Adeleh Gholipour-Kanani

Scopus Publications

Fabrication and Characterization of ZnO Nanoparticle-Loaded Nanofibers for Diabetic Wound Healing Applications: An in vivo Study
Atefe Rastegar, Hadi Baharifar, Keyvan Dabir, Hassan Maleki, Adeleh Gholipour-Kanani, Fatemeh Mozafari, Kamyar Khoshnevisan
Bionanoscience, 2025
Seed-assisted two-step ZIF-67 growth on CS/PVA nanofibers for high-efficiency cadmium and tetracycline adsorption
Zahra Mokhtari-Shourijeh, Mehdi Ardjmand, Niyaz Mohammad Mahmoodi, Adeleh Gholipour-Kanani, Feryal Nosratinia
Journal of Molecular Structure, 2025
A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract
Shadan Irantash, Adeleh Gholipour-Kanani, Najmeh Najmoddin, Mehdi Varsei
Scientific Reports, 2024
Hybrid structures made of natural-synthetic polymers have been interested due to high biological features combining promising physical–mechanical properties. In this research, a hybrid dressing consisting of a silk fibroin (SF)/polyvinyl alcohol (PVA) nanofibers and sodium alginate (SA)/gum tragacanth (GT) hydrogel incorporating cardamom extract as an antibacterial agent was prepared. Accordingly, SF was extracted from cocoons followed by electrospinning in blend form with PVA (SF/PVA ratio: 1:1) under the voltage of 18 kV and the distances of 15 cm. The SEM images confirmed the formation of uniform, bead free fibers with the average diameter of 199 ± 28 nm. FTIR and XRD results revealed the successful extraction of SF and preparation of mixed fibrous mats. Next, cardamom oil extract-loaded SA/GT hydrogel was prepared and the nanofibrous structure was placed on the surface of hydrogel. SEM analysis depicted the uniform morphology of hybrid structure with desirable matching between two layers. TGA analysis showed desired thermal stability. The swelling ratio was found to be 1251% after 24 h for the hybrid structure and the drug was released without any initial burst. MTT assay and cell attachment results showed favorable biocompatibility and cell proliferation on samples containing extract, and antibacterial activity values of 85.35% against S. aureus and 75% against E. coli were obtained as well. The results showed that the engineered hybrid nanofibrous-hydrogel film structure incorporating cardamom oil extract could be a promising candidate for wound healing applications and skin tissue engineering.
Synthesis and characterization of mupirocin-LDH/PVA nanofibrous composite as a dual-carrier drug release system
Zahra Majidi Qadikolaei, Sayed Mahmood Rabiee, Adeleh Gholipour-Kanani
International Journal of Biological Macromolecules, 2024
Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing
Vida Shadman-Manesh, Adeleh Gholipour-Kanani, Najmeh Najmoddin, Shahram Rabbani
Scientific Reports, 2023
Considering the great potential of egg yolk oil (EYO) in management of burn wounds and superb biological properties of polycaprolactone (PCL) and polyethylene glycol (PEG), hereby, a PCL-PEG-EYO scaffold was developed by electrospinning method for burn healing. The physico-chemical characterizations were performed using SEM, FTIR and contact angle tests. The biological properties of the fabricated scaffolds were evaluated by antibacterial test, in vitro cell culturing, MTT assay and in vivo experiments. The SEM images of PCL-PEG-EYO nanofibers demonstrated a uniform bead-free morphology with 191 ± 61 nm diameter. The fabricated scaffold revealed hydrophilicity with the water contact angel of 77°. No cytotoxicity was observed up to 7 days after cell culturing onto the PCL-PEG-EYO nanofibrous surface. The presence of EYO in the PCL-PEG-EYO scaffold meaningfully improved the cell viability, proliferation and attachment compared to PCL-PEG scaffold. Moreover, the PCL-PEG-EYO scaffolds demonstrated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria strain. Finally, a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis and collagen synthesis was observed at the end of 21-day treatment period using PCL-PEG-EYO nanofibrous scaffold. Overall, the PCL-PEG-EYO nanofibrous scaffolds demonstrated a great potential in management of full thickness burn wounds in vivo.
Surface activity characterization of synthesized polyvinyl alcohol-based nanogel at air-water interface under highly dynamic conditions
Mahyar Hesan, Marzieh Lotfi, Adeleh Gholipour-Kanani, Mojtaba Shafiee
Surfaces and Interfaces, 2023
Polymer-Based Nanofibers
Adeleh Gholipour-Kanani, Niloofar Eslahi
Handbook of Nanofibers and Nanocomposites Characteristics Synthesis and Applications in Textiles, 2023
