Eliete Dalla Corte Frantz

Scopus Publications

Genetic deletion of MrgD receptor disrupts cardiac protein homeostasis in mice
Beatriz Alexandre-Santos, Luiza Mazzali Ferraz, Ana Beatriz Proença, Nícia Pedreira Soares, Guilherme dos Santos Reis, Maria Eduarda Lima da Silva, D’Angelo Carlo Magliano, Maria Jose Campagnole-Santos, Antonio Claudio Lucas da Nóbrega, Robson Augusto Souza Santos, Eliete Dalla Corte Frantz
Molecular Biology Reports, 2026
Cardiovascular diseases are the leading cause of death worldwide. An important mechanism involved is the disruption in protein homeostasis by overactivation of the classical axis of the renin-angiotensin system. The counterregulatory axis counteracts these effects; however, the MrgD receptor has recently been described, and its effects are unknown. Thus, this study aims to evaluate the impact of MrgD deficiency on cardiac protein homeostasis. 16-week-old wild-type (WT) and MrgD knockout (MrgD KO) male C57BL/6J mice were evaluated for systolic blood pressure (SBP), cardiac morphology, MDA levels, carbonyl content, and protein homeostasis markers. SBP and heart mass remained unaltered. MrgD deficiency increased left ventricular mass and led to cardiac atrophy by reduced left ventricular wall thickness and cardiomyocyte cross-sectional area. Collagen (types 1 and 3) deposition and MMP-2 cardiac protein expression were elevated in MrgD KO. Genetic deletion of MrgD increased NOX2, NOX4, and ERO1α cardiac protein expression. MDA levels were similar between groups, and carbonyl content was higher in MrgD KO. GRP78, CHOP, MuRF-1, Atrogin-1, and polyubiquitinated proteins were increased in MrgD KO mice, indicating a loss of protein homeostasis. The genetic deletion of MrgD promoted cardiac remodeling and disrupted protein homeostasis, with increased pro-oxidative response and ER stress. This was associated with protein degradation by the activation of the ubiquitin-proteasome pathway.
Bisphenol S-induced cardiac remodeling is associated with an imbalance in the renin-angiotensin system
Guilherme dos Santos Reis, Maria Eduarda Lima da Silva, Luiza Mazzali Ferraz, Cristiane Matsuura, Antonio Claudio Lucas da Nóbrega, Leandro Miranda-Alves, D'Angelo Carlo Magliano, Eliete Dalla Corte Frantz, Beatriz Alexandre-Santos
Environmental Research, 2026
Cardiovascular diseases (CVD) are the leading cause of death worldwide, and cardiac remodeling is a key pathological feature. The renin-angiotensin system (RAS) plays a central role in CVD, but whether different doses of bisphenol S (BPS) modulate cardiac RAS remain unclear. Adult male C57BL/6 mice were assigned to control (C) or 4 (B4), 25 (B25), and 50 (B50) μg/kg/day of BPS in drinking water for 12 weeks. Body mass (BM), plasma cholesterol, left ventricle (LV) and cardiomyocyte morphology, RAS components and signaling markers, and remodeling mediators were assessed. B4 and B25 increased BM and plasma cholesterol, with a higher cardiac risk ratio. Regarding the RAS, all BPS doses overactivated the classical axis, evidenced by increased ACE activity and protein expression, and greater AT1R immunostaining, while suppressing the counterregulatory axis, with reduced ACE2 activity and protein expression and lower Mas receptor immunostaining. AT1R-related intracellular signaling (NOX2, NOX4, ERK 1/2 protein expression) increased in all groups. B4 and B25 presented ER stress, with increased GRP78 and CHOP protein expression, and ATF4 protein expression increased in all groups. B4 and B25 promoted pathological cardiac hypertrophy, with increased LV mass, wall thickness, chamber area and ANP protein expression. Inflammation markers protein expression was observed in all groups, particularly B4 and B25. All doses induced a pro-fibrotic profile with increased collagen deposition and TGFβ protein expression, more pronounced in B50. Overall, exposure to different BPS doses shifted the RAS activation towards the classical axis. These findings underscore the need for public policies regulating BPS.
