Marcelo Leite dos Santos
@ufs.br
Chemistry
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry
Scopus Publications
- Analysis of molecular changes induced by mineral trioxide aggregate on sPLA2
Murilo B Lopes, Veronica C.G Soares, Fabio H.R Fagundes, Alcides Gonini-Junior, Renan H Kaneshima, et al.
Brazilian Dental Journal, 2019
The aim of this study was to analyze the effects of MTA on the structure and enzymatic activity of sPLA2 in order to provide subsidies for improvement in the formulation of the product. MTA powder was incubated for 60 min in the presence of sPLA2 and was analyzed by chromatography, electrospray mass (ESI-MS) and small-angle X-ray scattering (SAXS). It was find that the elution profile, retention time, and fragmentation of sPLA2 were altered after treatment with MTA. Calcium was the MTA component that most amplified the inflammatory signal. Significant interactions were found between MTA and sPLA2, which could aid in our understanding of the mechanisms of action of MTA during the inflammatory process and it may facilitate the structural modification of MTA, thereby improving its biological safety and consequently the rate of the treatment success. - Crystal structure of a small heat-shock protein from Xylella fastidiosa reveals a distinct high-order structure
Emanuella Maria Barreto Fonseca, Valéria Scorsato, Marcelo Leite dos Santos, Atilio Tomazini Júnior, Susely Ferraz Siqueira Tada, et al.
Acta Crystallographica Section F Structural Biology Communications, 2017
Citrus variegated chlorosis is a disease that attacks economically important citrus plantations and is caused by the plant-pathogenic bacteriumXylella fastidiosa. In this work, the structure of a small heat-shock protein fromX. fastidiosa(XfsHSP17.9) is reported. The high-order structures of small heat-shock proteins from other organisms are arranged in the forms of double-disc, hollow-sphere or spherical assemblies. Unexpectedly, the structure reported here reveals a high-order architecture forming a nearly square cavity. - Oligomerization, membrane association, and in vivo phosphorylation of sugarcane UDP-glucose pyrophosphorylase
Jose Sergio M. Soares, Agustina Gentile, Valeria Scorsato, Aline da C. Lima, Eduardo Kiyota, et al.
Journal of Biological Chemistry, 2014 - Initial crystallographic studies of a small heat-shock protein from Xylella fastidiosa
Susely F. S. Tada, Antonio Marcos Saraiva, Gabriela S. Lorite, Luciana K. Rosselli-Murai, Alexandre César Pelloso, et al.
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012 - Crystallization and preliminary X-ray analysis of stationary phase survival protein e (SurE) from Xylella fastidiosa in two crystal forms
Marcelo Augusto dos Reis, Antonio Marcos Saraiva, Marcelo Leite dos Santos, Anete Pereira de Souza, Ricardo Aparicio
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2012 - A catalytically inactive Lys49 PLA2 isoform from Bothrops jararacussu venom that stimulates insulin secretion in pancreatic beta cells
Fabio H.R. Fagundes, Ricardo Aparicio, Marcelo L. dos Santos, Eduardo B.S. Diz Filho, Simone C.B. Oliveira, et al.
Protein and Peptide Letters, 2011 - Effect of PET on the crystallization of lithium/sodium acetate glasses studied by isothermal and non-isothermal kinetic methods
Silvanio S L da Costa, Marcelo L dos Santos, Marcelo A N Beltrao, Charlene R S Matos, Ana C S Alcantara, et al.
Journal of Physics Conference Series, 2010 - Purification and preliminary crystallographic analysis of a new Lys49-PLA2 from B. jararacussu
Marcelo L. Dos Santos, Fábio H. R. Fagundes, Bruno R. F. Teixeira, Marcos H. Toyama, Ricardo Aparicio
International Journal of Molecular Sciences, 2008
BjVIII is a new myotoxic Lys49-PLA2 isolated from Bothrops jararacussu venom that exhibits atypical effects on human platelet aggregation. To better understand the mode of action of BjVIII, crystallographic studies were initiated. Two crystal forms were obtained, both containing two molecules in the asymmetric unit (ASU). Synchrotron radiation diffraction data were collected to 2.0 °A resolution and 1.9 °A resolution for crystals belonging to the space group P212121 (a = 48:4 A° , b = 65:3 A° , c = 84:3 A° ) and space group P3121 (a = b = 55:7 A° , c = 127:9 A° ), respectively. Refinement is currently in progress and the refined structures are expected to shed light on the unusual platelet aggregation activity observed for BjVIII. - Crystallization and preliminary X-ray diffraction analysis of maize aldose reductase
Eduardo Kiyota, Sylvia Morais de Sousa, Marcelo Leite dos Santos, Aline da Costa Lima, Marcelo Menossi, et al.
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2007
