Shally Sharma

@fct.unl.pt

POST-DOCTORAL RESEARCHER
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa

Shally Sharma


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https://researchid.co/sharmashally666

EDUCATION

 Post-Doctoral Researcher (Life Sciences), NOVA School of Science and Technology, Portugal, started on 01/11/2024.
 Post-Doctoral Researcher (Biophysics), Indian Institute of Science and Technology (Mohali), India, started on 08/08/2023 to 31/01/2024.
 Ph.D. in Biotechnology (DST-INSPIRE Fellow) from Panjab University, Chandigarh (India) in August 2023.
 M.Sc. (Gold medalist) Biotechnology from Kurukshetra University Kurukshetra (KUK), India with 84.6% in 2015.
 B.Sc. (Honors) Biotechnology from Kurukshetra University Kurukshetra (KUK) India with 82.3% in 2013.
 Intermediate in medical science from Haryana Board of School Education with 82% in 2010.
 Matriculation from Haryana Board of School Education with 94.6% in 2008.

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Structural Biology, Cancer Research, Cell Biology
2

Scopus Publications

34

Scholar Citations

3

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Antimicrobial Studies on Garlic Lectin
    Shally Sharma, Khem Raj, Mohammad Riyaz, Desh Deepak Singh
    Probiotics and Antimicrobial Proteins, 2023
  • Investigations on the Biological Activity of Allium sativum Agglutinin (ASA) Isolated from Garlic
    Shally Sharma, Desh Deepak Singh
    Protein and Peptide Letters, 2022
    Background: Garlic (Allium sativum) from the family Amaryllidaceae is widely used in culinary and is reported to have potential anticancer, anti-diabetic, antimicrobial, and cardioprotective activities. Allium sativum agglutinin (ASA) is a bulb-type lectin (BTL) domaincontaining lectin isolated from garlic and has been studied for its various biological functions. Previous studies have reported the anti-cancer effects of ASA on histiocytic lymphoma (U937), promyelocytic leukemia (HL60), and oral cancer (KB). Methods: In this study, we have purified and characterized ASA and evaluated it for its anticancer effects on other cancer cell lines. MTT assay and FACS analysis was done to corroborate the anticancer findings against cervical (HeLa) and lung cancer (A549) cell lines. Results: IC50 value of 37 μg/ml in HeLa and a weak activity (26.4 ± 1.9% cellular inhibition at 100μg/ml treatment) in A549 were found in the MTT assay. FACS analysis further corroborated these findings and showed the apoptotic effects of ASA in these cell lines. Conclusion: Anticancer activity for members of bulb-type lectin (BTL) domain-containing lectins has been widely reported, and we hope that our study forms a basis for the development of ASA as a therapeutic agent.

RECENT SCHOLAR PUBLICATIONS

  • Short Mucin-Type O -Glycans in Cancer: Biomarker and Therapeutic Potential amid Analytical Barriers
    H Sousa, IAB Ribeiro, M Falcão, DF Barreira, M Barbosa, S Sharma, ...
    Glycobiology, cwaf077 , 2025
    2025
    Citations: 2
  • Cancer-associated O-glycans and microbiome interactions in colorectal cancer: insights into tumor progression and immune evasion
    Rocio Gonzalez-Soltero , Shally Sharma , Daniela F. Barreira , Ana Luísa ...
    Journal of Cancer Metastasis and Treatment 11 (26), 1-12 , 2025
    2025
    Citations: 1
  • Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome
    C Pascoal, P Granjo, P Mexia, D Gallego, RA Lourenço, S Sharma, ...
    Immunology Letters, 107057 , 2025
    2025
    Citations: 6
  • Chandigarh Science Congress-2022 (CHASCON-2022), A REPORT
    Sharma S., Sandhu J., Singh A., Singh A., Manniya. Mathur U., Sahajpal S.
    Panjab University Research Journal (Science) 72, 67-70 , 2022
    2022
  • Antimicrobial Studies on Garlic Lectin
    S Sharma, K Raj, M Riyaz, DD Singh
    Probiotics and Antimicrobial Proteins, 1-12 , 2022
    2022
    Citations: 12
  • Investigations on the biological activity of Allium sativum agglutinin (ASA) isolated from Garlic
    S Sharma, DD Singh
    Protein and Peptide Letters 29 (6), 555-566 , 2022
    2022
    Citations: 13

MOST CITED SCHOLAR PUBLICATIONS

  • Investigations on the biological activity of Allium sativum agglutinin (ASA) isolated from Garlic
    S Sharma, DD Singh
    Protein and Peptide Letters 29 (6), 555-566 , 2022
    2022
    Citations: 13
  • Antimicrobial Studies on Garlic Lectin
    S Sharma, K Raj, M Riyaz, DD Singh
    Probiotics and Antimicrobial Proteins, 1-12 , 2022
    2022
    Citations: 12
  • Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome
    C Pascoal, P Granjo, P Mexia, D Gallego, RA Lourenço, S Sharma, ...
    Immunology Letters, 107057 , 2025
    2025
    Citations: 6
  • Short Mucin-Type O -Glycans in Cancer: Biomarker and Therapeutic Potential amid Analytical Barriers
    H Sousa, IAB Ribeiro, M Falcão, DF Barreira, M Barbosa, S Sharma, ...
    Glycobiology, cwaf077 , 2025
    2025
    Citations: 2
  • Cancer-associated O-glycans and microbiome interactions in colorectal cancer: insights into tumor progression and immune evasion
    Rocio Gonzalez-Soltero , Shally Sharma , Daniela F. Barreira , Ana Luísa ...
    Journal of Cancer Metastasis and Treatment 11 (26), 1-12 , 2025
    2025
    Citations: 1
  • Chandigarh Science Congress-2022 (CHASCON-2022), A REPORT
    Sharma S., Sandhu J., Singh A., Singh A., Manniya. Mathur U., Sahajpal S.
    Panjab University Research Journal (Science) 72, 67-70 , 2022
    2022

Publications

 Sousa, H., Ribeiro, I., Falcão, M., Barreira, D.F., Barbosa, M., Sharma, S., de Haan, N., Wuhrer, M. & Videira, P.A. (2025). Short Mucin-Type O-Glycans in Cancer: Biomarker and Therapeutic Potential amid Analytical Barriers. Glycobiology, (Accepted, 10th October 2025) (IF 3.3).
 Gonzalez-Soltero R., Sharma S., Barreira D.F., Benavente A.L., Palma A.S., Videira P.A. (2025). Cancer-associated O-glycans and microbiome interactions in colorectal cancer: insights into tumor progression and immune evasion. Journal of Cancer Metastasis and Treatment, doi:10.20517/2394-4722.2025.78 (IF 1).
 Pascoal, C., Granjo, P., Mexia, P., Gallego, D., Lourenço, R. A., Sharma, S., Pérez B., Castro-Caldas M., Grosso A.R., Ferreira V.R. & Videira, P. A. (2025). Unraveling the biological potential of skin fibroblast: responses to TNF-α, highlighting intracellular signaling pathways and secretome. Immunology Letters, 107057. (IF 2.8).
 Sharma, S., Raj, K., Riyaz, M., & Singh, D.D. (2022). Antimicrobial Studies on Garlic Lectin. Probiotics and Antimicrobial Proteins, 1-12. (IF 5).
 Sharma, S., & Singh, D. D. (2022). Investigations on the biological activity of Allium sativum agglutinin (ASA) isolated from Garlic. Protein & Peptide Letters, 29(6), 555-566. (IF 1.4).