Liliany Souza de Brito Amaral

@ims.ufba.br

Universidade Federal da Bahia - Instituto Multidisciplinar em Saúde - Campus Anísio Teixeira
Universidade Federal da Bahia - Instituto Multidisciplinar em Saúde - Campus Anísio Teixeira

Liliany Souza de Brito Amaral


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https://researchid.co/liliany.amaral

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology
14

Scopus Publications

504

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • Anabolic-androgenic steroids at supraphysiological doses: Cardiovascular impacts and pathophysiological mechanisms
    Higor Souza Nascimento, Marcella Guerra Corrêa, Odonilton Lima Lemos, Hernando Nascimento Lima, Liliany Souza de Brito Amaral
    Journal of Steroid Biochemistry and Molecular Biology, 2026
    This narrative review explores the cardiovascular risks associated with the non-therapeutic use of anabolic-androgenic steroids (AAS) at supraphysiological doses. Initially indicated for clinical conditions like hypogonadism and anemia, AAS are increasingly misused for aesthetic and performance enhancement, often at doses far exceeding therapeutic recommendations. Through a literature review of 34 studies selected from PubMed (2015–2025), the review analyzes the molecular mechanisms and cardiovascular consequences of high-dose AAS use. Genomic and non-genomic pathways, along with modulation of the IGF-1 axis, underlie alterations in gene expression and cellular metabolism that lead to myocardial remodeling, hypertension, dyslipidemia, thrombosis, endothelial dysfunction, and systemic inflammation. These effects are further intensified by behavioral factors such as polypharmacy and substance abuse. Despite ethical limitations on clinical trials with supraphysiological doses, experimental and epidemiological data consistently suggest that excessive AAS use significantly elevates the risk of adverse cardiovascular events. This work highlights the urgent need for public health policies, educational initiatives, and longitudinal studies to assess real-world use patterns and mitigate harms associated with AAS abuse. • Supraphysiological AAS induce cardiac remodeling and vascular dysfunction. • Molecular mechanisms of AAS drive cardiovascular risks. • High-dose AAS elevate thrombosis, dyslipidemia, and inflammation. • Review urges public health policies and longitudinal studies. • Distinguishes supraphysiological AAS risks from testosterone therapy.
  • High-intensity interval training elicits superior effects than continuous training to improve renal redox status via klotho and Nrf2 signaling in female rats with cisplatin nephrotoxicity
    Érika Azenathe Barros Mercês, Caroline Assunção Oliveira, Fernanda Santos Portela, Lara Fabiana Luz Malheiro, Henrique Bruno Lopes Silva, Júlia Spínola Ávila, Bruna Santos Silva, Ana Jullie Veiga Fernandes, Laís Mafra De Benedictis, Thiago Macêdo Lopes Correia, Fabrício Freire de Melo, Márcio Vasconcelos Oliveira, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares, Liliany Souza de Brito Amaral
    Archives of Biochemistry and Biophysics, 2025
  • High-intensity interval training improves hepatic redox status via Nrf2 downstream pathways and reduced CYP2E1 expression in female rats with cisplatin-induced hepatotoxicity
    Fernanda Santos Portela, Lara Fabiana Luz Malheiro, Caroline Assunção Oliveira, Érika Azenathe Barros Mercês, Lais Mafra De Benedictis, Júlia Mafra De Benedictis, Ana Jullie Veiga Fernandes, Bruna Santos Silva, Júlia Spínola Ávila, Thiago Macêdo Lopes Correia, Márcio Vasconcelos Oliveira, Patrícia da Silva Oliveira, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares, Fabrício Freire de Melo, Liliany Souza de Brito Amaral
    Food and Chemical Toxicology, 2025
  • High-intensity interval training alleviates liver inflammation by regulating the TLR4/NF-κB signaling pathway and M1/M2 macrophage balance in female rats with cisplatin hepatotoxicity
    Lara Fabiana Luz Malheiro, Caroline Assunção Oliveira, Fernanda Santos Portela, Érika Azenatte Barros Mercês, Laís Mafra de Benedictis, Júlia Mafra de Benedictis, Everaldo Nery de Andrade, Amélia Cristina Mendes Magalhães, Fabrício Freire de Melo, Patrícia da Silva Oliveira, Telma de Jesus Soares, Liliany Souza de Brito Amaral
    Biochemical and Biophysical Research Communications, 2024
  • Renoprotective mechanisms of exercise training against acute and chronic renal diseases – A perspective based on experimental studies
    Lara Fabiana Luz Malheiro, Mariana Masimessi Fernandes, Caroline Assunção Oliveira, Isadora de Souza Barcelos, Ana Jullie Veiga Fernandes, Bruna Santos Silva, Júlia Spínola Ávila, Telma de Jesus Soares, Liliany Souza de Brito Amaral
    Life Sciences, 2024
  • Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role of IL-11
    Caroline Assunção Oliveira, Érika Azenathe Barros Mercês, Fernanda Santos Portela, Júlia Mafra De Benedictis¹, Laís Mafra De Benedictis, Antônio Victor Brito da Silva, João de Assis Gonçalves Campanati, Fabrício Freire de Melo, Márcio Vasconcelos Oliveira, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares, Liliany Souza de Brito Amaral
    Apoptosis, 2023
  • Role of the Microbiome in Aedes spp. Vector Competence: What Do We Know?
    Qesya Rodrigues Ferreira, Fabian Fellipe Bueno Lemos, Matheus Nascimento Moura, Jéssica Oliveira de Souza Nascimento, Ana Flávia Novaes, Isadora Souza Barcelos, Larissa Alves Fernandes, Liliany Souza de Brito Amaral, Fernanda Khouri Barreto, Fabrício Freire de Melo
    Viruses, 2023
    Aedes aegypti and Aedes albopictus are the vectors of important arboviruses: dengue fever, chikungunya, Zika, and yellow fever. Female mosquitoes acquire arboviruses by feeding on the infected host blood, thus being able to transmit it to their offspring. The intrinsic ability of a vector to infect itself and transmit a pathogen is known as vector competence. Several factors influence the susceptibility of these females to be infected by these arboviruses, such as the activation of the innate immune system through the Toll, immunodeficiency (Imd), JAK-STAT pathways, and the interference of specific antiviral response pathways of RNAi. It is also believed that the presence of non-pathogenic microorganisms in the microbiota of these arthropods could influence this immune response, as it provides a baseline activation of the innate immune system, which may generate resistance against arboviruses. In addition, this microbiome has direct action against arboviruses, mainly due to the ability of Wolbachia spp. to block viral genome replication, added to the competition for resources within the mosquito organism. Despite major advances in the area, studies are still needed to evaluate the microbiota profiles of Aedes spp. and their vector competence, as well as further exploration of the individual roles of microbiome components in activating the innate immune system.
  • COVID-19 and Acute Kidney Injury ― Direct and Indirect Pathophysiological Mechanisms Underlying Lesion Development
    ANTÔNIO V.B. DA SILVA, JOÃO DE A.G. CAMPANATI, ISADORA DE S. BARCELOS, ALBERTO C.L. SANTOS, UILDSON P. DE DEUS, TELMA DE J. SOARES, LILIANY S. DE B. AMARAL
    Anais Da Academia Brasileira De Ciencias, 2022
    COVID-19 is a pandemic disease caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) responsible for millions of deaths worldwide. Although the respiratory system is the main target of COVID-19, the disease can affect other organs, including the kidneys. Acute Kidney Injury (AKI), commonly seen in patients infected with COVID-19, has a multifactorial cause. Several studies associate this injury with the direct involvement of the virus in renal cells and the indirect damage stimulated by the infection. The direct cytopathic effects of SARS-CoV-2 are due to the entry and replication of the virus in renal cells, changing several regulatory pathways, especially the renin-angiotensin-aldosterone system (RAAS), with repercussions on the kallikrein-kinin system (KKS). Furthermore, the virus can deregulate the immune system, leading to an exaggerated response of inflammatory cells, characterizing the state of hypercytokinemia. The such exaggerated inflammatory response is commonly associated with hemodynamic changes, reduced renal perfusion, tissue hypoxia, generation of reactive oxygen species (ROS), endothelial damage, and coagulopathies, which can result in severe damage to the renal parenchyma. Thereby, understanding the molecular mechanisms and pathophysiology of kidney injuries induced by SARS-COV-2 is of fundamental importance to obtaining new therapeutic insights for the prevention and management of AKI.
