Dr. Abhijit Saha

@srmist.edu.in

Assistant Professor
SRM Institute of Science and Technology

The area of Research Experience: (a) Chemical synthesis of peptide, peptoid, peptide-based small molecules, and drug modification using peptide for targeted delivery, (b) Targeted delivery of a theranostic agent to cancer cells in vitro as well as in vivo mice model, (c) Bioimaging, confocal fluorescence microscopy, AFM, TEM, SEM imaging, (d) Study the aggregation of amyloid-beta peptide inside the cell like environment and SH-SY5Y cell line and its inhibition, (e) Anti-fouling, anti-bacterial study with synthesized molecules.

EDUCATION

Doctor of Philosophy ( (2011-2016) in Chemistry from the Department of Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India. (Guide: Prof. Surajit Ghosh)
CSIR-UGC NET with JRF (2011) in Chemical Science with rank CSIR-46
Master of Science (M.Sc.) (2009-2011) in Chemistry from the University of Calcutta, Raja-bazar Science College. Marks obtained: 77.5%
Bachelor of Science (B.Sc.) (2006-2009) in Chemistry (Honours) from the University of Calcutta, Ramakrishna Mission Vivekananda Centenary College, Rahara. Marks Obtained: 68.4%
Higher Secondary (2006) from West Bengal Council of Higher Secondary Examination. Sodepur High School. Marks Obtained: 78.9%
Class 10 Madhyamik (2004) from West Bengal Board of Secondary Education. Marks Obtained: 83.4%

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Organic Chemistry, Spectroscopy, Inorganic Chemistry
55

Scopus Publications

1012

Scholar Citations

20

Scholar h-index

29

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Tuning Anticancer Properties via Electron Distribution: Inducing Apoptosis Through Downregulation of Reactive Oxygen Species and Docking Studies on Bcl‐2 Protein by a 2, 4, 5 …
    H Elango, S Guha, S Ganesan, S Ganesh, G Munuswamy‐Ramanujam, ...
    ChemistrySelect 10 (44), e03541 , 2025
    2025
  • Sensing Redox Reaction by SPR Peak Shifting: Bioinspired Innovative Functionalization Enables Silver Nanoparticles as Ascorbic Acid Sensors
    H Elango, S Ganesh, A Saha
    ChemistrySelect 10 (34), e02048 , 2025
    2025
  • Overview of Small Molecules Used in Nanoparticle Functionalization to Prevent Protein Corona Formation and Improve the Therapeutic Potential
    S Ganesh, H Elango, A Saha
    ChemistrySelect 10 (25), e02177 , 2025
    2025
    Citations: 1
  • pH and Medium Polarity‐Induced Self‐Assembly of Fmoc‐Tryptophan Into Multiple Superstructures: An Experimental and Theoretical Investigations
    S Nayak, N Raghul, A Saha, R Lo, P Das
    ChemPlusChem 90 (6), e202500036 , 2025
    2025
    Citations: 3
  • Sticky tubes co-assembled by functionalised diphenylalanine and polydopamine nanoparticles form biocompatible antifouling coating
    S Sivagnanam, S Nayak, A Halder, O Mukherjee, A Saha, P Das
    RSC advances 15 (5), 3672-3685 , 2025
    2025
    Citations: 3
  • Liposomal Encapsulation of Chlorambucil with a Terpyridine-Based, Glutathione-Targeted Optical Probe Facilitates Cell Entry and Cancer Cell Death
    M Siva, K Das, P Rana, A Saha, D Mandal, A Barik, A Stewart, B Maity, ...
    ACS applied bio materials 8 (1), 570-581 , 2024
