Dr. Dhiraj Kabra

Scopus Publications

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice
Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger
Molecular Metabolism, 2024
With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play a role. Among these, members of the large histone deacetylase (HDAC) family are of particular importance as key metabolic determinants for healthy ageing, or metabolic dysfunction. Here, we aimed to interrogate the role of class 2 family member HDAC5 in controlling systemic metabolism and age-related obesity under non-obesogenic conditions. Starting at 6 months of age, we observed adult-onset obesity in chow-fed male global HDAC5-KO mice, that was accompanied by marked reductions in adrenergic-stimulated ATP-consuming futile cycles, including BAT activity and UCP1 levels, WAT-lipolysis, skeletal muscle, WAT and liver futile creatine and calcium cycles, and ultimately energy expenditure. Female mice did not differ between genotypes. The lower peripheral sympathetic nervous system (SNS) activity in mature male KO mice was linked to higher dopaminergic neuronal activity within the dorsomedial arcuate nucleus (dmARC) and elevated hypothalamic dopamine levels. Mechanistically, we reveal that hypothalamic HDAC5 acts as co-repressor of STAT5b over the control of Tyrosine hydroxylase (TH) gene transactivation, which ultimately orchestrates the activity of dmARH dopaminergic neurons and energy metabolism in male mice under non-obesogenic conditions.
Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
Matthias Dille, Aleksandra Nikolic, Natalie Wahlers, Pia Fahlbusch, Sylvia Jacob, Sonja Hartwig, Stefan Lehr, Dhiraj Kabra, Oleksiy Klymenko, Hadi Al-Hasani, Jörg Kotzka, Birgit Knebel
Biochimica Et Biophysica Acta Molecular Basis of Disease, 2022
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle
Oleksiy Klymenko, Tim Brecklinghaus, Matthias Dille, Christian Springer, Christian de Wendt, Delsi Altenhofen, Christian Binsch, Birgit Knebel, Jürgen Scheller, Christopher Hardt, Ralf Herwig, Alexandra Chadt, Paul T. Pfluger, Hadi Al-Hasani, Dhiraj G. Kabra
Molecular Metabolism, 2020
OBJECTIVE: Physical exercise training is associated with increased glucose uptake in skeletal muscle and improved glycemic control. HDAC5, a class IIa histone deacetylase, has been shown to regulate transcription of the insulin-responsive glucose transporter GLUT4 in cultured muscle cells. In this study, we analyzed the contribution of HDAC5 to the transcriptional network in muscle and the beneficial effect of muscle contraction and regular exercise on glucose metabolism. METHODS: HDAC5 knockout mice (KO) and wild-type (WT) littermates were trained for 8 weeks on treadmills, metabolically phenotyped, and compared to sedentary controls. Hdac5-deficient skeletal muscle and cultured Hdac5-knockdown (KD) C2C12 myotubes were utilized for studies of gene expression and glucose metabolism. Chromatin immunoprecipitation (ChIP) studies were conducted to analyze Il6 promoter activity using H3K9ac and HDAC5 antibodies. RESULTS: Global transcriptome analysis of Hdac5 KO gastrocnemius muscle demonstrated activation of the IL-6 signaling pathway. Accordingly, knockdown of Hdac5 in C2C12 myotubes led to higher expression and secretion of IL-6 with enhanced insulin-stimulated activation of AKT that was reversed by Il6 knockdown. Moreover, Hdac5-deficient myotubes exhibited enhanced glucose uptake, glycogen synthesis, and elevated expression levels of the glucose transporter GLUT4. Transcription of Il6 was further enhanced by electrical pulse stimulation in Hdac5-deficient C2C12 myotubes. ChIP identified a ∼1 kb fragment of the Il6 promoter that interacts with HDAC5 and demonstrated increased activation-associated histone marker AcH3K9 in Hdac5-deficient muscle cells. Exercise intervention of HDAC5 KO mice resulted in improved systemic glucose tolerance as compared to WT controls. CONCLUSIONS: We identified HDAC5 as a negative epigenetic regulator of IL-6 synthesis and release in skeletal muscle. HDAC5 may exert beneficial effects through two different mechanisms, transcriptional control of genes required for glucose disposal and utilization, and HDAC5-dependent IL-6 signaling cross-talk to improve glucose uptake in muscle in response to exercise.
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
Sonja C. Schriever, Dhiraj G. Kabra, Katrin Pfuhlmann, Peter Baumann, Emily V. Baumgart, Joachim Nagler, Fabian Seebacher, Luke Harrison, Martin Irmler, Stephanie Kullmann, Felipe Corrêa-da-Silva, Florian Giesert, Ruchi Jain, Hannah Schug, Julien Castel, Sarah Martinez, Moya Wu, Hans-Ulrich Häring, Martin Hrabe de Angelis, Johannes Beckers, Timo D. Müller, Kerstin Stemmer, Wolfgang Wurst, Jan Rozman, Ruben Nogueiras, Meri De Angelis, Jeffery D. Molkentin, Natalie Krahmer, Chun-Xia Yi, Mathias V. Schmidt, Serge Luquet, Martin Heni, Matthias H. Tschöp, Paul T. Pfluger
Journal of Clinical Investigation, 2020
Recent genome-wide association studies (GWAS) identified DUSP8, a dual-specificity phosphatase targeting MAP kinases, as type 2 diabetes (T2D) risk gene. Here, we unravel Dusp8 as gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male but not female Dusp8 loss-of-function mice, either with global or CRH neuron-specific deletion, had impaired systemic glucose tolerance and insulin sensitivity when exposed to high-fat diet (HFD). Mechanistically, we found impaired hypothalamic-pituitary-adrenal (HPA) axis feedback, blunted sympathetic responsiveness, and chronically elevated corticosterone levels driven by hypothalamic hyperactivation of Jnk signaling. Accordingly, global Jnk1 ablation, AAV-mediated Dusp8 overexpression in the mediobasal hypothalamus, or metyrapone-induced chemical adrenalectomy rescued the impaired glucose homeostasis of obese male Dusp8 KO mice, respectively. The sex-specific role of murine Dusp8 in governing hypothalamic Jnk signaling, insulin sensitivity and systemic glucose tolerance was consistent with fMRI data in human volunteers that revealed an association of the DUSP8 rs2334499 risk variant with hypothalamic insulin resistance in men. Further, expression of DUSP8 was increased in the infundibular nucleus of T2D humans. In summary, our findings suggest the GWAS-identified gene Dusp8 as novel hypothalamic factor that plays a functional role in the etiology of T2D.
Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing
Pranav Kumar Prabhakar, Karmveer Singh, Dhiraj Kabra, Jeena Gupta
Phytomedicine, 2020
Phytochemicals enriched in spices: a source of natural epigenetic therapy
Jeena Gupta, Sandeep Sharma, Neeta Raj Sharma, Dhiraj Kabra
Archives of Pharmacal Research, 2020
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465
Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschöp, Paul T. Pfluger
Diabetes, 2019
In the article listed above, ERX was erroneously omitted from the duality of interest for Matthias H. …
Functional identity of hypothalamic melanocortin neurons depends on Tbx3
Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser, Ilona C. Grunwald Kadow, Anne Moon, Cristina García-Cáceres, Matthias Mann, Mathias Treier, Claudia A. Doege, Matthias H. Tschöp
Nature Metabolism, 2019
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Peter Brown, Aik-Choon Tan, Mohamed A El-Esawi, Thomas Liehr, Oliver Blanck, Douglas P Gladue, Gabriel M F Almeida, Tomislav Cernava, Carlos O Sorzano, Andy W K Yeung, Michael S Engel, Arun Richard Chandrasekaran, Thilo Muth, Martin S Staege, Swapna V Daulatabad, Darius Widera, Junpeng Zhang, Adrian Meule, Ken Honjo, Olivier Pourret, Cong-Cong Yin, Zhongheng Zhang, Marco Cascella, Willy A Flegel, Carl S Goodyear, Mark J van Raaij, Zuzanna Bukowy-Bieryllo, Luca G Campana, Nicholas A Kurniawan, David Lalaouna, Felix J Hüttner, Brooke A Ammerman, Felix Ehret, Paul A Cobine, Ene-Choo Tan, Hyemin Han, Wenfeng Xia, Christopher McCrum, Ruud P M Dings, Francesco Marinello, Henrik Nilsson, Brett Nixon, Konstantinos Voskarides, Long Yang, Vincent D Costa, Johan Bengtsson-Palme, William Bradshaw, Dominik G Grimm, Nitin Kumar, Elvis Martis, Daniel Prieto, Sandeep C Sabnis, Said E D R Amer, Alan W C Liew, Paul Perco, Farid Rahimi, Giuseppe Riva, Chongxing Zhang, Hari P Devkota, Koichi Ogami, Zarrin Basharat, Walter Fierz, Robert Siebers, Kok-Hian Tan, Karen A Boehme, Peter Brenneisen, James A L Brown, Brian P Dalrymple, David J Harvey, Grace Ng, Sebastiaan Werten, Mark Bleackley, Zhanwu Dai, Raman Dhariwal, Yael Gelfer, Marcus D Hartmann, Pawel Miotla, Radu Tamaian, Pragashnie Govender, Oliver J Gurney-Champion, Joonas H Kauppila, Xiaolei Zhang, Natalia Echeverría, Santhilal Subhash, Hannes Sallmon, Marco Tofani, Taeok Bae, Oliver Bosch, Páraic O Cuív, Antoine Danchin, Barthelemy Diouf, Tuomas Eerola, Evangelos Evangelou, Fabian V Filipp, Hannes Klump, Lukasz Kurgan, Simon S Smith, Olivier Terrier, Neil Tuttle, David B Ascher, Sarath C Janga, Leon N Schulte, Daniel Becker, Christopher Browngardt, Stephen J Bush, Guillaume Gaullier, Kazuki Ide, Clement Meseko, Gijsbert D A Werner, Jan Zaucha, Abd A Al-Farha, Noah F Greenwald, Segun I Popoola, Md Shaifur Rahman, Jialin Xu, Sunny Y Yang, Noboru Hiroi, Ozgul M Alper, Chris I Baker, Michael Bitzer, George Chacko, Birgit Debrabant, Ray Dixon, Evelyne Forano, Matthew Gilliham, Sarah Kelly, Karl-Heinz Klempnauer, Brett A Lidbury, Michael Z Lin, Iseult Lynch, Wujun Ma, Edward W Maibach, Diane E Mather, Kutty S Nandakumar, Robert S Ohgami, Piero Parchi, Patrizio Tressoldi, Yu Xue, Charles Armitage, Pierre Barraud, Stella Chatzitheochari, Luis P Coelho, Jiajie Diao, Andrew C Doxey, Angélique Gobet, Pingzhao Hu, Stefan Kaiser, Kate M Mitchell, Mohamed F Salama, Ivan G Shabalin, Haijun Song, Dejan Stevanovic, Ali Yadollahpour, Erliang Zeng, Katharina Zinke, C G Alimba, Tariku J Beyene, Zehong Cao, Sherwin S Chan, Michael Gatchell, Andreas Kleppe, Marcin Piotrowski, Gonzalo Torga, Adugna A Woldesemayat, Mehmet I Cosacak, Scott Haston, Stephanie A Ross, Richard Williams, Alvin Wong, Matthew K Abramowitz, Andem Effiong, Senhong Lee, Muhammad Bilal Abid, Cyrus Agarabi, Cedric Alaux, Dirk R Albrecht, Gerald J Atkins, Charles R Beck, A M J J Bonvin, Emer Bourke, Thomas Brand, Ralf J Braun, James A Bull, Pedro Cardoso, Dee Carter, Robin M Delahay, Bernard Ducommun, Pascal H G Duijf, Trevor Epp, Eeva-Liisa Eskelinen, Mazyar Fallah, Debora B Farber, Jose Fernandez-Triana, Frank Feyerabend, Tullio Florio, Michael Friebe, Saori Furuta, Mads Gabrielsen, Jens Gruber, Malgorzata Grybos, Qian Han, Michael Heinrich, Heikki Helanterä, Michael Huber, Albert Jeltsch, Fan Jiang, Claire Josse, Giuseppe Jurman, Haruyuki Kamiya, Kim de Keersmaecker, Erik Kristiansson, Frank-Erik de Leeuw, Jiuyong Li, Shide Liang, Jose A Lopez-Escamez, Francisco J Lopez-Ruiz, Kevin J Marchbank, Rolf Marschalek, Carmen S Martín, Adriana E Miele, Xavier Montagutelli, Esteban Morcillo, Rosario Nicoletti, Monika Niehof, Ronan O’Toole, Toshihiko