Fabio Nakano

@usp.br

Professor MS-3 School of Arts Sciences and Humanities - University of Sao Paulo
Universidade de São Paulo

Fabio Nakano


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https://researchid.co/fnakano

RESEARCH, TEACHING, or OTHER INTERESTS

Information Systems, Nephrology
9

Scopus Publications

319

Scholar Citations

9

Scholar h-index

9

Scholar i10-index

Scopus Publications

  • When Wearable Computing Meets Smart Cities: Assistive Technology Empowering Persons With Disabilities
    João Soares de Oliveira Neto, André Luis Meneses Silva, Fábio Nakano, José J. Pérez-Álcazar, Sergio T. Kofuji
    Smart Cities and Smart Spaces Concepts Methodologies Tools and Applications, 2018
    In this chapter, wearables are presented as assistive technology to support persons with disabilities (PwD) to face the urban space in an autonomous and independently way. In the Inclusive Smart City (ISC), everyone has to be able to access visual and audible information that so far are available just for people that can perfectly see and listen. Several concepts and technologies – such as Accessibility and Universal Design, Pervasive Computing, Wearable Computing, Internet of Things, Artificial Intelligence, and Cloud Computing – are associated to achieve this aim. Also, this chapter discusses some examples of use of wearables in the context of Smart Cities, states the importance of these devices to the successful implementation of Inclusive Smart Cities, as well as presenting challenges and future research opportunities in the field of wearables in ISC.
  • Optimization models for reaction networks: Information divergence, quadratic programming and Kirchhoff's laws
    Julio Stern, Fabio Nakano
    Axioms, 2014
    This article presents a simple derivation of optimization models for reaction networks leading to a generalized form of the mass-action law, and compares the formal structure of Minimum Information Divergence, Quadratic Programming and Kirchhoff type network models. These optimization models are used in related articles to develop and illustrate the operation of ontology alignment algorithms and to discuss closely connected issues concerning the epistemological and statistical significance of sharp or precise hypotheses in empirical science.
  • Intentional sampling by goal optimization with decoupling by stochastic perturbation
    Marcelo De Souza Lauretto, Fábio Nakano, Carlos Alberto de Bragança Pereira, Julio Michael Stern
    Aip Conference Proceedings, 2012
  • TORC3: Token-ring clearing heuristic for currency circulation
    Carlos Humes Jr., Marcelo S. Lauretto, Fábio Nakano, Carlos A. B. Pereira, Guilherme F.G. Rafare, et al.
    Aip Conference Proceedings, 2012
  • Hierarchical forecasting with polynomial nets
    M. S. Lauretto, F. Nakano, C. A. B. Pereira, J. M. Stern
    Studies in Computational Intelligence, 2009
  • A straightforward multiallelic significance test for the Hardy-Weinberg equilibrium law
    Marcelo S. Lauretto, Fabio Nakano, Silvio R. Faria Jr, Carlos A.B. Pereira, Julio M. Stern
    Genetics and Molecular Biology, 2009
  • Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence
    Érico T. Costa, Fábio L. Forti, Tatiana G.F. Matos, Alexandre Dermargos, Fábio Nakano, et al.
    Cancer Research, 2008
