Ahmed Ragab

Scopus Publications

Recent advances in adamantane-linked heterocycles: synthesis and biological activity
Mohamed H. Helal, Moustafa S. Abusaif, Ahmed Ragab, Samir Y. Abbas, Radwa Ayman, et al.
Molecular Diversity, 2026
Novel chitosan hybrid fluorinated thiourea derivatives as dual anti-microbial and anti-biofilm agents: tailoring molecular interactions, in silico toxicity, and docking simulation
Moustafa S. Abusaif, Ahmed Ragab, Mohamed A. Salem, Nabila A. Maziad, Yousry A. Ammar
Materials Advances, 2026
This article presents the synthesis of chitosan isothiocyanate, followed by hybridization with promising fluorinated aromatic amines, producing three chitosan fluorinated-thiourea samples (CHTUD1–3).
Fabrication of bioactive gelatin boosted by vanillylideneacetone with enhanced antioxidant performance: in vitro, molecular docking, and pharmacokinetic studies
Tamer M. Tamer, Mohamed A. Hassan, Ahmed Ragab, Ruotong Yao, Mohamed S. Mohy-Eldin, et al.
Materials Chemistry and Physics, 2026
Aminated graphene oxide-inspired antibacterial and antioxidant potency of aminated chitosan bio-composite membrane toward biomedical applications: Integrated in vitro and molecular docking analysis
Ali M. Ali, Eman M. Abd El-Monaem, Ahmed Ragab, Xiao-kun Ouyang, Abdelazeem S. Eltaweil, et al.
Diamond and Related Materials, 2026
Thiazole tethered adamantane derivatives as potential FMDV inhibitors: Design, synthesis, antiviral activity, and molecular modeling simulations
Ola A.Abu Ali, Yousry A. Ammar, Moustafa S. Abusaif, Ahmed Ragab
Journal of Molecular Structure, 2026
Effect of Sulfonamide Functionalization on the Corrosion Inhibition Efficiency of Chitosan for Carbon Steel in 1.0 m HCl: Experimental and Computational Approaches
Moustafa S. Abusaif, Amr Gangan, Ahmed E. Hassan, Mohamed A. Salem, Yousry A. Ammar, et al.
Journal of Applied Polymer Science, 2026
This study successfully synthesized and evaluated a novel, eco‐friendly corrosion inhibitor based on chitosan functionalized with a quinoxaline moiety (DQDS). A series of modified chitosan sulfonamide inhibitors (CH‐DQDS1, CH‐DQDS2, CH‐DQDS3) was synthesized by reaction of chitosan with varying molar ratios of quinoxaline sulfonyl chloride under mild conditions (room temperature, stirring). In a corrosive solution of 1.0 M HCl, the samples were determined to be effective corrosion inhibitors for carbon steel. The most effective inhibitor (CH‐DQDS3) achieved a high inhibition efficiency of 91.36% at 400 ppm. Adsorption of inhibitors onto the surface of the steel occurs via a combination of physical and chemical interactions (mixed type), as confirmed by strongly negative Gibbs free energy values (Δ G °ads = −30 to −36 kJ mol −1 ), indicating a spontaneous process. Electrochemical Impedance Spectroscopy (EIS) demonstrated an increase in charge transfer resistance corresponding to the concentration of the inhibitor, as well as the modified chitosan sulfonamide samples exhibiting a higher capacitive semicircle and higher inhibition efficiency percentage than the native chitosan. SEM‐MAP and atomic force microscope (AFM) analyses provided visual confirmation of the creation of a protective adsorbed film. AFM specifically showed a dramatic reduction in surface roughness (from 852 to 210 nm) due to the inhibitor's protective action. Quantum chemical calculations, molecular dynamics (MD), and Monte Carlo simulations provided atomistic insights into the adsorption mechanism at the steel/solution interface. Lastly, the incorporation of the quinoxaline moiety significantly enhanced Chitosan's corrosion inhibition properties. Future work will focus on optimizing the molecular structures and testing performance in more complex, real‐world corrosive environments.
Development of antioxidant-enhanced hyaluronan derivatives functionalized with cinnamaldehyde and pyrogallol-4-carboxaldehyde: Integrated experimental and in silico evaluation
Mohamed E. Hassan, Tamer M. Tamer, Katarina Valachova, Mohamed A. Hassan, Ahmed Ragab, et al.
International Journal of Biological Macromolecules, 2026
Novel corrosion inhibitors and SRB resistivity hydrazones decorated thiazole derivatives as dual-target agent: Design, microwave irradiation synthesis, and DFT calculations
Moustafa S. Abusaif, Amira M. Hyba, Mohamed H. Helal, Yousry A. Ammar, Dina S. Aboul-Magd, et al.
Journal of Industrial and Engineering Chemistry, 2026
Amphiphilic cellulose and alginate–functionalized magnetic ZIF-8 nanocomposites for dinitrophenol removal, colorimetric H₂O₂ sensing, and antibacterial applications
Salah M. Tawfik, Hyejin Jang, Hyukjoo Kwon, Mohamed Fekry, Asmaa A. Roshdy, et al.
International Journal of Biological Macromolecules, 2026
Rational design, synthesis, and in silico evaluation of novel pyridine-based heterocyclic compounds as multifunctional antidiabetic agents: molecular docking and ADMET profiling
Mohamed H. Helal, Ahmed Ragab, Moustafa S. Abusaif, Entsar M. Ahmed, Sobhi M. Gomha, et al.