Ohtomo, Henrik Oster, Jose-Alberto Palma, Russell Paterson, Mark Peifer, Maribel Portilla, M C Portillo, Antonia L Pritchard, Stefan Pusch, Gajendra P S Raghava, Nicola J Roberts, Kehinde Ross, Birgitt Schuele, Kjell Sergeant, Jun Shen, Alessandro Stella, Olga Sukocheva, Vladimir N Uversky, Sven Vanneste, Martin H Villet, Miguel Viveiros, Julia A Vorholt, Christof Weinstock, Masayuki Yamato, Ioannis Zabetakis, Xin Zhao, Andreas Ziegler, Wan M Aizat, Lauren Atlas, Kristina M Bridges, Sayan Chakraborty, Mieke Deschodt, Helena S Domingues, Shabnam S Esfahlani, Sebastian Falk, J L Guisado, Nolan C Kane, Gray Kueberuwa, Colleen L Lau, Dai Liang, Enwu Liu, Andreas M Luu, Chuang Ma, Lisong Ma, Robert Moyer, Adam D Norris, Suresh Panthee, Jerod R Parsons, Yousong Peng, Inês Mendes Pinto, Cristina R Reschke, Elina Sillanpää, Christopher J Stewart, Florian Uhle, Hui Yang, Kai Zhou, Shu Zhu, Mohamed Ashry, Niels Bergsland, Maximilian Berthold, Chang-Er Chen, Vito Colella, Maarten Cuypers, Evan A Eskew, Xiao Fan, Maksymilian Gajda, Rayner Gonzálezlez-Prendes, Amie Goodin, Emily B Graham, Ewout J N Groen, Alba Gutiérrez-Sacristán, Mohamad Habes, Enrico Heffler, Daniel B Higginbottom, Thijs Janzen, Jayakumar Jayaraman, Lindsay A Jibb, Stefan Jongen, Timothy Kinyanjui, Rositsa G Koleva-Kolarova, Zhixiu Li, Yu-Peng Liu, Bjarte A Lund, Alexandre A Lussier, Liping Ma, Pablo Mier, Matthew D Moore, Katja Nagler, Mark W Orme, James A Pearson, Anilkumar S Prajapati, Yu Saito, Simon E Tröder, Florence Uchendu, Niklas Verloh, Denitza D Voutchkova, Ahmed Abu-Zaid, Joaira Bakkach, Philipp Baumert, Marcos Dono, Jack Hanson, Sandrine Herbelet, Emma Hobbs, Ameya Kulkarni, Narendra Kumar, Siqi Liu, Nikolai D Loft, Tristan Reddan, Thomas Senghore, Howard Vindin, Haotian Xu, Ross Bannon, Branson Chen, Johnny T K Cheung, Jeffrey Cooper, Ashwini K Esnakula, Karine A Feghali, Emilia Ghelardi, Agostino Gnasso, Jeffrey Horbar, Hei M Lai, Jian Li, Lan Ma, Ruiyan Ma, Zihang Pan, Marco A Peres, Raymond Pranata, Esmond Seow, Matthew Sydes, Ines Testoni, Anna L Westermair, Yongliang Yang, Masoud Afnan, Joan Albiol, Lucia G Albuquerque, Eisuke Amiya, Rogerio M Amorim, Qianli An, Stig U Andersen, John D Aplin, Christos Argyropoulos, Yan W Asmann, Abdulaziz M Assaeed, Atanas G Atanasov, David A Atchison, Simon V Avery, Paul Avillach, Peter D Baade, Lars Backman, Christophe Badie, Alfonso Baldi, Elizabeth Ball, Olivier Bardot, Adrian G Barnett, Mathias Basner, Jyotsna Batra, O M Bazanova, Andrew Beale, Travis Beddoe, Melanie L Bell, Eugene Berezikov, Sue Berners-Price, Peter Bernhardt, Edward Berry, Theolis B Bessa, Craig Billington, John Birch, Randy D Blakely, Mark A T Blaskovich, Robert Blum, Marleen Boelaert, Dimitrios Bogdanos, Carles Bosch, Thierry Bourgoin, Daniel Bouvard, Laura M Boykin, Graeme Bradley, Daniel Braun, Jeremy Brownlie, Albert Brühl, Austin Burt, Lisa M Butler, Siddappa N Byrareddy, Hugh J Byrne, Stephanie Cabantous, Sara Calatayud, Eva Candal, Kimberly Carlson, Sònia Casillas, Valter Castelvetro, Patrick T Caswell, Giacomo Cavalli, Vaclav Cerovsky, Monica Chagoyen, Chang-Shi Chen, Dong F Chen, Hao Chen, Hui Chen, Jui-Tung Chen, Yinglong Chen, Changxiu Cheng, Jianlin Cheng, Mai Chinapaw, Christos Chinopoulos, William C S Cho, Lillian Chong, Debashish Chowdhury, Andre Chwalibog, A Ciresi, Shamshad Cockcroft, Ana Conesa, Penny A Cook, David N Cooper, Olivier Coqueret, Enoka M Corea, Elisio Costa, Carol Coupland, Stephanie Y Crawford, Aparecido D Cruz, Huijuan Cui, Qiang Cui, David C Culver, Amedeo D’Angiulli, Tanya E S Dahms, France Daigle, Raymond Dalgleish, Håvard E Danielsen, Sébastien Darras, Sean M Davidson, David A Day, Volkan Degirmenci, Luc Demaison, Koenraad Devriendt, Jiandong Ding, Yunus Dogan, X C Dong, Claudio F Donner, Walter Dressick, Christian A Drevon, Huiling Duan, Christian Ducho, Nicolas Dumaz, Bilikere S Dwarakanath, Mark H Ebell, Steffen Eisenhardt, Naser Elkum, Nadja Engel, Timothy B Erickson, Michael Fairhead, Marty J Faville, Marlena S Fejzo, Fernanda Festa, Antonio Feteira, Patrick Flood-Page, John Forsayeth, Simon A Fox, Steven J Franks, Francesca D Frentiu, Mikko J Frilander, Xinmiao Fu, Satoshi Fujita, Ian Galea, Luca Galluzzi, Federica Gani, Arvind P Ganpule, Antonio García-Alix, Kristene Gedye, Maurizio Giordano, Cecilia Giunta, Paul A Gleeson, Cyrille Goarant, Haipeng Gong, Diop Gora, Michael J Gough, Ravinder Goyal, Kathryn E Graham, Ana Grande-Pérez, Patricia M Graves, Harm Greidanus, Darren Grice, Christoph Grunau, Yosephine Gumulya, Yabin Guo, Vsevolod V Gurevich, Oleg Gusev, Elke Hacker, Steffen R