    Fibroblast growth factor 2 (FGF2) is considered to be a bona fide oncogenic factor, although results from our group and others call this into question. Here, we report that exogenous recombinant FGF2 irreversibly inhibits proliferation by inducing senescence in Ras-dependent malignant mouse cells, but not in immortalized nontumorigenic cell lines. We report the following findings in K-Ras–dependent malignant Y1 adrenocortical cells and H-Ras V12–transformed BALB-3T3 fibroblasts: (a) FGF2 inhibits clonal growth and tumor onset in nude and immunocompetent BALB/c mice, (b) FGF2 irreversibly blocks the cell cycle, and (c) FGF2 induces the senescence-associated β-galactosidase with no accompanying signs of apoptosis or necrosis. The tyrosine kinase inhibitor PD173074 completely protected malignant cells from FGF2. In Y1 adrenal cells, reducing the constitutively high levels of K-Ras-GTP using the dominant-negative RasN17 mutant made cells resistant to FGF2 cytotoxicity. In addition, transfection of the dominant-negative RhoA-N19 into either Y1 or 3T3-B61 malignant cell lines yielded stable clonal transfectants that were unable to activate RhoA and were resistant to the FGF2 stress response. We conclude that in Ras-dependent malignant cells, FGF2 interacts with its cognate receptors to trigger a senescence-like process involving RhoA-GTP. Surprisingly, attempts to select FGF2-resistant cells from the Y1 and 3T3-B61 cell lines yielded only rare clones that (a) had lost the overexpressed ras oncogene, (b) were dependent on FGF2 for proliferation, and (c) were poorly tumorigenic. Thus, FGF2 exerted a strong negative selection that Ras-dependent malignant cells could rarely overcome. [Cancer Res 2008;68(15):6215–23]
  • Genuine Bayesian multiallelic significance test for the Hardy-Weinberg equilibrium law
    Genetics and Molecular Research, 2006
  • Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence
    Laura Beatriz da Silva Cardeal, Carla Abdo Brohem, Tatiana Caroline Silveira Corrêa, Sheila Maria Brochado Winnischofer, Fabio Nakano, et al.
    Biochemistry and Cell Biology, 2006
    Matrix metalloproteinases (MMPs) MMP–2, MMP–9, and MT1-MMP are required for basement membrane degradation in cervical carcinoma. We evaluated the expression and activity of MMPs and their inhibitors RECK and TIMP-2 in 3 human invasive cervical carcinoma cell lines. Two HPV16-positive cell lines (SiHa and CaSki) and an HPV-negative cell line (C33A) were cultured either onto a type-I collagen gel, Matrigel™, or plastic, to recreate their three-dimensional growth environment and evaluate the expression of these genes using quantitative real-time PCR. We also analyzed the gelatinolytic activity of MMP-2 and MMP–9 by zymography. We found that HPV (human papillomavirus)-positive cell lines express higher levels of MMP-2, MT1-MMP, and TIMP-2 than the HPV negative cell line. In addition, MMP-9 was expressed at very low levels in both HPV-negative and HPV-positive cell lines. We also observed that the expression of the RECK gene is higher in CaSki cells, being associated with higher pro-MMP-2 activity. Furthermore, Matrigel™ substrate influences MMP-2 expression in both SiHa and CaSki cells. On the other hand, we found that type-I collagen gel, but not Matrigel™, can enhance pro-MMP-2 activity in all cell lines. Our results suggest that the presence of HPV is related to increased expression of MMP-2, MT1-MMP, and TIMP-2, and that pro-MMP-2 activity is higher in HPV-positive than in HPV-negative cells.

RECENT SCHOLAR PUBLICATIONS

  • Evolução histórica do desempenho energético de tarefas cotidianas em uma distribuição Linux
    AE Launikas, F Nakano, FL Coutinho, D Cordeiro
    Simpósio em Sistemas Computacionais de Alto Desempenho (SSCAD), 81-88 , 2024
    2024
  • Desenvolvimento de um aplicativo para auxílio na tomada de decisão para pequenos agricultores: irrigação
    LMB Solera, DB Goncalves, FND Ribeiro, L Steinert, F Nakano
    Revista Univap 28 (58) , 2022
    2022
  • Estação meteorológica de baixo custo para pequenos agricultores
    LMB Solera, DB Goncalves, F Nakano, LS Freitas, FND Ribeiro
    29º SIICUSP-EACH 2021: Simpósio Internacional de Iniciação Científica e … , 2022
    2022
  • Otimizacao e processos estocasticos aplicados a economia e financas
    JM Stern, CAB Pereira, CO Ribeiro, C Dunder, F Nakano, M Lauretto
    arXiv preprint arXiv:2005.13459 , 2020
    2020
    Citations: 13
  • UMA FERRAMENTA BASEADA EM SEMÂNTICA PARA O APOIO NA NAVEGAÇÃO EM AMBIENTES INTELIGENTES INCLUSIVOS
    JJ Pérez-alcázar, F Nakano, HN Simões, JS Santana, ALM Silva, ...
    CIÊNCIA DA COMPUTAÇÃO: TECNOLOGIAS EMERGENTES EM COMPUTAÇÃO 1, 201-224 , 2020
    2020
  • Protótipo de sensor de movimento e luz com armazenamento de dados na nuvem para o monitoramento do sono
    LY Maruyama, M Pedrazzoli Neto, F Nakano
    Resumos , 2020
    2020
  • Usando Web Semântica para aprimorar a interoperabilidade em Domótica
    JS Santana, F Nakano, JJ Pérez-Alcázar
    Resumos , 2020
    2020
  • Desenvolvimento de componentes de visão computacional para programação por blocos
    CV Bezerril, F Nakano, FL Coutinho
    Resumos , 2020
    2020
  • Otimização de drones para voos em condições atmosféricas diferentes
    TL Terense, F Nakano
    Resumos , 2020
    2020
  • When wearable computing meets smart cities: Assistive technology empowering persons with disabilities
    JS de Oliveira Neto, ALM Silva, F Nakano, JJ Pérez-Álcazar, ST Kofuji
    Smart cities and smart spaces: concepts, methodologies, tools, and … , 2019
    2019
    Citations: 14
  • When Wearable Computing Meets Smart Cities
    JS de Oliveira Neto, ALM Silva, F Nakano, JJ Pérez-Álcazar, ST Kofuji
    2018
  • Abordagem semântica para o desenvolvimento de sistemas de suporte a ambientes inteligentes inclusivos
    FM Magami, JJ Pérez-Alcazar, F Nakano, ALM Silva, JS de Oliveira Neto, ...
    Simpósio Brasileiro de Computação Ubíqua e Pervasiva (SBCUP), 898-907 , 2017
    2017
    Citations: 1
  • Evasão de estudantes de enfermagem: desempenho acadêmico como fator preditor
    CHS Sigaud, LA Digiampietri, F Nakano, MS Lauretto
    Anais , 2017
    2017
  • Mineração de Dados Educacionais para a Revisão de Pré-Requisitos
    LA Digiampietri, F Nakano, M de Souza Lauretto
    Anais , 2017
    2017
  • Para vestir a cena contemporânea: século XVIII: desdobramentos artísticos a partir de um traje do século XVIII
    F Viana, IC Italiano, F Nakano
    Anais , 2017
    2017
  • P4040 Computer analysis of genetic parentage: application in equine diversity maintenance in Brazil
    A Atomiyama, MS Lauretto, F Nakano, JM Stern, D Levy, SP Bydlowski, ...
    Journal of Animal Science 94 (suppl_4), 98-98 , 2016
    2016
  • Estratégia de Análise Quantitativa para Revisao de Pré-requisitos em uma Matriz Curricular do Curso de Bacharelado em Sistemas de Informaçao
    LA Digiampietri
    iSys , 2016
    2016
    Citations: 2
  • Mineraçao de dados para identificaçao de alunos com alto risco de evasao: Um estudo de caso
    LA Digiampietri, F Nakano, M de Souza Lauretto
    Revista de Graduação USP 1 (1), 17-23 , 2016
    2016
    Citations: 30
  • Análise Quantitativa para Revisão de Pré-requisitos na Matriz Curricular do Curso de Sistemas de Informação da EACH/USP
    M de Souza Lauretto, LA Digiampietri, F Nakano
    PRÓ-REITORIA DE GRADUAÇÃO , 2016
    2016
  • Mineração de Dados Educacionais na Identiicação de Alunos com Alto Risco de Evasão
    LA Digiampietri, F Nakano, M de Souza Lauretto
    PRÓ-REITORIA DE GRADUAÇÃO , 2016
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence
    LBS Cardeal, CA Brohem, TCS Corrêa, SMB Winnischofer, F Nakano, ...
    Biochemistry and cell biology 84 (5), 713-719 , 2006
    2006
    Citations: 66
  • Intentional sampling by goal optimization with decoupling by stochastic perturbation