Dysfunctional white adipose tissue in the progression of endometriosis: The role of the renin-angiotensin system
Gabriela Rodrigues Medeiros, Flavia Maria Silva-Veiga, Ana Lívia Ladislau de Souza Vieira, Maria Júlia Amancio Lisboa, Roberto de Souza, Eliza Prodel, Eliete Dalla Corte Frantz, Vanessa Souza-Mello
Life Sciences, 2026
Obesity is a multifactorial chronic disease with pandemic-level prevalence, characterized by excessive or abnormal fat accumulation, dysregulation of body homeostasis, and chronic low-grade inflammation. This complex comorbidity shares some etiological pathways with other diseases such as endometriosis, an inflammatory and estrogen-dependent disorder that affects 5-10% women of reproductive age. The literature shows an inverse correlation between low body mass index (BMI) and the onset of endometriosis, linking obesity to more severe cases. Both endometriosis and obesity share similar underlying mechanisms, including inflammation and angiogenesis. Fat accumulation leads to overactivation of the classical renin-angiotensin system (RAS) axis, triggering impaired lipolysis and adipogenesis, increased lipogenesis, oxidative stress, inflammation, and insulin resistance in white adipose tissue (WAT). Although studies concerning the RAS activity of WAT in women with endometriosis are limited, the chronic inflammatory environment linked to obesity demands further investigation. This review examines the interconnections among RAS, adipogenesis, and inflammation in women with obesity and endometriosis, as well as their potential clinical implications.
Bisphenol S and high-fat diet drive structural and inflammatory remodeling of the colon in C57Bl/6 male mice
Beatriz Gouvêa de Luca, Beatriz Alexandre-Santos, Kauet de Matos Gama e Souza, Emanuelle Barreto-Reis, Ana Paula de Paula Alves, Thaís de Souza Carvalho-Laureano, Vinicius Sepúlveda-Fragoso, Luiza Gil Diniz, Milena Barcza Stockler-Pinto, Clarice Machado dos Santos, Denise Pires de Carvalho, Leandro Miranda-Alves, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano
Toxicology Letters, 2026
Bisphenol S chronic exposure impairs pancreatic function and induces obesity in male mice independently of high-fat diet intake
Ana Paula de Paula Alves, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca, Thaís de Souza Carvalho, Giovanna Palermo de Andrade, Vinicius Sepúlveda-Fragoso, Beatriz Alexandre-Santos, Ana Beatriz Proença Souza, Ana Lívia Ladislau de Souza Vieira, Milena Barcza Stockler-Pinto, Eliete Dalla Corte Frantz, Clarice Machado-Santos, Denise Pires de Carvalho, Leandro Miranda-Alves, D'Angelo Carlo Magliano
Molecular and Cellular Endocrinology, 2026
Exposure to bisphenol S promotes renal damage via aryl hydrocarbon receptor and NF-κB pathways in a mice model of obesity
Michele Lima Brito, Joana Ramos de Araujo, Patricia Pereira Almeida, Beatriz Alexandre-Santos, Beatriz Gouvêa de Luca, Kauet de Matos Gama e Souza, Denise Pires de Carvalho, Denise Mafra, Eliete Dalla Corte Frantz, Clarice Machado-Santos, Leandro Miranda-Alves, D'Angelo Carlo Magliano, Milena Barcza Stockler-Pinto
Environmental Research, 2025
Aerobic exercise training combined with enalapril treatment improves obesity-induced brown adipose tissue whitening
Gabriela Rodrigues Medeiros, Luiza França Losito, Ana Beatriz Proença, Guilherme Santos Reis, Nathalia Silva Carlos Oliveira, D’Angelo Carlo Magliano, Beatriz Alexandre-Santos, Antonio Claudio Lucas Nóbrega, Eliete Dalla Corte Frantz
Journal of Physiology and Biochemistry, 2025
Chronic exposure to bisphenol S impairs hepatic mitochondrial dynamics, induces endoplasmic reticulum stress, and worsens metabolism in high-fat diet fed mice
Emanuelle Barreto-Reis, Vinicius Sepúlveda-Fragoso, Luiza Gil Diniz, Débora Júlia Silva Soares, Thaís de Souza Carvalho-Laureano, Ana Paula de Paula Alves, Beatriz Gouvêa de Luca, Beatriz Alexandre-Santos, Milena Barcza Stockler-Pinto, Denise Pires de Carvalho, Eliete Dalla Corte Frantz, Leandro Miranda-Alves, D'Angelo Carlo Magliano
