Sanseray da Silveira Cruz-Machado

@.uesb.br

Graduate Program in Nursing and Health (PPGES)
State University of Southwest Bahia (UESB)

Sanseray da Silveira Cruz-Machado


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https://researchid.co/sanseray

RESEARCH, TEACHING, or OTHER INTERESTS

Neuroscience, Physiology, Endocrinology, Pharmacology (medical)
27

Scopus Publications

1471

Scholar Citations

21

Scholar h-index

24

Scholar i10-index

Scopus Publications

  • Biological Rhythms of Vital Signs in Newborns in a Neonatal Intensive Care Unit: A Prospective Observational Study
    Vanderlei Amadeu da Rocha, Mariana Bueno, Isília Aparecida Silva, Sanseray da Silveira Cruz-Machado
    Journal of Biological Rhythms, 2026
    To characterize the presence and relationships between the rhythms of axillary temperature, heart rate, respiratory rate, blood pressure, and peripheral oxygen saturation, from the first (D1) to the third day of life (D3) in newborns (NBs) hospitalized in the neonatal intensive care unit (NICU). Primary, descriptive, nested clinical study within a primary, observational, and prospective clinical study, conducted in the NICU of a public hospital in the city of São Paulo, Brazil. Demographic data and vital signs (axillary temperature, heart rate, respiratory rate, blood pressure, and peripheral oxygen saturation) recorded in clinical charts were collected between the first and third day of life (D1-D3) at 4-h intervals (8 h; 12 h; 16 h; 20 h; 24 h; 4 h). The biological rhythms of the vital signs were analyzed using the Cosinor algorithm. Eighty-eight NBs participated (44 preterm and 44 term). Incipient variability of vital signs was observed in the first days, with reduced amplitudes and unstable phases. There was a correlation between the amplitude of axillary temperature and length of hospital stay in preterm infants, and between the amplitude of diastolic blood pressure and length of stay in term infants, suggesting the clinical potential of variability as a marker of neonatal maturation and clinical vulnerability. Altogether, the findings indicate the presence of early physiological rhythmicity and reinforce the importance of chronosensitive care and the incorporation of chronobiological parameters in clinical management, aiming to optimize the development and outcomes of hospitalized newborns.
  • Sleep Disturbances and Obstructive Sleep Apnea in Children and Adolescents with Cerebral Palsy: An Observational Study
    Isabella Meneses da Silva, Maria Clara Helena do Couto, Sanseray da Silveira Cruz-Machado, Leticia Monteiro de Andrade, Ana Elisa Zuliani Stroppa Marques, Celia Maria Giacheti, Cristiane Rodrigues Pedroni, Luciana Pinato
    Neurology International, 2025
    Background/Objectives: Cerebral palsy (CP) is a neurodevelopmental disorder associated with sleep disturbances, particularly sleep-disordered breathing (SDB), and is often linked to an increased risk of obstructive sleep apnea (OSA). OSA is underdiagnosed in this population due to the lack of standardized methods and limited access to appropriate diagnostic technologies and appropriate equipment. Thus, this study aimed to investigate the presence and severity of sleep disorders, with a particular focus on OSA, in children and adolescents with CP compared to their typically developing peers. Methods: This observational, clinical, and prospective study included 28 children and adolescents with CP and 32 age- and sex-matched typically developing individuals. Sleep disturbances were assessed using the Sleep Disturbance Scale for Children (SDSC) and a high-resolution oximeter plus actigraphy combined with a cloud-based algorithm for the detection of obstructive sleep apnea (Biologix® system), which provided data on oxygen saturation, snoring, movement during sleep, and total sleep time. Results: According to the SDSC, 92% of children and adolescents with CP presented scores indicative of sleep disturbances, compared to 31% of typically developing individuals. SDB was the most prevalent subtype (64%) and overnight oximetry revealed that 100% of the CP group presented oxygen desaturation index (ODI) values consistent with a diagnosis of OSA. The CP group also exhibited significantly lower mean SpO2, longer snoring duration, shorter total sleep time, and prolonged sleep latency compared to the typically developing group. Conclusions: Children and adolescents with cerebral palsy (CP) exhibit a high prevalence of sleep disturbances, with increasing evidence indicating a significant occurrence of sleep-disordered breathing (SDB), particularly obstructive sleep apnea (OSA).
  • Identification of Inflammatory Mediators in Saliva Samples From Hospitalized Newborns: Potential Biomarkers?
    Vanderlei Amadeu da Rocha, Sanseray da Silveira Cruz-Machado, Isília Aparecida Silva, Pedro Augusto Carlos Magno Fernandes, Regina Pekelmann Markus, Mariana Bueno
    Clinical Nursing Research, 2024
    Saliva measurements serve as a noninvasive tool for clinically monitoring newborns (NB) and children, a vulnerable population with promising potential for both research and clinical practice. Saliva acts as a repository for various inflammatory biomarkers involved in diverse biological functions. Particularly for children, it offers numerous advantages when compared to plasma and urine sampling. Nevertheless, there is a significant knowledge gap regarding detectable levels of cytokines in the saliva of newborns and children, as well as studies aiming to assess the relationship of this content with physiological and pathological processes. Objectives: To characterize the levels of 11 inflammatory mediators (IFNg, IL1b, IL2, IL4, IL6, IL8, IL10, IL12, IL17, TNF, and VEGF) in saliva samples from NB on the first and second day of hospitalization in the Neonatal Intensive Care Unit (NICU). Method: Exploratory study, descriptive, nested within a primary clinical, observational, and prospective study, conducted in the NICU of a public hospital in São Paulo, Brazil. Demographic data and vital signs were recorded in the clinical records of 90 NB, and five saliva samples from 5 NB were collected between the first and second day of life (D1–D2) at approximately 8-hr intervals (8–9 am, 4–5 pm, and 11–12 pm). Saliva samples were used for the measurement of 11 cytokines (IFNg, IL1b, IL2, IL4, IL6, IL8, IL10, IL12, IL17, TNF, and VEGF). Results: Five NBs participated in this exploratory study, and the vital signs showed variability from the first (D1) to the second day (D2) of hospitalization, variability similar to that of the total population of the primary study. The presence and levels of the 11 cytokines were detected in the saliva samples, as well as a statistical correlation between 10 cytokines (IFNg, IL1b, IL2, IL4, IL6, IL10, IL12, IL17, TNF, and VEGF) and vital signs. Conclusions: The novelty of measuring inflammatory mediators in saliva samples from hospitalized NBs in the NICU is highlighted, providing support and new perspectives for the development of clinical and experimental research and an opportunity for developing and implementing new salivary biomarkers in different population segments.
  • LPS-induced inflammation in rats during pregnancy reduces maternal melatonin and impairs neurochemistry and behavior of adult male offspring
    Caio Sérgio Galina Spilla, Ana Luiza Decanini Miranda de Souza, Leila Maria Guissoni Campos, Sanseray da Silveira Cruz-Machado, Luciana Pinato
    Brain Research, 2024
  • Chronobiological parameters as predictors of early treatment response in major depression
    Nicóli B. Xavier, Ana Carolina V.O. Abreu, Guilherme Rodriguez Amando, Eduardo Giordani Steibel, Luísa K. Pilz, Juliana Jury Freitas, Sanseray da Silveira Cruz-Machado, Regina P. Markus, Benicio N. Frey, Maria Paz Hidalgo
    Journal of Affective Disorders, 2023
  • Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense
    Regina P. Markus, Kassiano S. Sousa, Sanseray da Silveira Cruz-Machado, Pedro A. Fernandes, Zulma S. Ferreira
    International Journal of Molecular Sciences, 2021
    Melatonin is a highly conserved molecule found in prokaryotes and eukaryotes that acts as the darkness hormone, translating environmental lighting to the whole body, and as a moderator of innate and acquired defense, migration, and cell proliferation processes. This review evaluates the importance of pineal activity in monitoring PAMPs and DAMPs and in mounting an inflammatory response or innate immune response. Activation of the immune–pineal axis, which coordinates the pro-and anti-inflammatory phases of an innate immune response, is described. PAMPs and DAMPs promote the immediate suppression of melatonin production by the pineal gland, which allows leukocyte migration. Monocyte-derived macrophages, important phagocytes of microbes, and cellular debris produce melatonin locally and thereby initiate the anti-inflammatory phase of the acute inflammatory response. The role of locally produced melatonin in organs that directly contact the external environment, such as the skin and the gastrointestinal and respiratory tracts, is also discussed. In this context, as resident macrophages are self-renewing cells, we explore evidence indicating that, besides avoiding overreaction of the immune system, extra-pineal melatonin has a fundamental role in the homeostasis of organs and tissues.
  • Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances
    Sanseray da Silveira Cruz‐Machado, Leila Maria Guissoni Campos, Cintia Cristina Fadini, George Anderson, Regina P. Markus, Luciana Pinato
    Journal of Pineal Research, 2021
    Sleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of Autism Spectrum Disorder (ASD) pathophysiology. The present study evaluated the daily urinary 6-sulfatoxymelatonin (aMT6s) excretion profile and the salivary levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in 20 controls and 20 ASD participants, as well as correlating these measures with sleep disturbances. Although 60% of ASD participants showed a significant nighttime rise in aMT6s excretion, this rise was significantly attenuated, compared to controls (p<0.05). The remaining 40% of ASD individuals showed no significant increase in nocturnal aMT6s. ASD individuals showed higher nocturnal levels of saliva TNF, but not IL-6. Dysfunction in the initiation and maintenance of sleep, as indicated by the Sleep Disturbance Scale for Children correlated with nighttime aMT6s excretion (r=-0.28, p<0.05). Dysfunction in sleep breathing was inversely correlated to aMT6s (r=-0.31, p<0.05) and positively associated with TNF level (r=0.42, p<0.01). Overall such data indicate immune-pineal axis activation, with elevated TNF but not IL-6 levels associated with disrupted pineal melatonin release and sleep dysfunction in ASD. It is proposed that circadian dysregulation in ASD is intimately linked to heightened immune-inflammatory activity. Such two-way interactions of the immune-pineal axis may underpin many aspects of ASD pathophysiology, including sleep disturbances, as well as cognitive and behavioral alterations.
  • Painful procedures and pain management in newborns admitted to an intensive care unit
    Vanderlei Amadeu da Rocha, Isília Aparecida Silva, Sanseray da Silveira Cruz-Machado, Mariana Bueno
    Revista Da Escola De Enfermagem, 2021
    Objective: To characterize painful procedures, analgesic strategies, vital signs, and pain scores in hospitalized newborns. Method: This is a primary, observational, prospective clinical study, developed in a Brazilian public hospital. Demographic data, painful procedures, pain relief measures, vital signs, and pain scores were collected from the clinical records of 90 newborns admitted to the intensive care unit and evaluated between admission and the third day of admission. For statistical analysis, the software Statistic Package for the Social Sciences and the R Software were used. Results: Newborns underwent 2,732 painful procedures, 540 non-pharmacological and 216 pharmacological strategies. The most frequently performed procedure was the heel prick (20.96%). The most commonly recorded non-pharmacological strategy was dim lighting (28.33%) and continuous fentanyl (48.83%) was the main pharmacological measure adopted. Pain score and vital signs show variability in the period evaluated. Conclusion: Despite the high number of painful procedures, pain assessment records do not reflect procedural pain and the use of analgesic strategies was insufficient.
  • Immune-pineal axis protects rat lungs exposed to polluted air
    Claudia Emanuele Carvalho‐Sousa, Eliana P. Pereira, Gabriela S. Kinker, Mariana Veras, Zulma S. Ferreira, Fernanda P. Barbosa‐Nunes, Joilson O. Martins, Paulo H.N. Saldiva, Russel J. Reiter, Pedro A. Fernandes, Sanseray da Silveira Cruz‐Machado, Regina P. Markus
    Journal of Pineal Research, 2020
    Environmental pollution in the form of particulate matter &lt;2.5 μm (PM2.5) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune‐pineal axis, reducing the pineal synthesis and increasing the extrapineal synthesis of melatonin. Herein, we report that the exposure of rats to polluted air for 6 hours reduced nocturnal plasma melatonin levels and increased lung melatonin levels. Melatonin synthesis in the lung reduced lipid peroxidation and increased PM2.5 engulfment and cell viability by activating high‐affinity melatonin receptors. Diesel exhaust particles (DEPs) promoted the synthesis of melatonin in a cultured cell line (RAW 264.7 cells) and rat alveolar macrophages via the expression of the gene encoding for AANAT through a mechanism dependent on activation of the NFκB pathway. Expression of the genes encoding AANAT, MT1, and MT2 was negatively correlated with cellular necroptosis, as disclosed by analysis of Gene Expression Omnibus (GEO) microarray data from the human alveolar macrophages of nonsmoking subjects. The enrichment score for antioxidant genes obtained from lung gene expression data (GTEx) was significantly correlated with the levels of AANAT and MT1 but not the MT2 melatonin receptor. Collectively, these data provide a systemic and mechanistic rationale for coordination of the pineal and extrapineal synthesis of melatonin by a standard damage‐associated stimulus, which activates the immune‐pineal axis and provides a new framework for understanding the effects of air pollution on lung diseases.
  • STAT1-NFκB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production
    Leila Eliza Barbosa Lima, Sandra Marcia Muxel, Gabriela S. Kinker, Cláudia Emanuele Carvalho‐Sousa, Sanseray da Silveira Cruz‐Machado, Regina P. Markus, Pedro Augusto Carlos Magno Fernandes
    Journal of Pineal Research, 2019
    Melatonin production by pineal glands is modulated by several immune signals. The nuclear translocation of nuclear factor kappa‐B (NFκB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)‐induced melatonin. Interferon gamma (IFN‐γ), on the other hand, increases melatonin synthesis. Furthermore, this cytokine activates the signal transducer as well as the activator of transcription 1 (STAT1) pathway, which was never evaluated as a melatonin synthesis modulator before. Reports demonstrated that IFN‐γ might also activate NFκB. The present study evaluated the role of STAT1‐NFκB crosstalk triggered by IFN‐γ regarding the regulation of NA‐induced pineal glands’ hormonal production. Moreover, IFN‐γ treatment increased NA‐induced Aanat transcription, in addition to the synthesis of N‐acetylserotonin (NAS) and melatonin. These effects were associated with STAT1 nuclear translocation, confirmed by the co‐immunoprecipitation of STAT1 and Aanat promoter. Pharmacological STAT1 enhancement augmented NA‐induced Aanat transcription as well as NAS and melatonin production. Additionally, IFN‐γ induced the nuclear translocation of RelA‐NFκB subunits. The blockade of this pathway prevented IFN‐γ effects on the pineal function. The present data show that STAT1 and NFκB crosstalk controls melatonin production through a synergistic mechanism, disclosing a new integrative mechanism regarding pineal hormonal activity control.
  • Dysregulation of circadian rhythms in autism spectrum disorders
    Luciana Pinato, Caio Sergio Galina Spilla, Regina Pekelmann Markus, Sanseray da Silveira Cruz-Machado
    Current Pharmaceutical Design, 2019
  • Site-specific reprogramming of macrophage responsiveness to bacterial lipopolysaccharide in obesity
    Evilin N. Komegae, Monique T. Fonseca, Sanseray da Silveira Cruz-Machado, Walter M. Turato, Luciano R. Filgueiras, Regina P. Markus, Alexandre A. Steiner
    Frontiers in Immunology, 2019
  • An antibody-based platform for melatonin quantification
    Laís C. Brazaca, Camila B. Bramorski, Juliana Cancino-Bernardi, Sanseray da Silveira Cruz-Machado, Regina P. Markus, Bruno C. Janegitz, Valtencir Zucolotto
    Colloids and Surfaces B Biointerfaces, 2018
  • Immune-pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
    Regina P Markus, Pedro A Fernandes, Gabriela S Kinker, Sanseray da Silveira Cruz‐Machado, Marina Marçola
    British Journal of Pharmacology, 2018
  • Non-metastatic cutaneous melanoma induces chronodisruption in central and peripheral circadian clocks
    Leonardo De Assis, Maria Moraes, Keila Magalhães-Marques, Gabriela Kinker, Sanseray Da Silveira Cruz-Machado, Ana De Lauro Castrucci
    International Journal of Molecular Sciences, 2018
  • Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome
    Erica B Mahany, Xingfa Han, Beatriz C Borges, Sanseray da Silveira Cruz-Machado, Susan J Allen, David Garcia-Galiano, Mark J Hoenerhoff, Nicole H Bellefontaine, Carol F Elias
    Endocrinology, 2018
  • Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program
    Sanseray da Silveira Cruz-Machado, Eduardo K. Tamura, Claudia E. Carvalho-Sousa, Vanderlei Amadeu Rocha, Luciana Pinato, Pedro A. C. Fernandes, Regina P. Markus
    Scientific Reports, 2017
  • Obesity-induced infertility in male mice is associated with disruption of Crisp4 expression and sperm fertilization capacity
    Beatriz C Borges, David Garcia-Galiano, Sanseray da Silveira Cruz-Machado, Xingfa Han, Galina B Gavrilina, Thomas L Saunders, Richard J Auchus, Saher S Hammoud, Gary D Smith, Carol F Elias
    Endocrinology, 2017
  • Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes in Danio rerio ZEM-2S Cells
    Jennifer Caroline Sousa, Keila Karoline Magalhães-Marques, Sanseray da Silveira Cruz-Machado, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci
    Biomed Research International, 2017
  • Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis
    Pedro A. Fernandes, Eduardo K. Tamura, Letícia D'Argenio-Garcia, Sandra M. Muxel, Sanseray da Silveira Cruz-Machado, Marina Marçola, Cláudia E. Carvalho-Sousa, Erika Cecon, Zulma S. Ferreira, Regina P. Markus
    Neuroendocrinology, 2016
  • The effect of white light on normal and malignant murine melanocytes: A link between opsins, clock genes, and melanogenesis
    L.V.M. de Assis, M.N. Moraes, S. da Silveira Cruz-Machado, A.M.L. Castrucci
    Biochimica Et Biophysica Acta Molecular Cell Research, 2016
  • Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis
    Luciana Pinato, Sanseray da Silveira Cruz-Machado, Daiane G. Franco, Leila M. G. Campos, Erika Cecon, Pedro A. C. M. Fernandes, Jackson C. Bittencourt, Regina P. Markus
    Brain Structure and Function, 2015
  • Endothelial cell adhesiveness is a function of environmental lighting and melatonin level
    Marina Marçola, Sanseray da Silveira Cruz‐Machado, Pedro Augusto Carlos Magno Fernandes, Alex Willian Arantes Monteiro, Regina P. Markus, Eduardo Koji Tamura
    Journal of Pineal Research, 2013
  • Glia-pinealocyte network: The paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF)
    Sanseray da Silveira Cruz-Machado, Luciana Pinato, Eduardo Koji Tamura, Cláudia Emanuele Carvalho-Sousa, Regina P. Markus
    Plos One, 2012
  • Long-lasting priming of endothelial cells by plasma melatonin levels
    Eduardo Koji Tamura, Pedro Augusto Fernandes, Marina Marçola, Sanseray da Silveira Cruz-Machado, Regina Pekelmann Markus
    Plos One, 2010
  • Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor
    Claudia Emanuele Carvalho-Sousa, Sanseray da Silveira Cruz-Machado, Eduardo Koji Tamura, Pedro A. C. M. Fernandes, Luciana Pinato, Sandra M. Muxel, Erika Cecon, Regina P. Markus
    Frontiers in Endocrinology, 2010
  • TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway
    Sanseray Da Silveira Cruz‐Machado, Claudia Emanuele Carvalho‐Sousa, Eduardo Koji Tamura, Luciana Pinato, Erika Cecon, Pedro Augusto Carlos Magno Fernandes, Maria Christina Werneck De Avellar, Zulma Silva Ferreira, Regina Pekelmann Markus
    Journal of Pineal Research, 2010

RECENT SCHOLAR PUBLICATIONS

  • Sleep disturbances and obstructive sleep apnea in children and adolescents with cerebral palsy: an observational study
    I Meneses da Silva, MCH do Couto, S da Silveira Cruz-Machado, ...
    Neurology International 17 (7), 101 , 2025
    2025
    Citations: 6
  • The potential impact of chronobiology in the care of newborns in the Neonatal Intensive Care Unit
    VA Rocha, SS Cruz-Machado
    Rev. Soc. Bras. Enferm. Ped 24, - , 2024
    2024
    Citations: 3
  • O potencial impacto da cronobiologia no cuidado ao recém-nascido em Unidade de Terapia Intensiva Neonatal
    VA Rocha, SS Cruz-Machado
    Rev. Soc. Bras. Enferm. Ped 24, - , 2024
    2024
  • Identification of inflammatory mediators in saliva samples from hospitalized newborns: potential biomarkers?
    VA Rocha, SS Cruz-Machado, IA Silva, PACM Fernandes, RP Markus, ...
    Clinical nursing research 33 (4), 207-219 , 2024
    2024
    Citations: 2
  • LPS-induced inflammation in rats during pregnancy reduces maternal melatonin and impairs neurochemistry and behavior of adult male offspring
    CSG Spilla, ALDM de Souza, LMG Campos, S da Silveira Cruz-Machado, ...
    Brain Research 1824, 148692 , 2024
    2024
    Citations: 4
  • Chronobiological parameters as predictors of early treatment response in major depression
    NB Xavier, ACVO Abreu, GR Amando, EG Steibel, LK Pilz, JJ Freitas, ...
    Journal of Affective Disorders 323, 679-688 , 2023
    2023
    Citations: 14
  • Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense
    RP Markus, KS Sousa, S da Silveira Cruz-Machado, PA Fernandes, ...
    International Journal of Molecular Sciences 22 (22), 12143 , 2021
    2021
    Citations: 61
  • Painful procedures and pain management in newborns admitted to an intensive care unit
    VA Rocha, IA Silva, SS Cruz-Machado, M Bueno
    Revista da Escola de Enfermagem da USP 55, e20210232 , 2021
    2021
    Citations: 41
  • Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances
    S da Silveira Cruz‐Machado, LM Guissoni Campos, CC Fadini, ...
    Journal of Pineal Research 70 (3), e12715 , 2021
    2021
    Citations: 50
  • 1www. scielo. br/reeusp Rev Esc Enferm USP· 2021; 55: e20210232
    VA da Rocha, IA Silva, S da Silveira Cruz-Machado, M Bueno
    Rev Esc Enferm USP 55, e20210232 , 2021
    2021
  • Procedimentos dolorosos e manejo da dor em recém-nascidos hospitalizados em unidade de terapia intensiva
    VA Rocha, IA Silva, SS Cruz-Machado, M Bueno
    Revista da Escola de Enfermagem da USP 55, e20210232 , 2021
    2021
    Citations: 5
  • Immune‐pineal axis protects rat lungs exposed to polluted air
    CE Carvalho‐Sousa, EP Pereira, GS Kinker, M Veras, ZS Ferreira, ...
    Journal of pineal research 68 (3), e12636 , 2020
    2020
    Citations: 39
  • Dysregulation of circadian rhythms in autism spectrum disorders
    L Pinato, CS Galina Spilla, RP Markus, S da Silveira Cruz-Machado
    Current pharmaceutical design 25 (41), 4379-4393 , 2019
    2019
    Citations: 51
  • STAT1‐NFκB crosstalk triggered by interferon gamma regulates noradrenaline‐induced pineal hormonal production
    LE Barbosa Lima, SM Muxel, GS Kinker, CE Carvalho‐Sousa, ...
    Journal of Pineal Research 67 (3), e12599 , 2019
    2019
    Citations: 27
  • Site-specific reprogramming of macrophage responsiveness to bacterial lipopolysaccharide in obesity
    EN Komegae, MT Fonseca, S da Silveira Cruz-Machado, WM Turato, ...
    Frontiers in Immunology 10, 1496 , 2019
    2019
    Citations: 17
  • An antibody-based platform for melatonin quantification
    LC Brazaca, CB Bramorski, J Cancino-Bernardi, ...
    Colloids and Surfaces B: biointerfaces 171, 94-100 , 2018
    2018
    Citations: 38
  • Immune‐pineal axis–acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
    RP Markus, PA Fernandes, GS Kinker, S da Silveira Cruz‐Machado, ...
    British Journal of Pharmacology 175 (16), 3239-3250 , 2018
    2018
    Citations: 212
  • Non-metastatic cutaneous melanoma induces chronodisruption in central and peripheral circadian clocks
    LVM De Assis, MN Moraes, KK Magalhães-Marques, GS Kinker, ...
    International journal of molecular sciences 19 (4), 1065 , 2018
    2018
    Citations: 50
  • Obesity and high-fat diet induce distinct changes in placental gene expression and pregnancy outcome
    EB Mahany, X Han, BC Borges, S da Silveira Cruz-Machado, SJ Allen, ...
    Endocrinology 159 (4), 1718-1733 , 2018
    2018
    Citations: 52
  • Melanoma affects clock gene machinery of several organs in tumor-bearing mice
    LVM de Assis, MN Moraes, KK Magalhaes-Marques, SDS Cruz-Machado, ...
    Annals of Oncology 28, v15 , 2017
    2017

MOST CITED SCHOLAR PUBLICATIONS

  • Immune‐pineal axis–acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
    RP Markus, PA Fernandes, GS Kinker, S da Silveira Cruz‐Machado, ...
    British Journal of Pharmacology 175 (16), 3239-3250 , 2018
    2018
    Citations: 212
  • TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway
    S Da Silveira Cruz‐Machado, CE Carvalho‐Sousa, EK Tamura, L Pinato, ...
    Journal of pineal research 49 (2), 183-192 , 2010
    2010
    Citations: 144
  • Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF)
    S da Silveira Cruz-Machado, L Pinato, EK Tamura, CE Carvalho-Sousa, ...
    PloS one 7 (7), e40142 , 2012
    2012
    Citations: 110
  • Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis
    L Pinato, S da Silveira Cruz-Machado, DG Franco, LMG Campos, ...
    Brain Structure and Function 220 (2), 827-840 , 2015
    2015
    Citations: 106
  • Long-lasting priming of endothelial cells by plasma melatonin levels
    EK Tamura, PA Fernandes, M Marçola, SS Cruz-Machado, RP Markus
    PLoS One 5 (11), e13958 , 2010
    2010
    Citations: 69
  • The effect of white light on normal and malignant murine melanocytes: A link between opsins, clock genes, and melanogenesis
    AMLC L.V.M. de Assis, M.N. Moraes, S. da Silveira Cruz-Machado
    BBA - Molecular Cell Research , 2016
    2016
    Citations: 67
  • Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor
    CE Carvalho-Sousa, S da Silveira Cruz-Machado, EK Tamura, ...
    Frontiers in endocrinology 2, 10 , 2011
    2011
    Citations: 66
  • Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense
    RP Markus, KS Sousa, S da Silveira Cruz-Machado, PA Fernandes, ...
    International Journal of Molecular Sciences 22 (22), 12143 , 2021
    2021
    Citations: 61
  • Dual effect of catecholamines and corticosterone crosstalk on pineal gland melatonin synthesis
    PA Fernandes, EK Tamura, L D'Argenio-Garcia, SM Muxel, ...
    Neuroendocrinology 104 (2), 126-134 , 2016
    2016
    Citations: 60
  • Obesity and high-fat diet induce distinct changes in placental gene expression and pregnancy outcome
    EB Mahany, X Han, BC Borges, S da Silveira Cruz-Machado, SJ Allen, ...
    Endocrinology 159 (4), 1718-1733 , 2018
    2018
    Citations: 52
  • Dysregulation of circadian rhythms in autism spectrum disorders
    L Pinato, CS Galina Spilla, RP Markus, S da Silveira Cruz-Machado
    Current pharmaceutical design 25 (41), 4379-4393 , 2019
    2019
    Citations: 51
  • Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances
    S da Silveira Cruz‐Machado, LM Guissoni Campos, CC Fadini, ...
    Journal of Pineal Research 70 (3), e12715 , 2021
    2021
    Citations: 50
  • Non-metastatic cutaneous melanoma induces chronodisruption in central and peripheral circadian clocks
    LVM De Assis, MN Moraes, KK Magalhães-Marques, GS Kinker, ...
    International journal of molecular sciences 19 (4), 1065 , 2018
    2018
    Citations: 50
  • Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity
    BC Borges, D Garcia-Galiano, S da Silveira Cruz-Machado, X Han, ...
    Endocrinology 158 (9), 2930-2943 , 2017
    2017
    Citations: 42
  • Painful procedures and pain management in newborns admitted to an intensive care unit
    VA Rocha, IA Silva, SS Cruz-Machado, M Bueno
    Revista da Escola de Enfermagem da USP 55, e20210232 , 2021
    2021
    Citations: 41
  • Endothelial cell adhesiveness is a function of environmental lighting and melatonin level
    M Marçola, S da Silveira Cruz‐Machado, PACM Fernandes, ...
    Journal of pineal research 54 (2), 162-169 , 2013
    2013
    Citations: 40
  • Immune‐pineal axis protects rat lungs exposed to polluted air
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