Shorter might be better: oligo(oxazoline)s for thermoresponsive polymersomes Léa Daoud, Laura Vasilica Arsenie, Belkacem Tarek Benkhaled, Kilian Caillaud, Mona Semsarilar, et al. Polymer Chemistry, 2024 Amphiphilic oligomers of poly(2-oxazoline)s self-assemble in well-defined polymersomes tuneable by its thermosensitivity.
Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications Morgane Morel, Mathieu Madau, Didier Le Cerf, Virginie Dulong, Anne-Claire Groo, et al. Journal of Materials Chemistry B, 2024 Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl-co-butyl oxazoline)) or P(iPrOx-co-BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus.
Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex Nanogels from Functionalized Hyaluronic Acid Huu Van Le, Virginie Dulong, Luc Picton, Didier Le Cerf Pharmaceutics, 2023 The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant type during reconstitution for different applications. However, lyophilization strategies must be adapted to each kind of nanoformulation in order to minimize aggregation after reconstitution. In this work, the effects of formulation aspects (i.e., charge ratio, polymer concentration, thermoresponsive grafts, polycation type, cryoprotectant type, and concentration) on particle integrity after lyophilization and reconstitution for different types of polyelectrolyte complex nanogels (PEC-NGs) from hyaluronic acid (HA) were investigated. The main objective was to find the best approach for freeze-drying thermoresponsive PEC-NGs from Jeffamine-M-2005-functionalized HA, which has recently been developed as a potential platform for drug delivery. It was found that freeze-drying PEC-NG suspensions prepared at a relatively low polymer concentration of 0.2 g.L−1 with 0.2% (m/v) trehalose as a cryoprotectant allow the homogeneous redispersion of PEC-NGs when concentrated at 1 g.L−1 upon reconstitution in PBS without important aggregation (i.e., average particle size remaining under 350 nm), which could be applied to concentrate curcumin (CUR)-loaded PEC-NGs for optimizing CUR content. The thermoresponsive release of CUR from such concentrated PEC-NGs was also reverified, which showed a minor effect of freeze-drying on the drug release profile.
Study on the synthesis and characterization of ph-sensitive xanthan chemical gels for controlled drug delivery substrates 8th World Biomaterials Congress 2008, 2008
Antioxidant functionalization of pullulan with ferulic acid using enzymatic catalysis K Boundaoui, X Falourd, C Loutelier-Bourhis, T Varacavoudin, L Picton, ... Carbohydrate Polymers, 125202 , 2026 2026
On the aggregative behavior of 4-O-Methyl-D-Glucurono-D-Xylan in aqueous solution: from optimized solvation at hot temperature to cold gelation R BURET, M MADAU, V DULONG, D LE CERF, C RIHOUEY, V Chaleix, ... 2026
Influence of mechanical properties of agarose hydrogels on bacterial growth and secretory activity L Dupont, VS Tadimarri, R Buret, S Sankaran, L Picton, AM Jonas, ... Biomaterials Advances, 214653 , 2025 2025
A review of thermosensitive polysaccharide-based composite hydrogels for therapeutic applications M Morel, V Dulong, AC Groo, A Malzert-Fréon, L Picton International Journal of Biological Macromolecules 319, 145292 , 2025 2025 Citations: 3
Exopolysaccharide from marine microalgae belonging to the Glossomastix genus: fragile gel behavior and suspension stability V Dulong, C Rihouey, C Gaignard, N Bridiau, P Gourvil, C Laroche, ... Bioengineered 15 (1), 2296257 , 2024 2024 Citations: 14
Polyelectrolyte complexes of chitosan and hyaluronic acid or carboxymethylpullulan and their aminoguaiacol derivatives with biological activities as potential drug delivery systems V Dulong, P Thebault, C Karakasyan, L Picton, D Le Cerf Carbohydrate Polymers 341, 122330 , 2024 2024 Citations: 21
