I am an accomplished pharmaceutical scientist with a robust academic and research background in drug discovery, structure-activity relationship (SAR) studies, and medicinal chemistry. My work focuses on designing and synthesising novel compounds to target Alzheimer's disease, and I bring with me a proven track record of contributing to cutting-edge research across leading institutions in Europe.
As a Postdoctoral Researcher at the Normandy Center for Studies and Research on Medicine (CERMN) in France, I am exploring the development of pleiotropic drugs for Alzheimer's disease. My expertise extends to synthesising and purifying natural and semi-synthetic compounds, computer-aided drug design, enzyme inhibition studies, and analytical techniques such as NMR, LC-MS, and IR spectroscopy.
I have authored multiple high-impact publications and presented my findings at international conferences, showcasing my ability to translate complex scientific data into actionable insights. I thrive in cr
RESEARCH, TEACHING, or OTHER INTERESTS
Drug Discovery, Multidisciplinary, Organic Chemistry, Pharmacology
337
Scholar Citations
11
Scholar h-index
12
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibition A Al Mamun, J Konecny, M Hrabinova, A Sorf, L Muckova, J Fibigar, ... Bioorganic Chemistry, 109894 , 2026 2026
Amaryllidaceae alkaloids of genus Narcissus and their biological activity. A Al Mamun Univerzita Karlova, Farmaceutická fakulta v Hradci Králové , 2023 2023 Citations: 1
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids-Design, synthesis, and biological evaluation F Pidany, J Kroustkova, A Al Mamun, D Suchankova, X Brazzolotto, ... European Journal of Medicinal Chemistry 252, 115301 , 2023 2023 Citations: 19
Short lecture “Isoquinoline alkaloids and their derivatives as a new class of antimycobacterial drugs” L Cahlíková, A Al Mamun, O Janďourek, K Sobolová, J Křoustková, ... Planta Medica 88 (15), SL-RDF-02 , 2022 2022 Citations: 2
Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton J Křoustková, A Ritomska, A Al Mamun, D Hulcova, L Opletal, J Kuneš, ... Phytochemistry 204, 113439 , 2022 2022 Citations: 15
Short lecture "Alkaloids of norbelladine type from Narcissus pseudonarcissus cv. Carlton as inspiration for development of highly selective butyrylcholinesterase inhibitors" Al Mamun, A., Hulcová, D., Křoustková, J., Cahlíková, L. Workshop: Recent progress in Pharmacognosy and Phytochemistry, 17 , 2022 2022
Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents N Maafi, AA Mamun, O Janďourek, J Maříková, K Breiterová, A Diepoltová, ... Molecules 26 (19), 6023 , 2021 2021 Citations: 11
Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer’s disease L Cahlikova, R Vrabec, F Pidaný, R Peřinová, N Maafi, AA Mamun, ... Molecules 26 (17), 5240 , 2021 2021 Citations: 51
Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation … AA Mamun, F Pidaný, D Hulcova, J Maříková, T Kučera, M Schmidt, ... International Journal of Molecular Sciences 22 (15), 8308 , 2021 2021 Citations: 23
Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids J Maříková, AA Mamun, LA Shammari, J Korábečný, T Kučera, D Hulcová, ... Molecules 26 (5), 1279 , 2021 2021 Citations: 24
Short lecture "New Amaryllidaceae alkaloids from Narcissus pseudonarcissus cv. Carlton as inspiration for the development of new drugs for Alzheimer's disease" AL MAMUN, A., CAHLÍKOVÁ, L., HULCOVÁ, D., MAŘÍKOVÁ, J. 11th Postgraduate and Postdoc Conference (Section - Pharmacognosy and … , 2021 2021
Exploring the role of aggregated proteomes in the pathogenesis of Alzheimer’s disease SE Narayanan, N Sekhar, RG Rajamma, A Marathakam, A Al Mamun, ... Current Protein and Peptide Science 21 (12), 1164-1173 , 2020 2020 Citations: 12
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease R Peřinová, N Maafi, J Korábečný, E Kohelová, A De Simone, ... Bioorganic Chemistry 100, 103928 , 2020 2020 Citations: 26
Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase A Al Mamun, J Maříková, D Hulcová, J Janoušek, M Šafratová, ... Biomolecules 10 (5), 800 , 2020 2020 Citations: 60
Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase J Marikova, A Ritomska, J Korabecny, R Perinova, A Al Mamun, T Kucera, ... Journal of natural products 83 (5), 1359-1367 , 2020 2020 Citations: 35
Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity L Al Shammari, A Al Mamun, D Koutová, M Majorošová, D Hulcová, ... Rec. Nat. Prod 14 (2), 154-159 , 2020 2020 Citations: 26
Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10: 800 A Al Mamun, J Marıková, D Hulcová, J Janoušek, M Šafratová, ... 2020 Citations: 6
Short lecture "Amaryllidaceae alkaloids isolated from Narcissus cv. Carlton and their biological activity" A Al Mamun 9th postgraduate and 7th postdoc conference , 2019 2019
