Mohamed Abouzid
@pums.ump.edu.pl
Department of Physical Pharmacy and Pharmacokinetics
Poznan University of Medical Sciences
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mohammad Tanashat, Mohamed Abuelazm, Mohamed Abouzid, Yazan A. Al-Ajlouni, Alaa Ramadan, Sumaya Alsalah, Abdulrahman Sharaf, Dina Ayman, Hesham Elharti, Sara Zhana,et al.
Elsevier BV
Mohamed Abouzid, Łukasz Kruszyna, Julia Kerner, Leonid Kagan, Aniceta Mikulska-Sauermann, Dorota Filipowicz, Matylda Resztak, Franciszek Krzysztof Główka, and Marta Karaźniewicz-Łada
Portland Press Ltd.
Roughly 90% of the Polish population experiences vitamin D deficiency. The 3-epi-25(OH)D2 and 3-epi-25(OH)D3 are stereoisomers of 25(OH)D2 and 25(OH)D3, and they can inadvertently be included in measurements of 25(OH)D levels, potentially leading to its overestimating. We aimed to measure 25(OH)D2 and 25(OH)D3, their epimers 3-epi-25(OH)D2 and 3-epi-25(OH)D3, and biologically active 1,25(OH)2D3 in patients with cardiovascular disease and healthy volunteers. We enrolled 27 adult patients with cardiovascular disease (64 ±15 years) and 35 healthy volunteers (36.37±12.29 years). We used a validated UPLC-MS/MS method to measure 25(OH)D2/3 concentrations and their epimers. Plasma concentrations of 1α,25(OH)2D3 were determined by sensitive and quantitative enzyme immunoassay following intra- and inter-day validation. Vitamin D insufficiency was observed in approximately 52% of the patients and 37% of healthy volunteers. Comparable levels of 25(OH)D3 and 25(OH)D2 were seen in both groups. The observed levels of the epimeric form 3-epi-25(OH)D3 appeared about 1.7 times higher in healthy volunteers, accounting for 9% misclassified according to vitamin D status. Also, patients had lower concentrations of 1,25(OH)2D3, and their 3-epi-25(OH)D2 levels were below the detection limit (2 ng/mL). In all studied subjects, 25(OH)D3 was negatively correlated with % 3-epi-25(OH)D3 (R=-0.758; p<0.001), and 3-epi-25(OH)D2 was negatively correlated with % 3-epi-25(OH)D2 (R = -0.842; p=0.002). While the mechanism of how vitamin D epimeric forms influence diseases remains unclear, we recommend maintaining 25(OH)D3 levels above 20 ng/mL.
Mohamed S. Hemeda, Heba Youssef Sayed, Amany A. Mostafa, Almaza Ali Salem, Ibrahim Arafa Reyad Arafa, Hesham Hafez Abdelkhalek Mosa, Mohamed Hafez Mohamed Younes, Samar S. Ahmed, Yasser M. Saqr, Amir Bastawisy,et al.
Elsevier BV
Obieda Altobaishat, Omar Abdullah Bataineh, Ahmed A. Ibrahim, Ahmad K. Al-zoubi, Ubaid Khan, Mahmoud Shaaban Abdelgalil, Mohamed Abouzid, Hazem Rezq, and Mohamed Abuelazm
Elsevier BV
OBJECTIVE
Acute type A aortic dissection (ATAAD) is a cardiovascular emergency with high mortality and morbidity. We compared the effects on outcomes of single arterial cannulation (SAC) via axillary, femoral, or ascending aorta with double arterial cannulation (DAC) via axillary and femoral artery during ATAAD repair.
METHODS
We conducted a systematic review and meta-analysis of observational studies from PubMed, Web of Science, Scopus, EMBASE, and Cochrane searches through April 30, 2024. Dichotomous data were pooled using risk ratio (RR), and continuous data were pooled using mean difference (MD), both with a 95% confidence interval (CI), using R version 4.3. The protocol is registered on PROSPERO (CRD42024535644).
RESULTS
Our analysis included 7 studies encompassing 3,534 patients. DAC was associated with a significantly longer intensive care unit stay than SAC (MD 0.45 days, 95% CI 0.10, 0.79, p = 0.01). However, there was no significant difference between DAC and SAC in the length of hospital stay (MD 1.39 days, 95% CI -2.70, 5.47, p = 0.51). Also, there was no significant difference between the two approaches in the incidence of stroke (RR 1.12, 95% CI 0.77, 1.64, p = 0.55), paraplegia (RR 0.59, 95% CI 0.32, 1.07, p = 0.08), or acute kidney injury (RR 0.83, 95% CI 0.55, 1.24, p = 1.24).