Hydrogels thermosensibles à base d'acide hyaluronique avec une température de gélification ajustable V Dulong, M Madau, D Le Cerf, V Lapinte, G Morandi, C Rihouey, ... Polymerix 2024 , 2024 2024
Linking formulation feedstock to printability by robocasting: a case study of eco-friendly alumina pastes D Gourdonnaud, J Bourret, V Pateloup, L Giardi, L Picton, V Chaleix, ... Open Ceramics 18, 100606 , 2024 2024 Citations: 3
Chemical characterization of polysaccharides from Gracilaria gracilis from Bizerte (Tunisia) K Yahyaoui, M Traikia, C Rihouey, L Picton, C Gardarin, WM Ksouri, ... International Journal of Biological Macromolecules 266, 131127 , 2024 2024 Citations: 19
Shorter might be better: oligo (oxazoline) s for thermoresponsive polymersomes L Daoud, LV Arsenie, BT Benkhaled, K Caillaud, M Semsarilar, L Picton, ... Polymer Chemistry 15 (36), 3641-3656 , 2024 2024 Citations: 3
Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications M Morel, M Madau, D Le Cerf, V Dulong, AC Groo, A Malzert-Fréon, ... Journal of Materials Chemistry B 12 (11), 2807-2817 , 2024 2024 Citations: 9
Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size C Jaudoin, MM Gehrke, I Grillo, F Cousin, M Ouldali, AA Arteni, E Ferrary, ... International Journal of Pharmaceutics 648, 123560 , 2023 2023 Citations: 13
NANOGELS OF POLYSACCHARIDES WITH ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES FOR DRUG DELIVERY V Dulong, P Thébault, B Labat, L Picton, D Le Cerf EPNOE 2023 , 2023 2023
Production de collagène et d’acide hyaluronique par des fibroblastes dermiques humains stimulés par des exopolysaccharides de microalgues: quelques aspects structuraux et … C Toucheteau, V Deffains, C Gaignard, G Pierre, C Laroche, C Rihouey, ... 10th COSM'ING , 2023 2023
Procollagen effect of microalgal exopolysaccharides on human dermal fibroblasts: some structural and mechanistic aspects C Toucheteau, V Deffains, C Gaignard, I Probert, G Pierre, C Laroche, ... 5th COSM'INNOV , 2023 2023
Thermosensitive nanocarriers for drug delivery from polyelectrolyte complexes of hyaluronic acid grafted with PEO PPO: old polymers, new combination H Van Le, V Dulong, L Picton, D Le Cerf 8th Nano Today Conference , 2023 2023
Lyophilization for formulation optimization of drug-loaded thermoresponsive polyelectrolyte complex nanogels from functionalized hyaluronic acid HV Le, V Dulong, L Picton, D Le Cerf Pharmaceutics 15 (3), 929 , 2023 2023 Citations: 11
Acetic acid-modulated room temperature synthesis of MIL-100 (Fe) nanoparticles for drug delivery applications M Ding, J Qiu, S Rouzière, C Rihouey, L Picton, R Gref International Journal of Molecular Sciences 24 (2), 1757 , 2023 2023 Citations: 13
Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex Nanogels from Functionalized Hyaluronic Acid. Pharmaceutics 2023, 15, 929 HV Le, V Dulong, L Picton, D Le Cerf 2023
Hybrid systems combining liposomes and entangled hyaluronic acid chains: Influence of liposome surface and drug encapsulation on the microstructure C Jaudoin, I Grillo, F Cousin, M Gehrke, M Ouldali, AA Arteni, L Picton, ... Journal of colloid and interface science 628, 995-1007 , 2022 2022 Citations: 9
MOST CITED SCHOLAR PUBLICATIONS
Structural investigations of the neutral polysaccharide of Linum usitatissimum L. seeds mucilage J Warrand, P Michaud, L Picton, G Muller, B Courtois, R Ralainirina, ... International Journal of Biological Macromolecules 35 (3-4), 121-125 , 2005 2005 Citations: 198
Analysis of a complex polysaccharide (gum arabic) by multi-angle laser light scattering coupled on-line to size exclusion chromatography and flow field flow fractionation L Picton, I Bataille, G Muller Carbohydrate Polymers 42 (1), 23-31 , 2000 2000 Citations: 181
Prickly pear nopals pectin from Opuntia ficus-indica physico-chemical study in dilute and semi-dilute solutions H Majdoub, S Roudesli, L Picton, D Le Cerf, G Muller, M Grisel Carbohydrate polymers 46 (1), 69-79 , 2001 2001 Citations: 180
