Histology, Embryology, Reproductive Medicine, Cancer Research
39
Scopus Publications
2590
Scholar Citations
26
Scholar h-index
35
Scholar i10-index
Scopus Publications
The Distribution of Foxp3 and CD68 in Preeclamptic and Healthy Placentas: A Histomorphological Evaluation Yasemin Ersoy Canillioglu, Gozde Erkanli Senturk, Hakan Sahin, Sadik Sahin, Yasemin Seval-Celik Journal of Histochemistry and Cytochemistry, 2023 Preeclampsia is a complication of pregnancy that affects 3–5% of pregnancies and is one of the major causes of maternal/neonatal mortality and morbidities worldwide. We aimed to investigate the distribution of Foxp3+ regulatory T-cells and CD68+ Hofbauer cells in the placenta of preeclamptic and healthy pregnant women with a special focus on correlating these findings with placental histology. Decidua and chorionic villi of the placenta obtained from healthy and preeclamptic pregnancies were evaluated in full-thickness sections. Sections were stained with hematoxylin and eosin and Masson’s trichrome and immunostained for Foxp3 and CD68 for histological analyses. The total histomorphological score for placentas was found to be higher in preeclamptic placentas than that in the controls. The CD68 immunoreactivity was higher in the chorionic villi of preeclamptic placentas than that in the controls. The immunoreactivity of Foxp3 was found widely distributed within the decidua in both the groups and did not differ significantly. Interestingly, Foxp3 immunoreactivity in the chorionic villi was found mainly in the villous core and, to a lesser extent, in the syncytiotrophoblasts. We found no significant relation between Foxp3 expressions and morphological changes observed in preeclamptic placentas. Although extensive research is being carried out regarding the pathophysiology of preeclampsia, the findings are still controversial.
Multidisciplinary case-based small group discussions to integrate basic medical sciences with clinical situations Ilgi Semin, Dilek Ersil Soysal, Yasemin Seval-Celik, Murvet Hayran, Ayse Banu Demir, Ali Burak Ozkaya, Sevinc V. Inan, Gul Akdogan Turkish Journal of Biochemistry, 2022 Objectives Integration of the basic medical sciences with clinical medicine motivates medical students by showing how the fundamental concepts they have learned will come into their future practice. In this context, we created clinical integration sessions (CIS) in our first-year medical curriculum. Methods The instructors of different disciplines wrote the clinical scenarios together. The scenarios were discussed in five sessions with 39 first-year students. The first session’s scenario consisted of four brief “anemia” cases. The next four sessions included a single case, according to the feedback of the students. Students formed groups of 7–8 participants. In the first 2 h, the scenarios were discussed in the groups and questions were answered by the students. In the third hour, the instructors answered the questions together with the students. After the first CIS, written feedback obtained from the students via a survey. Results The survey provided positive feedback on the benefits of active learning within small group discussions, and most of the students thought that their background was sufficient to solve the cases, with some literature search. Conclusion The scenarios, which provide multidisciplinary integration of basic medical sciences and clinical medicine, can be useful educational materials.
Expression of vascular endothelial growth factor and transforming growth factor alpha in rat testis during chronic renal failure Yasemin Seval-Celik, Gokhan Akkoyunlu, Erdogan Kocamaz, Ismail Turker Köksal, Sibel Özer, Mehmet Baykara, Ramazan Demir Folia Histochemica Et Cytobiologica, 2014 INTRODUCTION: Vascular endothelial growth factor (VEGF) is known to influence testis function. Transforming growth factor alpha (TGF-α) is expressed in the postnatal testis, and has been demonstrated to stimulate testis development. Systemic diseases such as chronic renal failure (CRF) interfere with hypothalamic-pituitary-gonadal axis, which may cause defective steroidogenesis and gonadal functions. The aim of this study was to investigate the expression and localization of VEGF and TGF-α in testicular tissues of experimental CRF model. MATERIAL AND METHODS: Experimental CRF was induced in rats by the resection of more than 85% of renal mass. The expression of VEGF and TGF-α in testicular tissues were assessed by immunohistochemistry on paraffin sections of control, CRF-nondialysed and CRF-dialysed rats. RESULTS: The microscopic evaluation of the testicular structure showed that CRF did not affect testicular histology. Immunohistochemical evaluation showed that VEGF was expressed in the cytoplasm of primary and secondary spermatocyte series as well as the early spermatids. Staining intensity was lower in spermatocytes going through the first meiotic division. TGF-α was expressed in the nuclei of spermatogonia and primary spermatocytes with stronger staining intensity in spermatogonia. The intensity of VEGF staining was similar in control and experimental animals, however, TGF-α expression was lower in the CRF group. CONCLUSIONS: The continuous expression of VEGF in spermatocytes and spermatids suggests that the applied model of CRF does not directly disrupt morphology of seminiferous epithelium, thus also spermiogenesis. However, difference between control rats and CRF group in TGF-α immunopositivity, which was localised in spermatogonial mitosis step, may suggest the interference of CRF with early stages of spermatogenesis.
Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of parkinson's disease Gulay Hacioglu, Yasemin Seval-Celik, Gamze Tanriover, Ozlem Ozsoy, Esen Saka-Topcuoglu, Sevin Balkan, Aysel Agar Folia Histochemica Et Cytobiologica, 2012 Docosahexaenoic acid (DHA), a major polyunsaturated fatty acid (PUFA) in the phospholipid fraction of the brain, is essential for normal cellular function. Neurodegenerative disorders such as Parkinson's disease (PD) often exhibit significant declines in PUFAs. The aim of this study was to observe the effects of DHA supplementation in an experimental rat model of PD created with '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine' (MPTP). Adult male Wistar rats were divided into four groups: (1) Control; (2) DHA-treated; (3) MPTP-induced; and (4) MPTP-induced + DHA-treated. Motor activity was investigated using the 'vertical pole' and 'vertical wire' tests. The dopaminergic lesion was determined by immunohistochemical analysis for tyrosine hydroxylase (TH)-immunopositive cells in substantia nigra (SN). Immunoreactivities of Bcl-2, Akt and phosphorylated-Akt (p-Akt) in SN were evaluated by immunohistochemistry. MPTP-induced animals exhibited decreased locomotor activity, motor coordination and loss of equilibrium. Diminished Parkinsonism symptoms and decreased dopaminergic neuron death were detected in the MPTP-induced + DHA-treated group compared to the MPTP-induced group. Moderate decreases in Akt staining were found in the MPTP-induced and MPTP-induced + DHA-treated groups compared to controls. p-Akt immunoreactivity decreased dramatically in the MPTP-induced group compared to the control; however, it was increased in the MPTP-induced + DHA-treated group compared to the MPTP-induced group. The staining intensity for Bcl-2 decreased prominently in the MPTP-induced group compared to the control, while it was stronger in the MPTP-induced + DHA-treated group compared to the MPTP-induced group. In conclusion, DHA significantly protects dopaminergic neurons against cell death in an experimental PD model. Akt/p-Akt and Bcl-2 pathways are related to this protective effect of DHA in experimental PD.
The distribution of Foxp3 and CD68 in Preeclamptic and Healthy Placentas: a histomorphological evaluation Y Ersoy Canillioglu, GE Senturk, H Sahin, S Sahin, Y Seval-Celik Journal of Histochemistry & Cytochemistry 71 (4), 211-225 , 2023 2023 Citations: 3
Multidisciplinary case-based small group discussions to integrate basic medical sciences with clinical situations I Semin, DE Soysal, Y Seval-Celik, M Hayran, AB Demir, AB Ozkaya, ... Turkish Journal of Biochemistry 47 (2), 187-190 , 2022 2022 Citations: 2
Repeated acetaminophen administration damaged hippocampal tissue but did not affect prefrontal cortex or anxiety behaviors A Karakilic, S Kizildag, Z Yuce, Y Celik, S Kandis, H Bozan, B Koc, ... Acta Neurobiologiae Experimentalis 82 (2), 170-178 , 2022 2022 Citations: 3
Tıp Eğitiminde COVID-19 Pandemi Etkisi:" İzmir Ekonomi Üniversitesi Tıp Fakültesi Deneyimi" I Bezircioglu, GD Horasan, Y Seval-çelik, GG Akdoğan, M Hayran, S İnan, ... Tıp Eğitimi Dünyası 20 (60-1), 102-108 , 2021 2021 Citations: 7
BÖLÜM 25 Sindirim Sistemi I M GÜL, M KURUŞ, S AKYOL BAHÇECİ, V İNAN, H HAYRAN, A DEMİR, ... Akademisyen Kitabevi , 2020 2020
Investigation of the Effect of Repeated Acetaminophen Usage on Hippocampus, Prefrontal Cortex and Liver Igf-1 and Mmp-2 Levels in Rats A Karakilic, S Kizildag, Z Yuce, Y Seval Çelik, S Kandis, HR Bozan, B Koc, ... Acta Physiologica , 2019 2019
