Manik Chandra Shill
@northsouth.edu
Associate Professor, Department of Pharmaceutical Sciences
Dr. Manik Chandra Shill has completed his PhD from Tokushima University, Japan. He worked in the development of anti-allergic lead(s) from Ayurvedic plants through the suppression of PKCδ dependent signaling pathway. Dr. Shill is expert in molecular pharmacology, toxicology and natural product chemistry. Before joining at North South University, Dr. Shill worked in pharmaceutical industry, market research and hospital to different capacities. Dr. Shill is highly experienced in hospital pharmacy with international training. Dr. Manik Chandra Shill is now working as Assistant Professor in the Department of Pharmaceutical Sciences. His research interests are pharmacology, toxicology, natural product chemistry, hospital and clinical pharmacy practices. Dr. Shill has published 65 pear reviewed journals.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Immunology and Allergy
Scopus Publications
Scopus Publications
Shimul Halder, Fatema-Tuz-Zohora, Tania Ahmed Chowdhury, Leon Bhowmik, Madhabi Lata Shuma, Harinarayan Das, Sulobh Sarkar, Md. Abdul Muhit, and Manik Chandra Shill
Springer Science and Business Media LLC
Leon Bhowmik, Ashikur Rahaman, Madhobi Karmakar, S. M. M. Sharif Nowaz Antu, Zahidul Islam Zahid, Madhabi Lata Shuma, Shazid Md. Sharker, Hasan Mahmud Reza, Shimul Halder, and Manik Chandra Shill
Wiley
ABSTRACTGynura procumbens, commonly known as longevity spinach, is traditionally used in Southeast Asia for its hepatoprotective, anti‐inflammatory, antihypertensive, and antihyperglycemic properties. This study aimed to enhance the hepatorenal protective effects of G. procumbens leaf extract (GLE) by incorporating it into a nanoliposomal drug delivery system (LIP), thereby improving its dispersibility/solubility and therapeutic efficacy. The resulting nano‐formulation, LIP–GLE, produced micelles with an average size of 112 ± 2.6 nm, showing a 6.6‐fold and 4.6‐fold improvement in dispersibility in water and simulated gastric fluid, respectively, compared to GLE. In a rat model of cisplatin‐induced acute hepatorenal injury (7.5 mg/kg, i.p.), oral administration of LIP–GLE (75 mg GLE/kg) significantly improved liver and kidney function, as indicated by reduced serum levels of ALT, AST, ALP, BUN, and creatinine. Histopathological investigations further confirmed reduced tissue damage in the liver and kidneys. Additionally, LIP–GLE enhanced antioxidant enzyme activities (SOD, GSH) and reduced oxidative stress markers (NO, AOPP), indicating strong protective effects against cisplatin‐induced oxidative injury. These findings demonstrate that liposomal encapsulation significantly enhances the bioavailability and therapeutic potential of GLE, making it a promising approach for enhancing the nutraceutical potential of G. procumbens.
Astrid Mukta Biswas, Tushar Emran, Sabrin Islam Khan, Sadia Shabnam, Preeti Jain, Asim Kumar Bepari, Manik Chandra Shill, Md Murad Hossain, and Hasan Mahmud Reza
Elsevier BV
Manik Chandra Shill, Md. Faisal Bin Jalal, Madhabi Lata Shuma, Patricia Prova Mollick, Md. Abdul Muhit, and Shimul Halder
Public Library of Science (PLoS)
Gynura procumbens, known as longevity spinach, is a plant traditionally used in tropical Asian countries for its anti-inflammatory, hepatoprotective, anti-hypertensive, and anti-hyperglycemic properties. The current study aimed to enhance the hepatorenal protective activity of Gynura procumbens leaf extract (GLE) by developing a self-microemulsifying drug delivery system (SMEDDS). SMEDDS-GLE exhibited the formation of small micelles with a mean droplet size of 231 nm. This resulted in a significant enhancement in the dispersion of GLE in water, as evidenced by a dispersibility that was at least 4.8 times greater than that of GLE alone. In the rat model of hepatic injury induced by cisplatin (7.5 mg/kg, i.p.), the administration of SMEDDS-GLE (75 mg-GLE/kg, p.o.) significantly reduced liver damage, observed by histological examination and reduced levels of plasma biomarkers associated with hepatic injury. Furthermore, according to histological examination findings and plasma biomarkers assessment, SMEDDS-GLE enhanced the nephroprotective benefits of GLE in the rat model of acute kidney injury. Based on these findings, a strategic application of the SMEDDS-based approach could be a viable choice to enhance GLE’s nutraceutical properties.