Hage, Guy Hagen, Steven Hahn, Dagmar M Haller, Sven Hammerschmidt, Jianwei Han, Renzhi Han, Martin Handfield, Hapuarachchige C Hapuarachchi, Timm Harder, Jennifer E Hardingham, Michelle Heck, Marcel Heers, Khe F Hew, Yohei Higuchi, Cynthia St Hilaire, Rachel Hilton, Enisa Hodzic, Andrew Hone, Yuichi Hongoh, Guoku Hu, Heinz P Huber, Luis E Hueso, Judith Huirne, Lisa Hurt, Helena Idborg, Kazuho Ikeo, Evan Ingley, Philip M Jakeman, Arne Jensen, Hong Jia, Husen Jia, Shuqin Jia, Jianping Jiang, Xingyu Jiang, Yi Jin, Daehyun Jo, Andrew M Johnson, Marie Johnston, Karen R Jonscher, Philippe G Jorens, Jens O L Jorgensen, Johan W Joubert, Sin-Ho Jung, Antonio M Junior, Thomas Kahan, Sunjeev K Kamboj, Yong-Kook Kang, Yannis Karamanos, Natasha A Karp, Ryan Kelly, Ralph Kenna, Jonathan Kennedy, Birgit Kersten, Roy A Khalaf, Javaria M Khalid, T Khatlani, Tarig Khider, Gregor S Kijanka, Sarah R B King, Tomasz Kluz, Paul Knox, Tatsuya Kobayashi, Karl-Wilhelm Koch, Maija R J Kohonen-Corish, Xiangpeng Kong, Deborah Konkle-Parker, Kalevi M Korpela, Leondios G Kostrikis, Peter Kraiczy, Harald Kratz, Günter Krause, Paul H Krebsbach, Søren R Kristensen, Prerna Kumari, Akira Kunimatsu, Hatice Kurdak, Young D Kwon, Carl Lachat, Malgorzata Lagisz, Brenda Laky, Jan Lammerding, Matthias Lange, Mar Larrosa, Andrew L Laslett, Elizabeth E LeClair, Kyung-Woo Lee, Ming-Yih Lee, Moon-Soo Lee, Genyuan Li, Jiansheng Li, Klaus Lieb, Yau Y Lim, Merry L Lindsey, Paul-Dag Line, Dengcai Liu, Fengbin Liu, Haiyan Liu, Hongde Liu, Vett K Lloyd, Te-Wen Lo, Emanuela Locci, Josef Loidl, Johan Lorenzen, Stefan Lorkowski, Nigel H Lovell, Hua Lu, Wei Lu, Zhiyong Lu, Gustavo S Luengo, Lars-Gunnar Lundh, Philippe A Lysy, Angela Mabb, Heather G Mack, David A Mackey, S R Mahdavi, Pamela Maher, Toby Maher, Sankar N Maity, Brigitte Malgrange, Charalampos Mamoulakis, Arduino A Mangoni, Thomas Manke, Antony S R Manstead, Athanasios Mantalaris, Jan Marsal, Hanns-Ulrich Marschall, Francis L Martin, Jose Martinez-Raga, Encarnacion Martinez-Salas, Daniel Mathieu, Yoichi Matsui, Elie Maza, James E McCutcheon, Gareth J McKay, Brian McMillan, Nigel McMillan, Catherine Meads, Loreta Medina, B Alex Merrick, Dennis W Metzger, Frederic A Meunier, Martin Michaelis, Olivier Micheau, Hisaaki Mihara, Eric M Mintz, Takuo Mizukami, Yann Moalic, D P Mohapatra, Antonia Monteiro, Matthieu Montes, John V Moran, Sergey Y Morozov, Matthew Mort, Noriyuki Murai, Denis J Murphy, Susan K Murphy, Shauna A Murray, Shinji Naganawa, Srinivas Nammi, Grigorios Nasios, Roman M Natoli, Frederique Nguyen, Christine Nicol, Filip van Nieuwerburgh, Erlend B Nilsen, Clarissa J Nobile, Margaret O’Mahony, Sophie Ohlsson, Oluremi Olatunbosun, Per Olofsson, Alberto Ortiz, Kostya Ostrikov, Siegmar Otto, Tiago F Outeiro, Songying Ouyang, Sabrina Paganoni, Andrew Page, Christoph Palm, Yin Paradies, Michael H Parsons, Nick Parsons, Pigny Pascal, Elisabeth Paul, Michelle Peckham, Nicoletta Pedemonte, Michael A Pellizzon, M Petrelli, Alexander Pichugin, Carlos J C Pinto, John N Plevris, Piero Pollesello, Martin Polz, Giovanna Ponti, Piero Porcelli, Martin Prince, Gwendolyn P Quinn, Terence J Quinn, Satu Ramula, Juri Rappsilber, Florian Rehfeldt, Jan H Reiling, Claire Remacle, Mohsen Rezaei, Eric W Riddick, Uwe Ritter, Neil W Roach, David D Roberts, Guillermo Robles, Tiago Rodrigues, Cesar Rodriguez, Jo Roislien, Monique J Roobol, J Alexandra Rowe, Andreas Ruepp, Jan van Ruitenbeek, Petra Rust, Sonia Saad, George H Sack, Manuela Santos, Aurore Saudemont, Gianni Sava, Simone Schrading, Alexander Schramm, Martin Schreiber, Sidney Schuler, Joost Schymkowitz, Alexander Sczyrba, Kate L Seib, Han-Ping Shi, Tomohiro Shimada, Jeon-Soo Shin, Colette Shortt, Patricia Silveyra, Debra Skinner, Ian Small, Paul A M Smeets, Po-Wah So, Francisco Solano, Daniel E Sonenshine, Jiangning Song, Tony Southall, John R Speakman, Mandyam V Srinivasan, Laura P Stabile, Andrzej Stasiak, Kathryn J Steadman, Nils Stein, Andrew W Stephens, Douglas I Stewart, Keith Stine, Curt Storlazzi, Nataliya V Stoynova, Wojciech Strzalka, Oscar M Suarez, Taranum Sultana, Anirudha V Sumant, Mathew J Summers, Gang Sun, Paul Tacon, Kozo Tanaka, Haixu Tang, Yoshinori Tanino, Paul Targett-Adams, Mourad Tayebi, Reema Tayyem, Christoph C Tebbe, Evelyn E Telfer, Wolfram Tempel, Julita A Teodorczyk-Injeyan, Gert Thijs, Sally Thorne, Amanda G Thrift, Celine Tiffon, Philip Tinnefeld, Daryono H Tjahjono, Fabrice Tolle, Ervin Toth, Andria L del Tredici, Apostolos Tsapas, Konstantinos Tsirigotis, Ayse Turak, George Tzotzos, Edet E Udo, Toshiaki Utsumi, Subramanian Vaidyanathan, Michel