CONCLUSION
Our meta-analysis shows that during ATAAD repair, DAC was associated with slightly longer intensive care stay, which was of doubtful clinical significance. However, both approaches were comparable for hospital stay, the incidence of stroke, paraplegia, or acute kidney injury.
IMPLICATIONS FOR CLINICAL PRACTICE
Despite comparable overall outcomes, we observed that DAC was associated with higher risks of requiring continuous renal replacement therapy or dialysis, and reintubation. This emphasizes the need to carefully consider cannulation strategies based on patient factors to balance potential benefits and risks.
Mohammad Al-Jafari, Marah Ahmad Aldarawsheh, Mohamed Abouzid, Ibrahim Serag, Mariam Akram Nofal, Ammar Ra’ed Altiti, Saja Zuaiter, Aya Sabri Al-Zurgan, Basil Aldiabat, Julie Feras Owaidat,et al.
Springer Science and Business Media LLC
Mohamed Hendawy, Mohamed Abouzid, Aliaa Gamal, Aseel Ghanayem, Muna Amer, Mohammad Tanashat, Nael Kamel Eltewacy, Mohamed Mustafa Mohamed, Eman Ayman Nada, and Ismail A. Ibrahim
Springer Science and Business Media LLC
Abstract Background Psychological distress has significantly impacted students in Egypt and Jordan. These countries have faced many challenges, including the COVID-19 pandemic, the fallout from the conflict in Syria, and the war in Ukraine. These crises have had far-reaching consequences, affecting the economy, food security, and energy supplies, particularly with the increased number of refugees in these countries. Amid these existing complexities, the ongoing war in Gaza further exacerbates the situation, compounding mental health challenges. Therefore, this study aimed to analyze how the war in Gaza impacted the mental health of students in Egypt and Jordan. Methods We conducted a cross-sectional study involving students from Egypt and Jordan between December 2023 and January 2024. The questionnaire incorporated the Brief Symptom Inventory 18 (BSI-18) to assess the overall general distress score, as well as the domains of anxiety, somatization, and depression. Results A total of 1509 Jordanian and Egyptian students were included in the study, of which 66% were female. Approximately 18% of the students had an elevation (≥ 50) in their BSI-18 total score. Females scored significantly higher in general distress [30 (18–44.25) vs. 24 (11–41), p < 0.001], and all three dimensions. The univariate predictors for elevated general distress (≥ 50) were being Egyptian (OR 1.49, 95% CI 1.08 to 2.08, p = 0.014), watching social media multiple times a day (OR 3.04, 95% CI 1.97 to 4.69, p < 0.001), and having a Palestinian connection (friend, neighbor, colleague, or relative) (OR 1.63, 95% CI 1.23 to 2.16, p < 0.001). These three predictors were retained in the backward stepwise multivariate regression analysis model. The univariate predictors for moderate and marked general distress (≥ 57) were watching social media multiple times a day (OR 3.26, 95% CI 1.78 to 5.99, p < 0.001) and having a Palestinian connection (OR 1.49, 95% CI 1.05 to 2.14, p = 0.026). Only the former was retained in the backward stepwise multivariate regression analysis. Conclusion General distress has increased among students in Egypt and Jordan throughout the War in Gaza. Mental, psychological, and social support activities are necessary for these students, particularly those watching social media multiple times daily. The development of coping skills to manage the additional stressors of war and socioeconomic status necessitates further research within this group of students.
