Potential of Dietary Agent Daidzein in Cancer Prevention and Treatment: Opportunities and Challenges Subhadas Chatterjee, Sabyasachi Banerjee, Sankhadip Bose, Kumar Ganesan, Cassandra R. Reilly, Anupam Bishayee Cancers, 2026 Background: Daidzein, a secondary metabolite primarily obtained from soybean (Glycine max L.) and other legumes, has significant nutritional and pharmacological value. Chemically, daidzein is an isoflavone and plays a crucial role in the therapeutic amelioration of numerous disorders, including allergies, inflammation, diabetes, cardiovascular, and neurodegenerative diseases. Emerging preclinical evidence suggests potential antineoplastic activity of daidzein against various cancers. This current work aims to perform a critical evaluation of daidzein’s potential as an anticancer molecule with an in-depth understanding of its mechanisms of action. Methods: The data for this review were obtained from various sources, including PubMed, Scopus, and Web of Science. Results: Daidzein, as a pure phytochemical or in combination with other phytochemicals and anticancer drugs, has been reported to induce apoptotic and autophagic cell death, impeding cell growth, viability, proliferation, and angiogenesis, and arresting cell division at various phases in vitro. Various daidzein formulations also exhibited similar anticancer effects by immunomodulation and genetic alteration in the cancer cells. In vivo anticancer studies of daidzein also suggest modulation of several hallmark pathways, such as inhibition of nuclear factor-κB, Janus kinase/signal transducer and activator of transcription, and rat sarcoma virus/rapidly accelerated fibrosarcoma. Conclusions: Irrespective of numerous promising preclinical studies, the absence of clinical studies provides a major challenge to establishing daidzein’s safety and efficacy in human cancers. Therefore, further advancements in clinical research of daidzein are vital for manifesting as an antineoplastic drug.
Exploring the anti-diabetic potential of Aloe vera: isolation and characterization of bioactive compounds Ivy Ghosh, Sabyasachi Banerjee, Subhasish Dutta, Himangshu Sekhar Maji, Arijit Mondal Natural Product Research, 2026 We investigated the anti-diabetic effects of the ethyl acetate fraction of Aloe vera and its isolated compounds using both in vitro and in vivo study models. In vitro tests showed that the ethyl acetate part of A. vera and its separate compounds had better activity blocking α-glucosidase, α-amylase, and α-lipase. The ethyl acetate fraction and its active constituents, barbaloin and gallic acid, significantly (p < 0.01) normalised blood glucose levels and serum biochemical parameters compared to those of STZ-induced controls. Both barbaloin and gallic acid exhibited maximum glucose-lowering effects in diabetic rats. Ethyl acetate fraction, barbaloin, and gallic acid also showed a significant increase in serum insulin and restoration of the biochemical and antioxidant status of STZ-induced diabetic rats. Therefore, the ethyl acetate fraction of A. vera, barbaloin, and gallic acid demonstrated remarkable anti-diabetic activity in STZ-induced diabetic rats.
Therapeutic and Diagnostic Implications of Carbon Dot: An Advancement in the Avenue towards Cancer, Diabetes and Neurodegenerative Disorders Sreejan Manna, Sabyasachi Banerjee, Arnab De, Subhasis Banerjee, Stabak Das, Pallabita Rakshit, Ashok Kumar S K, Kalyan Kumar Sen, Sourav De Pharmaceutical Nanotechnology, 2026 Introduction: Carbon dots (CDs), by virtue of their electrical and optical properties, emit intense light and fluorescence. They have attributes like photostability, high quantum yield (QY), high emission, and scalability. In the recent past, theranostic-CDs have been widely used in sensing, imaging, and medication administration. Furthermore, CDs may provide significant promise to detect and ability to cross blood-brain barrier (BBB) along with a drug to treat numerous neurodegenerative disorders (ND), such as Parkinson's disease (PD), Alzheimer's disease (AD), and multiple sclerosis. Method: This review aims at exploring the immense utility of CDs in the arena of theranostics. The immense utility of CDs was investigated through a systematic exploration of previously published data in the relevant field. The application of CDs is well extended to treat life-threatening disorders, like diabetes and cancer. In order to keep harmful substances out of the brain, the blood- -brain barrier (BBB) forms a defensive barrier. Results: Water and gases being simple molecules can traverse the BBB without getting filtered out, but several large molecules suffer to reach the site of action owing to their poor solubility. CDs have recently been employed for delivering drugs to the brain and to assess the central nervous system. An in-depth study of relevant literature indicates that CDs are the next-generation carrier with an innate potential to subside the drawbacks of conventional nanoparticles. Conclusion: This review illustrates several biomedical applications of CDs, primarily focusing on neurological illnesses, diabetes, and cancers. It also confers the usefulness of CDs in diagnostic imaging.
Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment Sabyasachi Banerjee, Avik Das, Sankhadip Bose, Subhasis Banerjee, Anusha Bishayee, Anupam Bishayee Journal of Ayurveda and Integrative Medicine, 2025 BACKGROUND: Barleria lupulina, a medicinal plant of India, South China and Southeast Asia, is known for its antioxidant and cytotoxic abilities. Although this plant has shown significant promise as an anticancer agent, the underlying mechanisms of action are yet to be explored. OBJECTIVE: This study aimed to assess antiproliferative and proapoptotic potential of B. lupulina leaf extract with understanding of cellular and molecular mechanisms. MATERIALS AND METHODS: The ethanolic extract was characterized using liquid chromatography-mass spectrometry and its anticancer activity was then assessed against Caco-2 colon cancer and A549 lung cancer cell lines. RESULTS: Phytochemical analysis of the extract revealed the presence of acetylbarlerin, decaffeoylacteoside, gallic acid, ipolamiide, leonuriside A, shanzhiside, and vanillic acid. The extract showed concentration-dependent cytotoxicity against both cancer cells. It induced early apoptosis at lower concentrations and late apoptosis at higher concentrations. Moreover, the extract noticeably reduced reactive oxygen species and mitochondrial membrane potential in a concentration-dependent way. The Western blot and quantitative reverse transcription polymerase chain reaction showed upregulation of Bax, caspase-8, caspase-9, and cluster of differentiation 95, and downregulation of Bcl-2. Molecular docking studies revealed that decaffeoylacteoside, gallic acid, and vanillic acid exhibited dual affinities for both caspase-8 and caspase-9, while acetylbarlerin, ipolamiide, leonuriside A, and shanzhiside showed selective affinities only for caspase-9. CONCLUSION: The ethanolic leaf extract shows significant cytotoxic and proapoptotic activities, confirming its potential as a useful resource of bioactive compounds against cancer. Nevertheless, more in-depth investigations are necessary to realize the full potential of this medicinal plant for cancer therapy.
Brazil nut (Bertholletia excelsa Bonpl.) in health and disease: A narrative review Larissa Naomi Takeda, Amanda Omine, Lucas Fornari Laurindo, Adriano Cressoni Araújo, Nathália Mendes Machado, Jefferson A. Dias, Joachim Kavalakatt, Sabyasachi Banerjee, Ricardo de Alvares Goulart, Atanas G. Atanasov, Anupam Bishayee, Sandra Maria Barbalho Food Chemistry, 2025
Nanotechnology Tools for Diagnosis and Therapy Arnab De, Santanu Ghosh, Sourav De, Sabyasachi Banerjee, Indranil Banerjee, Amit Kundu, Soumik Podder, Biplab Debnath Nanomaterial Based Sensors for Healthcare Application, 2025
Safed Musli: A critical review on its bioactive compounds, medicinal properties, and biological activity Advances in Medicinal and Aromatic Plants Production Processing and Pharmaceutics 2 Volume Set, 2024
Acorns calamus L. (Sweet Flag): Bioactive compounds, medicinal properties, and biological activity Advances in Medicinal and Aromatic Plants Production Processing and Pharmaceutics 2 Volume Set, 2024
Therapeutic Potential of the Indian Spice Trigonellafoenum-graecum L. (Fenugreek) Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Garcinia gummi-gutta (Malabar Tamarind): A Spice in Natural and Traditional Medicine Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Role of the Indian Spice Cardamom (Elettaria cardamomum) inNatural and Herbal Medicine Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