Shimul Halder, Faria Nasrin, Manik Chandra Shill, Madhabi Lata Shuma, Md. Zakir Sultan, and Md. Selim Reza
Wiley
Coenzyme Q10 (CoQ) is a powerful antioxidant with neuroprotective characteristics; nevertheless, its clinical use is constrained by inadequate solubility, diminished bioavailability, and limited blood–brain barrier (BBB) penetration. Solid lipid nanoparticles (SLNs) offer a promising approach to improve the biopharmaceutical characteristics and targeted delivery of CoQ to the brain. This study focuses on the strategic formulation and optimization of SLN‐CoQ to improve solubility, oral absorption, and BBB permeability. The SLNs with drug loading of 2.5% (w/w) were prepared using a solvent injection technique and physicochemically characterized employing encapsulation efficiency, drug loading, particle size, zeta potential, surface morphology, crystallinity, in vitro drug release behavior, and mucus penetrating behavior. Pharmacokinetic studies were conducted in rats (100 mg‐CoQ/kg, p.o.) after oral administration to elucidate the possible enhancement in the oral absorption of CoQ. The SLN‐CoQ (F2) exhibited favorable physicochemical characteristics, including optimal particle size (91.6 ± 8.2 nm), zeta potential (−41.7 ± 1.03 mV), high encapsulation efficiency (85.2 ± 5.0), distinct surface morphology, reduced crystallinity, enhanced drug release, and better mucus penetration than crystalline CoQ. In the dissolution test, SLN‐CoQ demonstrated a significant enhancement in the dissolution profile of CoQ as exhibited by an 83.6‐fold higher dissolved amount of CoQ in 120 min in water in the F2 formulation ratio. Moreover, in the artificial mucus test, a 42‐fold increase in mucus permeation was observed for the F2 formulation compared to the crystalline drug. Orally administered CoQ exhibited a higher systemic exposure of CoQ (3.6‐fold higher) in SLLN‐CoQ compared to crystalline CoQ, with prolonged circulation time and improved tissue distribution (3‐fold higher) in rats. The findings suggest that SLN‐CoQ offers a feasible nanotechnological method for enhanced drug transport to the brain, potentially aiding therapeutic approaches for neurodegenerative diseases, including Parkinson’s and Alzheimer’s.
Raihan Chowdhury, Shimul Bhuia, Asraful Islam Rakib, Sakib Al Hasan, Manik Chandra Shill, Heba A. S. El-Nashar, Mohamed El-Shazly, and Muhammad Torequl Islam
Informa UK Limited
Abstract Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown a number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol’s promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits potential anti-inflammatory properties in pre-clinical pharmacological test systems. It effectively reduced the levels of pro-inflammatory markers and arachidonic acid metabolites through various pathways, such as NF-κB, AKT, PI3K, and JNK/cPLA2/12-LOX. The in-silico investigations demonstrated that the MMP-13 enzyme served as the most promising target for gigantol with highest binding affinity (docking score = −8.8 kcal/mol). Encouragingly, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis of gigantol confirmed its compatibility with the necessary physiochemical, pharmacokinetic, and toxicity properties, bolstering its potential as a drug candidate. Gigantol, with its well-documented anti-inflammatory properties, could be a promising agent for treating inflammation in the near future. Graphical Abstract
Maima Matin, Rajeev K. Singla, Artur Jóźwik, Jarosław Olav Horbańczuk, Natalia Ksepka, Kamil Wysocki, Thadiyan Parambil Ijinu, Neenthamadathil Mohandas Krishnakumar, Sreejith Pongillyathundiyil Sasidharan, Ifeoma C. Ezenyi,et al.
