Soundarapandian Kannan

@periyaruniversity.ac.in

Senior Professor Department of Zoology
Periyar University

After having more than a decade of teaching and research experience in colleges, assumed charge as Assistant Professor in Bharathiar University, Coimbatore (from 2009- Aug. 2013), he had joined the Department of Zoology, Periyar University, as Professor and Head and serving in this position till date. His research interest contributes in the development of enhanced smart gene/drug delivery system to target cancers which is appreciated by publishing research papers in high impact journals with good number of citations. Interestingly, after having research training in Harvard Medical School & Massachusetts Institute of Technology on 3D Cell Biology and bioprinting, he geared-up his research in post operated-surgical cancer wound healing and its immunological interference by converting M1 Macrophages into M2 Macrophages. The research activities of Prof. S.K brought a novel input to biomedical sciences that site specific anticancer agent delivery to target breast and colo-rectal cancers.

EDUCATION

Dr. S.Kannan’s research group contributed in the development of smart phyto-drug delivery system to target cancers. The preliminary study has mainly focused on development of therapeutic agents for lung, breast, colon, cervical cancers, with enzyme targets, namely cytosolic phospholipase A2α (cPLA2α) and Cyclooxygenase (potential cancer biomarkers) (Sundarraj et al., 2014; 2015). Later the identified phytochemicals and anticancer drugs are prominently delivered into cancer cells using nano-biopolymers and its composites. The main objective of his lab is to target cancer at proteomic and sub-cellular level (Vivek and Kannan et al., 2012; 2014; 2016; 2018). In this context, his team rigorously investigates the impact of nano-formulated drugs/gene or siRNA on cancer cell cycle, cell proliferation and cell viability with special attention on cell organelles like endoplasmic reticulum, mitochondria, nucleus etc (Murugan and Kannan et al., 2016; Vimala et al., 2021). It is well p

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Oncology, Biomedical Engineering, Biomaterials
114