Environmental Pollution, 2025
Correction to: Renin–Angiotensin System Role in Cardiovascular Effects of Plasticizers: A Systematic Review (Cardiovascular Toxicology, (2025), 25, 8, (1249-1261), 10.1007/s12012-025-10016-4)
Guilherme dos Santos Reis, Luiza Mazzali Ferraz, Maria Eduarda Lima da Silva, Luiza da França Losito, Gabriel Ximenes de Oliveira, Antonio Claudio Lucas da Nóbrega, D.’Angelo Carlo Magliano, Eliete Dalla Corte Frantz, Beatriz Alexandre-Santos
Cardiovascular Toxicology, 2025
Renin–Angiotensin System Role in Cardiovascular Effects of Plasticizers: A Systematic Review
Guilherme dos Santos Reis, Luiza Mazzali Ferraz, Maria Eduarda Lima da Silva, Luiza da França Losito, Gabriel Ximenes de Oliveira, Antonio Claudio Lucas da Nóbrega, D.’Angelo Carlo Magliano, Eliete Dalla Corte Frantz, Beatriz Alexandre-Santos
Cardiovascular Toxicology, 2025
Environmental contamination by bisphenols: From plastic production to modulation of the intestinal morphophysiology in experimental models
Beatriz Gouvêa de Luca, Patricia Pereira Almeida, Reinaldo Röpke Junior, Débora Júlia Silva Soares, Eliete Dalla Corte Frantz, Leandro Miranda-Alves, Milena Barcza Stockler-Pinto, Clarice Machado dos Santos, D'Angelo Carlo Magliano
Food and Chemical Toxicology, 2025
Bisphenol S exposure induces cardiac remodeling and aggravates high-fat diet-induced cardiac hypertrophy in mice
Beatriz Alexandre-Santos, Guilherme dos Santos Reis, Gabriela Rodrigues Medeiros, Milena Barcza Stockler-Pinto, Nathalia Silva Carlos Oliveira, Leandro Miranda-Alves, Antonio Claudio Lucas da Nóbrega, D'Angelo Carlo Magliano, Eliete Dalla Corte Frantz
Environmental Research, 2024
ER stress improvement by aerobic training or enalapril differently ameliorates pathological cardiac remodeling in obese mice
Amanda Conceição Pimenta Salles, Beatriz Alexandre-Santos, Thais de Souza Carvalho, Ana Beatriz Proença, Vinicius Sepúlveda-Fragoso, Tiago Fernandes, Edilamar Menezes Oliveira, Antonio Claudio Lucas da Nóbrega, Eliete Dalla Corte Frantz, D’Angelo Carlo Magliano
Molecular and Cellular Biochemistry, 2024
Tributyltin-induced visceral adiposity is associated with impaired redox balance in white adipose tissue of male rats
Beatriz Alexandre-Santos, Ana Beatriz Araújo Mendes, Guilherme dos Santos Reis, Ana Paula de Paula Alves, Camila Oliveira Freitas, Gabriel Ferreira Lima, Jefferson Fernandes Evangelista, Cristiane Matsuura, Leandro Miranda-Alves, Antonio Claudio Lucas da Nóbrega, D'Angelo Carlo Magliano, Nadia Alice Vieira da Motta, Fernanda Carla Ferreira Brito, Eliete Dalla Corte Frantz
Molecular and Cellular Endocrinology, 2024
Experimental Model Exposed to Bisphenol and Submitted to a High-Fat Diet and Related Morphologic Testicular Parameters Alterations Analysis
Jorge Luiz Alves Pereira, Luiz Carlos Schrotke Pires, Eliete Dalla Corte Frantz, Dangelo Carlo Magliano, Luciano Alves Favorito
International Braz J Urol, 2024
Adipose tissue plasticity mediated by the counterregulatory axis of the renin-angiotensin system: Role of Mas and MrgD receptors
Ana Beatriz Proença, Gabriela Rodrigues Medeiros, Guilherme dos Santos Reis, Luiza da França Losito, Luiza Mazzali Ferraz, Thereza Cristina Lonzetti Bargut, Nícia Pedreira Soares, Beatriz Alexandre‐Santos, Maria Jose Campagnole‐Santos, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nobrega, Robson Augusto Souza Santos, Eliete Dalla Corte Frantz
Journal of Cellular Physiology, 2024
Obesity-induced skeletal muscle remodeling: A comparative analysis of exercise training and ACE-inhibitory drug in male mice
Ana Beatriz Proença, Beatriz Alexandre‐Santos, Isabele Gomes Giori, Jaime Silva Filho Alex‐Marques, Clarice Machado‐Santos, Marcus Machado, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz
Physiological Reports, 2024