Journal of Molecular Structure, 2026
Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis, in vitro bio-evaluation, and in silico toxicity prediction with molecular modeling simulations
Kholoud Hesham, Wael M. Aboulthana, Ahmed Ragab
Rsc Advances, 2026
Bridging the gap with amide linkers: rational design, synthesis, and multi-target evaluation of sulfonamide/acetamide-NSAID hybrids as dual COX-2/5-LOX inhibitors
Triveena M. Ramsis, Shaimaa Hussein, Moustafa S. Abusaif, Ahmed Ragab, Yousry A. Ammar, et al.
Future Medicinal Chemistry, 2026
Exploration Novel of Pyrazole and Isoxazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Structure Activity Relationship Study, and Antibiofilm Activity With Molecular Docking Simulation
Khadija E. Saadon, Ahmed Ragab, Nadia M. H. Taha, N. A. Mahmoud, Ali Kh. Khalil, et al.
Drug Development Research, 2025
Exploring novel of 1,2,4-triazolo[4,3-a]quinoxaline sulfonamide regioisomers as anti-diabetic and anti-Alzheimer agents with in-silico molecular docking simulation
Moustafa S. Abusaif, Ahmed M. Sh El-Sharief, Yehia A. Mohamed, Yousry A. Ammar, Mostafa A. Ismail, et al.
Scientific Reports, 2025
Sustainable novel chitosan sulfonamides conjugated with a phthalazine derivative for enhanced corrosion inhibition in acidic environments
Hamdy Khamees Thabet, Moustafa S. Abusaif, Amr Gangan, Ahmed E. Hassan, Yousry A. Ammar, et al.
Rsc Advances, 2025
Flufenamic acid-based sulfonohydrazide and acetamide derivatives NSAI as inhibitors of multi-targets COX-1/COX-2/5-LOX: design, synthesis, in silico ADMET and binding mode studies
Shaimaa Hussein, Eman A. Fayed, Ahmed Ragab, Moustafa S. Abusaif, Yousry A. Ammar, et al.
BMC Chemistry, 2025
Mentha spicata-mediated silver nanoparticles for combating Streptococcus mutans and oral cancer cells
Abdullah Yousef, Salem S. Salem, Ahmed Ragab, Omnia Mohamed El Shahaly, Habiba Omar Rateb, et al.
Scientific Reports, 2025
Novel antibacterial, antioxidant, and anti-inflammatory aminated chitosan hybrid quinoline Schiff base as multi-target agent: Design, molecular docking, and toxicity assessment
Yasser M. Abdel-Baky, Ahmed Ragab, Moustafa S. Abusaif, Yousry A. Ammar, Ahmed M. Omer
Carbohydrate Polymers, 2025
Development of new urea derivatives based on isoniazid as antiproliferative agents and apoptosis inducers targeting VEGFR-2 with in-silico ADMET and molecular docking simulation
Ahmed Ragab, Alžbeta Minarčíková, Angela Kleinová, Juraj Kronek, Zuzana Kroneková
Journal of Molecular Structure, 2025
Development of pyrazole and pyrazolopyrimidine derivatives as promising anti-MRSA agents targeting penicillin-binding protein (PBP2a) and mecA gene
Ahmed Ragab, Moustafa S. Abusaif, Heba Mohammed Refat M. Selim, Omnia Karem M. Riad, Mohamed H. Helal, et al.
Bioorganic Chemistry, 2025
Discovery and optimization of 2-pyridones as dual h-DHFR/EGFRTK inhibitors with immunomodulatory potential; design, synthesis, anti-proliferative activity, and apoptosis inducer
Ahmed Ragab, Reham R. Raslan, Moustafa S. Abusaif, Hamdy Khamees Thabet, Yousry A. Ammar, et al.
European Journal of Medicinal Chemistry, 2025
Discovery of new thiazolidin-4-one and thiazole nucleus incorporation sulfaguanidine scaffold as new class of antimicrobial agents: Design, synthesis, in silico ADMET, and docking simulation
Ola A. Abu Ali, Ahmed Ragab, Yousry A. Ammar, Moustafa S. Abusaif
Journal of Molecular Structure, 2025
Unveiling the antioxidant potential of new modified hyaluronan derivatives: Design, synthesis, characterization, antioxidant evaluation, and in-silico studies with molecular docking simulation
Mohamed E. Hassan, Tamer M. Tamer, Katarína Valachová, Ahmed Ragab, Ladislav Šoltés
International Journal of Biological Macromolecules, 2025
Tailoring 2-oxazoline based digradient copolymers for rifampicin delivery: Synthesis, physicochemical properties, and colloidal behavior
Pritam Guha, Rushita Shah, Zuzana Kroneková, Mohamed Shaalan, Anna Vykydalová, et al.