This chapter reviews the progress of fabrication techniques to produce nanofibers from different types of natural and synthetic polymers in different structures to accomplish the requirements of a particular application. Polymer-based nanofibers are considered for many applications in different industrial features such as filtration, chemical sensors, nanomedicine, tissue engineering, wound dressing, drug delivery, electronic devices, etc. According to the definition of nanotechnology by the National Nanotechnology Initiative, nanoscale materials are special structures that have at least one dimension below 100 nm. The methods for fabricating nanofibers can be divided into two main groups: non-electrospinning methods by using mechanical force including drawing, phase separation, self-assembly and template synthesis and electrospinning methods by using electrostatic force. In rotary spinning, centrifugal spinning, or force spinning, fibers are fabricated by centrifugal forces from a wide range of materials at high speed and low cost. Blown bubble-spinning as a low-cost simple process utilizes polymer melts or solutions to fabricate discontinuous nanofibers by using blowing air.
The synthesis and characterization of core-shell nanogels based on alginate and chitosan for the controlled delivery of mupirocin
Mahyar Hesan, Adeleh Gholipour-Kanani, Marzieh Lotfi, Mojtaba Shafiee
Biochemical Engineering Journal, 2023
Nanofibrous composite from polycaprolactone-polyethylene glycol-aloe vera as a promising scaffold for bone repairing
Fatemeh Dehghan, Adeleh Gholipour‐Kanani, Mehdi Kamali Dolatabadi, Seyed Hajir Bahrami
Journal of Applied Polymer Science, 2022
Recently, herbal extract‐loaded nanofibers have been developed using different types of components for tissue engineering applications. In this study, nanofibrous webs are fabricated from polycaprolactone (PCL)‐polyethylene glycol (PEG) 1:1 mass ratio blend incorporated with different amounts of aloe vera extract through electrospinning. Combining the potential therapeutic properties of aloe vera in bone repair with physicochemical and biological properties of the nanofibers leads to design a promising scaffold for bone repairing. The produced scaffolds are characterized using scanning electron microscopy, Fourier transform infrared (FTIR), and mechanical‐strength test. From the results, the electrospun PCL‐PEG‐aloe vera web with 1:1:1 mass ratio shows a bead‐less bimodal morphology consisting of nano‐scale and micro‐scale fibers with an average diameter of 280 and 670 nm, respectively. FTIR spectra revealed the possible hydrogen bonding between the three components. Mechanical investigation exhibited higher strength of aloe vera loaded nanofibers to unloaded nanofibers. From the MTT assay results, aloe vera‐loaded nanofibrous scaffolds showed a high level of cell compatibility as well as excellent penetration, cell growth, and proliferation. According to the result of calcination, the ability of bone repairing was verified. The result confirmed a higher amount of calcium deposition on nanofibrous scaffolds incorporated with aloe vera extract.
Fabrication and Characterization of Nanofibrous Scaffold Based on Chitosan Containing Cerium Oxide Nanoparticles for Wound Healing Application
Adeleh Gholipour-Kanani, Azadeh Asefnejad, Kimiya Azadbakht
Iranian Journal of Polymer Science and Technology, 2022
Hypothesis: Incorporating different types of nanoparticles, especially metal oxide nanoparticles, into the polymeric nanofiber substrate improves different properties of the web. In this research, citric acid is used as an environmentally friendly cross-linking agent to reduce the hydrophilic property of chitosan-polyvinyl alcohol web. Cerium oxide nanoparticles (nanoceria) as an antioxidant and antibacterial agent are used to increase the biological capabilities of the web for healing applications.Methods: Chitosan (CS)/poly(vinyl alcohol) (PVA)/citric acid (CA) nanofibers with the mass ratios of 1:1:0.5 and 2:3:1 (CS:PVA:CA) were prepared and electrospun. Nanoceria was loaded into the optimal blend prepared for electrospinning. In continuation, the physical-morphological properties, cell compatibility, non-cytotoxicity, and antibacterial activity of the resulting webs were investigated.Findings: Physical-morphological investigations show that the CS:PVA:CA (2:3:1) nanofiber which was electrospun under 15 kV and 18 cm is the optimal nanofiber with an average diameter of 175±29 nm. The contact angle is about 42 degrees, indicating a suitable decrease in hydrophilicity and maintaining the physical integrity of the web. The SEM images show a bead-less morphology with an average diameter of 274±38 nm for nanofibrous web containing 1.5% (by wt) CeO2. The presence of nanoceria and interactions of the functional groups in the components were evident in their EDS and FTIR spectra, respectively. The results of the cell-culturing demonstrate the proper growth and proliferation of fibroblast cells on both with and without-nanoceria webs. The result of the MTT test confirms the non-toxicity of both scaffolds. The antibacterial investigations show improvements in antibacterial activities of the nanofibers containing cerium-oxide against both gram-positive and gram-negative bacteria. In general, the results determined that the presence of nanoceria in chitosan-polyvinyl-alcohol-citric acid electrospun nanofibers has clearly improved the biological properties, especially the antibacterial behavior of the obtained web, so it can be used as a suitable dressing for wound healing application.
Production and Characterization of Keratin/Tragacanth Gum Nano Hydrogels for Drug Delivery in Medical Textiles
Nazanin Mansouri Shirazi, Niloofar Eslahi, Adeleh Gholipour-Kanani
Springer Proceedings in Materials, 2022
Novel non-enzymatic glucose biosensor based on electrospun PAN/PANI/CuO nano-composites
Golsa Jafari, Adeleh Gholipour-Kanani, Abosaeed Rashidi, Hamid Reza Moazami
Journal of the Textile Institute, 2022
Production and Characterization of Keratin/Tragacanth Gum Nanohydrogels for Drug Delivery in Medical Textiles
Nazanin Mansouri Shirazi, Niloofar Eslahi, Adeleh Gholipour-Kanani
Frontiers in Materials, 2021
The Effect of Bulk Electrospun Polycaprolactone-graphene Oxide Scaffold on the Healing of Defected Femur Cartilage on a Rabbit Model
Farnaz Moradi, Adeleh Gholipour-Kanani, Najmeh Najmoddin, Niloofar Eslahi, S. Hajir Bahrami, Shahram Rabbani
Fibers and Polymers, 2021
Study on release of cardamom extract as an antibacterial agent from electrospun scaffold based on sodium alginate
Shima Najafi, Adeleh Gholipour-Kanani, Niloofar Eslahi, S. Hajir Bahrami
Journal of the Textile Institute, 2021
Poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds for skin excisional and burn wounds in a canine model
Adeleh Gholipour‐Kanani, Monireh Mohsenzadegan, Mohammadreza Fayyazi, Hajir Bahrami, Ali Samadikuchaksaraei
Iet Nanobiotechnology, 2018
Nanofibrous scaffolds from chitosan and poly(caprolactone) for excision wound healing application in canine model
Adeleh Gholipour-Kanani, Ali Samadikuchaksaraei, Monire Mohsenzadegan, Mohahmadreza Fayyazi
Materials Today Proceedings, 2018
Effect of novel blend nanofibrous scaffolds on diabetic wounds healing
Adeleh Gholipour‐Kanani, S. Hajir Bahrami, Shahram Rabbani
Iet Nanobiotechnology, 2016
Novel blend scaffolds from poly(caprolactone)- chitosan-poly(vinyl alcohol): Physical, Morphological and biological studies
Adeleh Gholipour-Kanani, S. Hajir Bahrami, Ali Samadikuchaksaraei
Journal of Biomaterials and Tissue Engineering, 2014
Tissue engineered poly(caprolactone)-chitosan-poly (vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing
Adeleh Gholipour‐Kanani, S. Hajir Bahrami, Mohammad Taghi Joghataie, Ali Samadikuchaksaraei, Hossein Ahmadi‐Taftie, Shahram Rabbani, Alireza Kororian, Elham Erfani
Iet Nanobiotechnology, 2014
Mechanical reinforcement of chitosan-gelatin sponge with polycaprolactone electrospun nanofibrous sheets
F. Dastjani-Farahani, H. Keshvari, A. Gholipour-Kanani, Sh. Bonakdar, M. A. Shokrgozar
Journal of Biomaterials and Tissue Engineering, 2013
Effect of tissue-engineered chitosan-poly(vinyl alcohol) nanofibrous scaffolds on healing of burn wounds of rat skin
A. Gholipour-Kanani, S.H. Bahrami, A. Samadi-Kochaksaraie, H. Ahmadi-Tafti, S. Rabbani, A. Kororian, E. Erfani
Iet Nanobiotechnology, 2012
Morphological, mechanical and biological properties of novel PCL- Cs/PVA multi layer nanofibrous scaffolds
Digest Journal of Nanomaterials and Biostructures, 2012
Effect of changing solvents on poly(ε-Caprolactone) nanofibrous webs morphology
A. Gholipour Kanani, S. Hajir Bahrami
Journal of Nanomaterials, 2011
Effect of chitosan-polyvinyl alcohol blend nanofibrous web on the healing of excision and incision full thickness wounds
A.G. Kanani, S.H. Bahrami, H.A. Taftei, S. Rabbani, M. Sotoudeh
Iet Nanobiotechnology, 2010
Review on electrospun nanofibers scaffold and biomedical applications
Trends in Biomaterials and Artificial Organs, 2010
Optimization of chitosan-polyvinylalcohol electrospinning process by Response Surface Methodology (RSM)
A. Gholipour, S. H. Bahrami, M. Nouri
E Polymers, 2010
Chitosan-poly(vinyl alcohol) blend nanofibers: Morphology, biological and antimicrobial properties
A. Gholipour. K, S .H. Bahrami, M. Nouri
E Polymers, 2009
Nanofibers from Chitosan_ Poly Vinyl Alcohol blend and their biological and antimicrobial properties and Process optimization using response surface methodology
VDI Berichte, 2008
Nanofibers from Chitosan_ Poly Vinyl Alcohol blend and their biological and antimicrobial properties and Process optimization using response surface methodology
VDI Berichte, 2008

Adeleh Gholipour-Kanani

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Scopus Publications

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INDUSTRY EXPERIENCE