Ahmed M. Elgarahy, M. G. Eloffy, Ayman N. Saber, Mohamed Abouzid, Emanne Rashad, Mohamed A. Ghorab, Dina M. El-Sherif, and Khalid Z. Elwakeel
Springer Science and Business Media LLC
Khalid Sarhan, Reem Reda Elmahdi, Rashad G. Mohamed, Ibrahim Serag, and Mohamed Abouzid
Springer Science and Business Media LLC
AbstractSuturing techniques for wound closure in spine surgeries play a critical role in patient outcomes, including wound healing, reintervention, and risk of complications. Barbed sutures, characterized by their self-anchoring properties, have emerged as a potential alternative to conventional sutures in various surgical disciplines. While previous studies have underscored their efficacy and safety in spine surgeries, no meta-analysis has been conducted. Therefore, we are undertaking this study. Following the PRISMA guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 5, 2024. Our primary outcomes were operative time, wound closure time, and postoperative wound complications like seroma or hematoma formation and wound infection. The secondary outcomes were the length of hospital stay, reintervention rates, and costs. Data was pooled using a random effects model. We included seven eligible studies with a total of 8645 patients. Our meta-analysis showed that barbed sutures had shorter operative time and wound closure time compared to conventional sutures (MD -20.13 min, 95% CI [-28.47, -11.78], P < 0.001) and (MD -16.36 min, 95% CI [-20.9, -11.82], P < 0.001), respectively. Both suturing techniques showed comparable results in terms of overall postoperative wound complications (RR 0.83, 95% CI [0.60, 1.14], P = 0.25), postoperative infections (RR 0.59, 95% CI [0.33, 1.06], P = 0.08), length of hospital stay (MD -0.26 day, 95% CI [-0.75, 0.22], P = 0.28), rates of reintervention between the two groups (RR 0.99, 95% CI [0.48, 2.05], P = 0.98). Barbed sutures in spine surgeries are associated with significantly shortened wound closure and operative times. However, high-quality RCT’s with long-term follow-up and cost-effectiveness assessment are required to support the evidence.
Ahmed A. Abo Elnaga, Mohamed A. Alsaied, Abdelrahman M. Elettreby, Alaa Ramadan, Mohamed Abouzid, Raghda Shetta, and Yazan A. Al-Ajlouni
Springer Science and Business Media LLC
Abdelaziz A. Awad, Menna M. Aboelkhier, Rashad G. Mohamed, Ahmed W. Abbas, Ahmed W. Hageen, Yousef R. Alnomani, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Purpose of Review Ontamalimab is an anti-MAdCAM-1 monoclonal antibody. It directly restricts the binding of α4β7 + lymphocytes and does not affect the homing of lymphocytes in the central nervous system. Thus, it diminishes adverse effects while blocking their migration into the gut. Several clinical trials have validated the efficacy and safety of ontamalimab for Crohn's disease and ulcerative colitis. However, to date, there is no meta-analysis on the topic. Hence, we are conducting this meta-analysis. Using R version R.3.3, we reported outcomes as risk ratios (RRs) or mean difference (MD) and confidence intervals (CIs). A P-value ≤ 0.05 is considered as statistically significant. Recent Findings The meta-analysis included a total of three studies with 1384 patients. In patients with ulcerative colitis, compared to placebo, ontamalimab had significantly improved clinical remission (RR = 2.17, 95% CI [1.42 to 3.32], P < 0.01), clinical response (RR = 1.79, 95% CI [1.35 to 2.38], P < 0.01), endoscopic response (RR = 2.27, 95% CI [1.55 to 3.31], P < 0.01) and mucosal healing (RR = 2.39, 95% CI [1.63 to 3.50], P < 0.01). No significant differences favoring ontamalimab or the placebo were found regarding safety outcomes. In patients with Crohn's disease, ontamalimab showed superiority over placebo in endoscopic response (RR = 2.00, 95% CI [1.08 to 3.70], P = 0.03). However, ontamalimab was associated with a higher incidence of serious adverse events, and study discontinuations were due to adverse events. Summary Ontamalimab has shown promising results, particularly in patients with moderate to severe ulcerative colitis, as evidenced by better clinical response and remission. However, questions remain about its long-term effectiveness and safety; hence, extended follow-up and more extensive studies are necessary.
Yazan A. Al-Ajlouni, Mohamed Abouzid, Mohammad Tanashat, Ahmed Ahmed Basheer, Omar Al Ta’ani, Naciye Bilgin-Badur, and Mohammad Islam
Springer Science and Business Media LLC
Ibrahim Serag and Mohamed Abouzid
Springer Science and Business Media LLC
Alaa Ramadan, Heba Aboeldahab, Mohamed Nabih Bashir, Mohamed Mohamed Belal, Ahmed Wageeh, Ahmed Atia, Mohamed Elbanna, Tala Jouma Alhejazi, Mohamed Abouzid, Hady Atef,et al.
