test systems. It effectively reduced the levels of pro-inflammatory markers and arachidonic acid metabolites through various pathways, such as NF-κB, AKT, PI3K, and JNK/cPLA2/12-LOX. The in-silico investigations demonstrated that the MMP-13 enzyme served as the most promising target for gigantol with highest binding affinity (docking score = −8.8 kcal/mol). Encouragingly, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis of gigantol confirmed its compatibility with the necessary physiochemical, pharmacokinetic, and toxicity properties, bolstering its potential as a drug candidate. Gigantol, with its well-documented anti-inflammatory properties, could be a promising agent for treating inflammation in the near future. Graphical Abstract
Health-promoting and medicinal properties of Zingiberaceae family plants: A minireview with a special focus on galangal, turmeric, cardamom, and ginger Maima Matin, Rajeev K. Singla, Artur Jóźwik, Jarosław Olav Horbańczuk, Natalia Ksepka, Kamil Wysocki, Thadiyan Parambil Ijinu, Neenthamadathil Mohandas Krishnakumar, Sreejith Pongillyathundiyil Sasidharan, Ifeoma C. Ezenyi, John Igoli, Fabio Fusi, Sara Frazzini, Luciana Rossi, Michel-Edwar Mickael, Abhishek Joshi, Olga Adamska, Artur Stolarczyk, Esra Capanoglu, Deniz Gunal-Koroglu, Shi-Hui Cheng, Omar M. Atrooz, Kiran Kharat, Ibrahim M. Abu-Reidah, Neeraj Rani, Atul Kabra, Ruchika Kabra, Dama Sreedhar Preethidan, Prathyusha Surendran, Emad Mohamed Abdallah, Seetha Harilal, Rajesh Kumar, Syed Abidullah, Hemanth Kumar Boyina, Vimal Arora, Prasanna Srinivasan Ramalingam, Sujatha Elangovan, Sivakumar Arumugam, Tanveer Alam, Edlira Aruci, Elena González-Burgos, Isabel Ureña-Vacas, Visitación López-Miranda, Esperanza Herradón, Rupesh Kumar Gautam, Rajat Goyal, Shah Alam Khan, Logesh Rajan, Joel Ojogbane Onoja, Sharad Vats, Akinleye Akinrinde, Smith B. Babiaka, Conrad V. Simoben, Doris E. Enow, Kennedy O. Abuga, Priti Talwar, Palaniyandi Ravanan, Reda El Boukhari, Ahmed Fatimi, Fabien Schultz, Ren-You Gan, Jean Noël Nyemb, Gaetan Bayiha Ba Njock, Constant Anatole Pieme, Goh Bey Hing, Ricardo Lagoa, Nikolay T. Tzvetkov, Farhan Bin Matin, Antonello Santini, Jaya Arora, Aswathy Chankaramkandath Vasu, Suraj Kadunganattil, Abeer Essam Noman, Luay M Alsubhi, Indra Lasmana Tarigan, Shafaat Yar Khan, Ali Zarrabi, Hefa Mangzira Kemung, Kavitha Raj Varadaraju, Tomasz M. Karpiński, Md. Mohaiminul Islam, Shaikh Jamal Uddin, Carmela Fimognari, Hari Prasad Devkota, Ivana Carev, Dongdong Wang, Kenneth Anchang Yongabi, Luther Bob Mbeku, Sohini Chakraborty, Sourav S. Patnaik, Shanmugam Thangapandiyan, Bikash Baral, Siva Sai Chandragiri, Eliana B. Souto, Gérard Lizard, Fatiha Brahmi, Farid Khallouki, Adil El Midaoui, Ronan Lordan, Anupam Bishayee, Meng-Yao Li, Monika Szymańska-Czerwińska, Krzysztof Niemczuk, Manik Chandra Shill, Michał Ławiński, Oleh Lushchak, Iwona Wojtasik-Kalinowska, Agnieszka Wierzbicka, Thomas Jakschitz, Mathew Dan, Imen Ghzaiel, Leila Rezig, Anne Vejux, Amira Zarrouk, Ahmad Ali, Andy Wai Kan Yeung, Günther K. Bonn, Bairong Shen, Atanas G. Atanasov Current Research in Biotechnology, 2025 Liste complète des auteurs cf. URL éditeur.
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential Muahmmad Ali Khan, Dina M. El‐Kersh, Md. Shafiqul Islam, Shams Ara Khan, Hossam Kamli, Chandan Sarkar, Md. Shimul Bhuia, Tawhida Islam, Manik Chandra Shill, Glenda C. Gobe, Eda Sönmez Gürer, William N. Setzer, Javad Sharifi‐Rad, Muhammad Torequl Islam Chemistry and Biodiversity, 2023
Anxiolytic-like effect of succinic acid: A possible GABAergic intervention Md. Nayem Mia, Shanita Zaman Smrity, Mehedi Hasan Bappi, Hossam Kamli, Tawhida Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor, Md. Abdul Latif, Shoriful Islam, Kushal Bhakta, Manik Chandra Shill, Francisco Claudeni Pereira de Sousa, Gilberto de Luna, Henrique Douglas Melo Coutinho, Muhammad Torequl Islam Food Bioscience, 2023
Pollutants of the Guaribas river water and their toxicogenic effects João M. C. e Sousa, Vitor A. de Oliveira, Ana P. Peron, Ataíde M. V. Lima, Ila B. S. Sales, Felipe C. C. da Silva, Leonardo H. G. M. Lima, Leomá A. Matos, Marcus V. O. B. de Alencar, Luzia C. Rodrigues, Manik C. Shill, Muhammad T. Islam, Ana Amélia C. Melo-Cavalcante, Cláudia C. Bonecker, Horácio F. J. Junior International Aquatic Research, 2019
A systematic review on the neuroprotective perspectives of beta-caryophyllene Keylla da Conceição Machado, Muhammad Torequl Islam, Eunüs S. Ali, Razina Rouf, Shaikh Jamal Uddin, Shrabanti Dev, Jamil A. Shilpi, Manik Chandra Shill, Hasan Mahmud Reza, Asish Kumar Das, Subrata Shaw, Mohammad S. Mubarak, Siddhartha Kumar Mishra, Ana Amelia de Carvalho Melo‐Cavalcante Phytotherapy Research, 2018
Phytol: A review of biomedical activities Muhammad Torequl Islam, Eunüs S. Ali, Shaikh J. Uddin, Subrata Shaw, Md Amirul Islam, Md Iqbal Ahmed, Manik Chandra Shill, Utpal Kumar Karmakar, Nagendra Sastry Yarla, Ishaq N. Khan, Md Morsaline Billah, Magdalena D. Pieczynska, Gokhan Zengin, Clemens Malainer, Ferdinando Nicoletti, Diana Gulei, Ioana Berindan-Neagoe, Apostol Apostolov, Maciej Banach, Andy W.K. Yeung, Amr El-Demerdash, Jianbo Xiao, Prasanta Dey, Santosh Yele, Artur Jóźwik, Nina Strzałkowska, Joanna Marchewka, Kannan R.R. Rengasamy, Jarosław Horbańczuk, Mohammad Amjad Kamal, Mohammad S. Mubarak, Siddhartha K. Mishra, Jamil A. Shilpi, Atanas G. Atanasov Food and Chemical Toxicology, 2018
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms Antonio Luiz Gomes, Jana Dimitrova Tchekalarova, Milena Atanasova, Keylla da Conceição Machado, Maria Alexsandra de Sousa Rios, Márcia Fernanda Correia Jardim Paz, Mihnea-Alexandru Găman, Amelia Maria Găman, Santosh Yele, Manik Chandra Shill, Ishaq N. Khan, Md. Amirul Islam, Eunüs S. Ali, Siddhartha K. Mishra, Muhammad Torequl Islam, Mohammad S. Mubarak, Luciano da Silva Lopes, Ana Amélia de Carvalho Melo-Cavalcante Biomedicine and Pharmacotherapy, 2018
Correlations between risk factors for breast cancer and genetic instability in cancer patients-A clinical perspective study Márcia Fernanda Correia Jardim Paz, Marcus Vinícius Oliveira Barros de Alencar, Antonio Luiz Gomes Junior, Keylla da Conceição Machado, Muhammad Torequl Islam, Eunus S. Ali, Manik Chandra Shill, Md. Iqbal Ahmed, Shaikh Jamal Uddin, Ana Maria Oliveira Ferreira da Mata, Ricardo Melo de Carvalho, Kátia da Conceição Machado, André Luiz Pinho Sobral, Felipe Cavalcanti Carneiro da Silva, João Marcelo de Castro e Souza, Daniel Dias Rufino Arcanjo, Paulo Michel Pinheiro Ferreira, Siddhartha Kumar Mishra, Juliana da Silva, Ana Amélia de Carvalho Melo-Cavalcante Frontiers in Genetics, 2018
Medication practices in Bangladesh-roles of pharmacists at current circumstances International Journal of Pharmacy and Pharmaceutical Sciences, 2011
Investigation of antibacterial activities of ethanol extracts of musa paradisiaca lam Journal of Applied Pharmaceutical Science, 2011
Assessment of cytotoxicity, antibacterial activity and phytochemical screening of ethanol extract of phyllanthus acidus l. (family: Euphorbiacceae) bark Journal of Applied Pharmaceutical Science, 2011
Antidiarrheal, analgesic and antioxidant activities of Trapa bispinosa Roxb. fruits Research Journal of Pharmacy and Technology, 2011
