مصطفی رحیمی

@department of sport science, shahrekord university, shahrekord, iran

Department of Sport Science, Shahrekord University, Shahrekord, Iran
Shahrekord university

مصطفی رحیمی


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https://researchid.co/mostafarahimi
B.sc: Isfahon Univesity, physical education and sport scineces
MSc: Tehran University, exercise physiology
baqiyatallah university of medical sciences, exercise physiology

EDUCATION

Ph.D of exercise Physiology

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Physical Therapy, Sports Therapy and Rehabilitation, General Health Professions
25

Scopus Publications

Scopus Publications

  • The Effect of Resistance Training and Ursolic Acid on the PI3K-AKT-mTOR Pathway in Aged Diabetic Rats: A Comparative Study
    Ashkan Sadeghi, Safoura Alizade, Mohammad Faramarzi, Mostafa Rahimi, Rohit Kumar Thapa
    Aging Medicine, 2026
    Objectives Sarcopenia, characterized by age‐related muscle loss, worsens in diabetes due to anabolic resistance. Ursolic acid (UA), a natural compound with anabolic and anti‐catabolic effects, may mitigate sarcopenia by enhancing anabolic pathways. This study examined the effects of 8 weeks of resistance training and UA supplementation on PI3K‐AKT‐mTORC1 pathway proteins in muscle tissue of aged diabetic rats. Methods Fifty 21‐month‐old Wistar rats were divided into five groups: healthy control, diabetic control, diabetic + resistance training, diabetic + UA, and diabetic + resistance training + UA. Type 2 diabetes was induced using a high‐fat diet and low‐dose STZ. Resistance training consisted of 8 weeks of ladder climbing at 60% MVCC, 5 days per week. UA was administered daily to the UA and combination groups. Protein expression was analyzed using Western blot. Results AKT and mTORC1 or phosphorylated AKT levels did not differ significantly across groups. However, dephosphorylated PI3K ( p = 0.011) and phosphorylated mTORC1 ( p = 0.026) showed significant changes. PI3K expression decreased in diabetic, resistance training, and UA groups compared to controls, but not in the combination group. Phosphorylated mTORC1 was reduced in diabetic controls but maintained in the training, UA, and combination groups. Conclusion Diabetes reduces PI3K and mTORC1 protein expression. Resistance training or UA alone improved mTORC1 expression, while their combination enhanced both PI3K and mTORC1, suggesting synergistic anabolic benefits. Combining UA with resistance training may counteract diabetes‐induced muscle loss.
  • Feasibility and preliminary efficacy of different intensities of functional training in elderly type 2 diabetes patients with cognitive impairment: a pilot randomised controlled trial
    Majid Mardaniyan Ghahfarrokhi, Hossein Shirvani, Mostafa Rahimi, Behzad Bazgir, Alireza Shamsadini, Vahid Sobhani
    BMC Geriatrics, 2024
    BackgroundAging and type-2 diabetes (T2D) are the most important risk factors for cognitive impairment and Alzheimer’s disease. Exercise training is an effective, safe, and practical intervention in improving glucose metabolism, physical function, and cognitive disorders. This pilot study investigated the feasibility and preliminary efficacy of high-intensity low-volume (HIFT) vs. low-intensity high-volume (LIFT) functional training in elderly T2D patients with cognitive impairment.MethodsForty-eight elderly T2D patients (31 female, 17 male, age 67.5 ± 5.8 years, MMSE score 18.8 ± 2.6, FBG 209.5 ± 37.9) were randomly assigned to HIFT, LIFT and control groups. Cognitive impairment was diagnosed with MMSE ≤ 23 based Iranian society. The SDMT, CVLT-II, BVMT-R, and Stroop tests were used to evaluated processing speed, learning, memory and attention respectively. Physical fitness tests include: tandem stance and walk test; TUG; 6MWT, 10MWT; SSST; 5TSTS; and hand grip was used to evaluated static and dynamic balance, agility, walking endurance, gait speed, lower limb function and lower and upper body strength respectively. As well as, Biochemical (FBG, insulin, HOMA-IR, HbA1c) and physiological outcomes (SBP, and DBP) were assessed. The HIFT group performed six weeks of functional training (three sessions per week) with 120–125% of the lactate threshold. The LIFT group performed six weeks of functional training (five sessions per week) with a 70–75% lactate threshold. Feasibility, safety, and acceptability of exercise programs were assessed at the end of the study.ResultHIFT showed a higher adherence rate (91% vs. 87.5%), safety, and acceptability compared to LIFT. MMSE and Stroop scores, 6MWT, FBG, insulin, HOMA-IR, HbA1c, SBP, and DBP significantly improved in HIFT (all,P ≤ 0.004) and LIFT (all,P ≤ 0.023). Changes in 6MWT, FBG, insulin, HOMA-IR, and HbA1c in HIFT (all,P ≤ 0.001) and LIFT (all,P ≤ 0.008) were significant compared to the control group. Changes in Stroop scores were significant only in the HIFT group compared to the control group (P = 0.013). SDMT, CVLT-II, BVMT-R, balance test, 10MWT, SSST, TUG and hang grip significantly improved only in HIFT (all,P ≤ 0.038).ConclusionHIFT vs. LIFT is a safe, feasible, and effective approach for improving some aspects of physical, biochemical, and cognitive function in elderly T2D patients with cognitive impairment. This pilot study provides initial proof-of-concept data for the design and implementation of an appropriately powered randomised controlled trial (RCT) of HIFT vs. LIFT in a larger sample of elderly T2D patients with cognitive impairment.Trial registrationRandomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20230502058055N1. Date of registration: 11/06/2023.
  • Resistance Band Exercise: An Effective Strategy to Reverse Cardiometabolic Disorders in Women With Osteosarcopenic Obesity
    Ebrahim Banitalebi, Elahe Banitalebi, Majid Mardaniyan Ghahfarokhi, Mostafa Rahimi, Ismail Laher, Kade Davison
    Journal of Aging and Physical Activity, 2023
    We designed to evaluate the effects of resistance elastic band exercises (REBEs) on cardiometabolic/obesity-related biomarkers in older females with osteosarcopenic obesity. Sixty-three patients (aged 65–80 years) with osteosarcopenic obesity and a body mass index exceeding 30 kg/m2 were enrolled in the study. The participants were randomly assigned to either an experimental group (REBE, n = 32) or a usual care group (n = 31). The experimental group completed a 12-week REBE program, three times a week and 60 min per session. There were decreases in lipid accumulation product (p = .033), visceral adipose index (p = .001), triglyceride-glucose-body mass index (p = .034), and atherogenic index of plasma (p = .028) in the experimental group compared with the usual care group. Our findings highlight the importance of an REBE program in improving combined cardiometabolic/obesity-related indices in older women with osteosarcopenic obesity. The incorporation of an REBE program may benefit individuals who are unable to tolerate or participate in more strenuous exercise programs.
  • Bone–muscle crosstalk following exercise plus Ursolic acid by myomiR-133a/Cx43-Runx2 axis in aged type 2 diabetes rat models
    Maryam Asadi Farsani, Ebrahim Banitalebi, Mohammad Faramarzi, Nuredin Bakhtiari, Mostafa Rahimi, Gustavo Duque
    Chemico Biological Interactions, 2023
  • Therapeutic and preventive effects of exercise training on metabolic regulators/markers in mouse colorectal cancer cells
    Hossein Shirvani, Behzad Bazgir, Mostafa Rahimi, Amin Isanejad, Mohammad Samadi, Vahid Sobhani, Ali Mohammad Alizadeh, Ehsan Arabzadeh
    Sport Sciences for Health, 2022
  • SILVER NANOPARTICLES INHIBIT PROLIFERATION AND MIGRATION OF PROSTATE CANCER CELLS: AN EXPERIMENTAL REPORT
    Adele Jafari, Zahra Niknam, Mohsen Rahimi, Hakimeh Zali, Mostafa Rezaei–Tavirani
    World Cancer Research Journal, 2022
    Objective: Prostate carcinoma is a serious public health in men with increasing incidence and mortality rates. The present study aimed to investigate cytotoxic activities of silver nanoparticles (AgNPs) against PC-3 human prostate cancer cell line in vitro. Materials and Methods: The antiproliferative effect of AgNPs on PC-3 cells was assessed using various concentrations of AgNPs (5-80 µg/mL) by MTT assay. We have also investigated the effect of AgNPs on the migration property of cancers cells using a wound-healing assay. Then, obtained results were analyzed using ANOVA and Student’s t-test. Results: The AgNPs diminished significantly the viability of PC-3 cells in a dose and time-dependent manner. According to the dose-dependent viability curve, the IC50 (50% inhibiting concentration) at 48 h was calculated to be 65.7 µg/mL. Migration assay also confirmed the antimetastatic potential of the AgNPs against PC-3 cells. After 24 h, the migration rate was 2.5 fold lower for AgNPs-treated cells compared to control cells. Conclusions: Our findings support the use of AgNPs as an appropriate option for future therapeutic application in prostate cancer therapy.
