Electrochemical Biosensors in Hepatocellular Carcinoma: Diagnostic Advances and Pharmacological Perspectives Ramaiyan Velmurugan, Yokesh Shanmugam, Patibandla Jahnavi, Rajeshwar Vodeti, Elias Joel Mart, Konatham Teja Kumar Reddy, Balaji Pandiyan, Soniya Rani, Prem Shankar Gupta, Lokeshvar Ravikumar, Rahul Ambati Biomedical and Pharmacology Journal, 2025 Liver cancer, particularly hepatocellular carcinoma (HCC), has a poor prognosis and a high fatality rate, making it a serious global health issue that is primarily caused by late stage finding. Despite the widespread use of alpha-fetoprotein (AFP) and other conventional biomarkers, their low specificity and sensitivity, especially in the initial stages of disease, highlight the urgent need for improved diagnostic methods. In recent years, the development of novel protein (e.g., glypican-3, des-gamma-carboxy prothrombin) and genetic (e.g., microRNAs, circulating tumor DNA, long non-coding RNAs) biomarkers has significantly enhanced the prospects for HCC surveillance and early detection. Because of their great sensitivity, quick reaction time, and potential for point-of-care use, electrochemical biosensors have demonstrated remarkable promise among developing technologies. Significant advances in detection limits, frequently approaching femtogram levels and dynamic ranges, have been made possible by developments in nanomaterials, surface modification methods, and biorecognition components like aptamers and molecularly imprinted polymers. These innovations have enabled multiplexed and label-free sensing approaches that integrate with microfluidic platforms for more efficient, cost-effective diagnostics. Despite considerable progress, challenges such as reproducibility in complex biological matrices, standardization, and clinical validation remain. Future directions include the incorporation of artificial intelligence for signal processing, development of intelligent materials, and scalable fabrication methods for clinical translation. Overall, electrochemical biosensing represents a transformative approach in liver cancer diagnostics, providing fresh approaches to better patient outcomes, individualized care, and early identification.
Challenges and future perspective of illicit drug sensors and strategies Konatham Teja Kumar Reddy, G. Dharmamoorthy, Jeetendra Kumar Gupta, L. Karpagavalli, Selvaraja Elumalai, Shaik Kareemulla, M. Jeevitha, Karthickeyan Krishnan Nanotechnology Based Sensing Platforms for Illicit Drugs, 2025
Synthesis Strategies of Doped QDs Konatham Teja Kumar Reddy, A. Venkata Badarinath, Jeetendra Kumar Gupta, Yeluguri Manikanta, Nagam Santhi Priya, G. Vamseekrishna, Jimmy Alex, Alapati Sahithi Engineering Materials, 2024
Discovery and History of Quantum Dots Konatham Teja Kumar Reddy, B. Madhavi Latha, Jeetendra Kumar Gupta, A. Chaitanya, P. Srinivasa Babu, Vamseekrishna. G., Yeluguri Manikanta, Alapati Sahithi Engineering Materials, 2024
Magnetic Polymer Composites for Soft Robotics Anasuya Patil, A. Venkata Badarinath, Narayana Raju Padala, Kavati Ramkrishna, A. Raju, Rasapelly Ramesh Kumar, H. N. Deepakumari, Konatham Teja Kumar Reddy Magnetic Polymer Composites and their Emerging Applications, 2024
Cytotoxicity of Quantum Dots Based Nanocomposites Konatham Teja Kumar Reddy, N. Venkatesan, M. V. Saranya, Jeevanandham Somasundaram, Jeetendra Kumar Gupta, Nagam Santhi Priya, Prakash Srichand Sukhramani, Anasuya Patil Engineering Materials, 2024
Supercritical Fluid Extraction: A Green and Sustainable Approach for the Isolation of High-Value Compounds from Natural Sources KTKR Patibandla Jahnavi, Somasundaram Indirabanu , Ronald Darwin Chellappan ... Asian Journal of Green Chemistry 9 (5), 605-629 , 2026 2026 Citations: 8
Targeting NF-κB and JAK/STAT pathways in rheumatoid arthritis: emerging nanocarrier-based drug delivery approaches G Surendra, JK Gupta, E Susithra, AC Jesudoss Prabhakaran, ... Inflammopharmacology, 1-19 , 2026 2026
Computational Identification of Natural Product–Based Aryl Hydrocarbon Receptor Modulators for Psoriasis Therapy KTK Reddy, G Surendra, EJ Mart, RH Babu, MSA SA, P Erukulla, ... Chem. Methodol 10 (4), 450-464 , 2026 2026 Citations: 1