    2024
    Citations: 2
  • In-situ eco-friendly synthesis of a biomimetic robust antibacterial nanohybrid via catecholamine-induced metallization
    AK Rajeev, N Sathish, H Elango, S Sivagnanam, S Nayak, P Das, A Saha
    Inorganic Chemistry Communications 170, 113172 , 2024
    2024
    Citations: 6
  • Benzimidazole-based small molecules as anticancer agents targeting telomeric G-quadruplex and inhibiting telomerase enzyme
    H Elango, RN Das, A Saha
    Future Medicinal Chemistry 16 (19), 2043-2067 , 2024
    2024
    Citations: 7
  • Human Organs-on-a-chip Technology
    PV Mohanan
    Elsevier , 2024
    2024
    Citations: 4
  • Importance of soft lithography
    AK Rajeev, N Sathish, A Saha
    Human organs-on-a-chip technology, 43-61 , 2024
    2024
    Citations: 6
  • Liposomes containing zinc-based chemotherapeutic drug block proliferation and trigger apoptosis in breast cancer cells
    M Siva, K Das, S Guha, S Sivagnanam, G Das, A Saha, A Stewart, B Maity, ...
    ACS applied bio materials 6 (12), 5310-5323 , 2023
    2023
    Citations: 9
  • Vanillin benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in alzheimer’s disease brain
    PK Gharai, J Khan, R Mallesh, S Garg, A Saha, S Ghosh, S Ghosh
    ACS Chemical Neuroscience 14 (4), 773-786 , 2023
    2023
    Citations: 28
  • Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion
    G Mechrez, KA Mani, A Saha, O Lachman, N Luria, O Molad, ...
    ACS Applied Bio Materials 5 (8), 3859-3869 , 2022
    2022
    Citations: 1
  • Evidence for new enantiospecific interaction force in chiral biomolecules
    Y Kapon, A Saha, T Duanis-Assaf, T Stuyver, A Ziv, T Metzger, S Yochelis, ...
    Chem 7 (10), 2787-2799 , 2021
    2021
    Citations: 39
  • Nucleobase morpholino β amino acids as molecular chimeras for the preparation of photoluminescent materials from ribonucleosides
    R Bucci, A Bossi, E Erba, F Vaghi, A Saha, S Yuran, D Maggioni, ...
    Scientific Reports 10 (1), 19331 , 2020
    2020
    Citations: 20
  • Amphiphilic peptide with dual functionality resists biofouling
    A Saha, S Nir, M Reches
    Langmuir 36 (15), 4201-4206 , 2020
    2020
    Citations: 37
  • A bis-indole/carbazole based C5-curcuminoid fluorescent probe with large Stokes shift for selective detection of biothiols and application to live cell imaging
    P Bhattacharjee, S Chatterjee, A Achari, A Saha, D Nandi, C Acharya, ...
    Analyst 145 (4), 1184-1189 , 2020
    2020
    Citations: 17
  • AFM‐based spin‐exchange microscopy using chiral molecules
    A Ziv, A Saha, H Alpern, N Sukenik, LT Baczewski, S Yochelis, M Reches, ...
    Advanced Materials 31 (40), 1904206 , 2019
    2019
    Citations: 84
  • Multiplex optical detection and quantification of DNA fragments by metallo-peptide assemblies
    A Saha, M Reches
    Scientific Reports 9 (1), 8789 , 2019
    2019
    Citations: 3
  • Potential neuroprotective peptide emerged from dual neurotherapeutic targets: A fusion approach for the development of anti-Alzheimer’s lead
    P Mondal, G Das, J Khan, K Pradhan, R Mallesh, A Saha, B Jana, ...
    ACS Chemical Neuroscience 10 (5), 2609-2620 , 2019
    2019
    Citations: 20