(Short lecture and poster) Structural diversity and pharmacological activity of Amaryllidaceae alkaloids from Narcissus cv. Carlton A Al Mamun 47th Conference on Synthesis and Analysis of Drugs, 81 , 2018 2018
Short lecture "Phytochemical study of Amaryllidaceae alkaloids from Narcissus cv. Carlton and their biological activity" L AL MAMUN, A., CAHLÍKOVÁ 8th postgraduate and 6th postdoc conference (section-Pharmacognosy and … , 2018 2018
MOST CITED SCHOLAR PUBLICATIONS
Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase A Al Mamun, J Maříková, D Hulcová, J Janoušek, M Šafratová, ... Biomolecules 10 (5), 800 , 2020 2020 Citations: 60
Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer’s disease L Cahlikova, R Vrabec, F Pidaný, R Peřinová, N Maafi, AA Mamun, ... Molecules 26 (17), 5240 , 2021 2021 Citations: 51
Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase J Marikova, A Ritomska, J Korabecny, R Perinova, A Al Mamun, T Kucera, ... Journal of natural products 83 (5), 1359-1367 , 2020 2020 Citations: 35
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease R Peřinová, N Maafi, J Korábečný, E Kohelová, A De Simone, ... Bioorganic Chemistry 100, 103928 , 2020 2020 Citations: 26
Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity L Al Shammari, A Al Mamun, D Koutová, M Majorošová, D Hulcová, ... Rec. Nat. Prod 14 (2), 154-159 , 2020 2020 Citations: 26
Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region A Zaman, MSS Khan, L Akter, SH Syeed, J Akter, A Al Mamun, ME Alam, ... BMC complementary and alternative medicine 15 (1), 121 , 2015 2015 Citations: 26
Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids J Maříková, AA Mamun, LA Shammari, J Korábečný, T Kučera, D Hulcová, ... Molecules 26 (5), 1279 , 2021 2021 Citations: 24
Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation … AA Mamun, F Pidaný, D Hulcova, J Maříková, T Kučera, M Schmidt, ... International Journal of Molecular Sciences 22 (15), 8308 , 2021 2021 Citations: 23
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids-Design, synthesis, and biological evaluation F Pidany, J Kroustkova, A Al Mamun, D Suchankova, X Brazzolotto, ... European Journal of Medicinal Chemistry 252, 115301 , 2023 2023 Citations: 19
Structural analysis of unusual alkaloids isolated from Narcissus pseudonarcissus cv. Carlton J Křoustková, A Ritomska, A Al Mamun, D Hulcova, L Opletal, J Kuneš, ... Phytochemistry 204, 113439 , 2022 2022 Citations: 15
Exploring the role of aggregated proteomes in the pathogenesis of Alzheimer’s disease SE Narayanan, N Sekhar, RG Rajamma, A Marathakam, A Al Mamun, ... Current Protein and Peptide Science 21 (12), 1164-1173 , 2020 2020 Citations: 12
Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents N Maafi, AA Mamun, O Janďourek, J Maříková, K Breiterová, A Diepoltová, ... Molecules 26 (19), 6023 , 2021 2021 Citations: 11
Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10: 800 A Al Mamun, J Marıková, D Hulcová, J Janoušek, M Šafratová, ... 2020 Citations: 6
Short lecture “Isoquinoline alkaloids and their derivatives as a new class of antimycobacterial drugs” L Cahlíková, A Al Mamun, O Janďourek, K Sobolová, J Křoustková, ... Planta Medica 88 (15), SL-RDF-02 , 2022 2022 Citations: 2
Amaryllidaceae alkaloids of genus Narcissus and their biological activity. A Al Mamun Univerzita Karlova, Farmaceutická fakulta v Hradci Králové , 2023 2023 Citations: 1
Carltonine B derivatives: Synthesis and structure-activity relationship insights for selective butyrylcholinesterase inhibition A Al Mamun, J Konecny, M Hrabinova, A Sorf, L Muckova, J Fibigar, ... Bioorganic Chemistry, 109894 , 2026 2026
Short lecture "Alkaloids of norbelladine type from Narcissus pseudonarcissus cv. Carlton as inspiration for development of highly selective butyrylcholinesterase inhibitors" Al Mamun, A., Hulcová, D., Křoustková, J., Cahlíková, L. Workshop: Recent progress in Pharmacognosy and Phytochemistry, 17 , 2022 2022
Short lecture "New Amaryllidaceae alkaloids from Narcissus pseudonarcissus cv. Carlton as inspiration for the development of new drugs for Alzheimer's disease" AL MAMUN, A., CAHLÍKOVÁ, L., HULCOVÁ, D., MAŘÍKOVÁ, J. 11th Postgraduate and Postdoc Conference (Section - Pharmacognosy and … , 2021 2021
Short lecture "Amaryllidaceae alkaloids isolated from Narcissus cv. Carlton and their biological activity" A Al Mamun 9th postgraduate and 7th postdoc conference , 2019 2019
(Short lecture and poster) Structural diversity and pharmacological activity of Amaryllidaceae alkaloids from Narcissus cv. Carlton A Al Mamun 47th Conference on Synthesis and Analysis of Drugs, 81 , 2018 2018