Emerging Analytical Techniques for Detection of Environmental Pollutants: A Review P Erukulla, PVN Raju, KTK Reddy, VR Singamaneni, A Pathak, SK Yadav, ... 2026 Citations: 2
Electrochemical Biosensors in Hepatocellular Carcinoma: Diagnostic Advances and Pharmacological Perspectives R Velmurugan, Y Shanmugam, P Jahnavi, R Vodeti, EJ Mart, KTK Reddy Biomedical and Pharmacology Journal 18 (4), 2551-2570 , 2025 2025
Mechanistic insights into plant-derived natural compounds for the treatment of skin cancer: Targeting molecular signaling for therapeutic intervention A Pathak, G Surendra, SB Sridhar, P Jahnavi, JK Gupta, P Balaji, ... Pathology-Research and Practice, 156277 , 2025 2025 Citations: 1
Alkaloids as neuroprotectors: Targeting signaling pathways in neurodegenerative diseases BK Utpal, M Al Amin, M Zehravi, SH Sweilam, UVNV Arjun, YB Madhuri, ... Molecular and Cellular Biochemistry 480 (8), 4587-4612 , 2025 2025 Citations: 24
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus M Faysal, M Al Amin, M Zehravi, SH Sweilam, UVNV Arjun, JK Gupta, ... Naunyn-Schmiedeberg's Archives of Pharmacology 398 (7), 8215-8240 , 2025 2025 Citations: 19
ASSESSMENT OF ANTI-HYPERLIPIDEMIC POTENTIAL OF OCIMUM SANCTUM AND TRACHYSPERMUM AMMI IN HIGH FAT DIET INDUCED HYPERLIPIDEMIA. DE Tony, S Musharaff, AA Reddy, K Reddy, R Lohith, A Sai Mohan, ... Biochemical & Cellular Archives 25 (1) , 2025 2025
Biochemical Engineering of Green Nanomaterials for Targeted Drug Delivery and Therapeutic Applications PJ Rasapelly Ramesh Kumar , Karthickeyan Krishnan , Gowri Sankararao Burle ... Journal of Chemical Reviews 7 (2), 191-215 , 2025 2025 Citations: 10
Sustainable Extraction and Purification of Phytochemicals: A Review of Green Solvents and Techniques UVNVA Ronald Darwin , Rajachandrasekhar Valmon , Sivanna Chithanna , Sri ... Chemical Methodologies 9 (5), 356-385 , 2025 2025 Citations: 15
Bio-Inspired Green Synthesis of Nanoparticles for Psoriasis Treatment: A Review of Current Status and Future Directions Uppuluri Varuna Naga Venkata Arjun , Nithin Vidiyala , Pavani Sunkishala ... Asian Journal of Green Chemistry 9 (4), 373-403 , 2025 2025 Citations: 13
Revolutionizing diabetes care: the role of marine bioactive compounds and microorganisms KTK Reddy, K Rakesh, S Prathyusha, JK Gupta, K Nagasree, ... Cell biochemistry and biophysics 83 (1), 193-213 , 2025 2025 Citations: 6
Bioanalytical method development for monoclonal antibodies: advances and challenges SDM Kallam, A Bodapati, AS Reddy, KTK Reddy Cellular, Molecular and Biomedical Reports 5 (1), 48-62 , 2025 2025 Citations: 2
Recent breakthroughs in drug delivery systems for targeted cancer therapy: an overview KTK Reddy, AS Reddy Cellular, Molecular and Biomedical Reports 5 (1), 13-27 , 2025 2025 Citations: 58
Phytoconstituent-Based Green Synthesis of Nanoparticles: Sources and Biomedical Applications in Cancer Therapy SK Konatham Teja Kumar Reddy , G. Dharmamoorthy , Dasari Vasavi Devi ... Asian Journal of Green Chemistry 9 (3), 329-354 , 2025 2025 Citations: 11
In Depth in Silico Exploration of Some Natural Indole Alkaloids as Potential Plasmepsin II Inhibitors: ADMET Calculations, Molecular Docking Analysis, Molecular Dynamics … GP Konatham Teja Kumar Reddy, , Uppuluri Varuna Naga Venkata Arjun, Jehad F ... Chemical Methodologies 9 (4), 277-300 , 2025 2025 Citations: 2
Phyto-Nanotechnology for Cancer Therapy: A Review of Plant-Mediated Organic Nanoparticles for Targeted Drug Delivery Abdul Ajeed Mohathasim Billah , Ramenani Hari Babu , Kiran Khanna D ... Journal of Chemical Reviews 7 (2), 131-165 , 2025 2025 Citations: 3
Unlocking the potential of receptor-based approaches in diabetes treatment M Patwekar, F Patwekar, JP Kumar, PD Prasad, N Malik, AV Badarinath, ... BIO Integration 6 (1), 999 , 2025 2025 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Recent breakthroughs in drug delivery systems for targeted cancer therapy: an overview KTK Reddy, AS Reddy Cellular, Molecular and Biomedical Reports 5 (1), 13-27 , 2025 2025.0 Citations: 58