  • High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity
    Allyne Baía Leite, Hernando Nascimento Lima, Caleb de Oliveira Flores, Caroline Assunção Oliveira, Larissa Esterfanne Cavalcante Cunha, Jonas Luz Neves, Thiago Macêdo Lopes Correia, Fabrício Freire de Melo, Márcio Vasconcelos Oliveira, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares, Liliany Souza de Brito Amaral
    Life Sciences, 2021
  • Influence of exercise training on diabetic kidney disease: A brief physiological approach
    Liliany Souza de Brito Amaral, Cláudia Silva Souza, Hernando Nascimento Lima, Telma de Jesus Soares
    Experimental Biology and Medicine, 2020
    Sedentary lifestyle is associated with increased incidence of diabetes mellitus, whereas exercise training improves metabolic control and therefore may contribute to prevention of various chronic complications. Diabetic kidney disease is the most common microvascular complication of diabetes mellitus, and is associated with increased mortality from cardiovascular disease in diabetic patients. The literature highlights oxidative stress, renal inflammation, and activation of the renin-angiotensin-aldosterone system as the main pathophysiological mechanisms underlying tissue damage, extracellular matrix accumulation, and renal function deficit. Unfortunately, although the benefits of exercise training on cardiovascular diseases are well established, their impact on the pathophysiological mechanisms involved in the development and progression of diabetic kidney disease is not well understood. In addition, standardization of experimental models and physical rehabilitation programs in diabetic kidney disease are scarce. In this article, we present a brief review of the pathogenesis and pathophysiological mechanisms of diabetic kidney disease,and bring to light the latest findings in the literature on the impact of exercise training on diabetic kidney disease progression.Impact statementDiabetic kidney disease (DKD) is associated with increased mortality in diabetic patients and has a negative impact on public health. The identification of potential therapies that help the management of DKD can contribute to the improvement of health and quality of life of patients. Thus, this paper is timely and relevant because, in addition to presenting a concise review of the pathogenesis and major pathophysiological mechanisms of DKD, it addresses the most recent findings on the impact of exercise training on this disease. Thus, since non-pharmacological interventions have gained increasing attention in the fight against chronic diseases, this paper appears as an important tool to increase knowledge and stimulate innovative research on the impact of exercise on kidney disease.
  • Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes
    Cláudia Silva Souza, Bianca Silva de Sousa Oliveira, Geovanildo Nascimento Viana, Thiago Macêdo Lopes Correia, Ana Carolina de Bragança, Daniele Canale, Márcio Vasconcelos Oliveira, Amélia Cristina Mendes de Magalhães, Rildo Aparecido Volpini, Liliany Souza de Brito Amaral, Telma de Jesus Soares
    Experimental Biology and Medicine, 2019
  • Previous exercise training reduces markers of renal oxidative stress and inflammation in streptozotocin-induced diabetic female rats
    Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares
    Journal of Diabetes Research, 2018
  • Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats
    Liliany S de Brito Amaral, Fernanda A Silva, Vicente B Correia, Clara EF Andrade, Bárbara A Dutra, Márcio V Oliveira, Amélia CM de Magalhães, Rildo A Volpini, Antonio C Seguro, Terezila M Coimbra, Telma de J Soares
    Experimental Biology and Medicine, 2016
  • Predicting increased blood pressure using machine learning
    Hudson Fernandes Golino, Liliany Souza de Brito Amaral, Stenio Fernando Pimentel Duarte, Cristiano Mauro Assis Gomes, Telma de Jesus Soares, Luciana Araujo dos Reis, Joselito Santos
    Journal of Obesity, 2014

