Effect of surfactant administration in respiratory distress syndrome in terms of radiological changes in preterm infants: A multi-centre study Irum Qaisar, Ammara Ayub, Anam Zafar, Komal Wania, Manahil Haq, et al. Journal of the Pakistan Medical Association, 2026 Objective: To evaluate the immediate clinical and radiological outcomes of surfactant administration in preterm newborns with respiratory distress syndrome. Method: The multicentre cohort study was conducted from January to August 2024 at the Pakistan Railway Hospital/Islamic International Medical College, and Khan Research Laboratories Hospital, Islamabad, Pakistan, and comprised preterm newborns diagnosed with of respiratory distress syndrome who had been planned to receive surfactant therapy. Neonatal demographical and clinical characteristics were recorded along with the technique of surfactant administration. Post-surfactant management, the need for mechanical ventilation and chest X-ray findings were evaluated. Data was analysed using SPSS 26. Results: Of the 84 newborns, 64(76.2%) were boys. The overall mean birthweight was 1.86±0.76kg. The most frequent post-treatment complications were pneumothorax 19(22.6%), hypotension 6(7.1%) and pulmonary haemorrhage 4(4.8%). Mechanical ventilation was required in 81(96.4%) cases. The median duration of intensive care was 9.24±6.41 days. Pulmonary haemorrhage (p=0.024), hypotension (p=0.005), post-treatment arterial blood gas potential of hydrogen (p=0.024), and duration of stay under intensive care (p=0.009) were significantly associated with mortality. Post-treatment chest X-ray staging showed significant improvement in infants receiving surfactant therapy (p<0.001). Binary logistic regression identified low birthweight (p=0.005) and cyanosis (p=0.006) at the time of presentation as independent predictors of mortality. Conclusion: There were significant clinical and radiological benefits of surfactant therapy in preterm newborns with respiratory distress syndrome. Key Words: Low birthweight, Mechanical ventilation, Pneumothorax, Pulmonary haemorrhage, Respiratory distress syndrome, Surfactant.
Effects of high-intensity multi-modal exercise training (HIT-MMEX) on bone mineral density and muscle performance in postmenopausal women. A Pilot randomized controlled trial Journal of the Pakistan Medical Association, 2023
Effects of high-intensity multi-modal exercise training (HIT-MMEX) on bone mineral density and muscle performance in postmenopausal women. A Pilot randomized controlled trial Huma Riaz, Muhammad Naveed Babur, Ahsen Farooq Journal of the Pakistan Medical Association, 2022 Objectives: To determine the effects of high-intensity multimodal exercise training on bone mineral density and muscle performance in postmenopausal women. Method: The two-armed, parallel, pilot randomised controlled trial was conducted from November 2020 to July 2021 at Riphah Rehabilitation Centre, Rawalpindi, Pakistan, and comprised women aged 45-70 having been in the post-menopause phase for at least 3 years, with body mass index <30, community ambulant and willing to have exercise therapy. The subjects were randomised into two equal groups. The experimental group A received supervised high-intensity resistance, weight-bearing, balance and mobility training twice weekly for 8 months. The control group B received low-to–moderate intensity exercises. Femoral neck and lumbar spine bone mineral density (g/cm2) were taken through a dual-energy X-ray absorptiometry scan. Muscle performance was measured using 1 repetition maximum for leg and trunk extensors, and 30 sec sit to stand test. Data was analysed using SPSS 21. Results: Of the 101 women screened, 28(27.7%) were enrolled; 14(50%) in group A having mean age 53.36±6.28 years, and 14(50%) in group B having mean age 51.71±4.82 years (p>0.05). Group A showed significantly more improvement than group B both with respect to lumbar spine bone mineral density and muscle performance (p<0.05). Conclusion: Supervised high-intensity multimodal exercise training protocol had a positive effect on lumbar spine bone mineral density and muscle performance in postmenopausal women. Clinical Trial Number: NCT04653350 Link https://clinicaltrials.gov/ct2/show/NCT04653350 Key Words: Osteoporosis, Post-menopausal, Bone density, Strength, Muscle.
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