Doctorate of Philosophy, September 2020 (Pharmaceutical Sciences), Jawaharlal Nehru Technical University, Kukatpally, Hyderabad.
Master of Pharmacy, 2006 (Pharmaceutics), Manipal College of Pharmaceutical Sciences, MAHE, Manipal
Bachelor of Pharmacy, 2004, Manipal College of Pharmaceutical Sciences, MAHE, Manipal
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Drug Discovery
Targeting Gut Microbiota with a Novel Drug Delivery System to Treat Inflammatory Bowel Disease Inflammatory Bowel Disease and Gut Microbiota Current Strategies and Future Prospects in Nanomedicine, 2025
Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD Rajani THOUTREDDY, Koteswara Rao GSN, Narender MALOTHU, Chakravarthi GUNTUPALLI, Pavani SRIRAM, Rajasekhar Reddy ALAVALA Journal of Research in Pharmacy, 2023 Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs. Transdermal delivery of cubosomes is currently gaining more importance over conventional topical delivery of drugs. The proposed study aimed to produce Lidocaine hydrochloride loaded cubosomes. This study was designed to prepare various formulations of Lidocaine nano cubsomal dispersions at different concentrations of lipid and stabilizer using optimization technique. For the purpose of prolonging the duration of the local anaesthetic action, Lidocaine-loaded cubosomes were developed by bottom up method utilizing Glyceryl mono oleate and Poloxamer 407 in various ratios using the "Quality by Design" approach, 32 factorial design employing statistical software. Within the confidence intervals, the 32 statistical design was effective at forecasting the optimized formulation's composition. Surface morphology, particle size, drug content, poly dispersibility index, zeta potential, entrapment efficiency, and in vitro drug release studies were conducted on the prepared formulations. Several mathematical models were used to conduct and assess an in vitro drug release investigation. The maximal entrapment efficiency for the LH8 formulation, which was validated to have optimum cubosomes dispersion, was reported to be 78 % with vesicle size as 150 nm, Zeta potential 21.5 mV and Poly Dispersibility Index as 0.08 along with an in vitro drug release 80.03 % by the end of 24 hours. A stable dispersion with appreciable results of evaluation parameters of cubosomal dispersion was conferred with formulation LH8. Hence from amongst the nine formulations developed, it is concluded that LH8 is selected as the optimized dispersion to be incorporated into a gel formulation.
Formulation and Evaluation of Buccoadhesive Tablets of Diltiazem Hydrochloride Ashish . Suttee, Pavani . S International Journal of Drug Delivery Technology, 2022 Calcium channel blocker diltiazem hydrochloride is used to treat hypertension and angina. The study aimed to develop and evaluate bioadhesive buccal tablets that would bypass hepatic metabolism and boost bioavailability. With the use of bioadhesive polymers like kondagogu gum and guar gum in various concentrations, the direct compression method was used to manufacture buccal tablets. Fourier-transform spectroscopy (FT-IR) spectroscopy analysis of the physicochemical compatibility of the active ingredient and excipients demonstrates that the excipients are compatible with the active component. Permeation across porcine buccal mucosa, moisture absorbance, in-vitro drug release, surface pH, and swelling index were all tested on the developed tablets. The best formulation, which contained a combination of kondagogu gum and guar gum (F8), was the most effective, showing a flux of 208.46 μg hr-1 cm-2.
Effective use of Phytotherapy in the Management of Diabetes by Plant-based Medicine: A Review Shankaraiah . Pulipaka, Ashish . Suttee, M. Ravi . Kumar, Pavani . Sriram International Journal of Pharmaceutical Quality Assurance, 2022 >Objective: Herb-based restorative items have been recognized since prehistoric times, and a few therapeutic herbs and their active constituents were utilized for controlling diabetes in numerous people around the world. However, minimal toxicological data exist concerning conventional anti-diabetic plants. Several synthetic oral hypoglycemic agents are the essential treatment types for diabetes. As it may, apparent symptoms of similar medicament are the primary explanation behind an extended number of individuals looking for voluntary remedies that may have less severe or no reactions. This paper attempted to list the herbs with anti-diabetic and associated advantageous impacts from various parts of the world and polyherbal extractions. These herb’s impacts can defer diabetic difficulties and give a more basis of antioxidants they are acknowledged for preventing/postponing diverse ailing states. The literature review was carried out in a scientific database using diabetes, anti-diabetic agents, and phytotherapy to manage diabetes by plant-based medicine as the keywords. To overcome the research gap, optimizing phytotherapy in the management of diabetes by plant-based medicine is regarded as a good target for anti-diabetic agents to design the treatment of type 2 diabetes mellitus (T2DM). Diabetes is the world’s quick aborning emergent, and this disorder’s information will increase similar additional acceptable therapies. Traditional plant medicines are used throughout the world for diabetes. Therefore, studying such drugs will provide the natural key to unlocking a scientist in the future.The review focused on alternative medicine to cure kinds of diabetes problems using herbal preparation.
Fluorescent quantum dots: An insight on synthesis and potential biological application as drug carrier in cancer P. Tandale, Neeraj Choudhary, Joga Singh, Akanksha Sharma, Ananya Shukla, Pavani Sriram, Udit Soni, Neha Singla, Ravi P. Barnwal, Gurpal Singh, Indu Pal Kaur, Ashish Suttee Biochemistry and Biophysics Reports, 2021 Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from 2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical characteristics that can be used as drug carrier vehicle and as a diagnostic in the field of nanomedicine. Scientists from various fields are aggressively working for the development of single platform that can sense, can produce a microscopic image and even be used to deliver a therapeutic agent. QDs are the fluorescent nano dots with which the possibilities of the drug delivery to a targeted site and its biomedical imaging can be explored. This review is mainly focused on the different process of synthesis of QDs, their application especially in the areas of malignancies and as a theranostic tool. The attempt is to consolidate the data available for the use of QDs in the biomedical applications.
Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts Sunchu Harika, Y. Shravan Kumar, Y. Madhusudhan Rao, Pavani Sriram, Uma Shankar Current Drug Metabolism, 2021 Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate to sustained drug release to improve patient compliance, reduce dosing frequency, reduce the risk of dose dumping, and avoid the first-pass metabolism. They have better therapeutic efficacy and fewer side effects. Methods: The dental inserts were prepared using various polymers alone and in combination with the different ratios of polymers. The evaluation parameters like thickness, drug content, content uniformity, moisture reuptake, weight variation, swelling studies, and erosion studies of the optimized inserts were studied. The in-vivo studies were conducted to determine the reduction of pocket depth in human volunteers. Results: The system containing ethylcellulose and hydroxyl methyl propyl cellulose K100M (4:1) formulation F6 was optimized because drug release was sustained up to 120 hrs concerning other formulations. Optimized formulation followed first-order kinetics and Peppas release kinetics via fickian diffusion. There was no swelling, itching, irritation, and no reduction in the pocket depth in in-vivo studies. Conclusion: The study concluded that dental inserts could extend the release of Ornidazole for many hours and also enhance bioavailability. Furthermore, they also help in avoiding the first-pass effect. In vivo studies’ observations showed no itching, irritation, swelling, and pocket-depth reduction.
Formulation and taste masking of metronidazole oral disintegrating tablets by a novel approach Pavani Sriram, Ashish Suttee, Marasakatla Z International Journal of Pharmaceutical Quality Assurance, 2020 The anti-protozoal drug, metronidazole, is developed as an oral disintegrating tablet (ODT) to treat amoebiasis and to bypass hepatic metabolism. The work aimed to prepare, taste-masking oral disintegrating tablets of metronidazole using different proportions of the drug and disintegrants in various ratios by an effervescent method. The ODT was developed by direct compression with various concentrations of super disintegrating agents (1-7%). In this technique, sodium bicarbonate and tartaric acid were used to generate effervescence. The formulated tablets were assessed for physicochemical characteristics. The results of FTIR spectroscopy indicated the stable character of metronidazole. In vitro studies revealed that batch F6 was having a 97.65% cumulative amount of drug release at 20th minute compared to other formulations. Due to the effervescent method, there was a significant increase in drug release, seen at the 1:1.5 ratio. Taste evaluation studies were conducted on healthy human volunteers.
Formulation and evaluation of levocetirizine dihydrochloride and ambroxol hydrochloride lozenges A Suttee, P Sriram, P Arsham, R Reddy Thout International Journal of Pharmaceutical Quality Assurance, 2020 The present work aims to formulate and evaluate levocetirizine dihydrochloride and ambroxol hydrochloride hard candy lozenges to produce a slow-release of drugs for the management of cold and cough. The lozenges were prepared using sucrose, liquid glucose, hydroxyethylcellulose, and hydroxypropyl methylcellulose K4M by heating and congealing method. Sweetener with flavors was utilized to facade the bitter taste of the drug. The developed lozenges were exposed to various physical and chemical characters, and in vitro disintegration and dissolution. The developed formulations include hardness of 8 to 11 kg/cm², non-gritty, and agreeable mouthfeel. The optimized formula was examined for drug excipient interactions subjecting to Fourier transform infrared (FTIR) spectral analysis. Drug release for lozenges was highest in formulation FL8. The hard candy lozenges can present an attractive substitute formulation in allergic conditions.
Synergistic effect of chemical enhancer and iontophoresis for transdermal delivery of nebivolol hydrochloride Iranian Journal of Pharmaceutical Sciences, 2016
Preparation and in vitro evaluation of Chitosan microspheres of Eplerenone International Journal of Pharmacy and Pharmaceutical Sciences, 2013
Simplified informative study on nanoemulsion Research Journal of Pharmacy and Technology, 2013
Formulation and evaluation of rabeprazole sodium delayed release tablets Der Pharmacia Lettre, 2012
Formulation and evaluation of bilayered tablets of metformin hydrochloride and atorvastatin calcium International Journal of Pharmaceutical Sciences Review and Research, 2011
RECENT SCHOLAR PUBLICATIONS
Investigating the Role of Experimental Variables in Characterization of Lidocaine Hydrochloride Cubosomes by QbD R Thoutreddy, C Guntupalli, N Malothu, A RaoAreti, P Sriram Asian Journal of Pharmaceutics 19 (1), 182 , 2025 2025
Targeting Gut Microbiota with a Novel Drug Delivery System to Treat Inflammatory Bowel Disease P Sriram, S Bhatt, A Suttee Inflammatory Bowel Disease and Gut Microbiota, 117-143 , 2025 2025
Nanotechnology-based nanobiosystems in the development of nanomedicines P Sriram, A Suttee Intelligent Nanobiosystems in Medicine and Healthcare, Volume 1, 1-19 , 2025 2025
Dental inserts YMR Y Shravan Kumar, Pavani Sriram, S Harika, M Mounika Advances in drug delivery 5, 1-33 , 2024 2024
Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD RAR THOUTREDDY R, Rao GSN K, MALOTHU N, GUNTUPALLI C, SRIRAM P Journal of Research in Pharmacy 27 (5), 2067-2078 , 2023 2023 Citations: 4
Potential Role of Graphene Oxide in Diagnosis and Treatment of Breast Cancer-An overview PS Tandale, A Kumar, P Sriram, R Kasarla, A Suttee European Chemical Bulletin 12 (Special Issue 1, Part-B), 2609-2640 , 2023 2023
Formulation and Evaluation of Buccoadhesive Tablets of Diltiazem Hydrochloride AS Pavani S International Journal of Drug Delivery Technology 12 (3), 981-984 , 2022 2022
Effective use of Phytotherapy in the Management of Diabetes by Plant-based Medicine: A Review S Pulipaka, A Suttee, MR Kumar, P Sriram synthesis 13 (3), 337-346 , 2022 2022 Citations: 4
Fabrication and evaluation of lidocaine hydrochloride loaded cubosomes R Thoutreddy, U Kulandaivelu, GSNK Rao, RR Alavala, C Guntupalli, ... Research Journal of Pharmacy and Technology 14 (10), 5288-5292 , 2021 2021 Citations: 6
Potential Approaches of Nanotechnology for Cancer Therapy: An Insight V Mishra, P Sriram, A Suttee international journal of drug delivery technology 11 (3), 797-803 , 2021 2021 Citations: 5
Fluorescent quantum dots: An insight on synthesis and potential biological application as drug carrier in cancer P Tandale, N Choudhary, J Singh, A Sharma, A Shukla, P Sriram, U Soni, ... Biochemistry and Biophysics Reports 26, 100962 , 2021 2021 Citations: 89
Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts S Harika, YS Kumar, YM Rao, P Sriram, U Shankar Current Drug Metabolism 22 (7), 572-580 , 2021 2021
FORMULATION AND EVALUATION OF FENOVERINE FLOATING TABLETS PS Rashmitha V, Madhusudan Roa Y Asian journal of pharmaceutical and clinical research 14 (4), 175-180 , 2021 2021 Citations: 16
Development and evaluation of a novel time and pH-dependent colon targeted drug delivery of Ornidazole P Sriram Asian Journal of Pharmaceutical and Clinical Research , 2021 2021 Citations: 1
A review on nano drug delivery systems of herbal medicine S Pulipaka, MR Kumar, P Sriram, A Suttee Journal of Emerging Technologies and Innovative Research 8 (2), 1569-92 , 2021 2021 Citations: 5
Formulation and evaluation of propranolol hydrochloride oral disintegrating tablets LSSP M. Keerthana International journal of pharmaceutical sciences and research 12 (11), 5916-5921 , 2021 2021
Formulation and Evaluation of Valacyclovir Hydrochloride Effervescent Floating Tablets T Rajani, S Pavani, A Dharani, Y Shravan Kumar international journal of advances in pharmacy abd biotechnology 7 (1), 30-36 , 2021 2021 Citations: 2
Nanotechnology Advances, Benefits, and Applications in Daily Life P Sriram, A Suttee Nanotechnology Advances and real life applications, 23-44 , 2020 2020 Citations: 19
Niosomes: Potential Nanocarriers for Drug Delivery V Mishra, P Nayak, M Singh, P Sriram, A Suttee IJPQA 11 (3), 389-394 , 2020 2020 Citations: 39
An Update on Floating Drug Delivery System: A Review V Rashmitha, S Pavani, T Rajani International Journal of Advances in Pharmacy and Biotechnology 6 (4), 9-18 , 2020 2020 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Fluorescent quantum dots: An insight on synthesis and potential biological application as drug carrier in cancer P Tandale, N Choudhary, J Singh, A Sharma, A Shukla, P Sriram, U Soni, ... Biochemistry and Biophysics Reports 26, 100962 , 2021 2021 Citations: 89
Niosomes: Potential Nanocarriers for Drug Delivery V Mishra, P Nayak, M Singh, P Sriram, A Suttee IJPQA 11 (3), 389-394 , 2020 2020 Citations: 39
Formulation and evaluation of bilayered tablets of metformin hydrochloride and atorvastatin calcium S Mohindeen, B Jyothi, S Pavani, T Satyanarayana, SP Kumar, ... International Journal of Pharmaceutical Sciences Review and Research 10 (2 … , 2011 2011 Citations: 26
Nanotechnology Advances, Benefits, and Applications in Daily Life P Sriram, A Suttee Nanotechnology Advances and real life applications, 23-44 , 2020 2020 Citations: 19
Carbon Nanotubes as Emerging Nanocarriers in Drug Delivery: An Overview V Mishra, M Singh, P Nayak, P Sriram, A Suttee International Journal of Pharmaceutical Quality Assurance 11 (3), 373-378 , 2020 2020 Citations: 18
Elucidation of ultrasonic wave-assisted electrodeposited AgPd nanoalloy from ionic liquid as an efficient bifunctional electrocatalyst for methanol oxidation and hydrogen … P Sriram, MK Kumar, GT Selvi, NS Jha, N Mohanapriya, SK Jha Electrochimica Acta 323, 134809 , 2019 2019 Citations: 18
FORMULATION AND EVALUATION OF FENOVERINE FLOATING TABLETS PS Rashmitha V, Madhusudan Roa Y Asian journal of pharmaceutical and clinical research 14 (4), 175-180 , 2021 2021 Citations: 16
Use of Box-Behnken Experimental design for Optimization of process Variables in Iontophoretic delivery of Repaglinide P Sriram, YM Rao, YS Kumar Journal of Young Pharmacists 8 (4), 350-355 , 2016 2016 Citations: 15
Qualitative and quantitative phytochemical screening and in vitro anti oxidant and anti microbial activities of Elephantopus scaber Linn. BG Rao, YV Rao, S Pavani, VSP Dasari 2012 Citations: 13
A review on recent advances in enteric coating and enteric polymers P Mounica, S Pavani, P Mounica Rani World J. Pharm. Res 7, 475-495 , 2018 2018 Citations: 12
Formulation and evaluation of gastroretentive floating tablets of Venlafaxine hydrochloride G Anil, T Satyanarayana, P Suresh Kumar, S Pavani, NRBH CH, ... International Journal of Pharmacy and Industrial Research 1 (2), 72-79 , 2011 2011 Citations: 12
Development and evaluation of two layered tablet of glimepiride and metformin hydrochloride for the treatment of hyperglycemia S Mohideen, T Satyanarayana, PS Kumar, S Navneetha, R Mahalaxmi, ... International Journal of Biopharmaceutics 2 (1), 31-35 , 2011 2011 Citations: 11
Formulation and evaluation of oral elementary osmotic pump tablets of sumatriptan succinate JK Pavani, S Pavani, YS Kumar, A Venkatesh, YM Rao British Journal of Pharmaceutical Research International 4 (10), 1163-1173 , 2014 2014 Citations: 9
Preparation and in vitro evaluation of chitosan microspheres of eplerenone P Sriram, D Kamlekar, S Hazari International Journal of Pharmacy and Pharmaceutical Sciences 5 (suppl 3 … , 2013 2013 Citations: 9
A review on phytopharmacological activities of Alpinia mutica and tradescantia spathacea PS Shankaraiah Pulipaka, Ashish Suttee, M Ravi Kumar Plant Archives 20 (2), 9011-9018 , 2020 2020 Citations: 8
Formulation and evaluation of Acyclovir Microspheres K Mounika, K Naresh Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683-3597 E-ISSN 2521-3512 … , 2018 2018 Citations: 8
Formulation and evaluation of rabeprazole sodium delayed release tablets SDYS P. Suresh Kumar*, S. Navaneetha Krishnan, S. Pavani, Y. Surendarnath Der Pharmacia Lettre 4 (1), 287-296 , 2012 2012 Citations: 8
An Update on Floating Drug Delivery System: A Review V Rashmitha, S Pavani, T Rajani International Journal of Advances in Pharmacy and Biotechnology 6 (4), 9-18 , 2020 2020 Citations: 7
Fabrication and evaluation of lidocaine hydrochloride loaded cubosomes R Thoutreddy, U Kulandaivelu, GSNK Rao, RR Alavala, C Guntupalli, ... Research Journal of Pharmacy and Technology 14 (10), 5288-5292 , 2021 2021 Citations: 6
Potential Approaches of Nanotechnology for Cancer Therapy: An Insight V Mishra, P Sriram, A Suttee international journal of drug delivery technology 11 (3), 797-803 , 2021 2021 Citations: 5