Elsevier BV
Md. Showkoth Akbor, Mst. Farjanamul Haque, Ahmmed Zunaed Rahman, Manik Chandra Shill, Hossam Kamli, Catarina Martins Tahim, Ivo Cavalcante Pita Neto, Henrique D.M. Coutinho, and Muhammad Torequl Islam
Elsevier BV
Rashed Imtiaz, Protyaee Saha, Esfat M. Saim Brishty, Sadia Kamal, Manik Chandra Shill, Hasan Mahmud Reza, and Preeti Jain
Oman Medical Journal
Objectives: Antibiotic resistance in clinical isolates is often correlated to poor disease management or prolonged hospitalization. The study aimed to determine the prevalence of multidrug-resistant (MDR) Salmonella isolates in clinical samples collected from Dhaka, Bangladesh. Methods: We investigated 150 clinical samples for the presence of Salmonella. The Salmonella isolates were tested against 12 antibiotics categorizable into three groups based on action mechanism and nine classes based on chemical structure. The susceptibility patterns were analyzed using the Kirby-Bauer disk diffusion method on Mueller Hinton agar. The isolates were classified as MDR and extensively drug-resistant based on their resistance patterns against different antibiotics. Results: We used 100 Salmonella isolates for this study. The highest prevalence of resistance was observed against penicillin G (96.0%), cefuroxime (75.0%), and clindamycin (71.0%). The isolates exhibited 33.0% and 43.0% resistance against imipenem and meropenem, respectively. Almost all (98.0%) isolates showed MDR. A quarter of the isolates (23.0%) were resistant to five classes of antibiotics and 18.0% to six classes of antibiotics. Moreover, 20.0% of isolates exhibited extensive drug resistance. Among the cell wall synthesis inhibitors, the highest resistance was observed against penicillin G (31.0%). Resistance rates were in the range 20–30% against protein synthesis inhibitors, clindamycin (29.0%), tetracycline (21.0%), and chloramphenicol (21.0%). Among the Salmonella isolates, 90.0% showed multiple antibiotic resistance index scores of ≥ 0.3, while 65.0% scored ≥ 0.5. The carbapenem group accounted for the maximum sensitivity (62.0%), followed by 60.0% each for gentamicin and norfloxacin. Conclusions: The high prevalence of MDR Salmonella isolates in clinical samples from Bangladesh indicates a serious threat to public health. Our findings emphasize the urgent need to control MDR through promoting responsible use of suitable antibiotics and public awareness of the dangers of antibiotic misuse, increasing testing facilities, and promoting genetic research.
Leon Bhowmik, Md Kutubul Hasan, Tahmina Akter Bristy, Sadia Tasnim Etu, Reatul Karim, Md Shaki Mostaid, Manik Chandra Shill, and Hasan Mahmud Reza
Elsevier BV
Anika Tabassum Shama, Luluin Maknun Shova, Anika Tabassum Bristy, Tushar Emran, Sadia Shabnam, Manik Chandra Shill, Asim Kumar Bepari, and Hasan Mahmud Reza
Elsevier BV
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill, Afsana Kabir Chowdhury, Henrique Douglas Melo Coutinho, Davi Antas e Silva, António Raposo, and Muhammad Torequl Islam
Wiley
AbstractFerulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate the hepatoprotective effect of FA and its derivatives (methyl ferulic acid and trans‐ferulic acid) against oxidative stress and inflammation‐related hepatotoxicity due to toxicants based on the results of different non‐clinical and preclinical tests. For this, data was collected from different reliable electronic databases such as PubMed, Google Scholar, and ScienceDirect, etc. The results of this investigation demonstrated that FA and its derivatives have potent hepatoprotective effects against oxidative stress and inflammation‐related damage. The findings also revealed that these protective effects are due to the antioxidant and anti‐inflammatory effects of the chemical compound. FA and its analogues significantly inhibit free radical generation and hinder the effects of proinflammatory markers and inflammatory enzymes, resulting in diminished cytotoxic and apoptotic hepatocyte death. The compounds also prevent intracellular lipid accumulation and provide protective effects.
Manik Chandra Shill, Heba A. S. El‐Nashar, Patricia Prova Mollick, Rabindra Nath Acharyya, Silvia Afrin, Hemayet Hossain, Shimul Halder, Muhammad Torequl Islam, Md. Shimul Bhuia, Hasan Mahmud Reza,et al.
Wiley
AbstractThis study focused to assess the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect polyphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5 mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150 mg/kg, P.O.) for 7 consecutive days. Although GP extract significantly ameliorated CP‐mediated hepatorenal biomarkers like alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and blood urea nitrogen (BUN) levels in a dose‐dependent manner, GP extract at 150 mg/kg dose normalized hepatorenal biomarkers ALP (45.11 U/L), ALT (34 U/L), AST (29 U/L), creatinine (10.3 mg/dl) and BUN (11.19 mg/dl) while comparing to control and disease group. Similarly, though it significantly reduced CP‐induced oxidative stress inducers, including nitric oxide (NO) and advanced oxidative protein products (AOPP), higher dose (150 mg/kg) exhibited better activity in reducing NO (281.54 mmol/gm tissue in liver and 52.73 mmol/gm tissue in the kidney) and AOPP (770.95 mmol/mg protein in liver and 651.90 mmol/mg protein in the kidney). Besides, it showed better enhancement in the antioxidant enzymes superoxide dismutase, and glutathione levels at a higher dose (150 mg/kg). Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.
Mohammad Jakir Hosen, Rahatul Islam, Manik Chandra Shill, Muhammad Torequl Islam, Mohamed El-Shazly, and Heba A. S. El-Nashar
Informa UK Limited
Abstract Plant pathogenic nematodes pose a significant threat to banana production, causing symptoms such as root lesions, stunted growth, and reduced yield. A comprehensive study in Bangladesh’s Sylhet district aimed to assess nematode infestations in banana fields, involving interviews with farmers, soil sample collection, and microscopic examination. Results revealed the presence of multiple nematode species, with Helicotylenchus spp. being the most abundant. PCR analysis confirmed R. similis infestation in 35% of fields, highlighting its prevalence. Monoculture practices were observed among farmers, exacerbating nematode infestation risks. Limited communication between farmers and agricultural offices contributes to unawareness of nematode infestations. Country-wide studies and improved communication are crucial for implementing effective nematode mitigation strategies and safeguarding banana yield.
Shimul Halder, Sanjida Afrose, Manik Chandra Shill, Nahid Sharmin, Patricia Prova Mollick, Madhabi Lata Shuma, Md. Abdul Muhit, and S. M. Abdur Rahman
Informa UK Limited
Abstract The present study was designed to develop a self-micellizing solid dispersion (SMSD) containing Thymoquinone (TQM), a phytonutrient obtained from Nigella sativa seeds, aiming to improve its biopharmaceutical and nephroprotective functions. The apparent solubility of TQM in polymer solutions was used to choose an appropriate amphiphilic polymer that could be used to make an SMSD system. Based on the apparent solubility, Soluplus® was selected as an appropriate carrier, and mixing with TQM, SMSD-TQM with different loadings of TQM (5–15%) was made by solvent evaporation and freeze-drying techniques, respectively, and the formulations were optimized. The optimized SMSD-TQM was evaluated in terms of particle size distribution, morphology, release characteristics, pharmacokinetic behavior, and nephroprotective effects in a rat model of acute kidney injury. SMSD-TQM significantly improved the dissolution characteristics (97.8%) of TQM in water within 60 min. Oral administration of SMSD-TQM in rats exhibited a 4.9-fold higher systemic exposure than crystalline TQM. In a cisplatin-induced (6 mg/kg, i.p.) acute kidney-damaged rat model, oral SMSD-TQM (10 mg/kg) improved the nephroprotective effects of TQM based on the results of kidney biomarkers and histological abnormalities. These findings suggest that SMSD-TQM might be efficacious in enhancing the nephroprotective effect of TQM by overcoming biopharmaceutical limitations.
Muhammad Torequl Islam, Mehedi Hasan Bappi, Md Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Manik Chanda Shill, Tala Albayouk, Na’il Saleh, Mohamed El-Shazly, and Heba A. S. El-Nashar
Frontiers Media SA
Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate the anti-inflammatory effects and possible molecular mechanisms of THY via formalin-induced mouse and egg albumin-induced chick models alongside molecular docking and molecular dynamic (MD) simulations. THY (7.5, 15, and 30 mg/kg) was investigated, compared to celecoxib and ketoprofen (42 mg/kg), as anti-inflammatory standards. THY dose-dependently and significantly (p < 0.05) decreased paw-licking and edema diameter parameters in formalin (phases I and II) and egg albumin-induced models. Moreover, THY (15 mg/kg) exerted better anti-inflammatory effects in combination with the standard drug ketoprofen than alone and with celecoxib. In silico studies demonstrated elevated binding affinities of THY with cyclooxygenase-2 (COX-2) than the COX-1 enzyme, and the ligand binds at a similar location where ketoprofen and celecoxib interact. The results of MD simulations confirmed the stability of the test ligand. THY exerted anti-inflammatory effects on Swiss mice and young chicks, possibly by interacting with COX-2. As a conclusion, THY might be a hopeful drug candidate for the management of inflammatory disorders.