RECENT SCHOLAR PUBLICATIONS

  • Ureaplasma parvum infection alters the placental redox status and may contribute to spontaneous abortion: a case-control study
    FKA Freire, LFL Malheiro, TML Correia, BA Sampaio, LM Marques, ...
    Placenta , 2026
    2026
  • Anabolic-Androgenic Steroids at Supraphysiological Doses: Cardiovascular Impacts and Pathophysiological Mechanisms
    HS Nascimento, MG Corrêa, OL Lemos, HN Lima, LS de Brito Amaral
    The Journal of Steroid Biochemistry and Molecular Biology, 106938 , 2026
    2026
    Citations: 2
  • High-intensity interval training elicits superior effects than continuous training to improve renal redox status via klotho and Nrf2 signaling in female rats with cisplatin …
    ÉAB Mercês, CA Oliveira, FS Portela, LFL Malheiro, HBL Silva, JS Ávila, ...
    Archives of biochemistry and biophysics 770, 110480 , 2025
    2025
    Citations: 4
  • High-intensity interval training improves hepatic redox status via Nrf2 downstream pathways and reduced CYP2E1 expression in female rats with cisplatin-induced hepatotoxicity
    FS Portela, LFL Malheiro, CA Oliveira, EAB Merces, LM De Benedictis, ...
    Food and Chemical Toxicology 196, 115234 , 2025
    2025
    Citations: 2
  • High-intensity interval training alleviates liver inflammation by regulating the TLR4/NF-κB signaling pathway and M1/M2 macrophage balance in female rats with cisplatin …
    LFL Malheiro, CA Oliveira, FS Portela, ÉAB Mercês, LM de Benedictis, ...
    Biochemical and Biophysical Research Communications 733, 150712 , 2024
    2024
    Citations: 6
  • An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management
    CA Oliveira, ÉAB Mercês, FS Portela, LFL Malheiro, HBL Silva, ...
    Clinical and Experimental Nephrology 28 (8), 711-727 , 2024
    2024
    Citations: 42
  • Renoprotective mechanisms of exercise training against acute and chronic renal diseases–A perspective based on experimental studies
    LFL Malheiro, MM Fernandes, CA Oliveira, I de Souza Barcelos, ...
    Life Sciences 346, 122628 , 2024
    2024
    Citations: 8
  • Role of the Microbiome in Aedes spp. Vector Competence: What Do We Know?
    QR Ferreira, FFB Lemos, MN Moura, JOS Nascimento, AF Novaes, ...
    Viruses 15 (3), 779 , 2023
    2023
    Citations: 29
  • Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role …
    ALSB Oliveira CA, Mercês ÉAB, Portela FS, De Benedictis JM, De Benedictis LM ...
    Apoptosis 1, 1-10 , 2023
    2023
    Citations: 11
  • COVID-19 and acute kidney injury―direct and indirect pathophysiological mechanisms underlying lesion development
    AVBDA Silva, JDAG Campanati, IDS Barcelos, ACL Santos, UPDE Deus, ...
    Anais da Academia Brasileira de Ciências 94 (suppl 3), e20211501 , 2022
    2022
    Citations: 9
  • Ovariectomy exacerbates glycerol-induced acute kidney injury in rats
    LMDC Coimbra-Campos, SI de Souza, LS de Brito Amaral, FDA Silva, ...
    Journal of Health & Biological Sciences 10, 1-8 , 2022
    2022
  • High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity
    AB Leite, HN Lima, C de Oliveira Flores, CA Oliveira, LEC Cunha, ...
    Life Sciences 266, 118880 , 2021
    2021
    Citations: 49
  • Influence of exercise training on diabetic kidney disease: A brief physiological approach
    LSB Amaral, CS Souza, HN Lima, TJ Soares
    Experimental biology and medicine 245 (13), 1142-1154 , 2020
    2020
    Citations: 49
  • Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus
    MOR Silveira, LSB Amaral, SI Souza, HR Ferraz, JA Dias, EC Rocha, ...
    Brazilian Journal of Biological Sciences 6 (13), 331-345 , 2019
    2019
    Citations: 3
  • Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes
    CS Souza, BS de Sousa Oliveira, GN Viana, TML Correia, ...
    Experimental biology and medicine 244 (9), 758-769 , 2019
    2019
    Citations: 34
  • Previous exercise training reduces markers of renal oxidative stress and inflammation in streptozotocin‐induced diabetic female rats
    LSB Amaral, CS Souza, RA Volpini, MHM Shimizu, AC de Bragança, ...
    Journal of diabetes research 2018 (1), 6170352 , 2018
    2018
    Citations: 46
  • Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats
    LSB Amaral, FA Silva, VB Correia, CEF Andrade, BA Dutra, MV Oliveira, ...
    Experimental biology and medicine 241 (4), 437-445 , 2016
    2016
    Citations: 49
  • Renal changes in the early stages of diet-induced obesity in ovariectomized rats
    LS Amaral, JA Silva, TM Trindade, WB Ribas, CL Macedo, TM Coimbra, ...
    Physiol Res 63 (6), 723-732 , 2014
    2014
    Citations: 27
  • Predicting increased blood pressure using machine learning
    HF Golino, LSB Amaral, SFP Duarte, CMA Gomes, TJ Soares, LA Reis, ...
    Journal of obesity 2014 (1), 637635 , 2014
    2014
    Citations: 134