PP-018 APPLYING TEAM-BASED LEARNING FOR THE INTEGRATION OF BASIC MEDICAL DISCIPLINES ON TOPC “THE CELL:” A PILOT EVALUATION GG Akdoğan, MY Kartal, YS Çelik, B Demir, AB Özkaya, S İnan, ... Turkish Journal of Biochemistry 43 (s4), 23-24 , 2018 2018
p38 Mitogen-activated protein kinase is involved in the pathogenesis of endometriosis by modulating inflammation, but not cell survival H Cakmak, Y Seval-Celik, S Arlier, O Guzeloglu-Kayisli, F Schatz, A Arici, ... Reproductive Sciences 25 (4), 587-597 , 2018 2018 Citations: 39
PP-023 Multidisciplinary Case-Based Small Group Discussions to Integrate Basic Medical Sciences with Clinical Situations M Hayran Turkish Journal of Biochemistry , 2018 2018
Expression of vascular endothelial growth factor and transforming growth factor alpha in rat testis during chronic renal failure Y Seval-Celik, G Akkoyunlu, E Kocamaz, IT Köksal, S Özer, M Baykara, ... Folia histochemica et cytobiologica 52 (4), 308-316 , 2014 2014 Citations: 4
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis H Cakmak, M Basar, Y Seval-Celik, KG Osteen, AJ Duleba, HS Taylor, ... Reproductive sciences 19 (6), 572-579 , 2012 2012 Citations: 59
Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease G Hacioglu, Y Seval-Celik, G Tanriover, O Ozsoy, E Saka-Topcuoglu, ... Folia histochemica et cytobiologica 50 (2), 228-238 , 2012 2012 Citations: 57
The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease O Ozsoy, Y Seval-Celik, G Hacioglu, P Yargicoglu, R Demir, A Agar, ... Neurochemistry international 59 (5), 664-670 , 2011 2011 Citations: 79
Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis J Luk, Y Seval, M Ulukus, EC Ulukus, A Arici, UA Kayisli Reproductive Sciences 17 (3), 278-287 , 2010 2010 Citations: 36
The effects of eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol diet S Cayli, L Sati, Y Seval-Celik, MA Tuncer, B Yaymaci, Z Berkman, T Altug, ... Histology and histopathology 25 (1), 141 , 2010 2010 Citations: 16
The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. G Tanriover, Y Seval-Celik, O Ozsoy, G Akkoyunlu, F Savcioglu, ... Folia histochemica et cytobiologica 48 (3), 434-441 , 2010 2010 Citations: 84
Lung surfactant proteins in the early human placenta L Sati, Y Seval-Celik, R Demir Histochemistry and cell biology 133 (1), 85-93 , 2010 2010 Citations: 39
Differential regulation of Akt phosphorylation in endometriosis O Cinar, Y Seval, YH Uz, H Cakmak, M Ulukus, UA Kayisli, A Arici Reproductive biomedicine online 19 (6), 864-871 , 2009 2009 Citations: 94
The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta L Sati, Y Seval-Celik, G Unek, ET Korgun, R Demir Placenta 30 (10), 848-854 , 2009 2009 Citations: 24
CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta G Tanriover, Y Seval, L Sati, M Gunel, N Demir Histology and histopathology 24 (10), 1287 , 2009 2009 Citations: 10
MOST CITED SCHOLAR PUBLICATIONS
Vasculogenesis and angiogenesis in the early human placenta R Demir, Y Seval, B Huppertz Acta histochemica 109 (4), 257-265 , 2007 2007 Citations: 373
Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis R Demir, UA Kayisli, Y Seval, C Celik-Ozenci, ET Korgun, ... Placenta 25 (6), 560-572 , 2004 2004 Citations: 299
Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis Y Seval, ET Korgun, R Demir Placenta 28 (8-9), 841-845 , 2007 2007 Citations: 181