Sabrin I. Khan, Reatul Karim, Shahriar I. Khan, Mohiuddin A. K. Chowdhury, Manik C. Shill, Faisal M. Pasha, Md. H. Shohag, Ferdous Khan, Md. A. Islam, Ariful I. Mitul,et al.
Informa UK Limited
Abstract Objective Traumatic brain injury (TBI) proves to be an obstacle for Bangladeshi patients due to the lack of facilities and specialist doctors in regional sections of the country. This study aimed to record different attributes of Bangladeshi TBI patients over a year i.e., their injury characteristics, treatments received and understand their impacts on the severity of TBI. Method This cross-sectional study was carried out among 280 TBI patients treated in a tertiary care hospital in Dhaka. The physicians determined TBI's severity and prognosis as per the Glasgow Coma Scale (GCS) and Glasgow Outcome Score (GOS) respectively. Results Most TBI patients were male (76.1%) and aged between 18 and 50 years (52.2%), as in previous studies in South Asian countries. However, the prevalence of TBI due to road traffic accidents (RTAs) was much higher (67.9%) than in the earlier studies in South Asia. Additionally, more patients suffered from severe TBI (29.3%) and moderate TBI (35.7%), and a higher percentage of patients went through surgery (56.8%) compared to previous studies. A significant association of demographic (residence) and clinical characteristics (consciousness after injury, CT scan findings and treatment type) with the severity of TBI was found in bivariate analysis. It also revealed the significant dependence of clinical characteristics (TBI etiology, post-injury consciousness, treatment type and TBI severity) on TBI prognosis. Multivariate analysis showed that patients who were unconscious after TBI and with evident brain injury observed in CT scans have a substantially higher risk of having moderate or severe TBI than mild TBI. Moreover, patients with TBI due to RTAs or falls, evident brain injury in CT scans, post-surgical seizure, and moderate or severe TBI have a significantly higher risk of getting a more unfavorable TBI prognosis than moderate disability. Conclusions In this study, RTAs were found to be the major cause of TBI. Additionally, some variables were identified as possible determinants of TBI severity and prognosis among Bangladeshi patients. The correlation of these variables with TBI should be further studied with the hopes that steps will be taken to reduce TBI incidents and improve its management to reduce the overall burden.
Manik Chandra Shill, Abdullah All Rakib, Sabrin Islam Khan, Murad Hossain, Shaiful Alam, Hemayet Hossain, Utpal Kumar Karmakar, Md. Shimul Bhuia, Masum Shahriar, Hasan Mahmud Reza,et al.
Hindawi Limited
Background. Diabetes is a rising disorder that affects millions of people annually. It also creates more complications, such as neuropathy, oxidative stress, and hepatic and kidney impairment. Aphanamixis polystachya plant, which possesses multiple medicinal values, is used in this study to explore its potential in treating diabetes. Methods. A single dose (65 mg/kg) of intraperitoneal streptozotocin injection was utilized to mediate diabetes in Sprague-Dawley rats. Diabetic animals were treated orally with 250 or 500 mg/kg of standardized leaves’ extract of A. polystachya (AP) for 28 days to evaluate the antidiabetic and organ-protective effects of the plant. Different biochemical and histological markers are measured according to the established protocol. Results. Our results demonstrated a significant decrease in blood glucose (p <0.001) and HbA1c (p <0.05) levels in the diabetic animal after administering AP (250 and 500 mg/kg doses) compared to the control groups. AP can also regularize lipids, glycogen, alanine aminotransferase, and aspartate aminotransferase. Furthermore, serum urea nitrogen and creatinine decreased after treatment with AP in diabetic rats. AP also reduced oxidative stress markers and showed a substantial elevation in antioxidant enzymes in diabetic animals. Overall, AP at 500 mg/kg revealed comparable results against the standard antidiabetic drug glyburide. Besides, the histological investigation showed the AP’s efficacy in attenuating kidney tissue inflammation and damage. HPLC data elucidated that the AP leaf extract contains polyphenols with potential antioxidant, antidiabetic, and organ protective agents: gallic acid, rutin hydrate, and quercetin hydrate. Conclusion. Taken together, AP may be one of the potential sources of antidiabetic agents.
