@fmb.unesp.br
Biologist / Faculdade de Medicina de Botucatu
UNESP
Oropouche orthobunyavirus (OROV) is an emerging arbovirus in Latin America, transmitted by Culicoides paraensis and potentially by Culex quinquefasciatus. With no antivirals or vaccines, this study explores natural compounds as therapeutic candidates, focusing on JAK/STAT modulation. In vitro assays (SVG p12, Vero 81) and mosquito infection models will assess antiviral activity, gene expression, and microbiota changes. Findings are expected to reveal compounds that reduce viral load and identify biomarkers to guide novel therapies and vector control strategies.
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