T B Sridharan

@vit.ac.in

Professor, Department of Biotechnology, School of Biosciences and Technology
Vellore Institute of Technology (VIT)

T B Sridharan


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https://researchid.co/tbsridharan

EDUCATION

M.Sc., Ph. D., (DRDO)., PDF (Rockefeller Foundation) PDF (EGIDE- France)., FRES. (UK), FRSB (UK)., FRSC (UK)., FLS. (London), FICEZS., (India). FSED (India)

RESEARCH INTERESTS

Zoology, Entomology, Acarology, Neurobiology, Scanning and Transmission Electron Microscopy,
Gene Cloning, Molecular Entomology, Plant Molecular Biology, plant transformation, Plant tissue Cultue, Over Expression of Recombinant Proteins,
Human Male Infertility, Biology of infertile human Semen,
55

Scopus Publications

1952

Scholar Citations

29

Scholar h-index

42

Scholar i10-index

Scopus Publications

  • Impact of air pollution and heavy metal exposure on sperm quality: A clinical prospective research study
    Abilash D, Sridharan T B
    Toxicology Reports, 2024
    Exposure to air pollution poses significant risks to human health, including detrimental effects on the reproductive system, affecting both men and women. Our prospective clinical study aimed to assess the impact of prolonged air pollution exposure on sperm quality in male patients attending a fertility clinic. The current study was conducted at Sri Narayani Hospital and Research Centre in Vellore, Tamil Nadu, India, and the study examined sperm samples obtained from individuals with extended exposure to air pollution. Microscopic analysis, including scanning electron microscopy (SEM), was conducted to evaluate sperm morphology. At the same time, atomic absorption spectroscopy (AAS) determined the presence of heavy metals, including Zinc (Zn), Magnesium (Mg), Lead (Pb) and Cadmium (Cd), known to affect sperm production. Our findings revealed that long-term exposure to air pollution adversely affects sperm quality, manifesting in alterations during the spermatogenesis cycle, morphological abnormalities observed through SEM, and impaired sperm motility. Additionally, epidemiological evidence suggests that elevated levels of cadmium and lead in the environment induce oxidative stress, leading to sperm DNA damage and reduced sperm concentrations. These results underscore the urgent need for environmental interventions to mitigate air pollution and protect reproductive health.
  • Cinnamon-mediated nano emulsion and its cryogenic activity on ROS-affected human sperm—A short study
    Parameswari Ranganathan, TB Sridharan, R. Babujanarthanam, P. Madhan Kumar, R. Ganesamoorthy, K. Thirugnanasambandham
    Toxicology Reports, 2024
    Oil-mediated nano emulsion, a more advanced technology than other commercial extenders, will protect spermatozoa for extended periods against ROS and cryo injuries. The study is designed to elucidate the most suitable extender to preserve infertile subjects' sperm cells against ROS damage. This is a significant step forward for the andrology society, as it introduces the use of a nano emulsion extender (natural oil extract) for the first time, particularly for those who are undergoing urology-related defects. The study involved forty-four (44) infertile subjects with smoking habits and forty-two (42) fertile subjects without smoking habits, as per CASA guidelines. Semen preservatives (glycerol and egg yolk citrate), along with our naturally derived nano emulsion components (CN, EN, and EL), were prepared and used to preserve the semen sample for 24 hours. Standard semen parameters (morphology, viability, and integrity), ROS, and sperm acrosome state by staining were measured before and after cryopreservation. The results indicated that the morphology and motility of sperm features were better maintained in the CN-oil-mediated nano emulsion than in other emulsions, and ROS-induced DNA damage was reduced. Graphical Abstract • Cryopreservatives generally used to protect sperm cells during the person who undergone surgery or donated sperm at sperm bank for future purposes. • Nano emulsion is a new trend in sperm cryopresrvation. Nanoemulsion from natural sources than commercial will be less/zero side effects. • Less ROS or sustained stability of sperm cells were observed under nanoemulsion than other meidum. Easy preparation than Nano particles & cost.
  • The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study
    Kamini Rao, TB Sridharan, Parameswari Ranganathan
    International Journal of Infertility and Fetal Medicine, 2023
  • Identification and Structure Prediction of Human Septin-4 as a Biomarker for Diagnosis of Asthenozoospermic Infertile Patients—Critical Finding Toward Personalized Medicine
    A. S. Vickram, K. Anbarasu, Palanivelu Jeyanthi, G. Gulothungan, R. Nanmaran, S. Thanigaivel, T. B. Sridharan, Karunakaran Rohini
    Frontiers in Medicine, 2021
    Semen parameters are been found as a key factor to evaluate the count and morphology in the given semen sample. The deep knowledge of male infertility will unravel with semen parameters correlated with molecular and biochemical parameters. The current research study is to identify the motility associated protein and its structure through the in-silico approach. Semen samples were collected and initial analysis including semen parameters was analyzed by using the World Health Organization protocol. Semen biochemical parameters, namely, seminal plasma protein concentration, fructose content, and glucosidase content were calculated and evaluated for correlation. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) were carried out for identification of Septin-4 presence in the semen sample. Mascot search was done for protein conformation and in-silico characterization of Septin-4 by structural modeling in Iterative Threading Assembly Refinement (I-TASSER). Twenty-five nanoseconds molecular dynamics (MD) simulations results showed the stable nature of Septin-4 in the dynamic system. Overall, our results showed the presence of motility-associated protein in normospermia and control samples and not in the case of asthenospermia and oligoasthenospermia. Molecular techniques characterized the presence of Septin-4 and as a novel biomarker for infertility diagnosis.
  • Nanosilver reinforced Parmelia sulcata extract efficiently induces apoptosis and inhibits proliferative signalling in MCF-7 cells
    Arumugam Dhanesh Gandhi, Prasanna A. Miraclin, Doraiah Abilash, Sivaji Sathiyaraj, Rajendran Velmurugan, Yang Zhang, Khantong Soontarapa, Priyankar Sen, T.B. Sridharan
    Environmental Research, 2021
    The Lichen, Parmelia sulcata synthesizes various secondary metabolites, in which phenolic based compounds received much attention due to their importance in biomedical application. Especially the phenolic compound was effective against the cancer treatment. An effective administration of such plant natural product can represent a significant conventional management of cancer in terms of chemoprevention. The nanomedicines are group of agents that selectively interfere the cancer cells which leads to reduction of side effect thereby reducing the doses. Silver nanoparticles is a promising antitumor agent, however, the conventional production of silver nanoparticles have many drawbacks which led to increase in need of eco-friendly biological production methods. In this study, we made an attempt to synthesise a nano silver (Ps-AgNPs) from phenolic extract of lichen Parmelia sulcata extract. The Ps-AgNps was applied for anticancer activity using MCF-7 cells and the effect was characterised by western blotting method. The FTIR, XRD, UV and TEM results confirms the presence of silver nanoparticles in phenolic extract of lichen Parmelia sulcata. The cytotoxicity assay shows that the Ps-AgNPs is toxic against cancer cells (MCF-7) but not to normal cells (NIH3T3), which confirm the selective induction of cell death (apoptosis) against cancer cells. The western blot analysis also clearly indicates the down regulation of inflammatory genes (TNF-alpha and IL-6) and cell cycle genes (PCNA and Cyclin-D1) thus promoting intrinsic apoptotic pathway. The results suggest that Ps-AgNPs can effectively kill cancer cells and can be used as an alternative therapeutic agent for cancer treatment.
  • Cigarette smoking and its toxicological overview on human male fertility—a prospective review
    R. Parameswari, T. B. Sridharan
    Toxin Reviews, 2021
    One in seven couples worldwide is affected with the reproductive disorder called infertility and 40%–50% of cases are identified as male factor contributed infertility. Our aim of this review is to elucidate the smoking impact on semen parameters, reactive oxidative species (ROS) state, cigarette toxicity marker, and in detail how it is affecting semenogelin/chromatin structure by cadmium as one of the cigarette toxicants. Smoking stimulates the ROS activity which induces sperm DNA fragmentation or damage among smokers. Also it releases cadmium that is identified as reproductive metal toxicant in humans in detail. Cadmium has possible atomic to change sperm chromatin via zinc and semenogelin.
  • Oxidation driven surface hydrophobicity in human seminal plasma results in protein structural changes
    Archana Kumar, A.S. Vickram, T.B. Sridharan
    Journal of Molecular Liquids, 2020
    Oxidative stress induced changes in conformational properties of proteins are potential causes of functional impairment in protein system. This phenomenon becomes an important study area when the affected proteins present a role in disease aetiology. The current study was aimed at studying seminal plasma protein conformation changes under higher Reactive oxygen species levels. A total of 100 semen samples (control: n = 50 and infertile n = 50) were used after routine semen parameter analysis. Samples were analysed for their total protein content, ROS levels, total antioxidant capacity and polyacrylamide gel electrophoresis was performed under native conditions. A protein band of molecular weight less than 14 KDa was seen differentially in infertile sample presented with higher ROS levels(>72.6 μg formazan/107 sperm cells). MALDI analysis identified the protein to be Tumor Necrosis Factor alpha super family 18 (TNFα-18) ligand. Further analysis of biophysical properties of the protein showed a significant increase in surface hydrophobicity. Binding of seminal plasma TNFα-18 with ANS dye resulted in an increased fluorescence and broadening of emission curves in infertile samples. Changes in structural properties of TNFα-18ligand prevented it from forming stable oligomeric structures which are essential for effective functioning of the protein.
  • Oxidative Stress-induced Changes in Fertility Status of Cryopreserved Sperm: a Diagnosis Based on Sperm Chromatin Dispersion Assay
    Cryo Letters, 2020
  • Superparamagnetic hematite nanoparticle: Cytogenetic impact on onion roots and seed germination response of major crop plants
    Kalyani Rath, Parameswari Ranganathan, Rashmi Kanugodu Vasappa, Sridharan Thalaivarisai Balasundaram
    Iet Nanobiotechnology, 2020
    Augmented escape of nanostructures to the ecosystem has necessitated the comprehensive study of their impact, especially on plants. In the current study, hematite nanoparticles were prepared by employing garlic extract and checked for their cytogenetic effect on onion roots and germination characteristics of five agricultural crops (Vigna radiata, Triticum aestivum, Trigonella foenum-graecum, Cicer arietinum and Vicia faba) in the concentration range of 20-100 mg/L. Onion roots exhibited an increased mitotic index till 60 mg/L dosage, beyond which trend decreased marginally. Percentage of aberrant chromosomes reported for 100 mg/L exposure was very low (3.358 ± 0.13%) and included common defects such as clumped/sticky metaphase, ring chromosomes, laggards, spindle abnormality, chromosome bridges etc. Moreover, comet assay, DNA laddering experiment and electron micrograph study confirmed negligible damage to onion roots. Seed germination study indicated a positive response in different agronomic traits (germination index, root length, fold change in weight and vigour index) up to 60 mg/L, beyond which either negative or neutral effect was observed. However, none of the samples showed 50% inhibition in germination index; highest being 33.33% inhibition for V. faba, compared to the control. In brief, biogenic hematite nanoparticles caused insignificant phytotoxicity and were likely assimilated as iron source at lower dosage.
  • Human prostasomes an extracellular vesicle – Biomarkers for male infertility and prostrate cancer: The journey from identification to current knowledge
    A.S. Vickram, Hari Abdul Samad, Shyma K. Latheef, Sandip Chakraborty, Kuldeep Dhama, T.B. Sridharan, Thanigaivel Sundaram, G. Gulothungan
    International Journal of Biological Macromolecules, 2020
    Extracellular vesicles (EVs) are gaining attention among the cell biologists and researchers over the last two decades. Prostasomes are considered to be (Evs) secreted by prostate epithelial cells into the semen during emission or ejaculation. Prostasomes contain various proteins required for immune regulation namely, amino and dipeptidyl peptidase; endopeptidase (neutral); decay accelerating factor; angiotensin-converting enzyme. Sperm cells need a few prerequisites in order to fertilize the egg. The role of prostasomes in enhancing the male fertility was reviewed extensively throughout the manuscript. Also, prostasomes have an immunosuppressive, immunomodulatory, antibacterial role in the female reproductive tract, and in some cases they can be used as immunocontraceptive agent to regulate the fertility status. This review will give insights to many active researchers in the field of prostasomal research and male infertility/fertility research. This review will open many unanswered mechanisms of prostasomes with respect to structure-function analysis, fatty acids patterns in diagnosis as well as prognosis of male infertility/fertility. More scientific reports are in need to support the mechanism of prostasomes and its role in immunomodulation. The development of prostasomes as a biomarker for the prostate cancer is still miserable with a lot of controversial results by various researchers.
  • Reduction of polyphenolic exudation and enhancement of hardening efficiency in pomegranate tissue culture plants
    Indian Journal of Biotechnology, 2020
  • Biosynthesis and statistical optimization of polyhydroxyalkanoate (PHA) produced by Bacillus cereus VIT-SSR1 and fabrication of biopolymer films for sustained drug release
    Soruba Evangeline, T.B. Sridharan
    International Journal of Biological Macromolecules, 2019
  • Green synthesis of superparamagnetic iron oxide nanoparticles using Hibiscus rosa-sinensis and Allium sativum extract: A comparative analysis
    Research Journal of Chemistry and Environment, 2019
  • Deterioration of semen quality and sperm-DNA integrity as influenced by cigarette smoking in fertile and infertile human male smokers—A prospective study
    Parameswari Ranganathan, Kamini Aravind Rao, Sridharan Thalaivarasai Balasundaram
    Journal of Cellular Biochemistry, 2019
  • Gold nanoparticles embedded itaconic acid based hydrogels
    M. Sakthivel, D. S. Franklin, S. Sudarsan, G. Chitra, T. B. Sridharan, S. Guhanathan
    SN Applied Sciences, 2019
  • Improvements in morphology and membrane stability obtained from TPP-TAB, a cryopreservation medium treated infertile smoker sperm cells – An in vitro study
    Ranganathan Parameswari, T.B. Sridharan
    Toxicology Reports, 2019
  • Role of seminal plasma proteins in effective zygote formation- a success road to pregnancy
    Archana Kumar, T.B. Sridharn, Kamini A. Rao
    Protein and Peptide Letters, 2019
  • Ecofriendly pH-Tunable Hydrogels for Removal of Perilous Thiazine Dye
    S. Sudarsan, D. S. Franklin, M. Sakthivel, G. Chitra, T. B. Sridharan, S. Guhanathan
    Journal of Polymers and the Environment, 2018
  • Screening and optimization of polyhydroxyalkanoate (PHA) produced by Bacillus drentensis VIT-SSR3 isolated from industrial effluent contaminated soil
    Research Journal of Biotechnology, 2018
  • Cadmium effects on sperm morphology and semenogelin with relates to increased ROS in infertile smokers: An in vitro and in silico approach
    Parameswari Ranganathan, Kamini A. Rao, Jesu Jaya Sudan, Sridharan Balasundaram
    Reproductive Biology, 2018
  • Simple isolation and characterization of seminal plasma extracellular vesicle and its total RNA in an academic lab
    Nalini Eswaran, Vickram Agaram Sundaram, Kamini Arvind Rao, Sridharan Thalaivarisai Balasundaram
    3 Biotech, 2018
  • Tea poly phenol-zinc oxide nano particle effects on infertile smoker’s spermatozoa-a short report
    Sridharan Balasundaram, Parameswari Ranganathan, Kamini A Rao
    Research Journal of Pharmacy and Technology, 2018
  • A survey of biochemical parameters in fertile smokers - A clinical study
    TB Sridharan, V S Viswapriya, Moumita Basak, R Parameswari, Kamini A Rao
    Research Journal of Pharmacy and Technology, 2018
  • Identification and in silico characterization of semenogelin II protein in semen-a marker for diagnosis of male infertility
    A.S. Vickram, Krishnan Anbarasu, Kamini Arvind Rao, Sivaraman Jayanthi, Tb. B. Sridharan
    Current Proteomics, 2018
  • Investigation on pH/salt-responsive multifunctional itaconic acid based polymeric biocompatible, antimicrobial and biodegradable hydrogels
    M. Sakthivel, D.S. Franklin, S. Sudarsan, G. Chitra, T.B. Sridharan, S. Guhanathan
    Reactive and Functional Polymers, 2018
  • Optimization of human semen extender components for cryopreservation using statistical tools
    Cryo Letters, 2017
  • Human sperm DNA damage inhibition and antioxidant activity of T. arjuna bark: an in vitro study
    Parameswari R, Kamini A. Rao, K. Mano, M. Aruna, AS Vickram, M. Rameshpathy, TB Sridharan
    3 Biotech, 2017
  • Tea Polyphenol-T. Arjuna bark as sperm antioxidant extender in infertile smokers
    Cryo Letters, 2017
  • Screening, production, optimization and characterization of β-glucosidase using microbes from shellfish waste
    Samhita Mahapatra, A. S. Vickram, T. B. Sridharan, R. Parameswari, M. Ramesh Pathy
    3 Biotech, 2016
  • Oxidant-Antioxidant imbalance induced by influence of smoking in male fertile and infertile humans
    Research Journal of Chemistry and Environment, 2016
  • Formulation of herbal emulsion based anti-inflammatory cream for skin diseases
    International Journal of Pharmaceutical Sciences Review and Research, 2016
  • Validation of artificial neural network models for predicting biochemical markers associated with male infertility
    A. S. Vickram, A. Rao Kamini, Raja Das, M. Ramesh Pathy, R. Parameswari, K. Archana, T. B. Sridharan
    Systems Biology in Reproductive Medicine, 2016
  • Evolving trends in cryopreservation and parameters influencing semen extender preparation - a prospective review
    Cryo Letters, 2016
  • Correlation studies on the role of phospholipids and cholesterol with morphologically normal sperm cells for diagnosis of human male infertility
    Research Journal of Biotechnology, 2016
  • Analysis of seminal plasma proteins of south indian jersey and hybrid bulls and their correlation with semen quality
    A.S. Vickram, V. Devi Rajeswari, M. Ramesh Pathy, T.B. Sridharan
    Asian Journal of Animal Sciences, 2016
  • Effect of semen extender on protein concentration in each fraction of cryopreserved human semen
    Cryo Letters, 2015
  • Identification and analysis of the salt tolerant property of AHL lactonase (AiiATSAWB) of Bacillus species
    Nalini Easwaran, Sivashanmugam Karthikeyan, Balasundaram Sridharan, Kodiveri Muthukaliannan Gothandam
    Journal of Basic Microbiology, 2015
  • Assessment of DNA binding mode, chemical nuclease activity and docking studies of novel vanadyl complexes
    Journal of the Indian Chemical Society, 2015
  • Effects of various semen extenders on semen parameters for the purpose of human male fertility preservation
    Cryo Letters, 2015
  • Antioxidant, antibacterial and anti-inflammatory activity of Acalypha indica and Terminalia chebula: An in-Vitro analysis
    Research Journal of Pharmaceutical Biological and Chemical Sciences, 2015
  • Optimization and validation of β-lactamase production by Bacillus cereus VITMUT using response surface method and artificial neural network
    Journal of Pure and Applied Microbiology, 2014
  • Correlation studies on human seminal plasma proteins and their relation with semen freezablity
    A.S. Vickram, V. Devi Rajeswari, M. Srinivas, G. Jayaraman, R.A. Kamini, M. Ramesh Pathy, S. Ventat Kumar, T.B. Sridharan
    Asian Journal of Biochemistry, 2014
  • Antioxidant, phytochemical screening and antimicrobial activity of Couroupita Guianensis flower extract
    Der Pharmacia Lettre, 2014
  • Formulation of nano-encapsulated poly-herbal ointment for antiinflammation
    Der Pharmacia Lettre, 2013
  • Influence of trace elements and their correlation with semen quality in fertile and infertile subjects
    Vickram SUNDARAM, Muthugadhalli SRINIVAS, Jayaraman GURUNATHAN, Kamini RAO, Ramesh Pathy MANIYAN, Sridharan BALASUNDARAM
    Turkish Journal of Medical Sciences, 2013
  • Prediction of Zn concentration in human seminal plasma of Normospermia samples by Artificial Neural Networks (ANN)
    Vickram A. S., Raja Das, Srinivas M. S., Kamini A. Rao, Jayaraman G., Sridharan T. B.
    Journal of Assisted Reproduction and Genetics, 2013
  • Effect of various biomolecules for normal functioning of human sperm for fertilization: A review
    International Journal of Pharmacy and Pharmaceutical Sciences, 2012
  • A comparative study of distribution of protein and cholesterol in various fractions of human semen from infertile and fertile subjects
    MS Srinivas, Vickram Sundaram, M Ramesh Pathy, TB Sridharan
    International Journal of Infertility and Fetal Medicine, 2012
  • Synthesis and DNA binding study of Zinc (II) co-ordination complexes
    Poonam R. Inamdar, Jyotsna Hazarika, T.B. Sridharan, A. Sheela
    Advanced Materials Research, 2012
  • Emergence of a multidrug resistant Halomonas hydrothermalis strain VITP09 producing a class a β-lactamase, isolated from Kumta coast
    International Journal of Pharmacy and Pharmaceutical Sciences, 2012
  • Purification and characterization of extracellular protease from halotolerant bacterium virgibacillus dokdonensis VITP14
    V. Devi Rajeswari, G. Jayaraman, T.B. Sridharan
    Asian Journal of Biochemistry, 2012
  • Production and characterization of extracellular protease from halotolerant bacterium virgibacillus dokdonesis Vitp14
    Research Journal of Biotechnology, 2012
  • Effect of nickel stress on escherichia coli and saccharomyces cerevisiae
    Journal of Industrial Pollution Control, 2010
  • Effect of chromium on microbial growth
    Asian Journal of Microbiology Biotechnology and Environmental Sciences, 2008
  • Sensilla on the palps and legs of the adult soft tick Argas persicus Oken (Ixodoidea: Argasidae) and their projections to the central nervous system
    T.B Sridharan, Shri Prakash, R.S Chauhan, K.M Rao, Kusum Singh, R.Naresh Singh
    International Journal of Insect Morphology and Embryology, 1998

RECENT SCHOLAR PUBLICATIONS

  • Proteomic and functional characterization of seminal and epididymal plasma proteins associated with male fertility in cattle: A comprehensive review
    R Parameswari, K Kasthuri, PM Kumar, R Ganesamoorthy, ...
    Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 101840 , 2026
    2026
  • The Effects of Cigarette Smoking and Chronic Alcohol Consumption on Seminal Quality in Young Adults: A Cross-Sectional Study
    D Gupta, D Abilash, AD Gandhi, TB Sridharan
    Indian Journal of Clinical Biochemistry, 1-15 , 2026
    2026
  • Environmental determinants of male infertility: emerging threats and technological interventions
    P Jagadesh, TB Sridharan
    Frontiers in Medicine 13, 1770866 , 2026
    2026
    Citations: 1
  • Identification of Heavy Metals (Cd and Pb) and Essential Amino Acids in Semen and their Impact on Male Reproductive Health
    D Abilash, TB Sridharan
    Indian Journal of Clinical Biochemistry, 1-10 , 2025
    2025
  • The Ameliorative and Cryoprotective Activity of Senna auriculata. L Flower Extract on the Semen of Men Exposed to Air Pollution: A Prospective Study
    A Doraiah, ST Balasundharam
    International Journal of Infertility & Fetal Medicine 16 (3), 148-155 , 2025
    2025
    Citations: 2
  • A Study of the durability of sperm cell motility and deoxyribo-nucleic acid damage during cryopreservation
    D Abilash, TB Sridharan
    African Journal of Reproductive Health 29 (10), 30-39 , 2025
    2025
  • A Study on the Role of Oxidative Stress on the Sperm Quality of Individuals Occupationally Exposed to Air Pollution
    D Abilash, R Parameswari, P Madhan Kumar, TB Sridharan
    Indian Journal of Clinical Biochemistry, 1-11 , 2025
    2025
    Citations: 1
  • PERSPECTIVE: Additives to increase the quality of sperm extenders during cryopreservation: a meta-analysis review
    R Parameswari, TB Sridharan, PM Kumar, R Babujanarthanam, ...
    Cryoletters 46 (6), 355-364 , 2025
    2025
  • Heavy metal exposure and its consequences on sperm quality: a cross-sectional perspective study
    TB Sridharan, D Abilash
    Indian Journal of Clinical Biochemistry, 1-13 , 2025
    2025
    Citations: 4
  • A Simple and Rapid Biochemical Method for Measuring ROS in Infertile Semen Sample-A Technical Report
    P Ranganathan, TB Sridharan, KA Rao, R Babujanarthanam, ...
    Journal of Biological and Molecular Sciences, 40-47 , 2025
    2025
  • Cinnamon-mediated nano emulsion and its cryogenic activity on ROS-affected human sperm—A short study
    P Ranganathan, TB Sridharan, R Babujanarthanam, PM Kumar, ...
    Toxicology Reports 13, 101714 , 2024
    2024
    Citations: 4
  • Impact of air pollution and heavy metal exposure on sperm quality: A clinical prospective research study
    D Abilash, TB Sridharan
    Toxicology Reports 13, 101708 , 2024
    2024
    Citations: 23
  • The Effects of Cigarette Smoke-induced Biophysical ROS on Spermatozoa Heads and Telomere Shortening in Infertile Smokers: A Prospective Study
    TB Sridharan, K Rao, P Ranganathan
    International Journal of Infertility & Fetal Medicine 14 (3), 109-116 , 2023
    2023
  • Reduction of hexavalent chromium using sulphonated polyether ether ketone as proton exchange membrane in microbial fuel cells
    VS Gnanarathinam, A Balakrishnan, G Rajendran, A Arivarasu, ...
    Environmental Progress & Sustainable Energy 42 (5), e14158 , 2023
    2023
    Citations: 3
  • Cinnamon mediated-zinc oxide nanoparticles and its cryogenic effect on SARS-CoV-2 recovered HTPI patients–An in vitro cum pilot study
    R Parameswari, R Babujanarthanam, TB Sridharan, T Yogesh, ...
    Materials Today: Proceedings , 2023
    2023
    Citations: 5
  • Identification and Structure Prediction of Human Septin-4 as a Biomarker for Diagnosis of Asthenozoospermic Infertile Patients—Critical Finding Toward Personalized Medicine
    AS Vickram, K Anbarasu, P Jeyanthi, G Gulothungan, R Nanmaran, ...
    Frontiers in medicine 8, 723019 , 2021
    2021
    Citations: 36
  • Nanosilver reinforced Parmelia sulcata extract efficiently induces apoptosis and inhibits proliferative signalling in MCF-7 cells
    AD Gandhi, PA Miraclin, D Abilash, S Sathiyaraj, R Velmurugan, Y Zhang, ...
    Environmental research 199, 111375 , 2021
    2021
    Citations: 23
  • Reduction of polyphenolic exudation and enhancement of hardening efficiency in pomegranate tissue culture plants.
    S TB
    Indian Journal of Biotechnology 19 (2) , 2020
    2020
  • Superparamagnetic hematite nanoparticle: Cytogenetic impact on onion roots and seed germination response of major crop plants
    K Rath, P Ranganathan, RK Vasappa, ST Balasundaram
    IET nanobiotechnology 14 (2), 133-141 , 2020
    2020
    Citations: 10
  • Human prostasomes an extracellular vesicle–Biomarkers for male infertility and prostrate cancer: The journey from identification to current knowledge
    AS Vickram, HA Samad, SK Latheef, S Chakraborty, K Dhama, ...
    International journal of biological macromolecules 146, 946-958 , 2020
    2020
    Citations: 119

MOST CITED SCHOLAR PUBLICATIONS

  • Human prostasomes an extracellular vesicle–Biomarkers for male infertility and prostrate cancer: The journey from identification to current knowledge
    AS Vickram, HA Samad, SK Latheef, S Chakraborty, K Dhama, ...
    International journal of biological macromolecules 146, 946-958 , 2020
    2020
    Citations: 119
  • Validation of artificial neural network models for predicting biochemical markers associated with male infertility
    AS Vickram, AR Kamini, R Das, MR Pathy, R Parameswari, K Archana, ...
    Systems biology in reproductive medicine 62 (4), 258-265 , 2016
    2016
    Citations: 101
  • Prediction of Zn concentration in human seminal plasma of Normospermia samples by Artificial Neural Networks (ANN)
    V AS, R Das, S MS, KA Rao, J G, S TB
    Journal of assisted reproduction and genetics 30 (4), 453-459 , 2013
    2013
    Citations: 100
  • Influence of trace elements and their correlation with semen quality in fertile and infertile subjects
    V Sundaram, M Srinivas, J Gurunathan, K Rao, RP Maniyan, ...
    Turkish Journal of Medical Sciences 43 (6), 1000-1007 , 2013
    2013
    Citations: 92
  • Production and characterization of extracellular protease from halotolerant bacterium Virgibacillus dokdonesis Vitp14
    V Devi Rajeswari, G Jayaraman, M Rameshpathy, TB Sridharan
    Research Journal of Biotechnology 7 (2) , 2012
    2012
    Citations: 91
  • Screening, production, optimization and characterization of β-glucosidase using microbes from shellfish waste
    S Mahapatra, AS Vickram, TB Sridharan, R Parameswari, MR Pathy
    3 Biotech 6 (2), 213 , 2016
    2016
    Citations: 82
  • Biosynthesis and statistical optimization of polyhydroxyalkanoate (PHA) produced by Bacillus cereus VIT-SSR1 and fabrication of biopolymer films for sustained drug release
    S Evangeline, TB Sridharan
    International journal of biological macromolecules 135, 945-958 , 2019
    2019
    Citations: 81
  • Deterioration of semen quality and sperm‐DNA integrity as influenced by cigarette smoking in fertile and infertile human male smokers—A prospective study
    P Ranganathan, KA Rao, S Thalaivarasai Balasundaram
    Journal of cellular biochemistry 120 (7), 11784-11793 , 2019
    2019
    Citations: 63
  • Tea polyphenol-T. arjuna bark as sperm antioxidant extender in infertile smokers
    R Parameswari, KA Rao, P Manigandan, AS Vickram, K Archana, ...
    Cryoletters 38 (2), 95-99 , 2017
    2017
    Citations: 63
  • Effects of various semen extenders on semen parameters for the purpose of human male fertility preservation