European Polymer Journal, 2025
Unveiling a novel pyrazolopyrimidine scaffold as a dual COX-2/5-LOX inhibitor with immunomodulatory potential: Design, synthesis, target prediction, anti-inflammatory activity, and ADME-T with docking simulation
Ahmed Ragab, Radwa Ayman, Mohamed A. Salem, Yousry A. Ammar, Moustafa S. Abusaif
European Journal of Medicinal Chemistry, 2025
Novel 3-Substituted-2H-Chromene Scaffold Based Fluorinated Hydrophobic Fragment as In-Vitro Antiproliferative Agents and Apoptosis Inducers Targeting Both VEGFR-2/BRAFV600E and h-DHFR With Molecular Docking Simulation
Mohamed A. Salem, Moustafa S. Abusaif, Nirvana A. Gohar, Yousry A. Ammar, Ahmed Ragab
Drug Development Research, 2025
Recent advances in the synthesis, reaction, and bio-evaluation potential of purines as precursor pharmacophores in chemical reactions: a review
Ahmed Ragab
Rsc Advances, 2025
Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm Spodoptera litura: design, characterization, in vivo bio-evaluation, toxicological effectiveness, and study their mode of action
Doaa M. Elsisi, Moustafa S. Abusaif, Eman El-Said, Enayat M. Elqady, Mohamed A. Salem, et al.
Rsc Advances, 2025
Utilising UPLC-QTOF-MS/MS to determine the phytochemical profile and in vitro cytotoxic potential of Ziziphora capitata L. with molecular docking simulation
Youssif M. Youssif, Gameel A. M. Elhagali, Medhat A. Zahran, Fatma A. Ahmed, Ahmed Ragab
Natural Product Research, 2025
Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation
Moustafa S. Abusaif, Ahmed Ragab, Eman A. Fayed, Yousry A. Ammar, Ayah M.H. Gowifel, et al.
Bioorganic Chemistry, 2025
Insight into divergent chemical modifications of chitosan biopolymer: Review
Elsayed M. Elnaggar, Moustafa S. Abusaif, Yasser M. Abdel-Baky, Ahmed Ragab, Ahmed M. Omer, et al.
International Journal of Biological Macromolecules, 2024
Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation
Hamdy Khamees Thabet, Yousry A. Ammar, Mohd Imran, Mohamed Hamdy Helal, Saleh Ibrahim Alaqel, et al.
Bioorganic Chemistry, 2024
Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation
Hamdy Khamees Thabet, Ahmed Ragab, Mohd Imran, Mohamed Hamdy Helal, Saleh Ibrahim Alaqel, et al.
European Journal of Medicinal Chemistry, 2024
Applying UPLC-QTOF-MS/MS to profile the phytochemical constituents associated with docking studies of major components of Ziziphora capitata L as well as antimicrobial and antioxidant activity assessments of its subsequent fractions
Youssif M. Youssif, Ahmed Ragab, Medhat A. Zahran, Fatma A. Ahmed, Gameel A. M. Elhagali
Discover Applied Sciences, 2024
Amino Acid Profile, in vitro Cytotoxic Activity of Herniaria hemistemon J. Gay Extract and Isolated Chemical Constituents with Reference to Molecular Docking Simulation
Youssif M. Youssif, Ahmed Ragab, Atef E. M. Abozeed, Abdelnasser A. Kobisi, Gameel A. M. Elhagali
Chemistry Africa, 2024
Discovery of novel 6-(piperidin-1-ylsulfonyl)-2H-chromenes targeting α-glucosidase, α-amylase, and PPAR-γ: Design, synthesis, virtual screening, and anti-diabetic activity for type 2 diabetes mellitus
Hamdy Khamees Thabet, Moustafa S. Abusaif, Mohd Imran, Mohamed Hamdy Helal, Saleh Ibrahim Alaqel, et al.
Computational Biology and Chemistry, 2024
Design, characterization, theoretical studies, and dyeing properties of new novel diazo salicylaldehyde Schiff base catalyzed with ceric (IV) ammonium nitrate (CAN) as an eco-friendly catalyst
Ali A. Ali, H. Abd El-Wahab, Moustafa S. Abusaif, Ahmed Ragab, Omar A. Abdel-Jaid, et al.
Pigment and Resin Technology, 2024
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α-glucosidase, α-amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation
Ahmed Ragab, Mohamed A. Salem, Yousry A. Ammar, Wael M. Aboulthana, Mohamed H. Helal, et al.
Drug Development Research, 2024
New prospective insecticidal agents based on thiazolo[4,5-b]quinoxaline derivatives against cotton leafworm Spodoptera litura (Fabricius): Design, synthesis, toxicological, morphology, histological, and biomedical studies
Ahmed Ragab, Doaa M. Elsisi, Enayat M. Elqady, Eman EL-Said, Mohamed A. Salem, et al.
Pesticide Biochemistry and Physiology, 2024
Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with in silico molecular docking simulation
Hamdy Khamees Thabet, Ahmed Ragab, Mohd Imran, Mohamed Hamdy Helal, Saleh Ibrahim Alaqel, et al.
Rsc Advances, 2024
Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting α-amylase, and α-glucosidase: synthesis, molecular docking, and ADMET studies
Nirvana A. Gohar, Eman A. Fayed, Yousry A. Ammar, Ola A. Abu Ali, Ahmed Ragab, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2024
Developing a new multi-featured chitosan-quinoline Schiff base with potent antibacterial, antioxidant, and antidiabetic activities: design and molecular modeling simulation
Yasser M. Abdel-Baky, Ahmed M. Omer, Esmail M. El-Fakharany, Yousry A. Ammar, Moustafa S. Abusaif, et al.