An Insight into the Therapeutic Potential of Alkanet (Alkanna tinctoria) Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Impact of Asian Spider Flower (Cleome viscosa) on Human Health Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Therapeutic Efficacy of Zanthoxylum Species (Syn. Fagara species) Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Medicinal Spices and Herbs from India: Beneficial Health Effects of 20 Exotic Spices: Volume 2 Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Impact of Black Cumin (Nigella sativa) on Human Health Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Ceiba pentandra (Kapok Tree): An Overview of ItsMedicinal Benefits Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Therapeutic Applications of Moschus moschiferus (Musk) Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Saussurea lappa (Kushta): An Indian Spice and ItsPotential Health Benefits Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Healing Benefits of Indian Sandalwood (Santalum album L.) Medicinal Spices and Herbs from India Beneficial Health Effects of 20 Exotic Spices Volume 2, 2024
Pharmacological property of pentacyclic triterpenoids Sabyasachi Banerjee, Sankhadip Bose, Subhash C Mandal, Subhojit Dawn, Ujjwal Sahoo, Mohmmed Abdel Menaem Ramadan, Sudip Mandal Egyptian Journal of Chemistry, 2019
MEDICINAL SPICES AND HERBS FROM INDIA: Volume 1: Introduction, Therapeutic Properties, and Commercial Products Medicinal Spices and Herbs from India Volume 1 Introduction Therapeutic Properties and Commercial Products, 2004
Effect of Geographical Location and Climatic Variation on the Composition of Active Principles in Indian Spices Medicinal Spices and Herbs from India Volume 1 Introduction Therapeutic Properties and Commercial Products, 2004
Application of Spices in Dairy Products as Natural Medicine Medicinal Spices and Herbs from India Volume 1 Introduction Therapeutic Properties and Commercial Products, 2004
RECENT SCHOLAR PUBLICATIONS
Unmasking NLRX1: Exploring the broadening biological landscape of a mysterious mitochondrial sensor J Bag, S Banerjee, S Banerjee, SKA Kumar, S De Mitochondrion 88, 102133 , 2026 2026
Targeting signaling cascades by bioactive phytocompounds in osteosarcoma: A novel therapeutic approach KM Nakov, ME Gething, TK Kassis, GJ Rutt, B Ho, N Bhandari, ... Pharmacology & Therapeutics, 109014 , 2026 2026 Citations: 1
Mechanistic insights into the anticancer potential of ruthenium (II) paracymene complexes of phenolic acids S Banerjee, A Das, S Bose, S Banerjee, U Chakraborty, A Bishayee Naunyn-Schmiedeberg's Archives of Pharmacology, 1-27 , 2026 2026
Spice Allergens: Clinical Relevance and Cross-Reactivity S Banerjee, A Das, S Banerjee, S Bose, S Banerjee, S Mukhopadhyay Rare and Risky Food Allergens, 140-155 , 2026 2026
Therapeutic and diagnostic implications of carbon dot: an advancement in the avenue towards cancer, diabetes and neurodegenerative disorders S Manna, S Banerjee, A De, S Banerjee, S Das, P Rakshit, ... Pharmaceutical nanotechnology 14 (1), 94-121 , 2026 2026 Citations: 5
Miracle berry for management of cancer and cancer treatment-related adverse effects J Kavalakatt, AR Tummala, SK Patel, MR Pacheco, S Banerjee, G Sethi, ... Phytomedicine, 157685 , 2025 2025
Organorhenium Complexes as Theranostic Agents: Bridging Anticancer Activity and Molecular Sensing S Banerjee, S Banerjee, P Das, B Mandal, K Biswas, SKA Kumar, S De Coordination Chemistry Research, 100016 , 2025 2025 Citations: 1