Scopus Publications

7713

Scholar Citations

45

Scholar h-index

100

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Multifunctional MoSe₂/ZnO-PEG-cRGD nanocomposites for NIR/pH-responsive quercetin delivery in hepatocellular carcinoma treatment
    P Sasireka, K Vimala, A Asaikkutti, R Thangaraj, S Kannan
    Inorganic Chemistry Communications, 116087 , 2025
    2025
  • Fabrication of Biosynthesis CuO Nanoparticles Mediated by Artemisia vulgaris : A Novel Target for Colon Cancer Therapy Via Suppression of PI3K/AKT/mTOR …
    M Sakthivel, K Vimala, M Rajkumar, S Navaneethakrishnan, R Thangaraj, ...
    Journal of Cluster Science 36 (6), 221 , 2025
    2025
  • Stilbene-based fluorescent chemosensor for selective detection of cyanide ion in DMSO medium and its application in cell-imaging, fingerprint, and food sample analysis
    C Yesudhasan, A Siva, G Shanmugam, S Kannan
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 330, 125643 , 2025
    2025
    Citations: 4
  • Occupancy and co-occurrence patterns of bulbuls (family: Pycnonotidae) across various environmental gradients in Eastern Ghats, Tamil Nadu, India
    DD Tamiliniyan, N Prasanth, S Kannan
    Avian Biology Research 17 (4), 84-97 , 2024
    2024
    Citations: 1
  • Predicting covariate influence on white-browed bulbul Pycnonotus luteolus abundance using N-mixture model in Eastern Ghats, Tamil Nadu, India
    DD Tamiliniyan, N Prasanth, S Kannan
    Ornithology Research 33 (1), 7 , 2024
    2024
    Citations: 2
  • Chemically engineered CoOx-doped flower-like NiO nanoparticles for photodegradation of Bisphenol A and Orange II Dye, and genetic screening of toxicity via Caenorhaditis elegans
    V Manikandan, PSM Kumar, S Govindan, RS Kumar, S Kannan, F Zhang, ...
    Journal of Environmental Chemical Engineering 12 (5), 113677 , 2024
    2024
    Citations: 10
  • Retraction notice to “Gelatin/polyethylene glycol-loaded magnesium hydroxide nanocomposite to attenuate acetylcholinesterase, neurotoxicity, and activation of GPR55 protein in …
    M Rajkumar, S Navaneethakrishnan, S Muthukumar, R Thangaraj, ...
    Journal of Chemical Neuroanatomy 139, 102448 , 2024
    2024
  • Biosynthesis of Gelatin-Coated Zinc Oxide Nanocomposites from Coccinia indica Extract and its Antibacterial, Antioxidant, Anticancer and Wound Healing Properties
    K Senthilkumar, M Rajkumar, K Vimala, R Thangaraj, S Kannan
    BioNanoScience 14 (3), 2993-3010 , 2024
    2024
    Citations: 10
  • Chitosan/PLA-loaded magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease
    M Rajkumar, P Govindaraj, K Vimala, R Thangaraj, S Kannan
    Metabolic Brain Disease 39 (4), 487-508 , 2024
    2024
    Citations: 21
  • RETRACTED: Dieckol prevents prostate cancer cell proliferation by transcriptionally attenuating JAK/STAT3 signaling pathway
    V Karuppaiya, A Annamalai, S Krishnamurthy, K Soundarapandian
    Environmental Toxicology 39 (3), 1187-1196 , 2024
    2024
    Citations: 9
  • Biosynthesis of Gelatin-coated Zinc oxide nanocomposite from Coccinia indica extract and its antibacterial, antioxidant, anticancer and wound-healing properties
    K Senthikumar, M Rajkumar, K Vimala, R Thangaraj, S Kannan
    2024
    Citations: 2
  • Green synthesis of gelatin-loaded magnesium hydroxide nanocomposite biomaterial using Coleus amboinicus leaf extract for enhanced antibacterial, antioxidant …
    M Rajkumar, D Kirubakaran, K Selvam, N Prathap, R Thangaraj, K Vimala, ...
    Journal of Materials Research 39 (4), 548-564 , 2024
    2024
    Citations: 15
  • Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound …
    D Kirubakaran, K Selvam, M Subramanian Shivakumar, M Rajkumar, ...
    ChemistrySelect 9 (6), e202302792 , 2024
    2024
    Citations: 21
  • Recent advances in nanotechnology: a new paradigm toward wastewater treatment
    M Rajkumar, SID Presley, N Thiyagarajulu, R Thangaraj, S Kannan
    Bioremediation of Emerging Contaminants in Water. Volume 2, 89-110 , 2024
    2024
    Citations: 7
  • Voglibose attenuates cognitive impairment, Aβ aggregation, oxidative stress, and neuroinflammation in streptozotocin-induced Alzheimer’s disease rat model
    M Rajkumar, S Kannan, R Thangaraj
    Inflammopharmacology 31 (5), 2751-2771 , 2023
    2023
    Citations: 17
  • Silver nanoparticle production mediated by Goniothalamus wightii extract: characterization and their potential biological applications
    S Chinnaraj, V Palani, V Maluventhen, R Chandrababu, ...
    Particulate Science and Technology 41 (4), 517-531 , 2023
    2023
    Citations: 8
  • Gelatin/polyvinyl alcohol loaded magnesium hydroxide nanocomposite attenuates neurotoxicity and oxidative stress in Alzheimer's disease induced rats
    M Rajkumar, K Vimala, DD Tamiliniyan, R Thangaraj, R Jaganathan, ...
    International Journal of Biological Macromolecules 222, 2122-2143 , 2022
    2022
    Citations: 28
  • Biofabricated selenium nanoparticles mediated from Goniothalamus wightii gains biomedical applications and photocatalytic degrading ability
    C Santhosh, B Balasubramanian, P Vino, M Viji, C Rejeeth, S Kannan, ...
    Journal of King Saud University-Science 34 (8), 102331 , 2022
    2022
    Citations: 24
  • Galantamine tethered hydrogel as a novel therapeutic target for streptozotocin-induced Alzheimer's disease in Wistar rats
    R Manickam, S Murugesan, S Kottaisamy, T Ramasundaram, ...
    Current Research in Pharmacology and Drug Discovery, 100100 , 2022
    2022
    Citations: 35
  • 4P Antitumor efficacy of integrin αVβ3 antibody conjugated ZnO nanocarrier-based drug delivery system to target breast carcinoma
    K Vimala, S Kannan
    Annals of Oncology 33, S2 , 2022
    2022

