DR AVIJIT MAZUMDER
@nietpharmacy.co.in
DIRECTOR
NOIDA INSTITUTE OF ENGINEERING AND TECHNOLOGY (PHARMACY INSTITUTE)
EDUCATION
COMPLETED BPHARM, MPHARM, MPHD from Jadavpur University Kolkata
RESEARCH INTERESTS
PHARMACY, PHARMACOLOGY AND MICROBIOLOGY
Scopus Publications
Scopus Publications
Shivani Tyagi, Rakhi Mishra, Avijit Mazumder, Rupa Mazumder, Gurvinder Singh, and Pratibha Pandey
Wiley
AbstractThe research involves the synthesis of a series of new pyridine analogs 5(i‐x) and their evaluation for anti‐epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier‐Haack reaction principle. AutoDock 4.2 was used for their in silico screening against AMPA (‐amino‐3‐hydroxy‐5‐methylisoxazole) receptor (PDB ID:3m3f). For in vivo testing, the maximal electroshock seizure (MES) model was used. The physicochemical, pharmacokinetic, drug‐like, and drug‐score features of all synthesized compounds were assessed using the online Swiss ADME and Protein Plus software. The in silico results showed that all the synthesized compounds 5(i‐x) had 1–3 interactions and affinities ranging from −6.5 to −8.0 kJ/mol with the targeted receptor compared to the binding affinities of the standard drug phenytoin and the original ligand of the target (P99), which were −7.6 and −6.8 kJ/mol, respectively. In vivo study results showed that the compound 5‐Carbamoyl‐2‐formyl‐1‐[2‐(4‐nitrophenyl)‐2‐oxo‐ethyl]‐pyridinium gave 60% protection against epileptic seizures compared to 59% protection afforded by regular phenytoin. All of them met Lipinski's rule of five and had drug‐likeness and drug score values of 0.55 and 0.8, respectively, making them chemically and functionally like phenytoin. According to the findings of the studies, the synthesized derivatives have the potential to be employed as a stepping stone in the development of novel anti‐epileptic drugs.
Shorya Thakur, Ankita, Shubham Dash, Rupali Verma, Charanjit Kaur, Rajesh Kumar, Avijit Mazumder, and Gurvinder Singh
Springer Science and Business Media LLC
Chanchal Sharma and Avijit Mazumder
Bentham Science Publishers Ltd.
Abstract: Alzheimer's disease (AD) is an onset and incurable neurodegenerative disorder that has been linked to various genetic, environmental, and lifestyle factors. Recent research has revealed several potential targets for drug development, such as the prevention of Aβ production and removal, prevention of tau hyperphosphorylation, and keeping neurons alive. Drugs that target numerous ADrelated variables have been developed, and early results are encouraging. This review provides a concise map of the different receptor signaling pathways associated with Alzheimer's Disease, as well as insight into drug design based on these pathways. It discusses the molecular mechanisms of AD pathogenesis, such as oxidative stress, aging, Aβ turnover, thiol groups, and mitochondrial activities, and their role in the disease. It also reviews the potential drug targets, in vivo active agents, and docking studies done in AD and provides prospects for future drug development. This review intends to provide more clarity on the molecular processes that occur in Alzheimer's patient's brains, which can be of use in diagnosing and preventing the condition.
Upendra Kumar, Rajnish Kumar, Avijit Mazumder, Salahuddin, Himanshu Singh, Ranjit Kumar Yadav, and Greesh Kumar
Bentham Science Publishers Ltd.
Abstract: Quinoline and its derivatives have been utilized and marketed as antibacterial, antimalarial, anticancer, hypertension, asthma (COPD), etc. The diverse pharmacological properties of quinolone are related to its chemical structure. Nowadays, it is common practice to combine at least two pharmacophores to create a single molecule with powerful pharmacological effects. This helps to synergize pharmacological qualities, enables interaction with several targets, or lessens the negative effects related to them. Various synthetic approaches which have been used in recent times for the synthesis of quinoline and its derivatives are listed in the manuscript with their merits and demerit. The structure-activity relationship relating various pharmacological actions with molecular structure and interaction with several targets has also been highlighted to provide a good comprehension to the researchers for future studies on quinoline.
Himanshu Singh, Rajnish Kumar, and Avijit Mazumder
Informa UK Limited
Kinase is an enzyme that helps in the phosphorylation of the targeted molecules and can affect their ability to react with other molecules. So, kinase influences metabolic reactions like cell signaling, secretory processes, transport of molecules, etc. The increased activity of certain kinases may cause various types of cancer, i.e. leukemia, glioblastoma, and neuroblastomas. So, the growth of particular cancer cells can be prevented by the inhibition of the kinase responsible for those cancers. Natural products are the key resources for the development of new drugs where approximately 60% of anti-tumor drugs are being developed with the same including specific kinase dwellers. This study comprised molecular interactions of various molecules (obtained from natural sources) as kinase inhibitors for the treatment of cancer. It is expected that by analyzing the skeleton behavior, the process of action, and the body-related activity of these organic products, new cancer-avoiding molecules can be developed.
Sonakshi Tyagi, Salahuddin Salahuddin S, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Shabana Km Shabana, Abhishek Shankar Sharma, Mohamed Jawed Ahsan, and Mohammad Shahar Yar
EManuscript Technologies
Ayushi Singh, Rakhi Mishra, Avijit Mazumder, and Prashant Tiwari
International Allelopathy Foundation
Prashant Tiwari, Rakhi Mishra, Rupa Mazumder, Avijit Mazumder, and Ayushi Singh
Bentham Science Publishers Ltd.
Introduction: The purpose of this study was to extract, isolate, and evaluate in vitro the antioxidant and anticancer properties of rutin from Citrus reticulata and Citrus limon. Background: Bioflavonoids are a class of polyphenolic secondary metabolites that give plants their distinctive organoleptic properties. Rutin, also known as rutoside, is a citrus flavonoid that is found in a variety of plants, including citrus fruits, and has a wide range of pharmacological effects. Objective: This investigation's goal was to extract, isolate, and test the antioxidant and anti-cancer properties of rutin in vitro. Methods: By incorporating the appropriate solvent system, the Soxhlet apparatus was used to extract C. reticulata (R2) and C. limon (R3) from dried peel powder. Column chromatography was used in the isolation process. Various solvent systems on the basis of their polarity were used to isolate rutin, which further was evaluated for anti-oxidant and anti-cancer action by the use of in vitro tests. Results: Successful extraction and isolation of rutin from two sources were achieved. Additionally, their antioxidant and anticancer activity was also evaluated by in vitro methods. Both isolated rutins (R2 and R3) possessed optimal antioxidants in the range of 31.64 to 76.28 g/ml and anticancer activity with IC50 values of 4 to 7 g/ml, when compared to standard doxorubicin with an IC50 value of 3g/ml. In the comparison of rutin isolated from C. reticulata with rutin isolated from C. limon, rutin isolated from C. reticulata was found to be more abundant and more potent in terms of yield and activity. Conclusion: The study's findings are clear; Citrus reticulata species have a higher flavonoid and phenolic content, and the rutin extracted from them is an effective anti-oxidant and anti-cancer agent against lung cancer. The study can be used as a model for future studies on rutin’s role in cancer.
Deepika Pathak and Avijit Mazumder
Springer Science and Business Media LLC
Akshay Kumar, Chandana Majee, Rupa Mazumder, Ruchi Sharma, Avijit Mazumder, Rashmi Mishra, and Pankaj Wadhwa
Informatics Publishing Limited
The second most prevalent cancer in the world and the fifth most common malignant tumour is gastric carcinoma. It is thought that several factors, including genetics, epigenetics, and environmental impacts, contribute to the development of gastric cancer. One of the main pathogenic variables associated with stomach cancer risk has been identified as inflammation. There are currently few methods to treat the gastric carcinoma. Therefore, an alternative plan is urgently needed. Explaining the importance of curcumin derived from Curcuma longa Linn. in stomach cancer is the goal of this review. According to recent research, Curcumin (CUR) has a great effect against stomach mucosal injury brought on by non-steroidal anti-inflammatory medicines, gastric mucosal injury in rats, stress haemorrhage, and Helicobacter pylori infection. In this review article, we have discussed the chemistry of CUR, the role of CUR in immunomodulation, and gastric cancer. We have also highlighted the various signalling pathway of gastric cancer where CUR work. By controlling miRNAs on gastric cancer and other relevant signal pathways, CUR exhibits notable anti-inflammatory and anti-cancer properties. In future there are more research work will be done on CUR.