Angiotensins in obesity
Beatriz Alexandre-Santos, Vinícius Sepúlveda-Fragoso, D'Angelo Carlo Magliano, Eliete Dalla Corte Frantz
Angiotensin from the Kidney to Coronavirus, 2023
Comparison between aerobic exercise training and enalapril treatment as tools to improve diet-induced metabolic-associated fatty liver disease: Effects on endoplasmic reticulum stress markers
Vinicius Sepúlveda-Fragoso, Beatriz Alexandre-Santos, Emanuelle Barreto-Reis, Tiago Fernandes, Edilamar Menezes Oliveira, Soraia das Neves Vieira Cavalcanti, Georgia Correa Atella, Leandro Miranda-Alves, Manuel Vázquez-Carrera, Antonio Claudio Lucas da Nóbrega, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano
Life Sciences, 2022
Cilostazol attenuates cardiac oxidative stress and inflammation in hypercholesterolemic rats
Rosane de Oliveira Lopes, Gabriel Ferreira Lima, Ana Beatriz Araújo Mendes, Lis Jappour Autran, Nikolas Cunha de Assis Pereira, Stephani Correia Brazão, Beatriz Alexandre-Santos, Eliete Dalla Corte Frantz, Christianne Brêtas Vieira Scaramello, Fernanda Carla Ferreira Brito, Nadia Alice Vieira Motta
Naunyn Schmiedeberg S Archives of Pharmacology, 2022
Renin-angiotensin system modulation through enalapril and/or exercise training improves visceral adiposity in obese mice
Beatriz Alexandre-Santos, D'Angelo Carlo Magliano, Isabele Gomes Giori, Gabriela Rodrigues de Oliveira Medeiros, Carla P. Vieira, Carlos Adam Conte-Junior, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz
Life Sciences, 2022
Gender Disparity in First and Senior Authorship in Brazilian Cardiology Journals
Claudio Tinoco Mesquita, Aline Goneli de Lacerda, Isabella Carolina de Almeida Barros Urel, Eliete Dalla Corte Frantz, Vinícius de Pádua Vieira Alves, Luana Evelyn de Oliveira Amorim, Bruna de Almeida Coutinho, Letícia Rodrigues Dalben, Juliana Cadilho da Silva Abrantes, Vanessa Dias Veloso, Luíza Lucchesi Cabral de Mello, Gláucia Maria Moraes de Oliveira, Fernando de Amorim Fernandes
Arquivos Brasileiros De Cardiologia, 2022
Crosstalk between the renin-angiotensin system and the endoplasmic reticulum stress in the cardiovascular system: Lessons learned so far
Vinicius Sepúlveda-Fragoso, Beatriz Alexandre-Santos, Amanda Conceição Pimenta Salles, Ana Beatriz Proença, Ana Paula de Paula Alves, Manuel Vázquez-Carrera, Antonio Claudio Lucas Nóbrega, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano
Life Sciences, 2021
Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice
Isabele G. Giori, D'Angelo C. Magliano, Beatriz Alexandre‐Santos, Tiago Fernandes, Edilamar M. Oliveira, Carla P. Vieira, Carlos A. Conte‐Junior, Rolando B. Ceddia, Antonio C. L. Nobrega, Eliete D. C. Frantz
Journal of Cellular Physiology, 2021
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats
Guilherme de Oliveira França, Eliete Dalla Corte Frantz, D'Angelo Carlo Magliano, Thereza Cristina Lonzetti Bargut, Vinicius Sepúlveda-Fragoso, Raquel Rangel Silvares, Anissa Daliry, Alessandro Rodrigues do Nascimento, Juliana Pereira Borges
Life Sciences, 2020
Modulation of cardiac renin-angiotensin system, redox status and inflammatory profile by different volumes of aerobic exercise training in obese rats
Beatriz Alexandre-Santos, Renata Alves, Cristiane Matsuura, Vinicius Sepúlveda-Fragoso, Larissa Lírio Velasco, Marcus Vinícius Machado, Aline Bomfim Vieira, Tiago Fernandes, Edilamar Menezes Oliveira, Eduardo Tibiriçá, Antonio Claudio Lucas da Nóbrega, D'Angelo Carlo Magliano, Eliete Dalla Corte Frantz
Free Radical Biology and Medicine, 2020
Aerobic exercise modulates cardiac NAD(P)H oxidase and the NRF2/KEAP1 pathway in a mouse model of chronic fructose consumption
Renata Alves, Camila Liyoko Suehiro, Flavia Garcia de Oliveira, Eliete Dalla Corte Frantz, Renata Frauches de Medeiros, Rodolfo de Paula Vieira, Milton de Arruda Martins, Chin Jia Lin, Antonio Claudio Lucas da Nobrega, Alessandra Choqueta de Toledo-Arruda