Vaillant, Armand Valsesia, Roosmarijn E Vandenbroucke, Feliciano H Veiga, Marc Vendrell, Peter A Vesk, Paul Vickers, Victor M Victor, Richard Villemur, Marie-Claude Vohl, Christian R Voolstra, Anne Vuillemin, Steven Wakelin, Levi Waldron, Laurence J Walsh, Amanda Y Wang, Fuan Wang, Yun Wang, Yoichi Watanabe, Andreas Weigert, Jet-Chau Wen, Carol Wham, Ethan P White, Jan Wiener, Gottfried Wilharm, Simon Wilkinson, Raffaella Willmann, Coralie Wilson, Brunhilde Wirth, Timothy R Wojan, Mathieu Wolff, Bryan M Wong, Tzu-Wei Wu, Hanno Wuerbel, Xiangshu Xiao, Dong Xu, J W Xu, Jianping Xu, Bin Xue, Suayib Yalcin, Hong Yan, En-Cheng Yang, Shiqi Yang, Wei Yang, Yuzhen Ye, Zhi-Qiang Ye, Jari Yli-Kauhaluoma, Hiroshi Yoneyama, Ying Yu, Guo-Cheng Yuan, Chiou-Hwa Yuh, Manuela Zaccolo, Chen Zeng, Branko Zevnik, Chi Zhang, Li Zhang, Li Zhang, Yingkai Zhang, Yusen Zhang, Zhiyong Zhang, Zhong-Yin Zhang, Yuan Zhao, Min Zhou, Torsten Zuberbier, Carmen M Aanei, Rafi Ahmad, Manar Al-Lawama, Alexandre Alanio, Judith Allardyce, David Alonso-Caneiro, John M Atack, Dirk Baier, Abhisheka Bansal, Yannick Benezeth, Colette Berbesque, Frederik Berrevoet, Peter H W Biedermann, Erik Bijleveld, Florian Bittner, Fabian Blombach, Wouter van den Bos, Shellie A Boudreau, Adam D Bramoweth, Oliver Braubach, Yufeng Cai, Matthew Campbell, Zanxia Cao, Thibault Catry, Xin Chen, Shuiqin Cheng, Hee-Jung Chung, Miguel A Chávez-Fumagalli, Aaron Conway, Bruno M Costa, Normand Cyr, Lorraine T Dean, Martin S Denzel, S V Dlamini, Kevin J Dudley, Maeva Dufies, Thorsten Ecke, Denitsa Eckweiler, Elisenda Eixarch, Hosny El-Adawy, Julius V Emmrich, Alex J Eustace, Christine M Falter-Wagner, Johannes Fuss, Jianzhao Gao, Martin R Gill, Liz Gloyn, Robert Goggs, Usha Govinden, Garrett Greene, Victor Greiff, D S Grundle, Patrick Grüneberg, Nicksy Gumede, Gbaguidi Haore, Pille Harrison, Xavier Hoenner, Diego Hojsgaard, Hikaru Hori, Maria P Ikonomopoulou, Patrick Jeurissen, Daniel M Johnson, Dhiraj Kabra, Koji Kamagata, Chandan Karmakar, Olga Kasian, Linda K Kaye, Murad M Khan, Yong-Min Kim, J K Kish, Sebastian Kobold, Gary Kohanbash, Gregor Kohls, Jan-Michael Kugler, Gyanendra Kumar, Jon Lacy-Colson, Asam Latif, Volker M Lauschke, Bingling Li, Chinten J Lim, Fang Liu, Xiaodong Liu, Jin-Jian Lu, Qiang Lu, Poornima Mahavadi, Ugo Marzocchi, Christine A McGarrigle, Tom van Meerten, Rogier Min, Iain Moal, Massimiliano Molari, Lucas Molleman, Saiful R Mondal, Thea van de Mortel, W N Moss, Othonas A Moultos, Maheswari Mukherjee, Kazuhiko Nakayama, Edward Narayan, Navaratnarajah, Philipp-Alexander Neumann, Jiyun Nie, Yingjiu Nie, Frank Niemeyer, Fiona Nolan, Ogueri Nwaiwu, Wendy H Oldenmenger, Emmanuel Olumayede, Jianhong Ou, Menuka Pallebage-Gamarallage, Simon P Pearce, Tuula Pelkonen, Maria C Pelleri, Joana L Pereira, Mpho Pheko, Karina A Pinto, Allison Piovesan, Michael Pluess, Illya M Podolsky, Julie Prescott, Dongchen Qi, Xingshun Qi, Vaia D Raikou, Andreas Ranft, Johanna Rhodes, Jean-Yves Rotge, Anna D Rowe, Manish Saggar, Robert A Schuon, Shaouli Shahid, Vahid Shalchyan, Prasad Shirvalkar, Oleg Shiryayev, Jugpreet Singh, Michael J Smout, António Soares, Chunjiao Song, Kshitij Srivastava, Rupesh K Srivastava, Jim Sun, Attila Szabo, Wiktor Szymanski, Chan N P Tai, Hisashi Takeuchi, S Tanadini-Lang, Fei Tang, Wanyin Tao, G Theron, Chang F Tian, Yu-Shi Tian, Lisa M Tuttle, Anna Valenti, Pierre Verlot, Mirella Walker, Jun Wang, Danielle Welter, Matthew Winslade, Dalei Wu, Yi-Rui Wu, Han Xiao, Beisi Xu, Juan Xu, Ziyue Xu, Dongdong Yang, Mingjun Yang, Patricio Yankilevich, Yuyi You, Chenglong Yu, Jian Zhan, Gong Zhang, Kai Zhang, Tuo Zhang, Yi Zhang, Guoyan Zhao, Jing Zhao, Xiaofan Zhou, Zhenxing Zhu, Penelope A Ajani, Udunna C Anazodo, Saeed A Bagloee, Kasia Bail, Ido Bar, Joe Bathelt, David Benkeser, Meghan L Bernier, Adam M Blanchard, Dominic W Boakye, Vasileios Bonatsos, Michele H Boon, George Bouboulis, Elizabeth Bromfield, Joshua Brown, Kim C M Bul, Kathryn J Burton, Eugene G Butkowski, Grace Carroll, Fengqing Chao, Elisabeth E Charrier, Xiaoyin Chen, Yu-Chih Chen, Chenguang, Jane R Choi, Tore Christoffersen, João C Comel, Cyril Cosse, Yanru Cui, Pieter van Dessel, Dhaval, Daria Diodato, Maelle Duffey, Avik Dutt, Luis G Egea, Mohammed El-Said, Martin Faye, Beatriz Fernandez-Fernandez, Kieran G Foley, Luria L Founou, Fan Fu, Rabea A Gadelkareem, Evgeny Galimov, Gulcan Garip, Alison Gemmill, Quentin Gouil, James Grey, Zoya Gridneva, Michel J Grothe, Théophile Grébert, Fabricio Guerrero, Léo Guignard, Marco J Haenssgen, David Hasler, Joan Y Holgate, Ancheng Huang, Amanda