Agricultural and Biological Sciences, Physiology, General Agricultural and Biological Sciences, Aging
13
Scopus Publications
21
Scholar Citations
3
Scholar h-index
Scopus Publications
Aging Theories and Prevention of Age-Related Diseases Using Phytocomplexes Marat R. Khanturin, Georgiy A. Demchenko, Laura U. Koibasova, Serik N. Abdreshov, Makpal A. Yessenova, Sofia K. Imankulova, Yerkenaz N. Akhatayeva Biology, 2026 Aging is a multifactorial biological process characterized by a progressive decline in functional capacity at the molecular, cellular, tissue, and organismal levels. The aim of this review is to summarize current concepts of aging mechanisms and the prevention of age-related pathologies from a lymphological perspective, taking into account contemporary literature data and the results of our own studies. Currently, two major concepts dominate in gerontology: programmed aging, which considers aging as a genetically determined process, and damage accumulation theories, which associate aging with the progressive accumulation of molecular and cellular damage. The hallmarks of aging include genomic instability, telomere shortening, epigenetic alterations, impaired proteostasis and macroautophagy, dysregulation of nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis, hormonal imbalance, and disturbances in interstitial humoral transport and lymphatic outflow. At the tissue and organ levels, impairment of lymphatic drainage is of particular importance, leading to interstitial fluid stagnation and the accumulation of toxic metabolites, which exacerbate cellular and subcellular dysfunction. Phytotherapeutic agents containing flavonoids, phenolic compounds, terpenoids, glycosides, polysaccharides, and other biologically active substances exhibit antioxidant, anti-inflammatory, and cytoprotective properties. They inhibit lipid peroxidation, reduce excessive nitric oxide production, and contribute to the restoration of interstitial humoral transport and lymphatic outflow. Interstitial humoral transport and the lymphatic system, together with renal mechanisms, play key roles in maintaining body fluid homeostasis. Targeted regulation of lymphatic system function may help reduce tissue congestion, maintain physiological homeostasis, and improve quality of life in the elderly.
Morphological Changes in Brain Tissue During Experimental Hypoxia Aizhan Mussayeva, Ulbossin Kozhaniyazova, Laura Koibasova, Georgii Demchenko, Аnar Yeshmukhanbet, Makpal Yessenova, Rustembek Karjaubaev, Bayan Nurmakhanova, Zarina Orazymbetova, Sholpan Bakhtybekkyzy, Aidana Bekitayeva, Serik Аbdreshov Online Journal of Biological Sciences, 2026 The extensive application of hypoxic training to enhance cerebral circulation highlights its significant role in effectively realizing the therapeutic and health-promoting benefits of this method. The discrepancy between the data on the features of cerebral circulation and cellular metabolism in brain tissues during circulatory hypoxia and significant interest in the physiological patterns of the integrative response of the body determined the feasibility of this study. Hypoxic training is widely used in sports and rehabilitation medicine and it is relevant to study the adaptation mechanisms of this condition. To study the morpho-functional features of cerebral circulation, brain tissue after experimental hypoxic normobaric training. The experiments involved Sprague Dawley rats, which were placed in a hypoxic chamber for 45 minutes daily over periods of 15 and 30 days. Morphological and physiological assessments were performed. Blood flow velocity in the middle cerebral artery of the experimental animals was measured using ultrasound Doppler imaging. A cycle of hypoxic training led to a decrease in the rhythmic (pulse) index and an increase in the functional activity of cells, indicating the expression of cerebral vascular responses and an increase in cerebral blood flow velocity. To safeguard the brain from hypoxia, robust mechanisms regulating cerebral circulation enhance blood flow to compensate for the reduced oxygen levels in arterial blood. The data of this study showed that hypoxic training leads to an increase in brain metabolism and an improvement in cerebral circulation, which is an adaptive response of the cardiorespiratory system of the body after hypoxic training.
Effects of hypoxic training cycle on peripheral hemodynamics of wrestlers Georgiy A. Demchenko, Serik Abdreshov, Laura Koibasova, Oxsana Cherednichenko, U. N. Kozhaniyazova, et al. Polski Merkuriusz Lekarski, 2025 OBJECTIVE: Aim: To monitor peripheral hemodynamics in the upper and lower extremities of wrestlers practicing different wrestling styles to control adaptive changes in the body after a cycle of interval hypoxic training with intense physical activity. PATIENTS AND METHODS: Materials and Methods: The athletes trained intensively in a hypoxic chamber for 21 days, 2 hours a day. We monitored their ECG, heart rate, and central and peripheral hemodynamic parameters. The results obtained were processed using traditional methods of variation statistics in the Microsoft program Excel (Microsoft Corporation, Redmond, Washington, DC, USA). The arithmetic means, and the deviations (M + SE) were calculated as %. The significance of the difference in means was assessed using the Fisher and Student t-test. RESULTS: Results: Hypoxic training with varied loads using simulators and sparring resulted in the positive physiological adaptation of athletes. Interval hypoxic training for 120 minutes with an intense load and normoxic breaks at an O2 concentration of 14.2% to 12% effectively improved the hemodynamics of wrestlers. The changes affected all studied parameters of the cardiovascular system. Vascular reactions during muscular work were aimed at hydrodynamic optimization of the circulatory system. Complex changes in blood flow and elastic-viscous properties of blood vessels worked to optimize heart function during physical exercise. Higher elastic resistance of large arteries provided the necessary increase in blood flow rate in large, medium, and small arteries and veins. CONCLUSION: Conclusions: These results justify using interval hypoxic training with physical activity to increase the functionality of the cardiovascular system, peripheral hemodynamics, and microvasculature in the body of athletes. Based on the above, we could recommend an intense hypoxic training cycle with physical activity in 24 120-minute workouts with a protein and vitamin food supplement to increase the wrestlers' cardiovascular system functional capacity.
Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity S.N. Abdreshov, M.A. Yessenova, A.N. Yeshmukhanbet, G.A. Demchenko, V.N. Gorchakov, G.K. Atanbaeva, S.A. Mankibaeva International Journal of Biology and Chemistry, 2024 The article presents studies of the effect of fecal suspension by introducing into the abdominal cavity at the rate of 0.5 ml of a 10% solution per 100 g of animal body weight. The morpho-functional state and morphometric analyzes of the small intestine were studied in normal conditions and with inflammation of the abdominal organs by introducing fecal suspension. The results showed that inflammation of the abdominal organs led to significant changes in the wall of the small intestine, multiple hemorrhages and fibrin clots were found. In the intestine, there is a change and violation of the structures of the small intestine, the total thickness of the mucous membrane increases. Violation of goblet cells, villus height and crypt depth occur. Analysis of the study showed that the walls of the small intestine, revealed structural changes, mainly in the mucosa, submucosa and muscle membranes. The mean value of the mucosal thickness in the control group was 526.17±17.11 micrometer; submucous layer – 47.21±1.63 micrometer. Phenomena of edema, inflammatory infiltration, and separation of muscle fibers were noted in both layers of the muscular membrane. The average layer of thickness of the muscular membrane was 145.67±6.92 µm. Changes in the mucous membrane of the small intestine, at one time reflected in the structural changes in the villi-crypt of the small intestine. A violation of microcirculation in the tissues of the small intestine after the inflammatory process was revealed, which leads to aggravation of dystrophic and necrobiotic lesions of the overall state of the small intestine and is combined with the severity of the clinical picture in experimental animals.
Morphometric changes in the blood and lymphatic channels during inflammation Serik Abreshov, Makpal Yessenova, Anar Yeshmukhanbet, Gulshat Atanbaeva, Georgiy Demchenko Bio Web of Conferences, 2024 When the abdominal cavity is inflamed, the lymphatic channel, i.e. the system of lymph vessels and lymph nodes, which play an important role in protecting the body from infections and ensuring proper metabolism, may be affected. Inflammation of the lymphatic channel can lead to its enlargement, soreness and even the formation of purulent foci. The study of morphometric changes in the lymphatic channel during inflammation is an important task for a more detailed understanding of inflammatory processes occurring in the body. The results of our experiments showed that during inflammatory processes of the abdominal cavity there are changes in the blood and lymphatic vessels. Relative volumes of vessels of different types per unit significantly decreased compared to the indicators of the control group. In submucosa and muscularis the morphometry data confirm the fact of arterial vessels spasm, lymphatic vessel reduction and simultaneous persistent venous vessels expansion. In rats with the developed inflammatory process in lymphatic vessels the expansion of lymphatic slits and significant thickening of the wall of large lymphatic vessels was found, which is associated with an increase in the volume of blood plasma, increasing the load on lymphatic vessels as a drainage system of the body.
Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity Serik N. Abdreshov, Georgii A. Demchenko, Anar N. Yeshmukhanbet, Makpal A. Yessenova, Sandugash A. Mankibaeva, Gulshat K. Atanbaeva, Marzhan S. Kulbayeva Biology, 2024 This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.
The impact of hypoxic training at different altitudes on human physiology, biochemistry, and cytogenetics Georgiy A. Demchenko, Serik N. Abdreshov, Laura U. Koibasova, Makpal A. Yessenova, Anar N. Yeshmukhanbet Edelweiss Applied Science and Technology, 2024 This study investigated the impact of dosed hypoxic normobaric exercises on the physio-biochemical parameters of blood and lymph circulation, as well as cytogenetic changes in red blood cells (RBC), using a Sprague Dawley Rat Model. Hypoxic training was conducted in an animal hypoxic chamber. The session lasted 34-35 minutes. The O2 content was 20.5% at the beginning of the session; then, it dropped to 14.8% within 4-5 minutes, corresponding to a rise to an altitude of 2,900-3,000 m, and was maintained at that level until the end of the session. The hypoxic training cycle increased the RBC count by 4.1%, the hemoglobin count by 4.2%, the blood oxygen capacity by 8.3%, the circulating blood volume by 16.7%, and interstitial metabolism and lymph circulation by 30.6%. A cytogenetic study revealed an increase in erythropoiesis-reticulocyte count by 40.3% and a slightly higher frequency of micronucleated erythrocytes. We observed economization of the heart, respiration, activation of glucose transport by 33.5%, increased lipid utilization, and increased antioxidant protection. These parameters especially changed when hypoxic training was combined with physical activity. Hypoxic training with physical activity expands the body’s compensatory and adaptive capabilities by increasing the reserves of the respiratory, cardiovascular, and lymphatic systems.
Rates of Compartmentalization of Visceral Lymph Nodes in Aging Vladimir Gorchakov, Serik Abdreshov, Bayan Nurmakhanova, Anar Eshmukhanbet, Ekaterina Amansakhatova, Makpal Esenova 2023 IEEE Ural Siberian Conference on Computational Technologies in Cognitive Science Genomics and Biomedicine Csgb 2023 Proceedings, 2023
RECENT SCHOLAR PUBLICATIONS
Aging Theories and Prevention of Age-Related Diseases Using Phytocomplexes MR Khanturin, GA Demchenko, LU Koibasova, SN Abdreshov, ... Biology 15 (9), 733 , 2026 2026
New mineral and vitamin feed additive for small cattle S Abdreshov, M Yessenova, A Yeshmukhanbet, А Kalekeshov, ... Caspian Journal of Environmental Sciences 24 (2), 319-332 , 2026 2026
Immunomodulatory feed additives in cattle nutrition: A review L Koibasova, G Demchenko, M Khanturin, E Makashev, S Abdreshov, ... Ger. J. Vet. Res 6 (2), 108-124 , 2026 2026
Current state and prospects of using medicinal plants growing in the Zailiysky and Zhetysu Alatau, Kazakhstan B Joltukova, S Mankibaeva, B Oxikbayev, U Kozhaniyazova, N Issayeva, ... Caspian Journal of Environmental Sciences 24 (1), 273-280 , 2026 2026
Effects of hypoxic training cycle on peripheral hemodynamics of wrestlers GA Demchenko, S Abdreshov, L Koibasova, O Cherednichenko, ... Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 53 (6 … , 2025 2025
Reactive Changes in Lymph Node Structure in Peritonitis and during Treatment with a New Antibiotic SN Abdreshov, GA Demchenko, VN Gorchakov, MA Yessenova, ... Bulletin of Experimental Biology and Medicine 177 (6), 792-796 , 2024 2024 Citations: 1
Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity SN Abdreshov, MA Yessenova, AN Yeshmukhanbet, GA Demchenko, ... International Journal of Biology and Chemistry 17 (1), 70-77 , 2024 2024 Citations: 1
STUDY OF THE MICROBIAL LANDSCAPE OF PERITONEAL EXUDATE IN ABDOMINAL INFLAMMATION M Yessenova, A Yeshmukhanbet, G Atanbaeva, G Demchenko, ... Наука и образование 1 (1 (74)), 184-191 , 2024 2024
Morphofunctional alteration of mesenteric lymph nodes in the inflammation of the abdominal cavity SN Abdreshov, GA Demchenko, AN Yeshmukhanbet, MA Yessenova, ... Biology 13 (3), 166 , 2024 2024 Citations: 4
STUDY OF THE MICROBIAL LANDSCAPE OF PERITONEAL EXUDATE IN ABDOMINAL INFLAMMATION SN Abdreshov, MA Yessenova, AN Yeshmukhanbet, GK Atanbaeva Жәңгір хан атындағы БҚАТУ , 2024 2024
Fluxo linfático, indicadores iônicos e bioquímicos da linfa e do sangue durante a hipóxia SN Abdreshov, GA Demchenko, UN Kozhaniyazova, AN Yeshmukhanbet, ... Brazilian Journal of Biology 84, e284264 , 2024 2024
Lymph flow, ionic and biochemical indicators of lymph and blood during hypoxia SN Abdreshov, GA Demchenko, UN Kozhaniyazova, AN Yeshmukhanbet, ... Brazilian Journal of Biology 84, e284264 , 2024 2024 Citations: 2
The impact of hypoxic training at different altitudes on human physiology, biochemistry, and cytogenetics GA Demchenko, SN Abdreshov, LU Koibasova, MA Yessenova, ... Edelweiss Applied Science and Technology 8 (4), 1119-1130 , 2024 2024 Citations: 1
Morphometric changes in the blood and lymphatic channels during inflammation S Abreshov, M Yessenova, A Yeshmukhanbet, G Atanbaeva, ... BIO Web of Conferences 100, 01001 , 2024 2024
A physiological characterization of the high-fat diet on the induction of obesity in adult male Swiss mice A Babashev, MA Tumaevna, AS Nauryzbaevish, KA Maralovich, ... Caspian Journal of Environmental Sciences 21 (4), 931-938 , 2023 2023 Citations: 5
BLOOD CIRCULATION IN LARGE VESSELS AND IN THE ABDOMINAL ORGANS DURING THE EXPERIMENT. SN Abdreshov, AN Yeshmukhanbet, MA Yessenova, GA Demchenko, ... Experimental Biology (1563-0218) 97 (4) , 2023 2023 Citations: 1
Characteristics of bacterial microflora in rats with massive infection of the abdominal cavity AK Mussayeva, SN Abdreshov, NN Yegorova, AN Yeshmukhanbet, ... Микробиология и вирусология, 183-196 , 2023 2023 Citations: 2
Lymph flow and cellular composition, riieological properties of lymph and blood in animals with experimental peritonitis SN Abdreshov, GA Demchenko, VN Gorchakov, AN Yeshmukhanbet, ... Известия Национальной академии наук Республики Казахстан. Серия … , 2021 2021 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
A physiological characterization of the high-fat diet on the induction of obesity in adult male Swiss mice A Babashev, MA Tumaevna, AS Nauryzbaevish, KA Maralovich, ... Caspian Journal of Environmental Sciences 21 (4), 931-938 , 2023 2023 Citations: 5
Morphofunctional alteration of mesenteric lymph nodes in the inflammation of the abdominal cavity SN Abdreshov, GA Demchenko, AN Yeshmukhanbet, MA Yessenova, ... Biology 13 (3), 166 , 2024 2024 Citations: 4
Lymph flow and cellular composition, riieological properties of lymph and blood in animals with experimental peritonitis SN Abdreshov, GA Demchenko, VN Gorchakov, AN Yeshmukhanbet, ... Известия Национальной академии наук Республики Казахстан. Серия … , 2021 2021 Citations: 4
Lymph flow, ionic and biochemical indicators of lymph and blood during hypoxia SN Abdreshov, GA Demchenko, UN Kozhaniyazova, AN Yeshmukhanbet, ... Brazilian Journal of Biology 84, e284264 , 2024 2024 Citations: 2
Characteristics of bacterial microflora in rats with massive infection of the abdominal cavity AK Mussayeva, SN Abdreshov, NN Yegorova, AN Yeshmukhanbet, ... Микробиология и вирусология, 183-196 , 2023 2023 Citations: 2
Reactive Changes in Lymph Node Structure in Peritonitis and during Treatment with a New Antibiotic SN Abdreshov, GA Demchenko, VN Gorchakov, MA Yessenova, ... Bulletin of Experimental Biology and Medicine 177 (6), 792-796 , 2024 2024 Citations: 1
Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity SN Abdreshov, MA Yessenova, AN Yeshmukhanbet, GA Demchenko, ... International Journal of Biology and Chemistry 17 (1), 70-77 , 2024 2024 Citations: 1
The impact of hypoxic training at different altitudes on human physiology, biochemistry, and cytogenetics GA Demchenko, SN Abdreshov, LU Koibasova, MA Yessenova, ... Edelweiss Applied Science and Technology 8 (4), 1119-1130 , 2024 2024 Citations: 1
BLOOD CIRCULATION IN LARGE VESSELS AND IN THE ABDOMINAL ORGANS DURING THE EXPERIMENT. SN Abdreshov, AN Yeshmukhanbet, MA Yessenova, GA Demchenko, ... Experimental Biology (1563-0218) 97 (4) , 2023 2023 Citations: 1
Aging Theories and Prevention of Age-Related Diseases Using Phytocomplexes MR Khanturin, GA Demchenko, LU Koibasova, SN Abdreshov, ... Biology 15 (9), 733 , 2026 2026
New mineral and vitamin feed additive for small cattle S Abdreshov, M Yessenova, A Yeshmukhanbet, А Kalekeshov, ... Caspian Journal of Environmental Sciences 24 (2), 319-332 , 2026 2026
Immunomodulatory feed additives in cattle nutrition: A review L Koibasova, G Demchenko, M Khanturin, E Makashev, S Abdreshov, ... Ger. J. Vet. Res 6 (2), 108-124 , 2026 2026
Current state and prospects of using medicinal plants growing in the Zailiysky and Zhetysu Alatau, Kazakhstan B Joltukova, S Mankibaeva, B Oxikbayev, U Kozhaniyazova, N Issayeva, ... Caspian Journal of Environmental Sciences 24 (1), 273-280 , 2026 2026
Effects of hypoxic training cycle on peripheral hemodynamics of wrestlers GA Demchenko, S Abdreshov, L Koibasova, O Cherednichenko, ... Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 53 (6 … , 2025 2025
STUDY OF THE MICROBIAL LANDSCAPE OF PERITONEAL EXUDATE IN ABDOMINAL INFLAMMATION M Yessenova, A Yeshmukhanbet, G Atanbaeva, G Demchenko, ... Наука и образование 1 (1 (74)), 184-191 , 2024 2024
STUDY OF THE MICROBIAL LANDSCAPE OF PERITONEAL EXUDATE IN ABDOMINAL INFLAMMATION SN Abdreshov, MA Yessenova, AN Yeshmukhanbet, GK Atanbaeva Жәңгір хан атындағы БҚАТУ , 2024 2024
Fluxo linfático, indicadores iônicos e bioquímicos da linfa e do sangue durante a hipóxia SN Abdreshov, GA Demchenko, UN Kozhaniyazova, AN Yeshmukhanbet, ... Brazilian Journal of Biology 84, e284264 , 2024 2024
Morphometric changes in the blood and lymphatic channels during inflammation S Abreshov, M Yessenova, A Yeshmukhanbet, G Atanbaeva, ... BIO Web of Conferences 100, 01001 , 2024 2024