Ruchi Sharma, Chandana Majee, Rupa Mazumder, Avijit Mazumder, Pankaj Kumar Tyagi, and M. V. N. L. Chaitanya
Informatics Publishing Limited
Throughout the biliary tree, a variety of cells give rise to cholangiocarcinomas, a broad group of malignancies. The fact that these tumours are silent and asymptomatic, especially in their early stages, seriously impairs the effectiveness of available therapeutic options and contributes to their poor prognosis. Over the past few years, increased efforts have been made to identify the aetiology and signalling pathways of these tumours and to create more potent therapies. Since alkaloids are more potent and effective against cholangiocarcinoma cell lines, they have gained importance in the treatment of cholangiocarcinoma. In cell lines with cholangiocarcinoma, they promote apoptosis. and restrict the spread of cells, departure, and development. This review highlights the recent developments in the study of CCA, primarily concentrating on the regulation of the signalling pathway and revealing alkaloids demonstrating strong anti-cholangiocarcinoma efficacy, providing researchers with a rapid approach for the future development of powerful and efficient pharmaceutical compounds.
Shivani Tyagi, Rakhi Mishra, Avijit Mazumder, and Varsha Jindaniya
Bentham Science Publishers Ltd.
Abstract: Heterocyclic compounds and their derivatives epitomize the building blocks of many biological entities, e.g., alkaloids, antibiotics, enzymes, hormones, vitamins, and others that are abundant in nature. The Vilsmeier-Haack reaction has fascinated organic chemists due to its significant use in the synthesis of numerous heterocycles. This analytical evaluation provides a scrutinized overview of the literature on the synthesis of heterocyclic compounds. : A comprehensive review of the literature related to Vilsmeier- Haack reagents and reactions is done from PubMed and other sources like google scholar and Google websites. : This precise analytic evaluation provides a revolutionary update on the Vilsmeier-Haack reaction and its applications in the synthesis of natural and synthetic compounds. : Presently researchers are developing and looking for unconventional reagents that are inexpensive, have high chemical yields, are environmentally benign, recyclable, and robust. The information incorporated in this review paper may inspire more research on the Vilsmeier-Haack reagent and its usage in heterocycle synthesis.
Km Shabana, Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Sonakshi Tyagi, Mohammad Shahar Yar, Mohamed Jawed Ahsan, and Mohammad Sarafroz
Bentham Science Publishers Ltd.
Background: Benzimidazole (Benz-fused bicyclic ring system) is the most versatile class of heterocyclic compounds due to its numerous applications in industrial and synthetic organic chemistry because of its many biological actions. Benzimidazole analogs have been used to discover various medical problems, such as cancer, bacterial infections, fungi infections, etc. Researchers are studying nitrogencontaining hybrid heterocyclic compounds because they provide a broad range of therapeutic potential and have minimal side effects. Objective: The current literature review emphasizes recent developments in the design of new benzimidazole derivatives as possible anticancer agents with their relationship between structure and activity, which will give insight into the future design of more active benzimidazole molecules. Results: The present review consists of synthetic protocols for the synthesis of benzimidazole derivatives along with their pharmacological potentials and structure-activity relationship in correlation with synthetic molecules to provide a depth view of the work done on benzimidazole. Conclusion: It would be significant for further research in developing better drug molecules representing a potent derivative of medicinal agents.
Greesh Kumar, Rajnish Kumar, Avijit Mazumder, Salahuddin, and Upendra Kumar
Bentham Science Publishers Ltd.