M Hulse-Kemp, Claire Jean-Quartier, Sang-Min Jeon, Yangyang Jia, Catherine Jutzeler, Panagiotis Kalatzis, Masud Karim, Kathrin Karsay, Anne Keitel, Andreas Kempe, Jeremy R Keown, Chin M Khoo, Nyil Khwaja, Rogier A Kievit, Aleksandra Kosanic, Dimitrios A Koutoukidis, Paul Kramer, Dilip Kumar, Nükhet Kırağ, Giuseppe Lanza, Thuc D Le, Jung W Leem, Daniel Leightley, Andreia Leite, Lukas Lercher, Ying Li, Renly Lim, Luiz R A Lima, Li Lin, Tong Ling, Yuchen Liu, Zhonghua Liu, Yao Lu, Fok M Lum, Hang Luo, Jatin Machhi, Angus Macleod, Isaac Macwan, Hanumantha R Madala, Nima Madani, Nicola de Maio, Kalina Makowiecki, Daniel J Mallinson, Ruta Margelyte, Caracausi Maria, Y Markonis, Luca Marsili, Suzanne Mavoa, Lorna McWilliams, Moa Megersa, Caetano S M Mendes, Julia Menichetti, Rebecca Mercieca-Bebber, Jack J Miller, David-Paul M Minde, Alexander Minges, Eleanor Mishra, Virendra R Mishra, Carly Moores, Nicola Morrice, Alexander E Moskalensky, Nicolò Navarin, Edessa Negera, Philippe Nolet, Ana Nordberg, Rickard Nordén, Jessica P Nowicki, Nelly Olova, Paweł Olszewski, Robert Onzima, Chih-Long Pan, Charny Park, Dong Ik Park, Seyoung Park, Chandrashekhar D Patil, Sansoa A Pedro, Samuel R Perry, Jessica Peter, Brent M Peterson, Andrea Pezzuolo, Ilya Pozdnyakov, Siyu Qian, Lei Qin, Ali Rafe, Ishier Raote, Ali Raza, Henrike Rebl, Osama Refai, Tim Regan, Tambi Richa, Mark F Richardson, K R Robinson, Luca Rossoni, Romain Rouet, Soroush Safaei, Pierre H H Schneeberger, Daniela Schwotzer, Agata Sebastian, Jennifer Selinski, Stefanie Seltmann, Feng Sha, Nir Shalev, Jin-Long Shang, Josef Singer, Mandeep Singh, Taylor Smith, Emma Solomon-Moore, Lijuan Song, Samuele Soraggi, Ryan Stanley, Nico Steckhan, Frederic Strobl, Lorenzo Subissi, Irwan Supriyanto, Chinmay R Surve, Tomo Suzuki, Caitlin Syme, Karl Sörelius, Young Tang, Marwa Tantawy, Sumudu Tennakoon, Serafino Teseo, Christine Toelzer, Nikola Tomov, Miguel Tovar, Linh Tran, Sushil Tripathi, Anil M Tuladhar, Azubuike C Ukubuiwe, Carolina O L Ung, Kaspar Valgepea, Hamid Vatanparast, Arnau Vidal, Fang Wang, Qing Wang, Ricky Watari, Rebecca Webster, Ruth Webster, Junnian Wei, David Wibowo, Tanja S H Wingenbach, Rose M Xavier, Shumin Xiao, Peng Xiong, Shicai Xu, Shilin Xu, Ruifeng Yao, Wen Yao, Qinan Yin, Yongbo Yu, Masayoshi Zaitsu, Zian Zeineb, Xiao-Yong Zhan, Jilei Zhang, Rongqiang Zhang, Wei Zhang, Xianglilan Zhang, Shan Zheng, Bailing Zhou, Xiaoyan Zhou, Haroon Ahmad, Sayo A Akinwumi, Gregory F Albery, Ahmed Alhowimel, Junaid Ali, Mansour Alshehri, Mohammed Alsuhaibani, Andrey Anikin, Samuel O Azubuike, Anders Bach-Mortensen, Lior Baltiansky, Martin Bartas, Kiflemariam Y Belachew, Vivek Bhardwaj, Karin Binder, Nicholas S Bland, Michael Boah, Benjamin Bullen, Giovanna E Calabrò, Tiffany J Callahan, Bing Cao, Kelsey Chalmers, Wei Chang, Zhengping Che, Andrew T Y Chen, Haimin Chen, Huaming Chen, Youning Chen, Zhao Chen, YoungRok Choi, Mohiuddin A K Chowdhury, Martin R Christensen, Robert S C Cooke, Marzia Cottini, Natalie V Covington, Catriona Cunningham, Julien Delarocque, Lucie Devos, Aurup R Dhar, Ke-Feng Ding, Kexian Dong, Zheng Dong, Niklas Dreyer, Chelsea Ekstrand, Tanguy Fardet, Berhanu E Feleke, Thomas Feurer, Angela Freitas, Tian Gao, N G Asefa, Francesco Giganti, Piotr Grabowski, José R Guerra-Mora, Chengying Guo, Xinyi Guo, Himanshu Gupta, Shuonan He, Marloes Heijne, Stephanie Heinemann, Alexander Hogrebe, Zhengping Huang, Sophinese Iskander-Rizk, Lavanya M Iyer, Yasmin Jahan, Ameh S James, Emmanuel Joel, Bastian Joffroy, Clara Jégousse, George Kambondo, Priyanka Karnati, Cihan Kaya, An Ke, Daniel Kelly, Rob Kickert, Peter E Kidibule, Jennifer P Kieselmann, Hyeon J Kim, Takeshi Kitazawa, Aniek Lamberts, You Li, Huakang Liang, Sabrina N Linn, Thomas Litfin, Wang Liusuo, Vasiliki Lygirou, Ajay K Mahato, Zhi-Ming Mai, Rupert W Major, Samira Mali, Panagiotis Mallis, Wenzhi Mao, Wenzhi Mao, Katie Marvin-Dowle, Leanda D Mason, Ben Merideth, Maria J Merino-Plaza, Britt Merlaen, Rossella Messina, Anand K Mishra, Junaid Muhammad, Conrad Musinguzi, Afroditi Nanou, Amreen Naqash, Joe T Nguyen, Thi T H Nguyen, Duan Ni, Nida, Shirli Notcovich, Barnabas Ohst, Quinn R Ollivier, Daniël F Osses, Xiangda Peng, Arnoud Plantinga, Michael Pulia, Muhammad Rafiq, Ayush Raman, Delphine Raucher-Chéné, Rafał Rawski, Asit Ray, Lubna A Razak, Kevin Rudolf, Peter Rusch, Margaux L Sadoine, Axel Schmidt, Roey Schurr, Stephen Searles, Saurab Sharma, Barry Sheehan, Chunhu Shi, Belal Shohayeb, Andrew Sommerlad, Jan Strehlow, Xianbao Sun, Raghav Sundar, Ghazaleh Taherzadeh, Nur D M Tahir, Jun Tang, Jean Testa, Zhiqi Tian, Qian Tingting, Geert P Verheijen, Casey Vickstrom, Teng Wang, Xiaomin Wang, Zhenxing Wang, Pan Wei, Alex Wilson, Wyart, Abdul-Amir Yassine, Abbas Yousefzadeh, Asma Zare, Zhen Zeng, Chengrong Zhang, Haowen Zhang, Linxing Zhang, Tongchuan Zhang, Weijia Zhang, Zhe Zhang, Jianyu Zhou, Dongjie Zhu, Vincenzo Adamo, Adebolajo A Adeyemo, Maria Aggelidou, Adi M Al-Owaifeer, Arwa Z Al-Riyami, Saeed K Alzghari, Vibeke Andersen, Kathryn Angus, Muhammad Asaduzzaman, Hadi Asady, Dai Ato, Xiaoyong Bai, Rebecca L Baines, Maghan Ballantyne, Bo Ban, Jill Beck, Walid Ben-Nafa, Emma Black, Antoine Blancher, Ron Blankstein, Neil Bodagh, Paulo A V Borges, Anastasia Brooks, Josue Brox-Ponce, Arturo Brunetti, Colin D Canham, Piero Carninci, Richard Carvajal, Shun C Chang, Jie Chao, Pranab Chatterjee, He Chen, Yi-Chun Chen, Adnan K Chhatriwalla, Ibrahim Chikowe, Trees-Juen Chuang, Rosane G Collevatti, Diego A Valera-Cornejo, Ana Cuenda, Myriam Dao, Delphine Dauga, Zaian Deng, Kiran Devkota, Lisa V Doan, Yaser H A Elewa, Dongsheng Fan, Mohammed Faruk, Shi Feifei, Trevor S Ferguson, Francesco Fleres, Emma J Foster, C Stephen Foster, Tzvi Furer, Yibo Gao, Enid J Garcia-Rivera, Adi Gazdar, Ronald B George, Sayantan Ghosh, Elena Gianchecchi, Joshua M Gleason, Allan Hackshaw, Adam Hall, Richard Hall, Paul Harper, William E Hogg, Guangqun Huang, Kylie E Hunter, Adriaan P IJzerman, Carlos Jesus, Gao Jian, James S Lewis Jr, Souha S Kanj, Harsheen Kaur, Shona Kelly, Fayez Kheir, V S Kichatova, Musa Kiyani, Reinhild Klein, Tom Kovesi, Jennifer L Kraschnewski, Addanki P Kumar, Dmitry Labutin, Alejandro Lazo-Langner, Guy Leclercq, Maoteng Li, Qingchun Li, Tangliang Li, Yongzhe Li, Wei-Ting Liao, Zheng-yin Liao, Jessica Lin, J Lizer, Giambattista Lobreglio, Cher Lowies, Cheng Lu, Haroon Majeed, Adam Martin, Luis Martinez-Sobrido, Edwin Meresh, Marianne Middelveen, Alireza Mohebbi, Jorge Mota, Zahra Mozaheb, Ley Muyaya, Amar Nandhakumar, Sheryl H X Ng, Monther Obeidat, Deog-Hwan Oh, Mohammed Owais, Pia Pace-Asciak, Ajay Panwar, Caroline Park, Chris Patterson, Felipe Penagos-Tabaree, Paolo T Pianosi, Valentina Pinzi, Clare Pridans, Anna Psaroulaki, Ravi Kumar Pujala, Leonardo Pulido-Arjona, Peng-Fei Qi, Proton Rahman, Nayanjot K Rai, Tienush Rassaf, Julie Refardt, Walter Ricciardi, Olaf Riess, Alexandros Rovas, Frank M Sacks, Sherif Saleh, Christopher Sampson, Axel Schmutz, Robert Sepanski, Neeraj Sharma, Manisha Singh, Paul Spearman, Mehala Subramaniapillai, Ritu Swali, Cher M Tan, Juan I Tellechea, Lisa-Marie Thomas, Xin Tong, Demetrios G Vavvas, Ralf Veys, Veronica Vitriol, Horng-Dar Wang, Jinhui Wang, Jiucun Wang, Jason Waugh, S A Webb, Brendan A Williams, Alan D Workman, Tingxiu Xiang, Li-Xin Xie, Jun Xu, Taosheng Xu, Chongjun Yang, Jihoon G Yoon, Christina M Yuan, Arno Zaritsky, Yao Zhang, Haochen Zhao, Hannah Zuckerman, Ran Lyu, Wayne Pullan, Yaoqi Zhou, and
Database, 2019
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.
Celastrol-induced weight loss is driven by hypophagia and independent from UCP1
Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschöp, Paul T. Pfluger
Diabetes, 2018
Celastrol, a plant-derived constituent of traditional Chinese medicine, has been proposed to offer significant potential as an antiobesity drug. However, the molecular mechanism for this activity is unknown. We show that the weight-lowering effects of celastrol are driven by decreased food consumption. Although young Lepob mice respond with a decrease in food intake and body weight, adult Lepdb and Lepob mice are unresponsive to celastrol, suggesting that functional leptin signaling in adult mice is required to elicit celastrol’s catabolic actions. Protein tyrosine phosphatase 1 (PTP1B), a leptin negative-feedback regulator, has been previously reported to be one of celastrol’s targets. However, we found that global PTP1B knockout (KO) and wild-type (WT) mice have comparable weight loss and hypophagia when treated with celastrol. Increased levels of uncoupling protein 1 (UCP1) in subcutaneous white and brown adipose tissue suggest celastrol-induced thermogenesis as a further mechanism. However, diet-induced obese UCP1 WT and KO mice have comparable weight loss upon celastrol treatment, and celastrol treatment has no effect on energy expenditure under ambient housing or thermoneutral conditions. Overall, our results suggest that celastrol-induced weight loss is hypophagia driven and age-dependently mediated by functional leptin signaling. Our data encourage reconsideration of therapeutic antiobesity strategies built on leptin sensitization.
