Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats Mohd Basheeruddin, V. Lavanya, Neesar Ahmed, Shazia Jamal Brazilian Journal of Pharmaceutical Sciences, 2023 Diclofenac sodium (DF) is a non-steroidal anti-inflammatory drug (NSAID) that possesses antipyretic, analgesic, antinociceptive and anti-inflammatory activities. Like other NSAIDs, DF is known to be associated with renal, cardiovascular, and gastrointestinal complications. The present study was carried out to evaluate the adverse effects of DF in vivo in wistar albino rats and to assess if oral administration of the organic osmolyte betaine mitigates the adverse effect of DF. Eighteen male Wistar rats were divided into three groups, one group of animals was fed orally with 20 mg/kg of DF once/day, and the other group received a combination of 20 mg/kg of DF and 30 mg/kg of betaine, once/day. Apart from the hematological and biochemical parameters, histopathological changes in the liver, lungs, brain, heart and kidney were also investigated. Histopathological alterations that were found in the liver, kidney, and lungs of DF-treated animals were found to be minimal or absent in DF + betaine-treated animals, as compared to untreated control. The results showed that betaine mitigates the adverse effects associated with DF treatment.
Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach R. Logesh, V. Lavanya, Shazia Jamal, Neesar Ahmed Applied Biochemistry and Biotechnology, 2022 Mycobacterium tuberculosis (Mtb) is a respiratory pathogen that causes tuberculosis (TB). There are a large number of proteins that are involved in the pathogenesis of TB. Stimulating the immune response against TB is very important to clear the pathogens from host. In the present study, an immunoinformatics conduit is used for designing an epitope based chimeric vaccine against TB. Enhanced intracellular survival (EIS) protein from Mtb is used for designing the chimeric vaccine. One B cell epitope, 8 cytotoxic T lymphocyte (CTL), and 6 helper T lymphocyte (HTL) epitopes were predicted based on the MHC allele binding, immunogenicity, antigenicity, allergenicity, toxicity and IFN epitopes. The selected epitopes were used for chimeric vaccine designing. Furthermore, 3D structure elucidation, structural refinement and validation of the designed chimeric vaccine were carried out. The 3D structure was used for protein–protein docking studies with Toll-like receptor 4 (TLR-4), followed by molecular dynamic simulation (MDS) and the interaction between the chimeric vaccine and TLR-4 complex was verified.
Immunomodulatory Effects of Jacalin, a Dietary Plant Lectin on the Peripheral Blood Mononuclear Cells (PBMCs) V. Lavanya, Anil Kumar Bommanabonia, Neesar Ahmed, Shazia Jamal Applied Biochemistry and Biotechnology, 2022 The tumor microenvironment that refers to the tumor’s surroundings is a key modulator of tumor growth and invasion. The tumor-derived signals are known to downregulate the anti-tumor effects of the effector cells present in the TME. Thus, the cross-talk between the tumor cells with the surrounding immune cells helps in evading the tumor surveillance as well as aiding in tumor growth and proliferation. Hence, knowledge regarding the effects of drugs/compound on the tumor-stromal interactions is gaining importance. In the present study, the effects of jacalin, a dietary lectin on the proliferation and cytokine production of peripheral blood mononuclear cells (PBMCs), are investigated. Jacalin was shown to act as a mitogen of PBMCs, the key cytokine secreting immune cells. Also, jacalin initially induced increased mRNA expression of pro-inflammatory cytokine IFN-γ; however, prolonged stimulation of PBMCs resulted in increased expression of anti-inflammatory cytokine, mainly TGF-β. Furthermore, 6 h jacalin prestimulated PBMCs (Jac-PBMCs) were shown to inhibit HeLa cell proliferation while 24 h Jac-PBMCs were found to favor tumor growth. Thus, it may be postulated that while jacalin initially polarizes the PBMCs to hinder the tumor growth, after a stipulated time point, interaction of jacalin with PBMCs can lead to an immunosuppressive TME that may probably assist in tumor growth and progression.