Comparison of polysaccharide degradations by dynamic high-pressure homogenization A Villay, FL De Filippis, L Picton, D Le Cerf, C Vial, P Michaud Food Hydrocolloids 27 (2), 278-286 , 2012 2012 Citations: 152
High-resolution nuclear magnetic resonance spectroscopy studies of polysaccharides crosslinked by sodium trimetaphosphate: a proposal for the reaction mechanism S Lack, V Dulong, L Picton, D Le Cerf, E Condamine Carbohydrate Research 342 (7), 943-953 , 2007 2007 Citations: 147
Analysis of arabic gum: Study of degradation and water desorption processes C Cozic, L Picton, MR Garda, F Marlhoux, D Le Cerf Food Hydrocolloids 23 (7), 1930-1934 , 2009 2009 Citations: 135
Large-scale purification of water-soluble polysaccharides from flaxseed mucilage, and isolation of a new anionic polymer J Warr, P Michaud, L Picton, G Muller, B Courtois, R Ralainirina, ... Chromatographia 58 (5), 331-335 , 2003 2003 Citations: 131
Hyaluronan-based hydrogels particles prepared by crosslinking with trisodium trimetaphosphate. Synthesis and characterization V Dulong, S Lack, D Le Cerf, L Picton, JP Vannier, G Muller Carbohydrate Polymers 57 (1), 1-6 , 2004 2004 Citations: 114
New amphiphilic and pH-sensitive hydrogel for controlled release of a model poorly water-soluble drug I Colinet, V Dulong, G Mocanu, L Picton, D Le Cerf European journal of pharmaceutics and biopharmaceutics 73 (3), 345-350 , 2009 2009 Citations: 113
Entrapment and release of sodium polystyrene sulfonate (SPS) from calcium alginate gel beads I Rousseau, D Le Cerf, L Picton, JF Argillier, G Muller European Polymer Journal 40 (12), 2709-2715 , 2004 2004 Citations: 107
Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour A Bejenariu, M Popa, V Dulong, L Picton, D Le Cerf Polymer Bulletin 62 (4), 525-538 , 2009 2009 Citations: 100
Hydrogels based on pullulan crosslinked with sodium trimetaphosphate (STMP): rheological study S Lack, V Dulong, D Le Cerf, L Picton, JF Argillier, G Muller Polymer Bulletin 52 (6), 429-436 , 2004 2004 Citations: 99
Purification of a low molecular weight fucoidan for SPECT molecular imaging of myocardial infarction P Saboural, F Chaubet, F Rouzet, F Al-Shoukr, R Ben Azzouna, ... Marine drugs 12 (9), 4851-4867 , 2014 2014 Citations: 88
Hydrophobically modified xanthan: an amphiphilic but not associative polymer A Roy, S Comesse, M Grisel, N Hucher, Z Souguir, F Renou Biomacromolecules 15 (4), 1160-1170 , 2014 2014 Citations: 80
Composition, structure and solution properties of polysaccharides extracted from leaves of Mesembryanthenum crystallinum NH M’sakni, H Majdoub, S Roudesli, L Picton, D Le Cerf, C Rihouey, ... European polymer journal 42 (4), 786-795 , 2006 2006 Citations: 78
New amphiphilic modified polysaccharides with original solution behaviour in salt media I Colinet, V Dulong, T Hamaide, D Le Cerf, L Picton Carbohydrate polymers 75 (3), 454-462 , 2009 2009 Citations: 75
Potential of Exopolysaccharide from Porphyridium marinum to Contend with Bacterial Proliferation, Biofilm Formation, and Breast Cancer N Gargouch, F Elleuch, I Karkouch, O Tabbene, C Pichon, C Gardarin, ... Marine drugs 19 (2), 66 , 2021 2021 Citations: 69
Amphiphilic and thermosensitive copolymers based on pullulan and Jeffamine®: Synthesis, characterization and physicochemical properties V Dulong, G Mocanu, L Picton, D Le Cerf Carbohydrate polymers 87 (2), 1522-1531 , 2012 2012 Citations: 68
Synthesis, photopolymerization and adhesive properties of new hydrolytically stable phosphonic acids for dental applications Y Catel, M Degrange, L Le Pluart, PJ Madec, TN Pham, L Picton Journal of Polymer Science Part A: Polymer Chemistry 46 (21), 7074-7090 , 2008 2008 Citations: 67
Amphiphilic polysaccharides. Evidence for a competition between intra and intermolecular associations in dilute system S Simon, JY Dugast, D Le Cerf, L Picton, G Muller Polymer 44 (26), 7917-7924 , 2003 2003 Citations: 67