Scientific Reports, 2023
Novel Water-soluble quinoxaline-2,3-dione-6-sulfohydrazide derivatives as efficient acid corrosion inhibitors: Design, characterization, experimental, and theoretical studies
Moustafa S. Abusaif, Amira M. Hyba, Yousry A. Ammar, Mohamed A. Salem, Doaa M. Elsisi, et al.
Journal of the Taiwan Institute of Chemical Engineers, 2023
One-pot synthesis of pyrazolo[4,3-d]thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with radiosterilization and molecular modeling simulation
Ahmed Ragab, Seham A. Ibrahim, Dina S. Aboul-Magd, Mohamed H. Baren
Rsc Advances, 2023
Blue-green emitting cationic thiazole surfactants-based paper devices for highly sensitive and selective fluorescence detection of chromium oxyanions in wastewater
Salah M. Tawfik, Ahmed A. Farag, Atef S. Kobisy, Ahmed H. Elged, Moustafa S. Abusaif, et al.
Microchemical Journal, 2023
Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a LasR gene on P. aeruginosa
Yousry A. Ammar, Ahmed Ragab, M. A. Migahed, S. Al-Sharbasy, Mohamed A. Salem, et al.
Rsc Advances, 2023
Discovery a novel of thiazolo[3,2-a]pyridine and pyrazolo[3,4-d]thiazole derivatives as DNA gyrase inhibitors; design, synthesis, antimicrobial activity, and some in-silico ADMET with molecular docking study
Hazem Ali Mohamed, Yousry A. Ammar, Gameel A.M. Elhagali, Hassan A. Eyada, Dina S. Aboul-Magd, et al.
Journal of Molecular Structure, 2023
A new class of anti-proliferative activity and apoptotic inducer with molecular docking studies for a novel of 1,3-dithiolo[4,5-b]quinoxaline derivatives hybrid with a sulfonamide moiety
Mostafa A. Ismail, Moustafa S. Abusaif, Mohamed S. A. El-Gaby, Yousry A. Ammar, Ahmed Ragab
Rsc Advances, 2023
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′H-spiro-pyridine derivatives as a new class of EGFRWt and VEGFR-2 inhibitors with apoptotic inducers
Reham R. Raslan, Yousry A. Ammar, Sawsan A. Fouad, Sadia A. Hessein, Nadia A. M. Shmiess, et al.
Rsc Advances, 2023
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular modeling simulations
Ashraf S. Hassan, Nesrin M. Morsy, Wael M. Aboulthana, Ahmed Ragab
Rsc Advances, 2023
Development of novel pyrazole, imidazo[1,2-b]pyrazole, and pyrazolo[1,5-a]pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory potential
Radwa Ayman, Moustafa S. Abusaif, A.M. Radwan, Amira M. Elmetwally, Ahmed Ragab
European Journal of Medicinal Chemistry, 2023
A novel of quinoxaline derivatives tagged with pyrrolidinyl scaffold as a new class of antimicrobial agents: Design, synthesis, antimicrobial activity, and molecular docking simulation
Mostafa M. Abdelgalil, Yousry A. Ammar, Gameel A.M. Elhag Ali, Ali Kh. Ali, Ahmed Ragab
Journal of Molecular Structure, 2023
In vitro enzymatic evaluation of some pyrazolo[1,5-a]pyrimidine derivatives: Design, synthesis, antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic activities with molecular modeling simulation
Ashraf S. Hassan, Nesrin M. Morsy, Wael M. Aboulthana, Ahmed Ragab
Drug Development Research, 2023
Discovery of novel pyrazole and pyrazolo[1,5-a]pyrimidine derivatives as cyclooxygenase inhibitors (COX-1 and COX-2) using molecular modeling simulation
Radwa Ayman, A. M. Radwan, Amira M. Elmetwally, Yousry A. Ammar, Ahmed Ragab
Archiv Der Pharmazie, 2023
Development of new spiro[1,3]dithiine-4,11′-indeno[1,2-b]quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular modeling simulation
Ahmed Ragab, Moustafa S. Abusaif, Nirvana A. Gohar, Dina S. Aboul-Magd, Eman A. Fayed, et al.
Bioorganic Chemistry, 2023
Development and radiosterilization of new hydrazono-quinoline hybrids as DNA gyrase and topoisomerase IV inhibitors: Antimicrobial and hemolytic activities against uropathogenic isolates with molecular docking study
Yousry A. Ammar, Jehan A. Micky, Dina S. Aboul‐Magd, Sondos M. A. Abd El‐Hafez, Sadia A. Hessein, et al.