FGF21 regulates insulin sensitivity following long-term chronic stress
Tomas Jelenik, Matthias Dille, Sabrina Müller-Lühlhoff, Dhiraj G. Kabra, Zhou Zhou, Christian Binsch, Sonja Hartwig, Stefan Lehr, Alexandra Chadt, Eva M.J. Peters, Johannes Kruse, Michael Roden, Hadi Al-Hasani, Tamara R. Castañeda
Molecular Metabolism, 2018
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
Katrin Pfuhlmann, Sonja C. Schriever, Beata Legutko, Peter Baumann, Luke Harrison, Dhiraj G. Kabra, Emily Violette Baumgart, Matthias H. Tschöp, Cristina Garcia-Caceres, Paul T. Pfluger
Journal of Neuroinflammation, 2018
Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress
C. Binsch, T. Jelenik, A. Pfitzer, M. Dille, S. Müller-Lühlhoff, S. Hartwig, S. Karpinski, S. Lehr, D.G. Kabra, A. Chadt, M. Roden, H. Al-Hasani, T.R. Castañeda
Molecular Metabolism, 2017
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency
Sonja C. Schriever, Annemarie Zimprich, Katrin Pfuhlmann, Peter Baumann, Florian Giesert, Valentina Klaus, Dhiraj G. Kabra, Ulrich Hafen, Artem Romanov, Matthias H. Tschöp, Wolfgang Wurst, Marcus Conrad, Sabine M. Hölter, Daniela Vogt Weisenhorn, Paul T. Pfluger
Neuroscience, 2017
Hypothalamic leptin action is mediated by histone deacetylase 5
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Nature Communications, 2016
Calcineurin Links Mitochondrial Elongation with Energy Metabolism
Paul T. Pfluger, Dhiraj G. Kabra, Michaela Aichler, Sonja C. Schriever, Katrin Pfuhlmann, Verónica Casquero García, Maarit Lehti, Jon Weber, Maria Kutschke, Jan Rozman, John W. Elrod, Andrea L. Hevener, Annette Feuchtinger, Martin Hrabě de Angelis, Axel Walch, Stephanie M. Rollmann, Bruce J. Aronow, Timo D. Müller, Diego Perez-Tilve, Martin Jastroch, Maria De Luca, Jeffery D. Molkentin, Matthias H. Tschöp
Cell Metabolism, 2015
Tachykinin-1 in the central nervous system regulates adiposity in rodents
Chitrang Trivedi, Xiaoye Shan, Yi-Chun Loraine Tung, Dhiraj Kabra, Jenna Holland, Sarah Amburgy, Kristy Heppner, Henriette Kirchner, Giles S. H. Yeo, Diego Perez-Tilve
Endocrinology United States, 2015
Ablation of Ghrelin O-Acyltransferase Does Not Improve Glucose Intolerance or Body Adiposity in Mice on a Leptin-Deficient ob/ob Background
Henriette Kirchner, Kristy M. Heppner, Jenna Holland, Dhiraj Kabra, Matthias H. Tschöp, Paul T. Pfluger
Plos One, 2013
P62 Links β-adrenergic input to mitochondrial function and thermogenesis
Timo D. Müller, Sang Jun Lee, Martin Jastroch, Dhiraj Kabra, Kerstin Stemmer, Michaela Aichler, Bill Abplanalp, Gayathri Ananthakrishnan, Nakul Bhardwaj, Sheila Collins, Senad Divanovic, Max Endele, Brian Finan, Yuanqing Gao, Kirk M. Habegger, Jazzmin Hembree, Kristy M. Heppner, Susanna Hofmann, Jenna Holland, Daniela Küchler, Maria Kutschke, Radha Krishna, Maarit Lehti, Rebecca Oelkrug, Nickki Ottaway, Diego Perez-Tilve, Christine Raver, Axel K. Walch, Sonja C. Schriever, John Speakman, Yu-Hua Tseng, Maria Diaz-Meco, Paul T. Pfluger, Jorge Moscat, Matthias H. Tschöp
Journal of Clinical Investigation, 2013
High calorie diet triggers hypothalamic angiopathy
Chun-Xia Yi, Martin Gericke, Martin Krüger, Anneke Alkemade, Dhiraj G. Kabra, Sophie Hanske, Jessica Filosa, Paul Pfluger, Nathan Bingham, Stephen C. Woods, James Herman, Andries Kalsbeek, Marcus Baumann, Richard Lang, Javier E. Stern, Ingo Bechmann, Matthias H. Tschöp
Molecular Metabolism, 2012
Targeted estrogen delivery reverses the metabolic syndrome
Brian Finan, Bin Yang, Nickki Ottaway, Kerstin Stemmer, Timo D Müller, Chun-Xia Yi, Kirk Habegger, Sonja C Schriever, Cristina García-Cáceres, Dhiraj G Kabra, Jazzminn Hembree, Jenna Holland, Christine Raver, Randy J Seeley, Wolfgang Hans, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Joseph P Tiano, Franck Mauvais-Jarvis, Diego Perez-Tilve, Paul Pfluger, Lianshan Zhang, Vasily Gelfanov, Richard D DiMarchi, Matthias H Tschöp
Nature Medicine, 2012
The goat-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction
Chun-Xia Yi, Kristy M. Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D. Gaylinn, Timo D. Müller, Erin Bartley, Harold W. Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M. Habegger, Stephen C. Benoit, Martin Bidlingmaier, Michael O. Thorner, Diego Perez-Tilve, Matthias H. Tschöp, Paul T. Pfluger
Plos One, 2012
Contribution of formulation and excipients towards enhanced permeation of curcumin
B. Wahlang, D. Kabra, Y. Pawar, K. Tikoo, A. Bansal
Arzneimittel Forschung Drug Research, 2012
Pharmacological treatment of obesity
Dhiraj G. Kabra, Uma D. Kabra, Matthias H. Tschöp, Susanna Hofmann
Sleep Loss and Obesity Intersecting Epidemics, 2012
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
Timo D. Müller, Lorraine M. Sullivan, Kirk Habegger, Chun‐Xia Yi, Dhiraj Kabra, Erin Grant, Nickki Ottaway, Radha Krishna, Jenna Holland, Jazzminn Hembree, Diego Perez‐Tilve, Paul T. Pfluger, Michael J. DeGuzman, Marc E. Siladi, Vadim S. Kraynov, Douglas W. Axelrod, Richard DiMarchi, Jason K. Pinkstaff, Matthias H. Tschöp
Journal of Peptide Science, 2012
Insulin induced alteration in post-translational modifications of histone H3 under a hyperglycemic condition in L6 skeletal muscle myoblasts
Dhiraj G. Kabra, Jeena Gupta, Kulbhushan Tikoo
Biochimica Et Biophysica Acta Molecular Basis of Disease, 2009
Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy
Kulbhushan Tikoo, Karmveer Singh, Dhiraj Kabra, Vikram Sharma, Anil Gaikwad
Free Radical Research, 2008
Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
K Tikoo, R L Meena, D G Kabra, A B Gaikwad
British Journal of Pharmacology, 2008
Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
Kulbhushan Tikoo, Deepak Kumar Bhatt, Anil Bhanudas Gaikwad, Vikram Sharma, Dhiraj G. Kabra
FEBS Letters, 2007
Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
Kulbhushan Tikoo, Durga Nand Tripathi, Dhiraj G. Kabra, Vikram Sharma, Anil Bhanudas Gaikwad
FEBS Letters, 2007
Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat
Dhiraj G Kabra, Meenakshisundaram Thiyagarajan, Chaman L Kaul, Shyam S Sharma
Brain Research Bulletin, 2004

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