Develop and validate a highly sensitive method for the estimation of Molnupiravir in rat plasma by highperformance liquid chromatography-tandem mass spectroscopy and its … KTK Reddy, MA Haque Journal of Pharmaceutical Negative Results 13 , 2022 2022.0 Citations: 32
Determination of sodium, potassium, and magnesium as sulfate salts in oral preparations using ion chromatography and conductivity detection SR Yelampalli, K Gandla, KTK Reddy, AE Ibrahim, S El Deeb Separations 10 (2), 99 , 2023 2023.0 Citations: 31
PACLITAXEL NANOSPONGES'FORMULA AND IN VITRO EVALUATION JP Kumar, Y Ismail, KTK Reddy, UP Panigrahy, P Shanmugasundaram, ... Journal of Pharmaceutical Negative Results 13 (7), 2733-2740 , 2022 2022.0 Citations: 29
Novel Vesicular Drug Delivery Systems Proniosomes KTK Reddy, K Gandla Open Access journal of pharmaceutical Research 6 (3) , 2022 2022.0 Citations: 29
A critical review on bioanalytical method development and validation of few oncology drugs by using LC-MS-MS KTK Reddy, K Gandla, PV Babu, MVK Chakravarthy, P Chandrasekhar, ... Journal of Pharmaceutical Negative Results 13 (1), 16-27 , 2022 2022.0 Citations: 28
Bioanalytical method development and validation of atrasentan in human plasma using verapamil as internal standard by liquid chromatography coupled with tandem mass spectrometry Konatham Teja Kumar Reddy International journal of health sciences 6 (8), 625-638 , 2022 2022.0 Citations: 27
Alkaloids as neuroprotectors: Targeting signaling pathways in neurodegenerative diseases BK Utpal, M Al Amin, M Zehravi, SH Sweilam, UVNV Arjun, YB Madhuri, ... Molecular and Cellular Biochemistry 480 (8), 4587-4612 , 2025 2025.0 Citations: 24
A review of artificial intelligence in treatment of COVID-19 K Gandla, KTK Reddy, PV Babu, R Sagapola, P Sudhakar Journal of Pharmaceutical Negative Results 13 (01), 254-264 , 2022 2022.0 Citations: 21
Development and Validation of a High Throughput Lc-Ms/Ms Method for Quantitation of Ipilimumab in Human Plasma KTK Reddy, MA Haque Citations: 21
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus M Faysal, M Al Amin, M Zehravi, SH Sweilam, UVNV Arjun, JK Gupta, ... Naunyn-Schmiedeberg's Archives of Pharmacology 398 (7), 8215-8240 , 2025 2025.0 Citations: 19
A Systematic Review on Method Development and Validation of Few Antiviral Drugs by Using RP-HPLC TKR Konatham Ijppr. Human 21 (3), 651-661 , 2021 2021.0 Citations: 18
a stability indicating method development and validation of Telmisartan and Nifedipine in pure form using RP-HPLC TKR Konatham, M Anuradha, A Narmada International Journal of Pharmaceutical, Biological and Chemical Sciences 9 … , 2020 2020.0 Citations: 17
Sustainable Extraction and Purification of Phytochemicals: A Review of Green Solvents and Techniques UVNVA Ronald Darwin , Rajachandrasekhar Valmon , Sivanna Chithanna , Sri ... Chemical Methodologies 9 (5), 356-385 , 2025 2025.0 Citations: 15
A REVIEW ON VIRUSES THAT ORIGINATED FROM CHINA; SARS, MERS AND COVID-19 TK Konatham, K Satyanarayana Reddy, A Masipogu, N Vallakeerthi World Journal of Pharmaceutical Research 9 (5), 2010-2015 , 2020 2020.0 Citations: 15
Bio-Inspired Green Synthesis of Nanoparticles for Psoriasis Treatment: A Review of Current Status and Future Directions Uppuluri Varuna Naga Venkata Arjun , Nithin Vidiyala , Pavani Sunkishala ... Asian Journal of Green Chemistry 9 (4), 373-403 , 2025 2025.0 Citations: 13
Recent advancements in hyperthermia-driven controlled drug delivery from nanotherapeutics MS Baig, MA Haque, TKR Konatham, BD Mohammad, BA Yahya, ... Recent Advances in Drug Delivery and Formulation: Formerly Recent Patents on … , 2022 2022.0 Citations: 12
Phytoconstituent-Based Green Synthesis of Nanoparticles: Sources and Biomedical Applications in Cancer Therapy SK Konatham Teja Kumar Reddy , G. Dharmamoorthy , Dasari Vasavi Devi ... Asian Journal of Green Chemistry 9 (3), 329-354 , 2025 2025.0 Citations: 11
Cellular stress response and neuroprotection of flavonoids in neurodegenerative diseases: Clinical insights into targeted therapy and molecular signaling pathways BK Utpal, B Sutradhar, M Zehravi, SH Sweilam, TP Durgawale, ... Brain Research 1847, 149310 , 2025 2025.0 Citations: 11