Distribution patterns of matrix metalloproteinase (MMP)-2 and-9 and their inhibitors (TIMP-1 and TIMP-2) in the human decidua during early pregnancy Y Seval, G Akkoyunlu, R Demir, M Asar Acta histochemica 106 (5), 353-362 , 2004 2004 Citations: 120
The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta Y Seval, L Sati, C Celik-Ozenci, O Taskin, R Demir Placenta 29 (9), 809-815 , 2008 2008 Citations: 117
Regulation of angiogenic activity of human endometrial endothelial cells in culture by ovarian steroids UA Kayisli, J Luk, O Guzeloglu-Kayisli, Y Seval, R Demir, A Arici The Journal of Clinical Endocrinology & Metabolism 89 (11), 5794-5802 , 2004 2004 Citations: 113
Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium Y Seval, H Cakmak, UA Kayisli, A Arici The Journal of Clinical Endocrinology & Metabolism 91 (6), 2349-2357 , 2006 2006 Citations: 105
Differential regulation of Akt phosphorylation in endometriosis O Cinar, Y Seval, YH Uz, H Cakmak, M Ulukus, UA Kayisli, A Arici Reproductive biomedicine online 19 (6), 864-871 , 2009 2009 Citations: 94
Expression of interleukin-8 receptors in endometriosis M Ulukus, EC Ulukus, Y Seval, W Zheng, A Arici Human reproduction 20 (3), 794-801 , 2005 2005 Citations: 89
The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. G Tanriover, Y Seval-Celik, O Ozsoy, G Akkoyunlu, F Savcioglu, ... Folia histochemica et cytobiologica 48 (3), 434-441 , 2010 2010 Citations: 84
The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease O Ozsoy, Y Seval-Celik, G Hacioglu, P Yargicoglu, R Demir, A Agar, ... Neurochemistry international 59 (5), 664-670 , 2011 2011 Citations: 79
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability PC Piotrowski, J Kwintkiewicz, IJ Rzepczynska, Y Seval, H Cakmak, ... Biology of reproduction 75 (1), 107-111 , 2006 2006 Citations: 77
Matrix metalloproteinases-2,-3 and-9 in human term placenta AY Demir-Weusten, Y Seval, P Kaufmann, R Demir, G Yucel, B Huppertz Acta histochemica 109 (5), 403-412 , 2007 2007 Citations: 75
Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis EC Ulukus, M Ulukus, Y Seval, W Zheng, A Arici Human Reproduction 20 (10), 2958-2963 , 2005 2005 Citations: 65
Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis J Luk, Y Seval, UA Kayisli, M Ulukus, CE Ulukus, A Arici The Journal of Clinical Endocrinology & Metabolism 90 (3), 1805-1811 , 2005 2005 Citations: 65
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis H Cakmak, M Basar, Y Seval-Celik, KG Osteen, AJ Duleba, HS Taylor, ... Reproductive sciences 19 (6), 572-579 , 2012 2012 Citations: 59
Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease G Hacioglu, Y Seval-Celik, G Tanriover, O Ozsoy, E Saka-Topcuoglu, ... Folia histochemica et cytobiologica 50 (2), 228-238 , 2012 2012 Citations: 57
Do glucose transporters have other roles in addition to placental glucose transport during early pregnancy? ET Korgun, C Celik-Ozenci, Y Seval, G Desoye, R Demir Histochemistry and cell biology 123 (6), 621-629 , 2005 2005 Citations: 49
Effect of experimental varicocele on the expressions of Notch 1, 2, and 3 in rat testes: an immunohistochemical study Z Sahin, Z Bayram, C Celik-Ozenci, G Akkoyunlu, Y Seval, T Erdogru, ... Fertility and sterility 83 (1), 86-94 , 2005 2005 Citations: 48
Spatial and temporal distribution of Tie-1 and Tie-2 during very early development of the human placenta UA Kayisli, S Cayli, Y Seval, F Tertemiz, B Huppertz, R Demir Placenta 27 (6-7), 648-659 , 2006 2006 Citations: 45