Role of Major Bioactive Compounds in the Treatment of Anti-aging and Skincare: A Review. G Das, LA Jiménez-Ortega, S Banerjee, S Bose, G Deswal, AS Grewal, ... Current Pharmaceutical Biotechnology , 2025 2025 Citations: 1
Ruthenium (II) Paracymene complexes of phenolic acids: Synthesis, chemical characterization, in-silico biomolecular interaction and cytotoxicity studies S Banerjee, S De, SKA Kumar, S Bose, S Banerjee Journal of Inorganic Biochemistry, 113080 , 2025 2025 Citations: 3
Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment S Banerjee, A Das, S Bose, S Banerjee, A Bishayee, A Bishayee Journal of Ayurveda and Integrative Medicine 16 (5), 101220 , 2025 2025 Citations: 2
3 NanotechnologyforDiagnosis and Tools A De, S Ghosh, S De, S Banerjee, I Banerjee, A Kundu, S Podder, ... Nanomaterial-based Sensors for Healthcare Application, 35 , 2025 2025
Role of Gold Nanoparticles for Diagnosis and Therapy of Malignancy S De, S Banerjee, N Ghosh, G Dey, S Banerjee, ... Current Nanomedicine 15 (4), 383-406 , 2025 2025
Potential of phytochemicals for pharmacotherapy of glioblastoma multiforme: Progress, pitfalls, and promise A Bobak, M Steves, E McMahon, M Spahiu, ASW Rahman, N Casarcia, ... Phytomedicine 144, 156850 , 2025 2025 Citations: 4
Metformin and its Nanoformulations in Cancer Prevention and Therapy B Banerjee, S Banerjee, T Sharma, BC Nandy, AK Nayak, A Mondal Current Pharmaceutical Design 31 (27), 2169-2199 , 2025 2025 Citations: 4
Unraveling the Ties: Type 2 Diabetes and Parkinson's Disease-A Nano-Based Targeted Drug Delivery Approach S De, S Banerjee, P Rakshit, S Banerjee, SKA Kumar Current Diabetes Reviews 21 (6), E130524229900 , 2025 2025 Citations: 6
Brazil nut (Bertholletia excelsa Bonpl.) in health and disease: A narrative review LN Takeda, A Omine, LF Laurindo, AC Araujo, NM Machado, JA Dias, ... Food Chemistry 477, 143425 , 2025 2025 Citations: 9
Synthesis and Anticancer Activity of Metformin‐Phenolic Acid Conjugates B Banerjee, T Sharma, S Banerjee, S Banerjee, A Mondal Chemistry & Biodiversity 22 (6), e202403199 , 2025 2025 Citations: 3
Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects N Casarcia, P Rogers, E Guld, S Iyer, Y Li, JT Burcher, LK Deliberto, ... British journal of pharmacology 182 (10), 2181-2234 , 2025 2025 Citations: 14
Oats and Wheat Bran as Functional Food and Nutraceuticals S Bose, S Banerjee, S Chatterjee, M Baig, N Singh Dietary Supplements and Nutraceuticals, 1-17 , 2025 2025
Preparation, characterisation, anticancer potential and safety evaluation of a soy lecithin phytosome delivery system loaded with constituents from Barleria lupulina S Banerjee, S Mukhopadhyay, A Das, S Banerjee, S Bose, S Banerjee, ... Journal of Microencapsulation 42 (3), 209-229 , 2025 2025 Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
Targeting the JAK/STAT signaling pathway using phytocompounds for cancer prevention and therapy S Bose, S Banerjee, A Mondal, U Chakraborty, J Pumarol, CR Croley, ... Cells 9 (6), 1451 , 2020 2020 Citations: 233
Star anise ( Illicium verum ): Chemical compounds, antiviral properties, and clinical relevance JK Patra, G Das, S Bose, S Banerjee, CN Vishnuprasad, ... Phytotherapy Research 34 (6), 1248-1267 , 2020 2020 Citations: 219
Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations A Mondal, S Banerjee, S Bose, S Mazumder, RA Haber, MH Farzaei, ... Pharmacological research 175, 105837 , 2022 2022 Citations: 153
