Cell Biology, Biotechnology, Molecular Biology, Molecular Medicine
5
Scopus Publications
Scopus Publications
Comparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial Yaiza González-Rodríguez, Manuel A. La Nuez-García, Marina Jiménez, Vega Villar-Suárez, Alejandro Casado-Santos Frontiers in Nutrition, 2026 Introduction This study aimed to investigate the impact of fresh eggshell membrane (MKARE®) as a nutricosmetic ingredient, with a focus on its influence on skin properties. Biomechanical measurement devices were used to assess the effects on skin condition, and the results were compared with hydrolyzed collagen and a placebo. Methods Biophysical parameters were analyzed (using Cutometer®, Tewameter®, Corneometer®, and VISIA®) among participants showing signs of aging. These individuals consumed either 300 mg of fresh eggshell membrane (MKARE®) or 8,000 mg of hydrolyzed collagen, and the results were compared to a placebo group after 28 and 57 days. Results The results showed significant improvements in skin firmness/flexibility and elasticity after 57 days of MKARE® intake, compared to both the hydrolyzed collagen and placebo groups. Conclusion This study demonstrates that a 300 mg intake of fresh membrane MKARE® positively affects mechanical skin parameters compared to the group that consumed 8,000 mg of hydrolyzed collagen or the placebo group. These improvements suggest that MKARE® consumption regenerates the skin structure, primarily due to positive changes in collagen and elastin formation, which are key contributors to the improvement of skin firmness, elasticity, and barrier protection.
Equine Corneal Wound Healing Using Mesenchymal Stem Cell Secretome: Case Report Alejandro Casado-Santos, Elsa González-Cubero, Maria Luisa González-Fernández, Yaiza González-Rodríguez, Mª Belén García-Rodríguez, et al. Animals, 2024 Corneal ulcers are a common and potentially vision-threatening condition in horses that can be challenging to treat with conventional therapies alone. This case report describes the successful treatment of a non-healing corneal ulcer in a 28-year-old Hispano-Bretón mare using the secretome derived from adipose tissue-derived mesenchymal stem cells (ASCs). Despite initial treatment with antibiotics, anti-inflammatory drugs, and surgical debridement, the corneal ulcer failed to heal properly, exhibiting persistent epithelial defects and stromal complications. As an alternative regenerative approach, the ASC secretome, a rich source of trophic factors, cytokines, and extracellular vesicles, was topically administered to the affected eye. Remarkably, within one week of secretome treatment, the clinical signs of blepharospasm and epiphora resolved, and the corneal ulcer exhibited complete re-epithelialization, regained transparency, and reduced neovascularization. No recurrence was observed during the 1.5-year follow-up period. This case highlights the potential therapeutic benefits of the ASC secretome in promoting corneal wound healing and suggests its promise as a novel cell-free therapy for treating refractory corneal ulcers in horses.