Chemical Biology and Drug Design, 2023
A Novel of Azo-Thiazole Moiety Alternative for Benzidine-Based Pigments: Design, Synthesis, Characterization, Biological Evaluation, and Molecular Docking Study
Hala F. Rizk, Mohamed A. El-Borai, Ahmed Ragab, Seham A. Ibrahim, Mohamed E. Sadek
Polycyclic Aromatic Compounds, 2023
Synthesis, characterization, and biological target prediction of novel 1,3-dithiolo[4,5-b]quinoxaline and thiazolo[4,5-b]quinoxaline derivatives
Mohamed S. A. El-Gaby, Yousry A. Ammar, Mostafa A. Ismail, Ahmed Ragab, Moustafa S. Abusaif
Heterocyclic Communications, 2023
Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design, Synthesis, Radiosterilization, and Molecular Docking Studies
Ahmed Ragab, Sawsan A. Fouad, Yousry A. Ammar, Dina S. Aboul-Magd, Moustafa S. Abusaif
Antibiotics, 2023
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
Khadija E. Saadon, Nadia M. H. Taha, N. A. Mahmoud, Gameel A. M. Elhagali, Ahmed Ragab
Journal of the Iranian Chemical Society, 2022
A new exploration toward adamantane derivatives as potential anti-MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors
Ahmed Ragab, Moustafa S. Abusaif, Dina S. Aboul‐Magd, Mohammed M. S. Wassel, Gameel A. M. Elhagali, et al.
Drug Development Research, 2022
Novel cyclohepta[b]thiophene derivative incorporating pyrimidine, pyridine, and chromene moiety as potential antimicrobial agents targeting DNA gyrase
Eman A. Fayed, Marwa Mohsen, Shimaa M. Abd El-Gilil, Dina S. Aboul-Magd, Ahmed Ragab
Journal of Molecular Structure, 2022
Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes with 2-oxoindole derivatives
Ahmed Ragab, Yousry A. Ammar, Ahmed Ezzat, Ammar M. Mahmoud, Mahmoud Basseem I. Mohamed, et al.
Computers in Biology and Medicine, 2022
Synthesis, spectral characterization, antimicrobial evaluation and molecular docking studies of new Cu (II), Zn (II) thiosemicarbazone based on sulfonyl isatin
Ahmed Ezzat, Mahmoud Basseem I. Mohamed, Ammar M. Mahmoud, Rabie S. Farag, Abdou. S. El-Tabl, et al.
Journal of Molecular Structure, 2022
One-Pot Synthesis and Molecular Modeling Studies of New Bioactive Spiro-Oxindoles Based on Uracil Derivatives as SARS-CoV-2 Inhibitors Targeting RNA Polymerase and Spike Glycoprotein
Samar A. El-Kalyoubi, Ahmed Ragab, Ola A. Abu Ali, Yousry A. Ammar, Mohamed G. Seadawy, et al.
Pharmaceuticals, 2022
Anticancer Effects with Molecular Docking Confirmation of Newly Synthesized Isatin Sulfonamide Molecular Hybrid Derivatives against Hepatic Cancer Cell Lines
Mahmoud Eldeeb, Eman F. Sanad, Ahmed Ragab, Yousry A. Ammar, Khaled Mahmoud, et al.
Biomedicines, 2022
In Vitro Antimicrobial Evaluation, Single-Point Resistance Study, and Radiosterilization of Novel Pyrazole Incorporating Thiazol-4-one/Thiophene Derivatives as Dual DNA Gyrase and DHFR Inhibitors against MDR Pathogens
Hazem Ali Mohamed, Yousry A. Ammar, Gameel A.M. Elhagali, Hassan A. Eyada, Dina S. Aboul-Magd, et al.
ACS Omega, 2022
Coordination compounds of pyrazolone-based ligand: Design, characterization, biological evaluation, antitumor efficiency, and DNA binding evaluation supported by in silico studies
Seham A. Ibrahim, Ahmed Ragab, Hoda A. El‐Ghamry
Applied Organometallic Chemistry, 2022
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Ashraf S. Hassan, Nesrin M. Morsy, Hassan M. Awad, Ahmed Ragab
Journal of the Iranian Chemical Society, 2022
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study
Abdullah Y. Alzahrani, Yousry A. Ammar, Mohammed Abu-Elghait, Mohamed A. Salem, Mohammed A. Assiri, et al.
Bioorganic Chemistry, 2022
Experimental and theoretical investigation for 6-Morpholinosulfonylquinoxalin-2(1H)-one and its haydrazone derivate: Synthesis, characterization, tautomerization and antimicrobial evaluation
Doaa M. Elsisi, Ahmed Ragab, Ahmed A. Elhenawy, Awatef A. Farag, Abeer M. Ali, et al.
Journal of Molecular Structure, 2022
Therapeutic strategies for Covid-19 based on molecular docking and dynamic studies to the ACE-2 receptors, Furin, and viral spike proteins
Essam S. A. E. H. Khattab, Ahmed Ragab, Mahmoud A. Abol-Ftouh, Ahmed A. Elhenawy
Journal of Biomolecular Structure and Dynamics, 2022
Design, synthesis, molecular modeling, and antimicrobial potential of novel 3-[(1H-pyrazol-3-yl)imino]indolin-2-one derivatives as DNA gyrase inhibitors
Abdullah Y. Alzahrani, Yousry A. Ammar, Mohamed A. Salem, Mohammed Abu‐Elghait, Ahmed Ragab
Archiv Der Pharmazie, 2022
Design, synthesis of new novel quinoxalin-2(1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and molecular docking simulation
Ahmed Ragab, Doaa M. Elsisi, Ola A. Abu Ali, Moustafa S. Abusaif, Ahmed A. Askar, et al.
