Biochemistry, Genetics and Molecular Biology, Developmental Neuroscience, Cell Biology, Cellular and Molecular Neuroscience
4
Scopus Publications
Scopus Publications
Molecular Alterations in Ferroptosis and the Effects of Resveratrol: A Systematic Review Ana Beatriz Dos Santos, Júlio Santos‐Terra, Jaqueline Vieira Carletti, Iohanna Deckmann, Carmem Gottfried Journal of Biochemical and Molecular Toxicology, 2025 Ferroptosis is an iron‐dependent cell death. Different from other types of cell death, ferroptosis is hallmarked by disruptions in iron metabolism, redox imbalance, antioxidant system imbalance, and lipid peroxidation. Therefore, ferroptosis triggers mitochondrial impairment, inflammation, and affects several signaling pathways. As such, modulating ferroptosis holds a promising potential for preventing its deleterious effect. Resveratrol (RSV) is a promising polyphenolic compound that modulates ferroptosis due to its chelating properties. Here, we explore the preventive effects of RSV in the molecular alterations of ferroptosis. This review systematically summarizes insights about the properties of RSV in the hallmarks of ferroptosis in animal models, highlighting its beneficial effects in modulating iron metabolism, redox imbalance, glutathione metabolism, lipid peroxidation, mitochondrial impairment, signaling pathways, and inflammation. Importantly, we emphasize the promising effects of RSV in this context, indicating its relevance in further research.
Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and Female Drosophila melanogaster Karen Kich Gomes, Ana Beatriz dos Santos, Jaciana Sousa dos Anjos, Luana Paganotto Leandro, Maria Takemura Mariano, et al. Oxidative Medicine and Cellular Longevity, 2023 Aging is characterized by a functional decline in the physiological functions and organic systems, causing frailty, illness, and death. Ferroptosis is an iron- (Fe-) dependent regulated cell death, which has been implicated in the pathogenesis of several disorders, such as cardiovascular and neurological diseases. The present study investigated behavioral and oxidative stress parameters over the aging of Drosophila melanogaster that, together with augmented Fe levels, indicate the occurrence of ferroptosis. Our work demonstrated that older flies (30-day-old) of both sexes presented impaired locomotion and balance when compared with younger flies (5-day-old). Older flies also produced higher reactive oxygen species (ROS) levels, decreased glutathione levels (GSH), and increased lipid peroxidation. In parallel, Fe levels were augmented in the fly’s hemolymph. The GSH depletion with diethyl maleate potentiated the behavioral damage associated with age. Our data demonstrated biochemical effects that characterize the occurrence of ferroptosis over the age of D. melanogaster and reports the involvement of GSH in the age-associated damages, which could be in part attributed to the augmented levels of Fe.