MOST CITED SCHOLAR PUBLICATIONS

  • Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and its in vitro cytotoxic effect on MCF-7 cells
    R Vivek, R Thangam, K Muthuchelian, P Gunasekaran, K Kaveri, ...
    Process Biochemistry 47 (12), 2405-2410 , 2012
    2012
    Citations: 532
  • Green synthesis of gold nanoparticles using Citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) aqueous extract and its characterization
    MV Sujitha, S Kannan
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 102, 15-23 , 2013
    2013
    Citations: 478
  • Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: towards natural therapeutics
    S Afewerki, A Sheikhi, S Kannan, S Ahadian, A Khademhosseini
    Bioengineering & translational medicine 4 (1), 96-115 , 2019
    2019
    Citations: 462
  • Emergent contaminants: endocrine disruptors and their laccase-assisted degradation–a review
    C Barrios-Estrada, M de Jesús Rostro-Alanis, BD Muñoz-Gutiérrez, ...
    Science of the total environment 612, 1516-1531 , 2018
    2018
    Citations: 381
  • γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells
    S Sundarraj, R Thangam, V Sreevani, K Kaveri, P Gunasekaran, ...
    Journal of ethnopharmacology 141 (3), 803-809 , 2012
    2012
    Citations: 301
  • Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma
    K Vimala, S Sundarraj, M Paulpandi, S Vengatesan, S Kannan
    Process biochemistry 49 (1), 160-172 , 2014
    2014
    Citations: 294
  • C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest
    R Thangam, V Suresh, WA Princy, M Rajkumar, N Senthilkumar, ...
    Food chemistry 140 (1-2), 262-272 , 2013
    2013
    Citations: 222
  • pH-responsive drug delivery of chitosan nanoparticles as Tamoxifen carriers for effective anti-tumor activity in breast cancer cells
    R Vivek, VN Babu, R Thangam, KS Subramanian, S Kannan
    Colloids and Surfaces B: Biointerfaces 111, 117-123 , 2013
    2013
    Citations: 219
  • Characterization, antioxidant and cytotoxicity evaluation of green synthesized silver nanoparticles using Cleistanthus collinus extract as surface modifier
    N Kanipandian, S Kannan, R Ramesh, P Subramanian, R Thirumurugan
    Materials Research Bulletin 49, 494-502 , 2014
    2014
    Citations: 189
  • Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy
    R Vivek, R Thangam, V NipunBabu, C Rejeeth, S Sivasubramanian, ...
    ACS applied materials & interfaces 6 (9), 6469-6480 , 2014
    2014
    Citations: 187
  • Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: An improved nanomedicine strategy
    C Murugan, K Rayappan, R Thangam, R Bhanumathi, K Shanthi, R Vivek, ...
    Scientific reports 6 (1), 34053 , 2016
    2016
    Citations: 165
  • Quercetin conjugated superparamagnetic magnetite nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy applications
    SR Kumar, S Priyatharshni, VN Babu, D Mangalaraj, C Viswanathan, ...
    Journal of colloid and interface science 436, 234-242 , 2014
    2014
    Citations: 160
  • Separation, purification and preliminary characterization of sulfated polysaccharides from Sargassum plagiophyllum and its in vitro anticancer and antioxidant activity
    V Suresh, N Senthilkumar, R Thangam, M Rajkumar, C Anbazhagan, ...
    Process Biochemistry 48 (2), 364-373 , 2013
    2013
    Citations: 159
  • Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions
    R Thangam, M Sathuvan, A Poongodi, V Suresh, K Pazhanichamy, ...
    Carbohydrate polymers 107, 138-150 , 2014
    2014
    Citations: 137
  • Induction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles from Gossypium hirsutum and evaluation of in vivo toxicity
    N Kanipandian, D Li, S Kannan
    Biotechnology reports 23, e00339 , 2019
    2019
    Citations: 130
  • Culture and identification of Candida albicans from vaginal ulcer and separation of enolase on SDS-page
    SK P Saravana Bhavan, R Rajkumar, S Radhakrishnan, C
    International Journal of Biology 2 (1), P84 , 2009
    2009
    Citations: 129
  • Proximate composition and profiles of amino acids and fatty acids in the muscle of adult males and females of commercially viable prawn species Macrobrachium rosenbergii …
    PS Bhavan, S Radhakrishnan, C Seenivasan, R Shanthi, R Poongodi, ...
    International Journal of Biology 2 (2), 107 , 2010
    2010
    Citations: 108
  • Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: a “smart” drug delivery system to breast cancer cell therapy
    R Vivek, R Thangam, V Nipunbabu, T Ponraj, S Kannan
    International journal of biological macromolecules 65, 289-297 , 2014
    2014
    Citations: 107
  • Synergistic effect of chemo-photothermal for breast cancer therapy using folic acid (FA) modified zinc oxide nanosheet
    SK K.Vimala, K. Shanthi, S.Sundarraj
    Journal of Colloid and Interface Science 488, 92–108 , 2017
    2017
    Citations: 104
  • Drug-carrying capacity and anticancer effect of the folic acid-and berberine-loaded silver nanomaterial to regulate the AKT-ERK pathway in breast cancer
    R Bhanumathi, M Manivannan, R Thangaraj, S Kannan
    ACS omega 3 (7), 8317-8328 , 2018
    2018
    Citations: 102