Arabian Journal of Chemistry, 2022
Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA
Seham A. Ibrahim, Eman A. Fayed, Hala F. Rizk, Said E. Desouky, Ahmed Ragab
Bioorganic Chemistry, 2021
In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents
Eman A. Fayed, Ahmed Ragab, Rogy R. Ezz Eldin, Ashraf H. Bayoumi, Yousry A. Ammar
Bioorganic Chemistry, 2021
One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study
Yousry A. Ammar, Sondos M.A. Abd El-Hafez, Sadia A. Hessein, Abeer M. Ali, Ahmed A. Askar, et al.
Journal of Molecular Structure, 2021
Design, synthesis of new magenta dyestuffs based on thiazole azomethine disperse reactive dyes with antibacterial potential on both dyes and gamma-irradiated dyed fabric
Seham A. Ibrahim, Hala F. Rizk, Dina S. Aboul-Magd, Ahmed Ragab
Dyes and Pigments, 2021
Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors
Eman A. Fayed, Yousry A. Ammar, Marwa A. Saleh, Ashraf H. Bayoumi, Amany Belal, et al.
Journal of Molecular Structure, 2021
Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR
Mohammed M.S. Wassel, Yousry A. Ammar, Gameel A.M. Elhag Ali, Amany Belal, Ahmed B.M. Mehany, et al.
Bioorganic Chemistry, 2021
Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies
Sally I. Eissa, Amel M. Farrag, Samir Y. Abbas, Mohamed F. El Shehry, Ahmed Ragab, et al.
Bioorganic Chemistry, 2021
Sulfaguanidine hybrid with some new pyridine-2-one derivatives: Design, synthesis, and antimicrobial activity against multidrug-resistant bacteria as dual DNA gyrase and DHFR inhibitors
Ahmed Ragab, Sawsan A. Fouad, Ola A. Abu Ali, Entsar M. Ahmed, Abeer M. Ali, et al.
Antibiotics, 2021
Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives
Yousry A. Ammar, Awatef A. Farag, Abeer M. Ali, Ahmed Ragab, Ahmed A. Askar, et al.
Bioorganic Chemistry, 2020
Design, synthesis, biological evaluation and molecular docking study based on novel fused pyrazolothiazole scaffold
Hala F. Rizk, Mohamed A. El-Borai, Ahmed Ragab, Seham A. Ibrahim
Journal of the Iranian Chemical Society, 2020
Antiviral Activity of Adamantane-Pyrazole Derivatives Against Foot and Mouth Disease Virus Infection in vivo and in vitro With Molecular Docking Study
Mohammed M. S. Wassel, Wael M. Gamal Eldin, Ahmed Ragab, Gameel A. M. Elhag Ali, Yousry A. Ammar
Journal of Applied Veterinary Sciences, 2020
In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies
Eman A. Fayed, Yousry A. Ammar, Ahmed Ragab, Nirvana A. Gohar, Ahmed B.M. Mehany, et al.
Bioorganic Chemistry, 2020
Discovery of new schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA gyrase inhibitors with immunomodulatory activity
Ashraf S. Hassan, Ahmed A. Askar, Ahmed M. Naglah, Abdulrahman A. Almehizia, Ahmed Ragab
Molecules, 2020
Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies
Yousry A. Ammar, Awatef A. Farag, Abeer M. Ali, Sadia A. Hessein, Ahmed A. Askar, et al.
Bioorganic Chemistry, 2020
Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors
Mohamed A. Salem, Ahmed Ragab, Abeer El-Khalafawy, Abeer H. Makhlouf, Ahmed.A. Askar, et al.
Bioorganic Chemistry, 2020
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor
Mohamed A. Salem, Ahmed Ragab, Ahmed A. Askar, Abeer El-Khalafawy, Abeer H. Makhlouf
European Journal of Medicinal Chemistry, 2020
Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors
Mohammed M.S. Wassel, Ahmed Ragab, Gameel A.M. Elhag Ali, Ahmed B.M. Mehany, Yousry A. Ammar
Journal of Molecular Structure, 2020
Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers
Ahmed M. Sh. El-Sharief, Yousry A. Ammar, Amany Belal, Marwa A.M. Sh. El-Sharief, Yehia A. Mohamed, et al.
Bioorganic Chemistry, 2019
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity
Yousry A. Ammar, Ahmed M. Sh El-Sharief, Amany Belal, Samir Y. Abbas, Yehia A. Mohamed, et al.
European Journal of Medicinal Chemistry, 2018
New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: Synthesis, reactions and evaluation of antibacterial and antifungal activities
Marwa A.M.Sh. El-Sharief, Samir Y. Abbas, Medhat A. Zahran, Yehia A. Mohamed, Ahmed Ragab, et al.
Zeitschrift Fur Naturforschung Section B Journal of Chemical Sciences, 2016

RECENT SCHOLAR PUBLICATIONS

Chemical composition and biological activity of extracts and essential oils of Ziziphora capitata L and Ziziphora tenuior L: A review
Y YOUSSIF, A Ragab, MA Zahran, FA Ahmed
Egyptian Journal of Chemistry , 2026
2026
Fabrication of bioactive gelatin boosted by vanillylideneacetone with enhanced antioxidant performance: in vitro, molecular docking, and pharmacokinetic studies
TM Tamer, MA Hassan, A Ragab, R Yao, MS Mohy-Eldin, N Hassan, ...
Materials Chemistry and Physics, 132202 , 2026
2026
Amphiphilic cellulose and alginate–functionalized magnetic ZIF-8 nanocomposites for dinitrophenol removal, colorimetric H₂O₂ sensing, and antibacterial applications
SM Tawfik, H Jang, H Kwon, M Fekry, AA Roshdy, A Ragab, B Zakaria, ...
International Journal of Biological Macromolecules, 150699 , 2026
2026
Bridging the gap with amide linkers: rational design, synthesis, and multi-target evaluation of sulfonamide/acetamide-NSAID hybrids as dual COX-2/5-LOX inhibitors
TM Ramsis, S Hussein, MS Abusaif, A Ragab, YA Ammar, O Ali, A Musa, ...
Future Medicinal Chemistry, 1-18 , 2026
2026
Citations: 1
Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis, in vitro bio-evaluation, and in silico toxicity prediction …
K Hesham, WM Aboulthana, A Ragab
RSC advances 16 (4), 3509-3526 , 2026
2026
Citations: 3
Effect of Sulfonamide Functionalization on the Corrosion Inhibition Efficiency of Chitosan for Carbon Steel in 1.0 m HCl: Experimental and Computational Approaches
MS Abusaif, A Gangan, AE Hassan, MA Salem, YA Ammar, A Ragab
Journal of Applied Polymer Science, e70487 , 2026
2026
Citations: 1
Thiazole tethered adamantane derivatives as potential FMDV inhibitors: Design, synthesis, antiviral activity, and molecular modeling simulations
OAA Ali, YA Ammar, MS Abusaif, A Ragab
Journal of Molecular Structure, 145229 , 2026
2026
Rational Design, Synthesis, and In Silico Evaluation of Novel Pyridine-Based Heterocyclic Compounds as Multifunctional Antidiabetic Agents: Molecular Docking and ADMET Profiling
MH Helal, A Ragab, MS Abusaif, EM Ahmed, SM Gomha, YA Ammar, ...
Journal of Molecular Structure, 143703 , 2026
2026
Citations: 9
Exploration Novel of Pyrazole and Isoxazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Structure Activity Relationship Study, and Antibiofilm Activity …
KE Saadon, A Ragab, NMH Taha, NA Mahmoud, AK Khalil, GAM Elhagali
Drug Development Research 86 (8), e70189 , 2025
2025
Citations: 4
Recent advances in adamantane-linked heterocycles: synthesis and biological activity
MH Helal, MS Abusaif, A Ragab, SY Abbas, R Ayman, MSA El-Gaby, ...
Molecular Diversity, 1-49 , 2025
2025
Citations: 2
Mentha spicata -mediated silver nanoparticles for combating Streptococcus mutans and oral cancer cells
A Yousef, SS Salem, A Ragab, OM El Shahaly, HO Rateb, RA El-Esawy, ...
Scientific Reports 15 (1), 38474 , 2025
2025
Citations: 4
Development of new urea derivatives based on isoniazid as antiproliferative agents and apoptosis inducers targeting VEGFR-2 with in-silico ADMET and molecular docking simulation
A Ragab, A Minarčíková, A Kleinová, J Kronek, Z Kroneková
Journal of Molecular Structure 1341, 142584 , 2025
2025
Citations: 3
Flufenamic acid-based sulfonohydrazide and acetamide derivatives NSAI as inhibitors of multi-targets COX-1/COX-2/5-LOX: design, synthesis, in silico ADMET and binding mode studies
S Hussein, EA Fayed, A Ragab, MS Abusaif, YA Ammar, ...
BMC chemistry 19 (1), 271 , 2025
2025
Citations: 6
Discovery and optimization of 2-pyridones as dual h-DHFR/EGFRTK inhibitors with immunomodulatory potential; design, synthesis, anti-proliferative activity, and apoptosis inducer
A Ragab, RR Raslan, MS Abusaif, HK Thabet, YA Ammar, NA Gohar
European Journal of Medicinal Chemistry 294, 117751 , 2025
2025
Citations: 10
Development of pyrazole and pyrazolopyrimidine derivatives as promising anti-MRSA agents targeting penicillin-binding protein (PBP2a) and mecA gene
A Ragab, MS Abusaif, HMRM Selim, OKM Riad, MH Helal, AM Ali, ...
Bioorganic Chemistry, 108977 , 2025
2025
Citations: 11
Novel antibacterial, antioxidant, and anti-inflammatory aminated chitosan hybrid quinoline Schiff base as multi-target agent: Design, molecular docking, and toxicity assessment
YM Abdel-Baky, A Ragab, MS Abusaif, YA Ammar, AM Omer
Carbohydrate Polymers, 124049 , 2025
2025
Citations: 13
Novel corrosion inhibitors and SRB resistivity hydrazones decorated thiazole derivatives as dual-target agent: design, microwave irradiation synthesis, and DFT calculations
MS Abusaif, AM Hyba, MH Helal, YA Ammar, DS Aboul-Magd, A Ragab
Journal of Industrial and Engineering Chemistry , 2025
2025
Citations: 4
Discovery of new thiazolidin-4-one and thiazole nucleus incorporation sulfaguanidine scaffold as new class of antimicrobial agents: Design, synthesis, in silico ADMET, and …
OAA Ali, A Ragab, YA Ammar, MS Abusaif
Journal of Molecular Structure 1334, 141879 , 2025
2025
Citations: 13
Unveiling the antioxidant potential of new modified hyaluronan derivatives: Design, synthesis, characterization, antioxidant evaluation, and in-silico studies with molecular …
ME Hassan, TM Tamer, K Valachová, A Ragab, L Šoltés
International Journal of Biological Macromolecules 318, 145054 , 2025
2025
Citations: 6
Utilising UPLC-QTOF-MS/MS to determine the phytochemical profile and in vitro cytotoxic potential of Ziziphora capitata L. with molecular docking simulation
YM Youssif, GAM Elhagali, MA Zahran, FA Ahmed, A Ragab
Natural Product Research 39 (12), 3417-3425 , 2025
2025
Citations: 20

MOST CITED SCHOLAR PUBLICATIONS

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers
AMS El-Sharief, YA Ammar, A Belal, MAMS El-Sharief, YA Mohamed, ...