Journal of Applied Physiology, 2020
Exercise-induced cardiac opioid system activation attenuates apoptosis pathway in obese rats
Beatriz Alexandre-Santos, Marcus Vinícius Machado, Agatha Cristie Menezes, Larissa Lírio Velasco, Vinicius Sepúlveda-Fragoso, Aline Bomfim Vieira, Juliana Pereira Borges, Eduardo Tibiriçá, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nóbrega, Eliete Dalla Corte Frantz
Life Sciences, 2019
Effects of a high energy density diet in the “corpus cavernosum” of mice
Jorge L. Alves-Pereira, Eliete Dalla Corte Frantz, Lucas Alves Sarmento Pires, Marcio Antonio Babinski, Cristiane da Fonte Ramos
International Journal of Impotence Research, 2019
Modulation of the renin-angiotensin system in white adipose tissue and skeletal muscle: Focus on exercise training
Eliete Dalla Corte Frantz, Eliza Prodel, Igor Dutra Braz, Isabele Gomes Giori, Thereza Cristina Lonzetti Bargut, D’Angelo Carlo Magliano, Antonio Claudio Lucas Nobrega
Clinical Science, 2018
High, but not low, exercise volume shifts the balance of renin-angiotensin system toward ACE2/Mas receptor axis in skeletal muscle in obese rats
Eliete Dalla Corte Frantz, Isabele Gomes Giori, Marcus Vinícius Machado, D’Angelo Carlo Magliano, Fernanda Marques Freitas, Mariana Sodré Boêta Andrade, Aline Bomfim Vieira, Antonio Claudio Lucas Nóbrega, Eduardo Tibiriçá
American Journal of Physiology Endocrinology and Metabolism, 2017
Exercise training modulates the hepatic renin–angiotensin system in fructose-fed rats
Eliete Dalla Corte Frantz, Renata Frauches Medeiros, Isabele Gomes Giori, Juliana Bittencourt Silveira Lima, Thais Bento‐Bernardes, Thaiane Gadioli Gaique, Caroline Fernandes‐Santos, Tiago Fernandes, Edilamar Menezes Oliveira, Carla Paulo Vieira, Carlos Adam Conte‐Junior, Karen Jesus Oliveira, Antonio Claudio Lucas Nobrega
Experimental Physiology, 2017
Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny
Francielle Graus-Nunes, Eliete Dalla Corte Frantz, Wilian Rodrigues Lannes, Mariel Caroline da Silva Menezes, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Nutrition, 2015
Beneficial effects of renin-angiotensin system blockers on testicular steroidogenesis
Jorge Luiz Alves-Pereira, Eliete Dalla Corte Frantz, Cristiane da Fonte Ramos
Journal of Urology, 2014
Comparative effects of the renin-angiotensin system blockers on nonalcoholic fatty liver disease and insulin resistance in C57Bl/6 mice
Eliete Dalla Corte Frantz, Aline Penna-de-Carvalho, Thais de Medeiros Batista, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Metabolic Syndrome and Related Disorders, 2014
Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice
Thereza C. Lonzetti Bargut, Eliete D. C. Frantz, Carlos A. Mandarim‐de‐Lacerda, Marcia Barbosa Aguila
Lipids, 2014
Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice
Eliete Dalla Corte Frantz, Camila Crespo-Mascarenhas, Andre Rodrigues C. Barreto-Vianna, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Plos One, 2013
Pancreas: Anatomy, diseases and health implications
Pancreas Anatomy Diseases and Health Implications, 2012
Endocrine pancreas development: Effects of metabolic and intergenerational programming caused by a protein-restricted diet
Eliete Dalla Corte Frantz, Nayara Peixoto-Silva, Alessandra Pinheiro-Mulder
Pancreas, 2012
Maternal protein restriction in mice causes adverse metabolic and hypothalamic effects in the F1 and F2 generations
Nayara Peixoto-Silva, Eliete Dalla Corte Frantz, Carlos Alberto Mandarim-de-Lacerda, Alessandra Pinheiro-Mulder
British Journal of Nutrition, 2011
Transgenerational endocrine pancreatic adaptation in mice from maternal protein restriction in utero
Eliete Dalla Corte Frantz, Marcia Barbosa Aguila, Alessandra da Rocha Pinheiro-Mulder, Carlos Alberto Mandarim-de-Lacerda
Mechanisms of Ageing and Development, 2011

Eliete Dalla Corte Frantz

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications