Osama Hamadelseed

I am a resident of radiology and a researcher focusing on Down syndrome and Alzheimer's disease

EDUCATION

2014 bachelor's degree in medicine from the Faculty of Medicine, Khartoum University, Khartoum, Sudan
2020 German medical license (Approbation), University Clinics Heidelberg, Germany
2023 Dr. med. in Neuroanatomy, Heidelberg University, Germany
Since 2023, Postdoc Dept. of Neuroanatomy, Heidelberg University, Germany

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Cell Biology, Radiology, Nuclear Medicine and imaging, Neuroscience

Scopus Publications

Stem cell-based therapeutic strategies for down syndrome and Alzheimer’s disease
Osama Hamadelseed, Thomas Skutella
Stem Cell Research and Therapy, 2025
Background Down syndrome (DS) and Alzheimer’s disease (AD) are two distinct yet interconnected neurological conditions that share overlapping pathological features, including amyloid-beta plaque accumulation, neuroinflammation, and progressive neurodegeneration. Individuals with DS are at increased risk of developing AD-like dementia owing to the overexpression of the amyloid precursor protein-encoding gene on chromosome 21. Despite significant research efforts, effective disease-modifying treatments remain unavailable for both conditions, necessitating the exploration of novel therapeutic approaches. Methods We analyzed and synthesized the existing literature on stem cell therapy as a treatment for DS and AD. We conducted a comprehensive search of PubMed, Google Scholar, and Web of Science databases, focusing on recent, high-quality, and peer-reviewed studies on stem cell therapy in DS and AD. Results The findings indicate that stem cell therapy represents a promising therapeutic approach for both conditions. Preclinical trials using neural, mesenchymal, and induced pluripotent stem cells have shown their potential to mitigate disease pathology, restore neuronal function, modulate neuroinflammation, enhance neurogenesis, and improve cognitive performance in DS and AD models; these findings suggest the viability of stem cell-based interventions as a disease-modifying strategy. However, despite promising findings, the efficacy and safety of these approaches require further validation through well-designed human clinical trials before clinical translation. Furthermore, AD research in stem cell therapy is currently more advanced than DS research, with a greater number of preclinical and early clinical investigations. In fact, people with DS have been previously excluded from clinical trials. Conclusions While both DS and AD share common neurodegenerative mechanisms and are potential candidates for stem cell therapeutic approaches, the therapeutic focus varies. This study underscores the potential of stem cell therapy as a novel disease-modifying approach for both conditions while emphasizing the need for further research to refine therapeutic protocols, address ethical and safety concerns, and evaluate the feasibility of translating these therapies into clinical practice.
Applications of 3D Bioprinting in Nanoneuroscience
Mojtaba Barzegar, Helena R. Pereira, Osama Hamadelseed, Shima Shahjouei, Hugo A. Ferreira, et al.
Textbook of Nanoneuroscience and Nanoneurosurgery Second Edition, 2024
Correlating MRI-based brain volumetry and cognitive assessment in people with Down syndrome
Osama Hamadelseed, Thomas Skutella
Brain and Behavior, 2023
IntroductionDown syndrome (DS) is the most common genetic cause of intellectual disability. Children and adults with DS show deficits in language performance and explicit memory. Here, we used magnetic resonance imaging (MRI) on children and adults with DS to characterize changes in the volume of specific brain structures involved in memory and language and their relationship to features of cognitive‐behavioral phenotypes.MethodsThirteen children and adults with the DS phenotype and 12 age‐ and gender‐matched healthy controls (age range 4–25) underwent an assessment by MRI and a psychological evaluation for language and cognitive abilities.ResultsThe cognitive profile of people with DS showed deficits in different cognition and language domains correlating with reduced volumes of specific regional and subregional brain structures, confirming previous related studies. Interestingly, in our study, people with DS also showed more significant parahippocampal gyrus volumes, in agreement with the results found in earlier reports.ConclusionsThe memory functions and language skills affected in studied individuals with DS correlate significantly with the reduced volume of specific brain regions, allowing us to understand DS's cognitive‐behavioral phenotype. Our results provide an essential basis for early intervention and the design of rehabilitation management protocols.
Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review
Osama Hamadelseed, Mike K. S. Chan, Michelle B. F. Wong, Thomas Skutella
Frontiers in Neuroscience, 2023
ObjectivesWe critically review research findings on the unique changes in brain structure and cognitive function characteristic of Down syndrome (DS) and summarize the similarities and differences with other neurodevelopmental disorders such as Williams syndrome, 22q11.2 deletion syndrome, and fragile X syndrome.MethodsWe conducted a meta-analysis and systematic literature review of 84 studies identified by searching PubMed, Google Scholar, and Web of Science from 1977 to October 2022. This review focuses on the following issues: (1) specific neuroanatomic and histopathological features of DS as revealed by autopsy and modern neuroimaging modalities, (2) language and memory deficits in DS, (3) the relationships between these neuroanatomical and neuropsychological features, and (4) neuroanatomic and neuropsychological differences between DS and related neurodevelopmental syndromes.ResultsNumerous post-mortem and morphometric neuroimaging investigations of individuals with DS have reported complex changes in regional brain volumes, most notably in the hippocampal formation, temporal lobe, frontal lobe, parietal lobe, and cerebellum. Moreover, neuropsychological assessments have revealed deficits in language development, emotional regulation, and memory that reflect these structural changes and are more severe than expected from general cognitive dysfunction. Individuals with DS also show relative preservation of multiple cognitive, linguistic, and social domains compared to normally developed controls and individuals with other neurodevelopmental disorders. However, all these neurodevelopment disorders exhibit substantial heterogeneity among individuals.ConclusionPeople with Down syndrome demonstrate unique neurodevelopmental abnormalities but cannot be regarded as a homogenous group. A comprehensive evaluation of individual intellectual skills is essential for all individuals with neurodevelopment disorders to develop personalized care programs.
Psychosocial Risk Factors for Alzheimer’s Disease in Patients with Down Syndrome and Their Association with Brain Changes: A Narrative Review
Osama Hamadelseed, Ibrahim H. Elkhidir, Thomas Skutella
Neurology and Therapy, 2022
3D surgical planning of pediatric tumors: a review
Helena Rico Pereira, Mojtaba Barzegar, Osama Hamadelseed, Arnau Valls Esteve, Josep Munuera
International Journal of Computer Assisted Radiology and Surgery, 2022