Abstract: The 1,2,5-oxadiazole framework has garnered a lot of interest among many nitrogen heterocycles because of its capacity to give off NO under physiological circumstances. Because of this, major efforts by chemical scientists have been made to create novel drug possibilities in medicinal, material, and agriculture science that include the NO-donor 1,2,5-oxadiazole N-oxide subunit coupled to a known drug or a possible pharmacophore by C-C/C-N links or by using a suitable spacer. In the last few years, 1,2,5-oxadiazole and its derivatives have been reported as good pharmacophores as carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc. In the presented manuscript, we reviewed granted patents (last 10 years), different synthetic strategies (last 27 years) of 1,2,5- oxadiazoles and their N-oxide derivatives synthesis such as cycloaddition, dimerization, cyclodehydration, condensation, thermolysis, nitration, oxidation, ring-conversion, etc. These synthetic methods have also been analyzed for their merits and demerits. The manuscript also highlighted various applications of 1,2,5-oxadiazole and its derivatives. We hope that researchers across the scientific streams will benefit from the presented review articles for designing their work related to 1,2,5-oxadiazoles.
Greesh Kumar, Rajnish Kumar, Avijit Mazumder, Salahuddin, and Upendra Kumar
Bentham Science Publishers Ltd.
Abstract: Among the deadliest diseases, cancer is characterized by tumors or an increased number of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the current era concentrated on the development of highly selective anticancer medications due to the substantial toxicities of conventional cytotoxic drugs. Several marketed drug molecules have provided resistance against cancer through interaction with certain targets/growth factors/enzymes, such as Telomerase, Histone Deacetylase (HDAC), Methionine Aminopeptidase (MetAP II), Thymidylate Synthase (TS), Glycogen Synthase Kinase-3 (GSK), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Focal Adhesion Kinase (FAK), STAT3, Thymidine phosphorylase, and Alkaline phosphatase. The molecular structure of these drug molecules contains various heterocyclic moieties that act as pharmacophores. Recently, 1,3,4- oxadiazole (five-membered heterocyclic moiety) and its derivatives attracted researchers as these have been reported with a wide range of pharmacological activities, including anti-cancer. 1,3,4- oxadiazoles have exhibited anti-cancer potential via acting on any of the above targets. The presented study highlights the synthesis of anti-cancer 1,3,4-oxadiazoles, their mechanism of interactions with targets, along with structure-activity relationship concerning anti-cancer potential.
Pushkar Kumar Ray, Salahuddin, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, and Mohamed Shahar Yar
Bentham Science Publishers Ltd.
Background: Pyrazoline is a heterocyclic compound with five members, two nitrogen atoms in a circle, and one endocyclic bond. Pyrazoline is a popular electron-rich nitrogen carrier that combines exciting electronic properties with the potential for dynamic applications. Pyrazine derivatives have been synthesized using a variety of methods, all of which have shown to have a strong biological effect. Objective: The study of the biological activity of pyrazoline derivatives has been a fascinating field of pharmaceutical chemistry. Pyrazolines are used in a wide range of applications. The pyrazoline derivatives described in the literature between 2000 and 2021 were the focus of this study. Pyazolines have been discussed in terms of their introduction, general synthetic method, and anticancer potential in the current review. Conclusion: Pyrazolines are well-known heterocyclic compounds. Pyrazoline is a five-membered ring containing three carbon and two nitrogen atoms nearby. The synthesis of pyrazolines has been described using a variety of methods. Anticancer activity has been discovered in a number of pyrazoline derivatives, which encourages further research. The use of pyrazoline to treat cancer has piqued researchers' interest in learning more about this moiety.
Ayushi Singh, Rakhi Mishra, and Avijit Mazumder
Wiley
AbstractBreast cancer is a common and deadly disease, so there is a constant need for research to find efficient targets and therapeutic approaches. Breast cancer can be classified on a molecular and histological base. Breast cancer can be divided into ER (estrogen receptor)‐positive and ER‐negative, HER2 (human epidermal growth factor receptor2)‐positive and HER2‐negative subtypes based on the presence of specific biomarkers. Targeting hormone receptors, such as the HER2, progesterone receptor (PR), and ER, is very significant and plays a vital role in the onset and progression of breast cancer. Endocrine treatments and HER2‐targeted drugs are examples of targeted therapies now being used against these receptors. Emerging immune‐based medicines with promising outcomes in the treatment of breast cancer include immune checkpoint inhibitors, cancer vaccines, and adoptive T‐cell therapy. It is also explored how immune cells and the tumor microenvironment affect breast cancer development and treatment response. The major biochemical pathways, signaling cascades, and DNA repair mechanisms that are involved in the development and progression of breast cancer, include the PI3K/AKT/mTOR system, the MAPK pathway, and others. These pathways are intended to be inhibited by a variety of targeted drugs, which are then delivered with the goal of restoring normal cellular function. This review aims to shed light on types of breast cancer with the summarization of different therapeutic approaches which can target different pathways for tailored medicines and better patient outcomes.
Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Singh, and Shikha Srivastava
Bentham Science Publishers Ltd.
Background: Multiple myeloma (MM) is a hematological malignancy of plasma cells that produce a monoclonal immunoglobulin protein. Despite significant advances in the treatment of MM, currently available therapies are associated with toxicity and resistance. As a result, there is an increasing demand for novel, effective therapeutics. Inhibition of histone deacetylases (HDACs) is emerging as a potential method for treating cancer. HDAC6 is one of 18 different HDAC isoforms that regulate tubulin lysine 40 and function in the microtubule network. HDAC6 participates in tumorigenesis and metastasis through protein ubiquitination, tubulin, and Hsp90. Several studies have found that inhibiting HDAC6 causes AKT and ERK dephosphorylation, which leads to decreased cell proliferation and promotes cancer cell death via the PI3K/AKT and MAPK/ERK signaling pathways. Objective: The objective of this study is to target HDAC6 and identify potent inhibitors for the treatment of multiple myeloma by employing computer-aided drug design. Materials and Methods: A total of 199,611,439 molecules from five different chemical databases, such as CHEMBL25, ChemSpace, Mcule, MolPort, and ZINC, have been screened against HDAC6 by structure- based virtual screening, followed by filtering for various drug-likeness, ADME, toxicity, consensus molecular docking, and 100 ns MD simulation. Results: Our research work resulted in three molecules that have shown strong binding affinity (CHEMBL2425964 -9.99 kcal/mol, CHEMBL2425966 -9.89 kcal/mol, and CSC067477144 -9.86 kcal/mol) at the active site HDAC6, along with effective ADME properties, low toxicity, and high stability. Inhibiting HDAC6 with these identified molecules will induce AKT and ERK dephosphorylation linked to reduced cell proliferation and promote cancer cell death. Conclusion: CHEMBL2425964, CHEMBL2425966, and CSC067477144 could be effective against multiple myeloma.
Vaibhav Kumar Sharma, Veena Devi Singh, Avijit Mazumder, Vijay Kumar Singh, and Sanjay J. Daharwal
A and V Publications
Aim of study: To isolate bioactive compound from methanolic extract of Carica papaya leaves (MECPL) and investigate their anti-inflammatory potential. Material and Methods: Soxhlet extraction of C. papaya leaves powder was performed by using methanol as a solvent. The isolation of MECPL extract was performed by using column chromatography. All fractions obtained from column chromatography were subjected to HPLC, LCMS, FTIR, 1HNMR studies to identify and confirm isolated bioactive compound. The anti-inflammatory activity of isolated compound was performed by using Carrageenan induce models. Animals (Rats) of either sex were divided into six groups (n=6) at random. Group I-II control and negative control werereceived saline and carrageenan (1% w/v in 0.9% saline) respectively. Group III-VI were treated with 10, 150, 300 mg/kg and 10 mg/kg of isolated compound, MECPL and indomethacin respectively. Result: As a result, the compounds identified in the MECPL extract by HPLC, LCMS, FTIR, 1HNMR was Quercetin. The anti-inflammatory potential of MECPL and quercetin was investigated and Quercetin showed the best anti-inflammatory activity as compared to Indomethacin (standard) and MECPL. Conclusion: The present work used to identify and confirm the phenolic compounds (quercetin) in MECPL. It was suggested that this compound could be responsible to the anti-inflammatory activity, as reported by ethnomedicinal use of this plant. Through the experimental models performed, we can conclude that the results obtained with the MECPL support its potential use for the treatment of inflammatory disorders.
AVIJIT MAZUMDER, NAVEEN KUMAR, and SAUMYA DAS
BSP Books Private Limited
Gastroesophageal reflux disease (GERD) occurs by regurgitation of food in the stomach. Aggressive factors increase GERD whereas defensive factors decrease GERD progression. GERD if mild can be put under control by lifestyle modification and giving non-pharmacological treatment methods to patients however if the disease progresses non-pharmacological methods are ineffective. Drugs reduce GERD progression and also maintain the pH of the stomach to a normal level and prevent abnormal acid exposure to the oesophagus. Antacids and alginate protect oesophagus by reducing acidity and increasing viscosity. Proton pump inhibitors and histamine 2 receptor antagonists reduce acid secretion by inhibiting its secretion. Prokinetic agents increase the motility of the stomach and reduce obesity. Metabotropic glutamate receptors, gamma-aminobutyric acid receptor agonists, and cannabinoid receptors are receptor-specific drugs that act on receptors underlying the gastrointestinal tract and alter the function of receptors which increases reflux disease. Combination of antacid and alginate, domperidone and omeprazole, omeprazole and baclofen, aluminum hydroxide, magnesium, and simethicone are frequently given in GERD to expedite the healing rate and reduce acid secretion. Combinations of suitable medications reduce the adverse effects of a single medication and also make it therapeutically more effective than using monotherapy drugs. The pharmacological method is safe and effective and treats GERD completely.
V Singh Chauhan, Avijit Mazumder, and Shobhini Chandel
Dr. Yashwant Research Labs Pvt. Ltd.
Thevetia peruviana, a member of the Apocynaceae family, is also known as digoxin, fortunate nut, yellow oleander, and other names. After consumption, T. peruviana plants have the potential to be fatal. In South Asian countries, especially in Sri Lanka and India, T. peruviana is frequently used for international self-harm. Around the world’s tropical and subtropical regions, T. peruviana is a common cause of toxicological emergencies. The entire plant is hazardous due to the presence of several cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B. Oleander consumption causes hyperkalemia, vomiting, diarrhea, abdominal pain, and all of the above. In the majority of cases, supportive care and the administration of activated charcoal are used in the clinical therapy of either N. oleander or T. peruviana poisoning. T. peruviana-related information is compiled in this article.
Saumya Das, Avijit Mazumder, and Anchit Dogra
Informatics Publishing Limited
Camel milk has been demonstrated to be effective in treating a broad range of illnesses. Camel’s milk is regarded to have therapeutic properties because of its unique composition. Some people consider camel milk to be a precious commodity. White camel milk is made by combining fat and water. Several clinical studies have shown that camel’s milk is effective in treating a broad variety of diseases, including chronic ones. Most of the medicinal advantages of camel milk are included in this study. Camel Milk ingredients and qualities are similar to those found in mother’s milk, making it superior than cow’s milk. Insulin-like and protective proteins are found in abundance, along with lactose, which is the primary carbohydrate. It has anti-tumor qualities, and the robust immune system components assist combat disorders, including diabetes, autism, and diarrhea. It has been used by Nomads and Bedouins (Arabian tribals) for millennia because of these properties. The main objective of this review article is to demonstrate its various pharmacological roles. Camel’s milk is regarded as a vast medicinal property, as it contains a unique composition of bioactive moieties like lactose, proteins (Lactoferrin, Lactoperoxidase, Insulin, Casein), vitamins (A, B1, B2, C, D, E), minerals (Calcium, phosphorus, magnesium, iron, zinc and copper) carbohydrates etc. Most of the medicinal advantages of camel milk are covered in this paper, like its role in the management of autism, Crohn’s disease, allergic conditions, Hepatitis B and C, as antiviral and antibacterial agent. Hence, this study was planned to collect the updated latest information regarding use of camel’s milk, which will be very beneficial in the field of medicines and managing various ailments for the benefit of mankind.
Industry, Institute, or Organisation Collaboration
NOIDA INSTITUTE OF ENGINEERING AND TECHNOLOGY (PHARMACY INSTITUTE)