    MS Lauretto, F Nakano, CAB Pereira, JM Stern
    AIP Conference Proceedings 1490 (1), 189-201 , 2012
    2012
    Citations: 48
  • A straightforward multiallelic significance test for the Hardy-Weinberg equilibrium law
    MS Lauretto, F Nakano, SR Faria Jr, CAB Pereira, JM Stern
    Genetics and Molecular Biology 32 (3), 619-625 , 2009
    2009
    Citations: 48
  • Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence
    ÉT Costa, FL Forti, TGF Matos, A Dermargos, F Nakano, J Salotti, ...
    Cancer Research 68 (15), 6215-6223 , 2008
    2008
    Citations: 33
  • Mineraçao de dados para identificaçao de alunos com alto risco de evasao: Um estudo de caso
    LA Digiampietri, F Nakano, M de Souza Lauretto
    Revista de Graduação USP 1 (1), 17-23 , 2016
    2016
    Citations: 30
  • Genuine Bayesian multiallelic significance test for the Hardy-Weinberg equilibrium law
    CAB Pereira, F Nakano, JM Stern, MR Whittle
    Genet Mol Res 5, 619-631 , 2006
    2006
    Citations: 18
  • When wearable computing meets smart cities: Assistive technology empowering persons with disabilities
    JS de Oliveira Neto, ALM Silva, F Nakano, JJ Pérez-Álcazar, ST Kofuji
    Smart cities and smart spaces: concepts, methodologies, tools, and … , 2019
    2019
    Citations: 14
  • Otimizacao e processos estocasticos aplicados a economia e financas
    JM Stern, CAB Pereira, CO Ribeiro, C Dunder, F Nakano, M Lauretto
    arXiv preprint arXiv:2005.13459 , 2020
    2020
    Citations: 13
  • Complementando o aprendizado em programaçao: Experiências no curso de sistemas de informaçao da USP
    LA Digiampietri, SM Peres, F Nakano, NT Roman, BBC Silva, B Teodoro, ...
    Simpósio Brasileiro de Sistemas de Informação (SBSI), 540-551 , 2012
    2012
    Citations: 12
  • Hierarchical forecasting with polynomial nets
    MS Lauretto, F Nakano, CAB Pereira, JM Stern
    New Advances in Intelligent Decision Technologies: Results of the First KES … , 2009
    2009
    Citations: 8
  • Optimization models for reaction networks: information divergence, quadratic programming and Kirchhoff’s laws
    JM Stern, F Nakano
    Axioms 3 (1), 109-118 , 2014
    2014
    Citations: 6
  • REAL: real attribute learning algorithm
    JM Stern, CO Ribeiro, MS Lauretto, F Nakano
    Procedings of ISAS-98±International Conference on Information Systems … , 1998
    1998
    Citations: 5
  • Complementando o aprendizado em programaçao: Revisitando experiências no curso de sistemas de informaçao da usp
    LA Digiampietri, SM Peres, F Nakano, NT Roman, PK Wagner, BBC Silva, ...
    iSys-Journal of Information Systems 6, 5-29 , 2013
    2013
    Citations: 3
  • Estratégia de Análise Quantitativa para Revisao de Pré-requisitos em uma Matriz Curricular do Curso de Bacharelado em Sistemas de Informaçao
    LA Digiampietri
    iSys , 2016
    2016
    Citations: 2
  • TORC3 : Token-ring clearing heuristic for currency circulation
    C Humes Jr, MS Lauretto, F Nakano, CAB Pereira, GFG Rafare, JM Stern
    AIP conference proceedings 1490 (1), 179-188 , 2012
    2012
    Citations: 2
  • Avaliação da eficiência dos processos de tratamento de efluentes de estações de Tratamento de Esgoto da Sabesp de Caraguatatuba/SP, usando reatores com aeradores submersíveis e …
    FDEP NAKANO
    Escola de engenharia de Lorena–EEL/USP , 2012
    2012
    Citations: 2
  • Um novo modelo para cálculo de probabilidade de paternidade-concepção e implementação
    F Nakano
    Universidade de São Paulo , 2006
    2006
    Citations: 2
  • Abordagem semântica para o desenvolvimento de sistemas de suporte a ambientes inteligentes inclusivos
    FM Magami, JJ Pérez-Alcazar, F Nakano, ALM Silva, JS de Oliveira Neto, ...
    Simpósio Brasileiro de Computação Ubíqua e Pervasiva (SBCUP), 898-907 , 2017
    2017
    Citations: 1
  • Análise do Histórico Escolar dos Estudantes Visando à Adaptação Curricular e do Processo de Ensino e Avaliação
    LA Digiampietri, MS LAURETTO, F NAKANO
    1º CONGRESSO DE GRADUAÇÃO DA UNIVERSIDADE DE SÃO PAULO, 265-266 , 2015
    2015
    Citations: 1
  • Hierarchical Forecasting with Functional Trees
    M Lauretto, F Nakano, CAB Pereira, JM Stern, M de Souza Lauretto, ...
    AIP Conference Proceedings 1073 (1), 317 , 2008
    2008
    Citations: 1