Health Professions, Food Science, Plant Science, Multidisciplinary
82
Scopus Publications
Scopus Publications
DUAL-LOADED PHYTOSOMES OF PAPAIN AND ALOE VERA: FORMULATION AND EVALUATION OF DIABETIC WOUND HEALING PROPERTIES SAJISHA VS, ASWIN VISWANATH, SAURABH SINGH, SHEETU WADHWA International Journal of Applied Pharmaceutics, 2026 Objective: The goal of this study was to prepare and evaluate phytosomes containing Aloe vera extract and papain using the solvent evaporation method. Methods: We prepared phytosomes of aloe vera extract and papain by the solvent evaporation technique. Design-Expert® software (version 11.0.5) was used for the optimisation procedure. Out of 17 formulations, F8 was selected as the best, on the basis of particle size, polydispersity index (PDI), and entrapment efficiency (EE). Mixing the best formulation (F8) with carbopol 940, a phytosomal gel was prepared for better compliance. The gel was tested for its physicochemical properties, antioxidant properties by DPPH assay, cytotoxicity by MTT assay, and α-amylase inhibitory activity as an indicator of antidiabetic potential. In vivo diabetic wound healing was tested on streptozotocin (STZ)-induced wistar rats for 25 d. Results: The optimised formulation (F8) had a particle size of 87.3±0.05 nm, a polydispersity index of 0.30±0.001, and a zeta potential of −55.6 mV, indicating high colloidal stability due to electrostatic repulsion. The entrapment efficiency of F8 for papain was 95.62±0.01% and 96.35±0.01% for aloe vera extract. pH 6.4±0.05, viscosity 20.11±0.00057 Pa·s, and spreadability 21.72±0.58 g·cm/s of the gel formulation were considered in the acceptable range. The SEM analysis verified a consistent and distinct vesicular morphology. The formulation showed strong antioxidant activity (IC₅₀ = 35.3 µg/ml), 85.71% cell viability, and moderate α-amylase inhibition (56±9.19%) without implying systemic glycaemic control. In vivo studies showed that the higher the dose, the faster the wound healed. By day 17, the high-dose group had 92.09±1.77% wound contraction, and by day 25, the wound was completely closed (100%), which was much better than the control group (p<0.05). Conclusion: The active ingredients were successfully shielded from oxidation and degradation by encapsulating papain and aloe vera polysaccharides in lipid-based phytosomes. This delivery system offers a promising therapeutic strategy for treating diabetic wounds and oxidative stress.
PSORIASIS: AN INTEGRATED REVIEW OF A COMPLEX IMMUNE-MEDIATED DISEASE SHRUTI SHARMA, DILEEP SINGH BAGHEL, RAVINDER KUMAR, GURVINDER SINGH, SAURABH SINGH Asian Journal of Pharmaceutical and Clinical Research, 2026 Psoriasis manifests as persistent inflammation of the skin, often presenting with distinct scaly plaques. However, the precise cause of this condition is not clear but is known to be a complex consequence of several factors. These factors include environmental, genetic, microbial, and immunity dysregulation. An estimate of the total number of affected persons pertaining to psoriasis is estimated at more than 125 million at present. Recent innovations in therapeutics, chiefly “biologics” therapeutics, have introduced new possibilities for developing highly targeted personalized treatments with more efficacy. This multifactorial disease is characterized by various types, where “Plaque Psoriasis” is the prevalent one. This article explores the multifaceted aspects of psoriasis, an inflammatory long-term disease defined by distinct plaques as well as scales. This review provides an integrated perspective on psoriasis by outlining recent insights into its immunopathogenesis and highlighting how these advances have supported the development of targeted biologic treatments while continuing to shape future research and clinical innovation.
Ugly Truth About Technology and Mental Health Stigma Sachin, Vineet Kumar, Popu Ram, Palvi, Saurabh Singh, Dileep Singh Baghel, Bimlesh Kumar, Narendra Kumar Pandey Confronting Mental Health Stigma with AI and Machine Learning, 2026 In recent years, the relationship between technology and mental health has grown to be a major source of worry, particularly as digital platforms increasingly influence societal perceptions and personal experiences. While technology has enabled unprecedented access to mental health resources, it has also exacerbated mental health stigma in subtle yet pervasive ways. The “ugly truth” is how digital communication, social media, and online culture all play a part in the stigma of mental health problems. This is frequently done by promoting toxic optimism, disseminating false information, and damaging stereotypes. Additionally, the anonymity of online interactions can lead to cyberbullying and the trivialization of serious mental health conditions. This chapter explores the dual-edged nature of technology's role in mental health, examining both its potential for positive impact and the significant challenges it poses. By analyzing the influence of digital platforms on public discourse and individual behavior, this study highlights the need for a more nuanced approach to integrating technology into mental health initiatives, emphasizing the importance of digital literacy, ethical design, and inclusive policies to combat stigma and support mental well-being in the digital age.
Applications of Green Technology: A Protection Against Environmental Toxicants Shashi, Bimlesh Kumar, Narendra Kumar Pandey, Saurabh Singh Ecotoxicity and Herbal Health A Symbiotic Approach, 2025 Using medicinal plants to treat or prevent disease is known as phytotherapy. This longstanding practice employs various medicinal compounds in different combinations. Herbal products provide primary medical treatment for 65%–80% of the world’s population. Environmental toxins, including mycotoxins, metals, and microbes, impact these treatments. Overuse of pesticides and contaminated water further influence the safety and efficacy of herbal remedies. Green technology, though still relatively new, offers promising ways to reduce the adverse effects of human activity on the environment. This field is expanding rapidly as societies strive to build a resilient, low-carbon, and sustainable future, leading to reductions in waste, air pollution, and water consumption.
Comparative analysis of PLGA ocuserts of brimonidine tartrate prepared with different methods Paramjot, Sheetu Wadhwa, Saurabh Singh, Dileep Singh Baghel, Bimlesh Kumar European Pharmaceutical Journal, 2025 The eye is a highly sensitive organ with multiple physiological barriers that limit drug bioavailability and reduce patient compliance. Research studies are still going on to discover a novel drug delivery system for ocular delivery. The current research aims to develop and compare the PLGA ocuserts of brimonidine tartrate (BT) by different methods. These BT-loaded PLGA ocuserts offer a promising alternative to commercially available BT eye drops. Ocuserts could significantly minimize the challenges encountered with eye drops like lacrimation, blinking-induced washout, dosing frequency, penetration, stability, and controlled release issues. The BT-loaded PLGA ocuserts were prepared using two methods: solvent casting method (SCM) and glass substrate method (GSM). Both SCM and GSM formulations exhibited smooth texture, pH levels within the range of 6.88±0.24 to 6.90±0.28, uniform thickness (SCM: 0.47±0.10 mm; GSM: 0.29±0.03 mm), minimal weight variation (SCM: 7.83±0.38 mg; GSM: 6.55±0.76 mg), sterility, and appropriate swelling indices (SCM: 6.69±0.33%; GSM: 5.40±0.27%). The evaluation results of SCM and GSM ocuserts revealed positive attributes for ophthalmic use. Noteworthy distinctions emerged in folding endurance, with SCM ocuserts demonstrating significantly higher endurance (87.17±4.34 folds) than GSM ocuserts (71.33±4.82 folds). Moreover, SCM ocuserts exhibited superior drug entrapment efficiency (88.26±3.33 %) to GSM ocuserts (74.91±4.39 %). Stability studies confirmed good stability over a 6-month period, while in vitro (italics) drug release study indicated better controlled release properties for SCM than GSM. Findings demonstrate that SCM emerged as an effective method for preparation of polymeric films in various pharmaceutical industries, including transdermal patches, scaffolds in tissue engineering, flexible wound healing films, biodegradable drug delivery systems, and pharmaceutical packaging as well.
Design, Characterization, and Evaluation of Solid-Self-Nano-Emulsifying Drug Delivery of Benidipine with Telmisartan: Quality by Design Approach Sheetal S. Buddhadev, Kevinkumar C. Garala, Mohamed Rahamathulla, Ali H. Alamri, Umme Hani, M. Yasmin Begum, Saurabh Singh Baghel, Mohammed Muqtader Ahmed, Ismail Pasha ACS Omega, 2025 The main purpose of this study was to design and develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) for the oral administration of benidipine (BD) and telmisartan (TEL) using the adsorption method with eucalyptus oil, Transcutol P, and Kolliphor EL via the Box–Behnken design approach. The prepared SNEDDS formulations were characterized using FTIR, DSC, SEM, and PXRD techniques and evaluated for zeta potential, refractive index, drug concentration, resistance to dilution, viscosity, and thermodynamic stability. Additionally, in vitro and stability studies were conducted. The results revealed that all prepared formulations (BT1–BT15) exhibited favorable zeta potential (17.2–28.39 mV) and polydispersity index (PDI) values (0.226–0.354). Among them, formulation BT11 demonstrated a desirable droplet size of 175.12 ± 2.70 nm, a PDI of 0.226, a zeta potential of −24.98 ± 0.18 mV, a self-emulsification time of 53.00 ± 2.10 s, a transmittance percentage of 99.6 ± 0.3%, and a drug release of 92.65 ± 1.70% within 15 min. BT11 exhibited significantly faster drug release compared to the commercially available product benidipine T (4 mg/40 mg) and the pure drugs BD and TEL, releasing more than 96% of both drugs in 0.1 N HCl within 60 min. Furthermore, BT11 demonstrated stability throughout the product’s stability testing. These findings suggest that the oral S-SNEDDS formulation of BD and TEL can enhance the drugs’ water solubility, potentially improving therapeutic outcomes and increasing patient compliance.
AYURVEDIC INSIGHTS INTO PERSONALIZED MEDICINE: A HOLISTIC APPROACH Dileep Singh Baghel, Saurabh Singh, Muskan Verma, Sunidhi Sunidhi Journal of Ayurveda and Holistic Medicine, 2025 In Ayurveda, individualized medicine is a common practice although it is new to modern medicine. Ayurvedic science illustrates how two individuals with the same disease might just be treated with different Ayurvedic medications. A single disease can also be treated with customized Ayurvedic medications as it develops and evolves inside a single person. Individualized healthcare is the upcoming approach to providing medical treatment that is tailored to an individual's unique genetic makeup, epigenetic patterns, and clinical data. This enables a clear understanding of their distinct genomic profile and ensures uncompromising medical care. PM (personalized medicine) is a treatment based on the genomic profile of the patients that can influence the response to the drug. One of the strategies in the field of healthcare management PM allows a doctor to choose a medicine based on a patient's genetic profile, avoiding negative side effects and increasing the likelihood of successful treatment. In addition, this will be a more affordable method of treating diseases than the current "trial-and-error" method currently in use.
Pharmacognostic study of male leaves of Trichosanthes dioica Roxb. with special emphasis on microscopic technique Journal of Pharmacognosy and Phytotherapy, 2010