Marine cyanobacteria and microalgae metabolites—A rich source of potential anticancer drugs A Mondal, S Bose, S Banerjee, JK Patra, J Malik, SK Mandal, KL Kilpatrick, ... Marine drugs 18 (9), 476 , 2020 2020 Citations: 145
Molecular mechanisms of action of eugenol in cancer: recent trends and advancement I Padhy, P Paul, T Sharma, S Banerjee, A Mondal Life 12 (11), 1795 , 2022 2022 Citations: 88
Natural polymeric nanobiocomposites for anti-cancer drug delivery therapeutics: a recent update A Mondal, AK Nayak, P Chakraborty, S Banerjee, BC Nandy Pharmaceutics 15 (8), 2064 , 2023 2023 Citations: 82
Cancer preventive and therapeutic potential of banana and its bioactive constituents: a systematic, comprehensive, and mechanistic review A Mondal, S Banerjee, S Bose, PP Das, EN Sandberg, AG Atanasov, ... Frontiers in oncology 11, 697143 , 2021 2021 Citations: 82
Phenolic phytochemicals for prevention and treatment of colorectal cancer: a critical evaluation of in vivo studies S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia, A Mondal, ... Cancers 15 (3), 993 , 2023 2023 Citations: 70
Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant S Banerjee, S Banerjee Physiologia 3 (2), 173-207 , 2023 2023 Citations: 57
Isatin: a scaffold with immense biodiversity P Nath, A Mukherjee, S Mukherjee, S Banerjee, S Das, S Banerjee Mini Reviews in Medicinal Chemistry 21 (9), 1096-1112 , 2021 2021 Citations: 51
Pharmacological property of pentacyclic triterpenoids S Banerjee, S Bose, SC Mandal, S Dawn, U Sahoo, M A Ramadan, ... Egyptian Journal of Chemistry 62 (Special Issue (Part 1) Innovation in … , 2019 2019 Citations: 50
A critical review of benzimidazole: Sky-high objectives towards the lead molecule to predict the future in medicinal chemistry S Banerjee, S Mukherjee, P Nath, A Mukherjee, S Mukherjee, SKA Kumar, ... Results in Chemistry 6, 101013 , 2023 2023 Citations: 47
Barleria prionitis L.: An Illustrative Traditional, Phytochemical and Pharmacological Review S Banerjee, S Banerjee, GK Jha, S Bose The Natural Products Journal , 2021 2021 Citations: 42
Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression A Mondal, S Banerjee, W Terang, A Bishayee, J Zhang, L Ren, ... Phytotherapy Research 38 (3), 1191-1223 , 2024 2024 Citations: 37
Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment S Banerjee, S Banerjee, A Bishayee, MN Da Silva, OA Sukocheva, E Tse, ... Phytomedicine 132, 155858 , 2024 2024 Citations: 33
Pharmacology and Ethnomedicinal Potential of Selected Plants Species from Apiaceae (Umbelliferae) G Das, S Das, AD Talukdar, CK Venil, S Bose, S Banerjee, HS Shin, ... Combinatorial chemistry & high throughput screening 26 (2), 256-288 , 2023 2023 Citations: 29
Metallotherapeutic complexes with high selective properties for anti-neoplastic therapy S De, S Kazi, S Banerjee, S Banerjee, N Sarkar, SK Shah, YC Kuo, ... Coordination Chemistry Reviews 498, 215462 , 2024 2024 Citations: 25
Phytochemical screening and antibacterial activity study of Syzygium cumini (Myrtaceae) seed extracts A Aziz, S Banerjee Pharmatutor 6 (4), 70-73 , 2018 2018 Citations: 25
Nanotechnology for cargo delivery with a special emphasis on pesticide, herbicide, and fertilizer S Banerjee, S Mazumder, D Chatterjee, S Bose, SB Majee Nano-enabled agrochemicals in agriculture, 105-144 , 2022 2022 Citations: 24
Litchi (Litchi chinensis Sonn.): A comprehensive and critical review on cancer prevention and intervention A Bishayee, J Kavalakatt, C Sunkara, O Johnson, SS Zinzuwadia, ... Food chemistry 457, 140142 , 2024 2024 Citations: 21