Bioorganic chemistry 85, 399-412 , 2019
2019
Citations: 129
Novel Structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies
SI Eissa, AM Farrag, SY Abbas, MF El Shehry, A Ragab, EA Fayed, ...
Bioorganic Chemistry 110, 104803 , 2021
2021
Citations: 122
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity
YA Ammar, AMS El-Sharief, A Belal, SY Abbas, YA Mohamed, ...
European journal of medicinal chemistry 156, 918-932 , 2018
2018
Citations: 114
Discovery of new Schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA gyrase inhibitors with …
AS Hassan, AA Askar, AM Naglah, AA Almehizia, A Ragab
Molecules 25 (11), 2593 , 2020
2020
Citations: 98
In vitro enzymatic evaluation of some pyrazolo[1,5‐ a ]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy, WM Aboulthana, A Ragab
Drug Development Research 84 (1), 3-24 , 2023
2023
Citations: 95
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular …
AS Hassan, NM Morsy, WM Aboulthana, A Ragab
RSC advances 13 (14), 9281-9303 , 2023
2023
Citations: 91
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: synthesis, antimicrobial, and antibiofilm activities with …
AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem, MA Assiri, TE Ali, ...
Bioorganic Chemistry 119, 105571 , 2022
2022
Citations: 86
Development of adamantane scaffold containing 1, 3, 4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR
MMS Wassel, YA Ammar, GAME Ali, A Belal, ABM Mehany, A Ragab
Bioorganic Chemistry 110, 104794 , 2021
2021
Citations: 85
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA gyrase inhibitor
MA Salem, A Ragab, AA Askar, A El-Khalafawy, AH Makhlouf
European Journal of Medicinal Chemistry 188, 111977 , 2020
2020
Citations: 85
Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies
YA Ammar, AA Farag, AM Ali, SA Hessein, AA Askar, EA Fayed, DM Elsisi, ...
Bioorganic Chemistry 99, 103841 , 2020
2020
Citations: 80
Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes with 2 …
A Ragab, YA Ammar, A Ezzat, AM Mahmoud, MBI Mohamed, AS El-Tabl, ...
Computers in Biology and Medicine 145, 105473 , 2022
2022
Citations: 76
Discovery of novel pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation
R Ayman, AM Radwan, AM Elmetwally, YA Ammar, A Ragab
Archiv der Pharmazie 356 (2), e2200395 , 2023
2023
Citations: 75
Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors
MA Salem, A Ragab, A El-Khalafawy, AH Makhlouf, AA Askar, YA Ammar
Bioorganic Chemistry 96, 103619 , 2020
2020
Citations: 75
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
KE Saadon, NMH Taha, NA Mahmoud, GAM Elhagali, A Ragab
Journal of the Iranian Chemical Society 19 (9), 3899-3917 , 2022
2022
Citations: 73
Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines
M Eldeeb, EF Sanad, A Ragab, YA Ammar, K Mahmoud, MM Ali, ...
Biomedicines 10 (3), 722 , 2022
2022
Citations: 73
Sulfaguanidine hybrid with some new pyridine-2-one derivatives: design, synthesis, and antimicrobial activity against multidrug-resistant bacteria as dual DNA gyrase and DHFR …
A Ragab, SA Fouad, OAA Ali, EM Ahmed, AM Ali, AA Askar, YA Ammar
Antibiotics 10 (2), 162 , 2021
2021
Citations: 73
Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies …
SA Ibrahim, EA Fayed, HF Rizk, SE Desouky, A Ragab
Bioorganic Chemistry 116, 105339 , 2021
2021
Citations: 71
Design, synthesis of new novel quinoxalin-2 (1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and …
A Ragab, DM Elsisi, OAA Ali, MS Abusaif, AA Askar, AA Farag, YA Ammar
Arabian Journal of Chemistry 15 (1), 103497 , 2022
2022
Citations: 70
Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors
EA Fayed, YA Ammar, MA Saleh, AH Bayoumi, A Belal, ABM Mehany, ...
Journal of Molecular Structure 1236, 130317 , 2021
2021
Citations: 70
Development of novel pyrazole, imidazo [1, 2-b] pyrazole, and pyrazolo [1, 5-a] pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory potential
R Ayman, MS Abusaif, AM Radwan, AM Elmetwally, A Ragab
European Journal of Medicinal Chemistry 249, 115138 , 2023
2023
Citations: 69

Ahmed Ragab

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RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS