JUAN SANZ-VILLAFRUELA

Scopus Publications

π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light
Diego Abad-Montero, Eduardo Izquierdo-García, Pierre Mesdom, Albert Gandioso, Elena de la Torre-Rubio, et al.
Journal of the American Chemical Society, 2025
Profiting from light-induced metal-to-metal intramolecular electron transfer: towards highly efficient heterodinuclear photosensitizers for photodynamic therapy
Juan Sanz-Villafruela, Lisa-Marie Servos, Nicolás Montesdeoca, José V. Cuevas-Vicario, Artur J. Moro, et al.
Inorganic Chemistry Frontiers, 2025
This study introduces a novel Ruthenium(ii)–Platinum(ii) bimetallic conjugate that undergoes intramolecular electron transfer upon light exposure, producing singlet oxygen with higher efficiency than the separate metal complexes.
Advanced strategies in the design of Ir(III) biscyclometalated complexes for PDT
Juan Sanz-Villafruela, Arancha Carbayo, Marta Martínez-Alonso, Gustavo Espino
Coordination Chemistry Reviews, 2025
Bombesin-Targeted Delivery of β-Carboline-Based Ir(III) and Ru(II) Photosensitizers for a Selective Photodynamic Therapy of Prostate Cancer
Juan Sanz-Villafruela, Cristina Bermejo-Casadesús, Gerard Riesco-Llach, Mònica Iglesias, Marta Martínez-Alonso, et al.
Inorganic Chemistry, 2024
Insights into the anticancer photodynamic activity of Ir(III) and Ru(II) polypyridyl complexes bearing β-carboline ligands
Juan Sanz-Villafruela, Cristina Bermejo-Casadesus, Elisenda Zafon, Marta Martínez-Alonso, Gema Durá, et al.
European Journal of Medicinal Chemistry, 2024
Towards efficient Ir(iii) anticancer photodynamic therapy agents by extending π-conjugation on N^N ligands
Juan Sanz-Villafruela, Cristina Bermejo-Casadesús, Marta Martínez-Alonso, Artur Moro, João C. Lima, et al.
Dalton Transactions, 2024
By extending π-conjugation on the N^N ligand, we have found an efficient Ir(iii) photosensitizer for anticancer PDT, which shows a long-lived excited state, excellent 1O2 production and mitochondrial membrane depolarization activity.
One-pot photocatalytic transformation of indolines into 3-thiocyanate indoles with new Ir(iii) photosensitizers bearing β-carbolines
Juan Sanz-Villafruela, Carmen Martínez-Alonso, Igor Echevarría, Mónica Vaquero, Arancha Carbayo, et al.
Inorganic Chemistry Frontiers, 2021
Herein, we harness the combination of two photocatalytic reactions, promoted by new Ir(iii) photosensitizers, for the direct access to 3-thiocyanato indoles from indolines in a one-pot process.

RECENT SCHOLAR PUBLICATIONS

π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light
D Abad-Montero, E Izquierdo-García, P Mesdom, A Gandioso, ...
Journal of the American Chemical Society 147 (50), 46291-46304 , 2025
2025
Citations: 3
π-Extended Ru-COUBPY photosensitizers for in vivo anticancer phototherapy using one-photon 780 nm near-infrared light.
J Galino, ME Alberto, A Francés-Monerris, G Gasser, V Marchán Sancho, ...
American Chemical Society , 2025
2025
Advanced strategies in the design of Ir (III) biscyclometalated complexes for PDT
J Sanz-Villafruela, A Carbayo, M Martinez-Alonso, G Espino
Coordination Chemistry Reviews 534, 216572 , 2025
2025
Citations: 23
Profiting from light-induced metal-to-metal intramolecular electron transfer
J Sanz-Villafruela, LM Servos, N Montesdeoca, JV Cuevas-Vicario, ...
2025
Profiting from light-induced metal-to-metal intramolecular electron transfer: towards highly efficient heterodinuclear photosensitizers for photodynamic therapy
J Sanz-Villafruela, LM Servos, N Montesdeoca, JV Cuevas-Vicario, ...
Inorganic Chemistry Frontiers 12 (19), 5770-5782 , 2025
2025
Citations: 2
Synthesis, characterization and biological evaluation of New β-carboline-based Ir (III) and Ru (II) Photosensitizers for anticancer photodynamic therapy
J Sanz Villafruela
2025
Insights into the anticancer photodynamic activity of Ir (III) and Ru (II) polypyridyl complexes bearing β-carboline ligands
J Sanz-Villafruela, C Bermejo-Casadesus, E Zafon, M Martínez-Alonso, ...
European Journal of Medicinal Chemistry 276, 116618 , 2024
2024
Citations: 21
Bombesin-Targeted Delivery of β-Carboline-Based Ir (III) and Ru (II) Photosensitizers for a Selective Photodynamic Therapy of Prostate Cancer
J Sanz-Villafruela, C Bermejo-Casadesus, G Riesco-Llach, M Iglesias, ...
Inorganic Chemistry 63 (41), 19140-19155 , 2024
2024
Citations: 12
Towards efficient Ir (III) anticancer photodynamic therapy agents by extending π-conjugation on N^ N ligands
J Sanz-Villafruela, C Bermejo-Casadesús, M Martínez-Alonso, A Moro, ...
Dalton Transactions 53 (27), 11393-11409 , 2024
2024
Citations: 8
Complejos de Iridio (III)
G Espino Ordóñez, M Carbayo Martín, M Vaquero Gutiérrez, ...
Oficina Española de Patentes y Marcas , 2022
2022
One-pot photocatalytic transformation of indolines into 3-thiocyanate indoles with new Ir (III) photosensitizers bearing β-carbolines
J Sanz-Villafruela, C Martínez-Alonso, I Echevarría, M Vaquero, ...
Inorganic Chemistry Frontiers 8 (5), 1253-1270 , 2021
2021
Citations: 11

MOST CITED SCHOLAR PUBLICATIONS

Advanced strategies in the design of Ir (III) biscyclometalated complexes for PDT
J Sanz-Villafruela, A Carbayo, M Martinez-Alonso, G Espino
Coordination Chemistry Reviews 534, 216572 , 2025
2025
Citations: 23
Insights into the anticancer photodynamic activity of Ir (III) and Ru (II) polypyridyl complexes bearing β-carboline ligands
J Sanz-Villafruela, C Bermejo-Casadesus, E Zafon, M Martínez-Alonso, ...
European Journal of Medicinal Chemistry 276, 116618 , 2024
2024
Citations: 21
Bombesin-Targeted Delivery of β-Carboline-Based Ir (III) and Ru (II) Photosensitizers for a Selective Photodynamic Therapy of Prostate Cancer
J Sanz-Villafruela, C Bermejo-Casadesus, G Riesco-Llach, M Iglesias, ...
Inorganic Chemistry 63 (41), 19140-19155 , 2024
2024
Citations: 12
One-pot photocatalytic transformation of indolines into 3-thiocyanate indoles with new Ir (III) photosensitizers bearing β-carbolines
J Sanz-Villafruela, C Martínez-Alonso, I Echevarría, M Vaquero, ...
Inorganic Chemistry Frontiers 8 (5), 1253-1270 , 2021
2021
Citations: 11
Towards efficient Ir (III) anticancer photodynamic therapy agents by extending π-conjugation on N^ N ligands
J Sanz-Villafruela, C Bermejo-Casadesús, M Martínez-Alonso, A Moro, ...
Dalton Transactions 53 (27), 11393-11409 , 2024
2024
Citations: 8
π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light
D Abad-Montero, E Izquierdo-García, P Mesdom, A Gandioso, ...
Journal of the American Chemical Society 147 (50), 46291-46304 , 2025
2025
Citations: 3
Profiting from light-induced metal-to-metal intramolecular electron transfer: towards highly efficient heterodinuclear photosensitizers for photodynamic therapy
J Sanz-Villafruela, LM Servos, N Montesdeoca, JV Cuevas-Vicario, ...
Inorganic Chemistry Frontiers 12 (19), 5770-5782 , 2025
2025
Citations: 2
π-Extended Ru-COUBPY photosensitizers for in vivo anticancer phototherapy using one-photon 780 nm near-infrared light.
J Galino, ME Alberto, A Francés-Monerris, G Gasser, V Marchán Sancho, ...
American Chemical Society , 2025
2025
Profiting from light-induced metal-to-metal intramolecular electron transfer
J Sanz-Villafruela, LM Servos, N Montesdeoca, JV Cuevas-Vicario, ...
2025
Synthesis, characterization and biological evaluation of New β-carboline-based Ir (III) and Ru (II) Photosensitizers for anticancer photodynamic therapy
J Sanz Villafruela
2025
Complejos de Iridio (III)
G Espino Ordóñez, M Carbayo Martín, M Vaquero Gutiérrez, ...
Oficina Española de Patentes y Marcas , 2022
2022