Increased ERK phosphorylation and caveolin-1 expression on K562 human chronic myelogenous leukemia cells by jacalin, a dietary plant lectin Lavanya V, Shazia Jamal, Neesar Ahmed Glycoconjugate Journal, 2021 The potential antitumor effects of jacalin, the plant lectin that specifically recognizes the tumor-associated Thomsen-Friedenreich antigen has been extensively studied. We had earlier reported jacalin to be mitogenic to K562, the Bcr-Abl expressing erythroleukemia cell line. The dearth of studies highlighting the proliferative effects of jacalin and other lectins motivated us to unveil the mechanism underlying the mitogenic effects of jacalin. Caveolin-1 (cav-1) is an integral membrane protein, known to play a crucial role in cell signaling, lipid transport, and membrane trafficking. The role of cav-1 in tumorigenesis is considered to be controversial as it can suppress as well as promote tumor growth, depending on the cellular context. In the present study, we propose that cav-1 plays the central role in the mitogenic effects of jacalin on the K562 cells. In accordance, the mRNA, as well as protein expression of cav-1 was found to be upregulated in the jacalin-treated K562 cells as compared to the untreated control. Further, jacalin stimulation also increased the phosphorylation of ERK and Akt. The rationale that leads to the initial conjecture about cav-1 was that the sequence of jacalin possesses a cav-1-binding site.
BSA binding interactions, molecular docking, and DFT studies of copper (I) complexes of N, N-bidentate ligands LM Abraham, B Dkhar, A Arunkumar, V Lavanya, V Srinivasan, ... Polyhedron, 118073 , 2026 2026
Enhanced anti-proliferative activity of Jacalin, a plant lectin in combination with taxol in MDA-MB-468 triple-negative breast cancer cells BA Kumar, B Thaslima, V Lavanya, S Jamal, N Ahmed Glycoconjugate journal 43 (1), 12 , 2026 2026
Copper (I) complexes of a Triazine Derived Schiff Base: Synthesis, Crystal Structure and Biological Applications B Dkhar, A Arunkumar, V Rajendiran, V Srinivasan, V Lavanya, ... Journal of Molecular Structure, 144042 , 2025 2025 Citations: 4
Atomic-level binding interaction analysis of Mycobacterium tuberculosis membrane protein Rv1085c with Toll-Like receptor 2 to investigate its role in immune response L Radhakrishnan, I Navabshan, V Lavanya, S Jamal, N Ahmed In Silico Pharmacology 13 (2), 1-12 , 2025 2025
Lipopolysaccharide Purified from Salmonella typhi Sensitizes Human Red Blood Cells at Hemagglutinin concentration, leading to complete Hemolysis upon the addition of Jacalin-a … L Radhakrishnan, V Lavanya, S Jamal, N Ahmed Exon 2 (1), 76-85 , 2025 2025
Coral Reef Metabolites for Cancer Treatment RA Rafiudeen, NH Anwardeen, V Lavanya, S Jamal, N Ahmed Current Pharmacology Reports 11 (1), 3 , 2024 2024 Citations: 3
Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats M Basheeruddin, V Lavanya, N Ahmed, S Jamal Brazilian Journal of Pharmaceutical Sciences 59, e201178 , 2023 2023 Citations: 3
Targeting Soluble Factors Involved in Inflammatory Cancer Microenvironment M Gayathri, V Lavanya, S Jamal, N Ahmed Current Pharmacology Reports 8 (4), 253-261 , 2022 2022
The Effectiveness of Various Chemotherapeutic Agents in Cancer Treatment NA J Kashifa Fathima, V Lavanya, Shazia Jamal Current Pharmacology Reports , 2022 2022 Citations: 40
Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach R Logesh, V Lavanya, S Jamal, N Ahmed Applied Biochemistry and Biotechnology 194 (1), 187-214 , 2022 2022 Citations: 8
Immunomodulatory effects of jacalin, a dietary plant lectin on the Peripheral Blood Mononuclear Cells (PBMCs) V Lavanya, AK Bommanabonia, N Ahmed, S Jamal Applied Biochemistry and Biotechnology 194 (1), 587-599 , 2022 2022 Citations: 8
Increased ERK phosphorylation and caveolin-1 expression on K562 human chronic myelogenous leukemia cells by jacalin, a dietary plant lectin S Jamal, N Ahmed Glycoconjugate Journal 38 (3), 361-368 , 2021 2021 Citations: 1
Increased expression of TGF-β and IFN-γ in peripheral blood mononuclear cells (PBMCs) cultured in conditioned medium (CM) of K562 cell culture AAM Adil, L Vallinayagam, K Chitra, S Jamal, AK Pandurangan, N Ahmed Journal of Environmental Pathology, Toxicology and Oncology 38 (2) , 2019 2019 Citations: 3
Ubiquitin Mediated Posttranslational Modification of Proteins Involved in Various Signaling Diseases V Lavanya, S Jamal, N Ahmed Protein Modificomics, 109-130 , 2019 2019 Citations: 2
A computational model for monitoring the hexose monophosphate (HMP) shunt pathway FA Basha, V Lavanya, SJ Kumaar, CVJ Kumar 2017 2nd International Conference on Computing and Communications … , 2017 2017 Citations: 1
Sub-micellar concentration of sodium dodecyl sulphate prevents thermal denaturation induced aggregation of plant lectin, jacalin V Lavanya, B Anil Kumar, S Jamal, MKA Khan, N Ahmed The Protein Journal 36 (1), 17-27 , 2017 2017 Citations: 2
Sustained mitogenic effect on K562 human chronic myelogenous leukemia cells by dietary lectin, jacalin V Lavanya, N Ahmed, MKA Khan, S Jamal Glycoconjugate journal 33 (6), 877-886 , 2016 2016 Citations: 10
Cancer immunotherapy: Targeting immunosuppressive tumor microenvironment AM Adil, V Lavanya, S Jamal, N Ahmed Oncobiology and Targets 1 (1), 16-16 , 2014 2014 Citations: 5
Small molecule inhibitors as emerging cancer therapeutics V Lavanya, M Adil, N Ahmed, AK Rishi, S Jamal Integr. Cancer Sci. Ther 1 (3), 39-46 , 2014 2014 Citations: 89
Lectins-the promising cancer therapeutics V Lavanya, AM Adil, N Ahmed, S Jamal Oncobiology and Targets 1 (1), 12-12 , 2014 2014 Citations: 11
MOST CITED SCHOLAR PUBLICATIONS
Small molecule inhibitors as emerging cancer therapeutics V Lavanya, M Adil, N Ahmed, AK Rishi, S Jamal Integr. Cancer Sci. Ther 1 (3), 39-46 , 2014 2014 Citations: 89
The Effectiveness of Various Chemotherapeutic Agents in Cancer Treatment NA J Kashifa Fathima, V Lavanya, Shazia Jamal Current Pharmacology Reports , 2022 2022 Citations: 40
Expression profile of toll-like receptor 2 mRNA in selected tissues of shark (Chiloscyllium sp.) C Anandhakumar, V Lavanya, G Pradheepa, KG Tirumurugaan, GD Raj, ... Fish & shellfish immunology 33 (5), 1174-1182 , 2012 2012 Citations: 21
Lectins-the promising cancer therapeutics V Lavanya, AM Adil, N Ahmed, S Jamal Oncobiology and Targets 1 (1), 12-12 , 2014 2014 Citations: 11
Sustained mitogenic effect on K562 human chronic myelogenous leukemia cells by dietary lectin, jacalin V Lavanya, N Ahmed, MKA Khan, S Jamal Glycoconjugate journal 33 (6), 877-886 , 2016 2016 Citations: 10
Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach R Logesh, V Lavanya, S Jamal, N Ahmed Applied Biochemistry and Biotechnology 194 (1), 187-214 , 2022 2022 Citations: 8
Immunomodulatory effects of jacalin, a dietary plant lectin on the Peripheral Blood Mononuclear Cells (PBMCs) V Lavanya, AK Bommanabonia, N Ahmed, S Jamal Applied Biochemistry and Biotechnology 194 (1), 587-599 , 2022 2022 Citations: 8
Cancer immunotherapy: Targeting immunosuppressive tumor microenvironment AM Adil, V Lavanya, S Jamal, N Ahmed Oncobiology and Targets 1 (1), 16-16 , 2014 2014 Citations: 5
Copper (I) complexes of a Triazine Derived Schiff Base: Synthesis, Crystal Structure and Biological Applications B Dkhar, A Arunkumar, V Rajendiran, V Srinivasan, V Lavanya, ... Journal of Molecular Structure, 144042 , 2025 2025 Citations: 4
Coral Reef Metabolites for Cancer Treatment RA Rafiudeen, NH Anwardeen, V Lavanya, S Jamal, N Ahmed Current Pharmacology Reports 11 (1), 3 , 2024 2024 Citations: 3
Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats M Basheeruddin, V Lavanya, N Ahmed, S Jamal Brazilian Journal of Pharmaceutical Sciences 59, e201178 , 2023 2023 Citations: 3
Increased expression of TGF-β and IFN-γ in peripheral blood mononuclear cells (PBMCs) cultured in conditioned medium (CM) of K562 cell culture AAM Adil, L Vallinayagam, K Chitra, S Jamal, AK Pandurangan, N Ahmed Journal of Environmental Pathology, Toxicology and Oncology 38 (2) , 2019 2019 Citations: 3
Ubiquitin Mediated Posttranslational Modification of Proteins Involved in Various Signaling Diseases V Lavanya, S Jamal, N Ahmed Protein Modificomics, 109-130 , 2019 2019 Citations: 2
Sub-micellar concentration of sodium dodecyl sulphate prevents thermal denaturation induced aggregation of plant lectin, jacalin V Lavanya, B Anil Kumar, S Jamal, MKA Khan, N Ahmed The Protein Journal 36 (1), 17-27 , 2017 2017 Citations: 2
Increased ERK phosphorylation and caveolin-1 expression on K562 human chronic myelogenous leukemia cells by jacalin, a dietary plant lectin S Jamal, N Ahmed Glycoconjugate Journal 38 (3), 361-368 , 2021 2021 Citations: 1
A computational model for monitoring the hexose monophosphate (HMP) shunt pathway FA Basha, V Lavanya, SJ Kumaar, CVJ Kumar 2017 2nd International Conference on Computing and Communications … , 2017 2017 Citations: 1
BSA binding interactions, molecular docking, and DFT studies of copper (I) complexes of N, N-bidentate ligands LM Abraham, B Dkhar, A Arunkumar, V Lavanya, V Srinivasan, ... Polyhedron, 118073 , 2026 2026
Enhanced anti-proliferative activity of Jacalin, a plant lectin in combination with taxol in MDA-MB-468 triple-negative breast cancer cells BA Kumar, B Thaslima, V Lavanya, S Jamal, N Ahmed Glycoconjugate journal 43 (1), 12 , 2026 2026
Atomic-level binding interaction analysis of Mycobacterium tuberculosis membrane protein Rv1085c with Toll-Like receptor 2 to investigate its role in immune response L Radhakrishnan, I Navabshan, V Lavanya, S Jamal, N Ahmed In Silico Pharmacology 13 (2), 1-12 , 2025 2025
Lipopolysaccharide Purified from Salmonella typhi Sensitizes Human Red Blood Cells at Hemagglutinin concentration, leading to complete Hemolysis upon the addition of Jacalin-a … L Radhakrishnan, V Lavanya, S Jamal, N Ahmed Exon 2 (1), 76-85 , 2025 2025