  • The effects of resistance training on body and liver fat stores and insulin resistance in peoples with non-alcoholic fatty liver disease
    Iranian Journal of Public Health, 2020
  • Effects of circadian rhythm on physical and physiological performance of military forces- narrative review
    محمد فرامرزی, بهزاد بازگیر, مصطفی رحیمی, حسین شیروانی
    Journal of Military Medicine, 2020
  • Physical fitness status of scholarship female students in a military medical center
    مصطفی رحیمی, بهزاد بازگیر, مریم کاظمی پور, ابوالفضل شکیبایی
    Journal of Military Medicine, 2020
  • Effect of eight weeks aerobic training and supplementation of green tea on apelin plasma levels and insulin resistance in elderly women with type 2 diabetes
    Journal of Mazandaran University of Medical Sciences, 2019
  • Study of physical-motor fitness level of scholarship male students in a military center and determination of current status
    Journal of Military Medicine, 2019
  • Changes in monocarboxylate transporter 1 and p53 gene expression by aerobic interval training in the experimental colon carcinoma of mouse
    Tehran University Medical Journal, 2018
  • Oxytocin mediates the beneficial effects of the exercise training on breast cancer
    Ali Mohammad Alizadeh, Zahra Heydari, Mostafa Rahimi, Behzad Bazgir, Hossein Shirvani, Sadaf Alipour, Yassaman Heidarian, Solmaz Khalighfard, Amin Isanejad
    Experimental Physiology, 2018
  • Effects of whole body vibration training and mental training on mobility, neuromuscular performance, and muscle strength in older men
    Maryam Goudarzian, Samira Ghavi, Ardalan Shariat, Hossein Shirvani, Mostafa Rahimi
    Journal of Exercise Rehabilitation, 2017
  • Mobility, balance, and muscle strength adaptations to short-term whole body vibration training plus oral creatine supplementation in elderly women
    Maryam Goudarzian, Mostafa Rahimi, Noureddin Karimi, Ali Samadi, Reza Ajudani, Robab Sahaf, Samira Ghavi
    Asian Journal of Sports Medicine, 2017
  • Effects of high intensity interval training and moderate-intensity continuous training on VEGF gene expression in visceral and subcutaneous adipose tissues of male wistar rats
    Iranian Journal of Endocrinology and Metabolism, 2017
  • Acute cardiovascular and hemodynamic responses to low intensity eccentric resistance exercise with blood flow restriction
    Behzad Bazgir, Mojtaba Rezazadeh Valojerdi, Hamid Rajabi, Rouhollah Fathi, Seyed Mojtaba Ojaghi, Mohammad Kazem Emami Meybodi, Gabriel R. Neto, Mostafa Rahimi, Alireza Asgari
    Asian Journal of Sports Medicine, 2016
  • Alteration in cardiac uncoupling proteins and eNOS gene expression following high-intensity interval training in favor of increasing mechanical efficiency
    Iranian Journal of Basic Medical Sciences, 2016
  • Effect of a karate competition on indicators of inflammation and muscletissue injury in soldier's karate-ka
    Journal of Military Medicine, 2015
  • The effect of high intensity interval training on cardioprotection against ischemia-reperfusion injury in wistar rats
    Mostafa Rahimi, Shahnaz Shekarforoush, Ali Reza Asgari, Ali Khoshbaten, Hamid Rajabi, et al.
    Excli Journal, 2015
  • The role of exercise preconditioning in cardioprotection against ischemia-reperfusion injury
    Physiology and Pharmacology, 2014
  • The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma
    Iranian Journal of Basic Medical Sciences, 2014
  • Sport injuries of karatekas at international competitions
    Journal of Military Medicine, 2012
  • Effect of various ratios of carbohydrate-protein supplementation on resistance exercise-induced muscle damage
    Journal of Sports Medicine and Physical Fitness, 2012
  • Effect of lateral cerebroventricular injection of orexin a on swimming performance in rats
    Physiology and Pharmacology, 2012