Springer Science and Business Media LLC
Abstract Background Cardiovascular disease (CVD) represents a significant health challenge in Egypt, yet there exists limited understanding regarding the knowledge, attitudes, and physical activity levels associated with CVD. These factors play a pivotal role in developing effective prevention and management strategies. Hence, this cross-sectional study aimed to evaluate Egyptian adults’ knowledge, attitudes, and physical activity (KAP) levels. Methods Data were collected using a previously validated questionnaire encompassing demographic characteristics, CVD knowledge (including risk factors and symptoms), attitudes toward CVD, and self-reported physical activity levels. The survey was distributed among social media channels, and trained researchers administered the questionnaire via face-to-face interviews with adult patients with and without CVD admitted to Cairo University Hospital clinics. Results The study involved 591 participants, of whom 21.7% had CVD. Overall, participants exhibited poor knowledge regarding CVD, with a mean score of 21 ± 7 out of 40, equivalent to 52.5%. Attitudes toward CVD were moderate, with a mean score of 66.38 ± 8.7 out of 85, approximately 78%. Physical activity levels per week were also moderate, averaging 1188 MET-min with a range of 1121–18,761. Subgroup analysis revealed that individuals with CVD had lower average knowledge, attitude, and physical activity levels than those without CVD. Working in the healthcare field was a predictor of higher knowledge score (standard error (SE) 5.89, 95% confidence interval (CI) 4.61 to 7.17, P < 0.001), while those with CVD and smokers were predictors of lower attitude score (SE -4.08, 95% CI -6.43 to -1.73, P < 0.001) and (SE -2.54, 95% CI -4.69 to -0.40, P = 0.02), respectively. Conclusion The study findings highlight a significant disparity in knowledge, attitudes, and physical activity levels related to CVD in Egypt. Targeted interventions aimed at improving awareness, fostering positive attitudes, and promoting physical activity among individuals at risk for CVD are crucial for effective prevention and management.
Mariam Ahmed Abdelhady, Ahmed Aljabali, Mohammad Al-Jafari, Ibrahim Serag, Amr Elrosasy, Ahmed Atia, Aya Ehab, Shrouk F. Mohammed, Ibraheem M. Alkhawaldeh, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Background Surgery is the primary treatment for chronic subdural hematoma, and anesthesia significantly impacts the surgery's outcomes. A previous systematic review compared general anesthesia to local anesthesia in 319 patients. Our study builds upon this research, analyzing 4,367 cases to provide updated and rigorous evidence. Methods We systematically searched five electronic databases: PubMed, Cochrane Library, Scopus, Ovid Medline, and Web of Science, to identify eligible comparative studies. All studies published until September 2023 were included in our analysis. We compared six primary outcomes between the two groups using Review Manager Software. Results Eighteen studies involving a total of 4,367 participants were included in the meta-analysis. The analysis revealed no significant difference between the two techniques in terms of 'recurrence rate' (OR = 0.95, 95% CI [0.78 to 1.15], P = 0.59), 'mortality rate' (OR = 1.02, 95% CI [0.55 to 1.88], P = 0.96), and 'reoperation rate' (OR = 0.95, 95% CI [0.5 to 1.79], P = 0.87). Local anesthesia demonstrated superiority with a lower 'complications rate' than general anesthesia, as the latter had almost 2.4 times higher odds of experiencing complications (OR = 2.4, 95% CI [1.81 to 3.17], P < 0.00001). Additionally, local anesthesia was associated with a shorter 'length of hospital stay' (SMD = 1.19, 95% CI [1.06 to 1.32], P < 0.00001) and a reduced 'duration of surgery' (SMD = 0.94, 95% CI [0.67 to 1.2], P < 0.00001). Conclusion Surgery for chronic subdural hematoma under local anesthesia results in fewer complications, a shorter length of hospital stay, and a shorter duration of the operation.
Ahmed Aljabali, Ibrahim Serag, Sherein Diab, Abdulhameed Zeyad Alhadeethi, Mariam Abdelhady, Ibraheem M. Alkhawaldeh, and Mohamed Abouzid
Springer Science and Business Media LLC
Ibrahim Serag, Mohamed Abouzid, Ahmed Elmoghazy, Khalid Sarhan, Saad Ashraf Alsaad, and Rashad G. Mohamed
Springer Science and Business Media LLC
Ibrahim A. Bakry, Mohamed Abouzid, Wei Wei, Jun Jin, Xingguo Wang, Ning Li, Ahmed Fathy Ghazal, Abdelaziz Elbarbary, Amal Gohary, and Ahmed H. Mousa
Elsevier BV
Mohammad Tanashat, Almothana Manasrah, and Mohamed Abouzid
Springer Science and Business Media LLC
Valery L Feigin, Melsew Dagne Abate, Yohannes Habtegiorgis Abate, Samar Abd ElHafeez, Foad Abd-Allah, Ahmed Abdelalim, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi,et al.