MOST CITED SCHOLAR PUBLICATIONS

  • Predicting increased blood pressure using machine learning
    HF Golino, LSB Amaral, SFP Duarte, CMA Gomes, TJ Soares, LA Reis, ...
    Journal of obesity 2014 (1), 637635 , 2014
    2014
    Citations: 134
  • High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity
    AB Leite, HN Lima, C de Oliveira Flores, CA Oliveira, LEC Cunha, ...
    Life Sciences 266, 118880 , 2021
    2021
    Citations: 49
  • Influence of exercise training on diabetic kidney disease: A brief physiological approach
    LSB Amaral, CS Souza, HN Lima, TJ Soares
    Experimental biology and medicine 245 (13), 1142-1154 , 2020
    2020
    Citations: 49
  • Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats
    LSB Amaral, FA Silva, VB Correia, CEF Andrade, BA Dutra, MV Oliveira, ...
    Experimental biology and medicine 241 (4), 437-445 , 2016
    2016
    Citations: 49
  • Previous exercise training reduces markers of renal oxidative stress and inflammation in streptozotocin‐induced diabetic female rats
    LSB Amaral, CS Souza, RA Volpini, MHM Shimizu, AC de Bragança, ...
    Journal of diabetes research 2018 (1), 6170352 , 2018
    2018
    Citations: 46
  • An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management
    CA Oliveira, ÉAB Mercês, FS Portela, LFL Malheiro, HBL Silva, ...
    Clinical and Experimental Nephrology 28 (8), 711-727 , 2024
    2024
    Citations: 42
  • Preventive effect of exercise training on diabetic kidney disease in ovariectomized rats with type 1 diabetes
    CS Souza, BS de Sousa Oliveira, GN Viana, TML Correia, ...
    Experimental biology and medicine 244 (9), 758-769 , 2019
    2019
    Citations: 34
  • Role of the Microbiome in Aedes spp. Vector Competence: What Do We Know?
    QR Ferreira, FFB Lemos, MN Moura, JOS Nascimento, AF Novaes, ...
    Viruses 15 (3), 779 , 2023
    2023
    Citations: 29
  • Renal changes in the early stages of diet-induced obesity in ovariectomized rats
    LS Amaral, JA Silva, TM Trindade, WB Ribas, CL Macedo, TM Coimbra, ...
    Physiol Res 63 (6), 723-732 , 2014
    2014
    Citations: 27
  • Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity – possible modulatory role …
    ALSB Oliveira CA, Mercês ÉAB, Portela FS, De Benedictis JM, De Benedictis LM ...
    Apoptosis 1, 1-10 , 2023
    2023
    Citations: 11
  • COVID-19 and acute kidney injury―direct and indirect pathophysiological mechanisms underlying lesion development
    AVBDA Silva, JDAG Campanati, IDS Barcelos, ACL Santos, UPDE Deus, ...
    Anais da Academia Brasileira de Ciências 94 (suppl 3), e20211501 , 2022
    2022
    Citations: 9
  • Renoprotective mechanisms of exercise training against acute and chronic renal diseases–A perspective based on experimental studies
    LFL Malheiro, MM Fernandes, CA Oliveira, I de Souza Barcelos, ...
    Life Sciences 346, 122628 , 2024
    2024
    Citations: 8
  • High-intensity interval training alleviates liver inflammation by regulating the TLR4/NF-κB signaling pathway and M1/M2 macrophage balance in female rats with cisplatin …
    LFL Malheiro, CA Oliveira, FS Portela, ÉAB Mercês, LM de Benedictis, ...
    Biochemical and Biophysical Research Communications 733, 150712 , 2024
    2024
    Citations: 6
  • High-intensity interval training elicits superior effects than continuous training to improve renal redox status via klotho and Nrf2 signaling in female rats with cisplatin …
    ÉAB Mercês, CA Oliveira, FS Portela, LFL Malheiro, HBL Silva, JS Ávila, ...
    Archives of biochemistry and biophysics 770, 110480 , 2025
    2025
    Citations: 4
  • Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus
    MOR Silveira, LSB Amaral, SI Souza, HR Ferraz, JA Dias, EC Rocha, ...
    Brazilian Journal of Biological Sciences 6 (13), 331-345 , 2019
    2019
    Citations: 3
  • Anabolic-Androgenic Steroids at Supraphysiological Doses: Cardiovascular Impacts and Pathophysiological Mechanisms
    HS Nascimento, MG Corrêa, OL Lemos, HN Lima, LS de Brito Amaral
    The Journal of Steroid Biochemistry and Molecular Biology, 106938 , 2026
    2026
    Citations: 2
  • High-intensity interval training improves hepatic redox status via Nrf2 downstream pathways and reduced CYP2E1 expression in female rats with cisplatin-induced hepatotoxicity
    FS Portela, LFL Malheiro, CA Oliveira, EAB Merces, LM De Benedictis, ...
    Food and Chemical Toxicology 196, 115234 , 2025
    2025
    Citations: 2
  • Ureaplasma parvum infection alters the placental redox status and may contribute to spontaneous abortion: a case-control study
    FKA Freire, LFL Malheiro, TML Correia, BA Sampaio, LM Marques, ...
    Placenta , 2026
    2026
  • Ovariectomy exacerbates glycerol-induced acute kidney injury in rats
    LMDC Coimbra-Campos, SI de Souza, LS de Brito Amaral, FDA Silva, ...
    Journal of Health & Biological Sciences 10, 1-8 , 2022
    2022