MOST CITED SCHOLAR PUBLICATIONS

  • Indolicidin targets duplex DNA: structural and mechanistic insight through a combination of spectroscopy and microscopy
    A Ghosh, RK Kar, J Jana, A Saha, B Jana, J Krishnamoorthy, D Kumar, ...
    ChemMedChem 9 (9), 2052-2058 , 2014
    2014
    Citations: 138
  • AFM‐based spin‐exchange microscopy using chiral molecules
    A Ziv, A Saha, H Alpern, N Sukenik, LT Baczewski, S Yochelis, M Reches, ...
    Advanced Materials 31 (40), 1904206 , 2019
    2019
    Citations: 84
  • Excited state proton transfer in the lysosome of live lung cells: normal and cancer cells
    R Chowdhury, A Saha, AK Mandal, B Jana, S Ghosh, K Bhattacharyya
    The Journal of Physical Chemistry B 119 (6), 2149-2156 , 2015
    2015
    Citations: 62
  • Spatial position regulates power of tryptophan: discovery of a major-groove-specific nuclear-localizing, cell-penetrating tetrapeptide
    D Bhunia, P Mondal, G Das, A Saha, P Sengupta, J Jana, S Mohapatra, ...
    Journal of the American Chemical Society 140 (5), 1697-1714 , 2018
    2018
    Citations: 53
  • Apoferritin nanocage delivers combination of microtubule and nucleus targeting anticancer drugs
    S Ghosh, S Mohapatra, A Thomas, D Bhunia, A Saha, G Das, B Jana, ...
    ACS Applied Materials & Interfaces 8 (45), 30824-30832 , 2016
    2016
    Citations: 45
  • Confocal microscopy of cytoplasmic lipid droplets in a live cancer cell: number, polarity, diffusion and solvation dynamics
    R Chowdhury, B Jana, A Saha, S Ghosh, K Bhattacharyya
    MedChemComm 5 (4), 536-539 , 2014
    2014
    Citations: 42
  • Evidence for new enantiospecific interaction force in chiral biomolecules
    Y Kapon, A Saha, T Duanis-Assaf, T Stuyver, A Ziv, T Metzger, S Yochelis, ...
    Chem 7 (10), 2787-2799 , 2021
    2021
    Citations: 39
  • Amphiphilic peptide with dual functionality resists biofouling
    A Saha, S Nir, M Reches
    Langmuir 36 (15), 4201-4206 , 2020
    2020
    Citations: 37
  • Novel hexapeptide interacts with tubulin and microtubules, inhibits Aβ fibrillation, and shows significant neuroprotection
    A Biswas, P Kurkute, S Saleem, B Jana, S Mohapatra, P Mondal, A Adak, ...
    ACS Chemical Neuroscience 6 (8), 1309-1316 , 2015
    2015
    Citations: 32
  • α-Cyclodextrin interacts close to vinblastine site of tubulin and delivers curcumin preferentially to the tubulin surface of cancer cell
    B Jana, S Mohapatra, P Mondal, S Barman, K Pradhan, A Saha, S Ghosh
    ACS Applied Materials & Interfaces 8 (22), 13793-13803 , 2016
    2016
    Citations: 30
  • Dual Functionalized Graphene Oxide Serves as a Carrier for Delivering Oligohistidine‐and Biotin‐Tagged Biomolecules into Cells
    B Jana, G Mondal, A Biswas, I Chakraborty, A Saha, P Kurkute, S Ghosh
    Macromolecular Bioscience 13 (11), 1478-1484 , 2013
    2013
    Citations: 29
  • Vanillin benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in alzheimer’s disease brain
    PK Gharai, J Khan, R Mallesh, S Garg, A Saha, S Ghosh, S Ghosh
    ACS Chemical Neuroscience 14 (4), 773-786 , 2023
    2023
    Citations: 28
  • Cancer cell specific delivery of photosystem I through integrin targeted liposome shows significant anticancer activity
    A Saha, S Mohapatra, G Das, B Jana, S Ghosh, D Bhunia, S Ghosh
    ACS applied materials & interfaces 9 (1), 176-188 , 2017
    2017
    Citations: 28
  • In vitro reconstitution of a cell-like environment using liposomes for amyloid beta peptide aggregation and its propagation
    A Saha, G Mondal, A Biswas, I Chakraborty, B Jana, S Ghosh
    Chemical Communications 49 (55), 6119-6121 , 2013
    2013
    Citations: 25
  • Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells
    A Saha, S Mohapatra, P Kurkute, B Jana, P Mondal, D Bhunia, S Ghosh, ...
    Chemical Communications 51 (12), 2249-2252 , 2015
    2015
    Citations: 24
  • Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform
    S Khanna, B Jana, A Saha, P Kurkute, S Ghosh, S Verma
    Dalton Transactions 43 (26), 9838-9842 , 2014
    2014
    Citations: 24
  • Rational design of amphiphilic peptides and its effect on antifouling performance
    SL Gaw, G Sakala, S Nir, A Saha, ZJ Xu, PS Lee, M Reches
    Biomacromolecules 19 (9), 3620-3627 , 2018
    2018
    Citations: 22
  • Synergistic anticancer effect of peptide‐docetaxel nanoassembly targeted to tubulin: Toward development of dual warhead containing nanomedicine
    S Mohapatra, A Saha, P Mondal, B Jana, S Ghosh, A Biswas, S Ghosh
    Advanced healthcare materials 6 (2), 1600718 , 2017
    2017
    Citations: 21
  • Nucleobase morpholino β amino acids as molecular chimeras for the preparation of photoluminescent materials from ribonucleosides
    R Bucci, A Bossi, E Erba, F Vaghi, A Saha, S Yuran, D Maggioni, ...
    Scientific Reports 10 (1), 19331 , 2020
    2020
    Citations: 20
  • Potential neuroprotective peptide emerged from dual neurotherapeutic targets: A fusion approach for the development of anti-Alzheimer’s lead
    P Mondal, G Das, J Khan, K Pradhan, R Mallesh, A Saha, B Jana, ...
    ACS Chemical Neuroscience 10 (5), 2609-2620 , 2019
    2019
    Citations: 20