    AS Vickram, KA Rao, K Archana, G Jayaraman, V Kumar S, TB Sridharan
    Cryoletters 36 (3), 182-186 , 2015
    2015
    Citations: 63
  • Antioxidant, antibacterial and anti-inflammatory activity of Acalypha indica and Terminalia chebula : an in-vitro analysis.
    E Soruba, VS Vickram Sundaram, RP Manian, ...
    2015
    Citations: 60
  • Investigation on pH/salt-responsive multifunctional itaconic acid based polymeric biocompatible, antimicrobial and biodegradable hydrogels
    M Sakthivel, DS Franklin, S Sudarsan, G Chitra, TB Sridharan, ...
    Reactive and Functional Polymers 122, 9-21 , 2018
    2018
    Citations: 59
  • Simple isolation and characterization of seminal plasma extracellular vesicle and its total RNA in an academic lab
    N Eswaran, V Agaram Sundaram, KA Rao, S Thalaivarisai Balasundaram
    3 Biotech 8 (3), 139 , 2018
    2018
    Citations: 50
  • Emergence of a multidrug resistant Halomonas hydrothermalis strain VITP09, producing a class-A β-lactamase, isolated from Kumta Coast
    M Rameshpathy, G Jayaraman, GD Rajeswari, AS Vickram, TB Sridharan
    Int. J. Pharm. Pharm. Sci 4, 639-644 , 2012
    2012
    Citations: 50
  • Cadmium effects on sperm morphology and semenogelin with relates to increased ROS in infertile smokers: An in vitro and in silico approach
    P Ranganathan, KA Rao, JJ Sudan, S Balasundaram
    Reproductive biology 18 (2), 189-197 , 2018
    2018
    Citations: 49
  • Optimization of human semen extender components for cryopreservation using statistical tools
    R Pathy M, AS Vickram, TB Sridharan, R Parameswari, K Archana, ...
    CryoLetters 38 (6), 434-444 , 2017
    2017
    Citations: 44
  • Human sperm DNA damage inhibition and antioxidant activity of T. arjuna bark: an in vitro study
    KA Rao, K Mano, M Aruna, AS Vickram, M Rameshpathy, TB Sridharan
    3 Biotech 7 (3), 1-9 , 2017
    2017
    Citations: 44
  • Formulation of nano-encapsulated poly-herbal ointment for anti-inflammation
    MA Megha, U Unnma, M Rameshpathy, K Karikalan, S Vickram, ...
    Pharm Lett 5 (2013), 164-70 , 2013
    2013
    Citations: 42
  • Analysis of seminal plasma proteins of South Indian Jersey and Hybrid Bulls and their correlation with semen quality
    AS Vickram, VD Rajeswari, MR Pathy, TB Sridharan
    Asian J. Anim. Sci 10 (1), 92-98 , 2016
    2016
    Citations: 41
  • Effect of Semen Extender on Protein Concentration in Each Fraction of Cryopreserved Human Semen
    AS Vickram, K Rao, RM Pathy, C Thomas, R Parameswari, TB Sridharan
    CryoLetters 36 (6), 405-412 , 2015
    2015
    Citations: 39