Elsevier BV
Hany Atwan, Ibrahim Serag, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Introduction Failed Back Surgery Syndrome (FBSS) presents a formidable challenge, marked by the persistence of chronic lower back pain and leg pain despite undergoing surgical interventions. Multicolumn spinal cord stimulation (m-SCS) has recently emerged as a promising therapeutic strategy for addressing the pain associated with FBSS. This meta-analysis aims to study the efficacy of m-SCS in mitigating chronic back and leg pain among patients with FBSS. Methods A comprehensive search of electronic databases (PubMed, Web of Science, Scopus, Cochrane Library) was conducted to identify relevant studies published up to October 25th, 2023. Inclusion criteria encompassed randomized controlled trials and cohort studies evaluating the outcomes of m-SCS in patients with FBSS. The primary outcome measured was the Visual Analog Scale (VAS) score for low back and leg pain at baseline, six months, and 12 months. Results A total of eight studies, including 271 patients, were analyzed. At six months, there was a statistically significant reduction in the VAS scores for low back pain (MD, 4.76; 95% CI, 3.78 to 5.74) and leg pain (MD, 4.41; 95% CI, 2.93 to 5.90) compared to baseline. Similarly, at 12 months, there was a statistically significant reduction in the VAS scores for low back pain (MD, 4.77; 95% CI, 4.34 to 5.20) and leg pain (MD, 2.78; 95% CI, 0.72 to 4.85) compared to baseline. Conclusion m-SCS effectively manages chronic back and leg pain in FBSS patients, providing sustained pain relief. Studies with more extended follow-up periods and qualitative analysis for the functional outcomes and overall improvement for the patients with FBSS are recommended.
Ibrahim Serag, Mona Mahmoud Elsakka, Mostafa Hossam El din Moawad, Hossam Tharwat Ali, Khalid Sarhan, Sally Shayeb, Islam Nadim, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Background Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics. It is a condition that affects between 0.3% and 0.7% of children, and its pathophysiology remains largely elusive. TS is associated with structural and functional alterations in corticostriatal circuits and neurochemical imbalances. Even though TS is currently incurable, there are established treatment options available, including behavioral therapy and neuroleptics. The use of cannabis-based medicine for tic management is an emerging therapeutic strategy, although its efficacy is still under investigation. It is hypothesized to interact with the endogenous cannabinoid system, but further research is required to ascertain its safety and effectiveness in TS. Aim In our systematic review and meta-analysis, we aim to assess the effectiveness of cannabis-based medicine in the treatment of TS. Methods We searched PubMed, Cochrane, Scopus, and Web of Sciences until February 2024. We included clinical trials and cohort studies investigating the efficacy of cannabis-based medicine in the treatment of TS. Data extraction focused on baseline characteristics of the included studies and efficacy outcomes, including scores on the Yale Global Tic Severity Scale (YGTSS), Premonitory Urge for Tics Scale (PUTS), and Yale-Brown Obsessive Compulsive Scale (Y-BOCS). We conducted the meta-analysis using Review Manager version 5.4. software. We compared the measurements before and after drug intake using mean difference (MD) and 95% confidence interval (CI). Results In total, 357 articles were identified for screening, with nine studies included in the systematic review and 3 in the meta-analysis. These studies involved 401 adult patients with TS treated with cannabis. YGTSS revealed a significant reduction in total scores (MD = -23.71, 95% CI [-43.86 to -3.55], P = 0.02), PUTS revealed a significant decrease in scores (MD = -5.36, 95% CI [-8.46 to -2.27], P = 0.0007), and Y-BOCS revealed no significant difference in score reduction (MD = -6.22, 95% CI [-12.68 to 0.23], P = 0.06). Conclusion The current study indicates promising and potentially effective outcomes with the use of cannabis-based medicine in mitigating the severity of tics and premonitory urges. However, there is a need for larger, placebo-controlled studies with more representative samples to validate these findings.
Mohammad Tanashat, Osama Bisht, Mohamed Abuelazm, Obieda Altobaishat, Ubaid Khan, and Mohamed Abouzid
Ovid Technologies (Wolters Kluwer Health)
Ibrahim Serag, Mariam Abdelhady, Abdelaziz A. Awad, Ahmed Wageeh, Ahmed Shaboub, Rowan H. Elhalag, Ahmed Aljabali, and Mohamed Abouzid
Springer Science and Business Media LLC
Abstract Background Chronic subdural hematoma (CSDH) is a prevalent type of intracranial hemorrhage. Surgical interventions, such as Twist Drill Craniostomy and Burr Hole Craniostomy, are employed for its treatment. However, limited information exists regarding the impact of postoperative head position (supine vs. elevated) on clinical outcomes. We aim to assess whether patients’ head position after surgery influences their prognosis. Method We conducted a PRISMA-compliant systematic review and meta-analysis. Our search encompassed PubMed, Cochrane CENTRAL, Scopus, Web of Science, and Embase databases to identify relevant published studies. Data were meticulously extracted, pooled using a fixed model, and reported as risk ratios (RR) with 95% confidence intervals (CI). Statistical analysis was performed using R and Stata MP v.17. Results Five studies involving 284 patients were included in our meta-analysis. We focused on three primary clinical outcomes, comparing the supine and elevated header positions. Notably, there was no statistically significant difference between the supine and elevated positions in terms of recurrence rate (RR 0.77, 95% CI [0.44, 1.37]), second intervention for recurrence (RR 1.07, 95% CI [0.42, 2.78]) and postoperative complications (RR 1.16, 95% CI [0.70, 1.92]). Conclusion Current studies have proved no difference between supine and elevated bed header positions regarding recurrence rate, second intervention for recurrence, and postoperative complications. Future RCTs with long-term follow-ups are recommended.
Obieda Altobaishat, Mohamed Abouzid, Mostafa Hossam El Din Moawad, Abdulrahman Sharaf, Yazan Al-Ajlouni, Tungki Pratama Umar, Abdallah Bani-salameh, Mohammad Tanashat, Omar Abdullah Bataineh, and Abdulqadir J. Nashwan
Springer Science and Business Media LLC
Abstract Introduction Growth hormone deficiency occurs when the pituitary gland does not produce enough growth hormone. Norditropin®, a recombinant human growth hormone, and Sogroya®, an albumin-binding growth hormone derivative, are prescribed for patients with growth hormone deficiency. This systematic review assesses the efficacy, safety, and patient satisfaction associated with Norditropin and Sogroya. Methods We systematically searched PubMed, Web of Science, and Scopus databases to identify eligible comparative studies. All studies published until June 2023 were included in our analysis. Our outcomes for children included height velocity and height velocity standard deviation score. In contrast, adult outcomes included adverse events, insulin-like growth factor 1-standard deviation score (IGF-1 SDS), and the Treatment Satisfaction Questionnaire for Medication-9 (TSQM-9). Results are reported as odds ratio (OR) and mean difference (MD) with a 95% confidence interval (95% CI). Results Ten studies involving 1058 participants (665 children and 393 adults) were included in the meta-analysis. In children, Norditropin at doses of 0.034 and 0.067 mg/kg/day was compared to Sogroya at doses of 0.04, 0.08, 0.16, and 0.24 mg/kg/week. The results showed that 0.034 mg/kg/day Norditropin had a favorable impact on height velocity (MD −2.01, 95% CI −3.7 to −2.12, p < 0.00001) and height velocity standard deviation score (Mean Difference −3.61, 95% CI −5.06 to −2.16, p < 0.00001) when compared to Sogroya 0.04 mg/kg/day. Other doses showed comparable results. In adults, the only significant side effect noted was rash, which favored Sogroya (OR 0.1, 95% CI 0.04–0.27, p < 0.00001). Additionally, IGF-1 SDS was significantly higher in the Sogroya group than in the Norditropin group (MD 0.25, 95% CI 0.02–0.48, p = 0.03). Furthermore, the overall score of the TSQM-9 questionnaire, which includes three domains: convenience, effectiveness, and satisfaction, was significantly higher in the Sogroya group compared to the Norditropin group (OR 6.36, 95% CI 3.92–8.8, p < 0.00001). Conclusion Norditropin and Sogroya showed comparable efficacy and safety profiles, except for the prevalence of rash in the Norditropin group, and Sogroya has higher satisfaction among adults. More high-quality studies with more patients are required to confirm these results.
Alaa Ramadan and Mohamed Abouzid
Elsevier BV