Muahmmad Ali Khan, Dina M. El‐Kersh, Md. Shafiqul Islam, Shams Ara Khan, Hossam Kamli, Chandan Sarkar, Md. Shimul Bhuia, Tawhida Islam, Manik Chandra Shill, Glenda C. Gobe,et al.
Wiley
AbstractMikania micranthais utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities ofM. micranthabased on obtainable information screened from different databases. An up‐to‐date search was performed onM. micranthain PubMed, Science Direct, clinicaltrials.gov, and Google Scholar databases with specific keywords. No language restrictions were imposed. Published articles, theses, seminar/conference papers, abstracts, and books on ethnobotany, phytochemistry and pharmacological evidence were considered. Based on the inclusion criteria, this study includes 53 published records from the above‐mentioned databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals.M. micranthapossesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date.M. micranthamight be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.
Manik Chandra Shill, Bisshojit Biswas, Sadia Kamal, Moriam Islam, Sharmin Sultana Rima, Farhana Afrin Ferdausi, Qamruzzaman Chowdhury, Hasan Mahmud Reza, and Asim Kumar Bepari
Elsevier BV
Md. Nayem Mia, Shanita Zaman Smrity, Mehedi Hasan Bappi, Hossam Kamli, Tawhida Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor, Md. Abdul Latif, Shoriful Islam, Kushal Bhakta,et al.
Elsevier BV
Murad Hossain, Tamanna Tanjim Suchi, Farzana Samiha, M.M. Monirul Islam, Fahima Abdullah Tully, Javed Hasan, Md Ashrafur Rahman, Manik Chandra Shill, Asim Kumar Bepari, G.M. Sayedur Rahman,et al.
Elsevier BV
Manik Chandra Shill, Md Nurul Absar Bin Mohsin, Usha Showdagor, Sharif Nahid Hasan, Md Zahidul Islam Zahid, Sabrin Islam Khan, Murad Hossain, Ghazi Mohammad Sayedur Rahman, and Hasan Mahmud Reza
Elsevier BV
Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M. El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md. Moniruzzaman, Mala Khan,et al.
Elsevier BV
Md. Ashrafur Rahman, Arif Anzum Shuvo, Asim Kumar Bepari, Mehedi Hasan Apu, Manik Chandra Shill, Murad Hossain, Mohammed Uddin, Md. Rabiul Islam, Monjurul Kader Bakshi, Javed Hasan,et al.
Public Library of Science (PLoS)
Aging-induced memory impairment is closely associated with oxidative stress. D-Galactose (D-gal) evokes severe oxidative stress and mimics normal aging in animals. Curcumin, a natural flavonoid, has potent antioxidant and anti-aging properties. There are several proteins like glutathione S-transferase A1 (GSTA1), glutathione S-transferase omega-1 (GSTO1), kelch-like ECH-associated protein 1 (KEAP1), beta-secretase 1 (BACE1), and amine oxidase [flavin-containing] A (MAOA) are commonly involved in oxidative stress and aging. This study aimed to investigate the interaction of curcumin to these proteins and their subsequent effect on aging-associated memory impairment in two robust animal models: D-Gal and normal aged (NA) mice. The aging mice model was developed by administering D-gal intraperitoneally (i.p). Mice (n = 64) were divided into the eight groups (8 mice in each group): Vehicle, Curcumin-Control, D-gal (100mg/kg; i.p), Curcumin + D-gal, Astaxanthin (Ast) + D-gal, Normal Aged (NA), Curcumin (30mg/kg Orally) + NA, Ast (20mg/kg Orally) + NA. Retention and freezing memories were assessed by passive avoidance (PA) and contextual fear conditioning (CFC). Molecular docking was performed to predict curcumin binding with potential molecular targets. Curcumin significantly increased retention time (p < 0.05) and freezing response (p < 0.05) in PA and CFC, respectively. Curcumin profoundly ameliorated the levels of glutathione, superoxide dismutase, catalase, advanced oxidation protein products, nitric oxide, and lipid peroxidation in mice hippocampi. In silico studies revealed favorable binding energies of curcumin with GSTA1, GSTO1, KEAP1, BACE1, and MAOA. Curcumin improves retention and freezing memory in D-gal and nature-induced aging mice. Curcumin ameliorates the levels of oxidative stress biomarkers in mice. Anti-aging effects of curcumin could be attributed to, at least partially, the upregulation of antioxidant enzymes through binding with GSTA1, GSTO1, KEAP1, and inhibition of oxidative damage through binding with BACE1 and MAOA.