Denise Medeiros Selegato

@embl.org/sites/heidelberg

Chemistry
EMBL Heidelberg, Structural and Computational Biology



                 

https://researchid.co/denisemselegato

In 2019-2020, she was a postdoctoral fellow at the Centre of Magnetic Resonance (CERM) from the University of Florence (Italy), working with scientific programming to facilitate the analysis of integrative structural biology and NMR-metabolomics. In between 2020-2021, she was a postdoctoral researcher at Fundación MEDINA (Spain), where her research focuses on the discovery of new potential antibiotics by high throughput screening of microbial species. Currently, she is a Metabolomics Specialist in the Zimmermann Group (Metabolic host-microbiome interactions) from the European Laboratory of Molecular Biology (EMBL) in Heidelberg.

EDUCATION

Denise M. Selegato has a Bachelor's degree in Pharmacy and Biochemistry from São Paulo State University, UNESP (2008-2013), and a Ph.D. in Chemistry from the same University (2014-2019). Her main work was to investigate the chemical profile of plants and microbes for the purposes of drug discovery and the understanding of metabolic variation affected by different genetic and environmental perturbations. This includes the development and application of computational tools (mainly molecular networking and multivariate data analysis) to overcome analytical challenges in LC-MS and NMR-based metabolomics. During that period, she was also a guest researcher at the Natural Products Laboratory from Leiden University (Netherlands), under the supervision of Prof. Dr. Young H. Choi, in which she continued to explore metabolomics for drug discovery purposes, with a particular interest in overcoming microbial resistance to current antimicrobial therapy.

RESEARCH INTERESTS

Currently, she is a research staff in the Zimmermann Group (Metabolic host-microbiome interactions) from the European Laboratory of Molecular Biology (EMBL) in Heidelberg.

238

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Application of feature-based molecular networking and MassQL for the MS/MS fragmentation study of depsipeptides
    DM Selegato, AC Zanatta, AC Pilon, J Veloso, I Castro-Gamboa
    Frontiers in Molecular Bioscience 10, XX 2023

  • Enhancing Chemical and Biological Diversity by Co-cultivation
    DM Selegato, I Castro-Gamboa
    Frontiers in Microbiology 14, 67 2023

  • Acknowledgment to the Reviewers of Molecules in 2022
    AKMM Islam, AM Nafchi, ANM Mamun-Or-Rashid, A Boucekkine, ...
    Molecules 28, 1072 2023

  • Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant
    DS Chacon, MDM Santos, B Bonilauri, J Vilasboa, CT Da Costa, ...
    Frontiers in Plant Science 13, 947558 2022

  • Time-related multivariate strategy for the comprehensive evaluation of microbial chemical data
    DM Selegato, TR Freitas, M Pivatto, AD Pivatto, AC Pilon, ...
    Metabolomics 18 (6), 33 2022

  • Erythrina velutina Willd. alkaloids: Piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves
    D Sotero Chacon, T Melo Torres, I Bezerra da Silva, T Ferreira de Arajo, ...
    Journal of Advanced Research, 2021, vol. 34, p. 123-136 2021

  • Erythrina velutina Willd. alkaloids: piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves

    Journal of Advanced Research, 00 2021

  • Comparison of different reweighting approaches for the calculation of conformational variability of macromolecules from molecular simulations
    DM Selegato, C Bracco, C Giannelli, G Parigi, C Luchinat, L Sgheri, ...
    ChemPhysChem 2020

  • Plant metabolomics: Methods and challenges
    AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ...
    Soc Brasileira Quimica 2020

  • METABOLMICA DE PLANTAS: MTODOS E DESAFIOS
    AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ...
    Qumica Nova 43 (3), 329-354 2020

  • Quim. Nova
    AC Pilon, D Selegato, R Fernandes, P Bueno, D Pinho, F Carnevale Neto, ...
    2020

  • Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification
    DM Selegato, RT Freire, AC Pilon, CR Biasetto, HC de Oliveira, ...
    Magnetic Resonance in Chemistry 57 (8), 458-471 2019

  • Estudos metabolmicos de fungos associados a plantas: desenvolvimento de mtodos para o aumento da produo e identificao de metablitos secundrios bioativos microbianos
    DM Selegato
    Universidade Estadual Paulista (Unesp) 2019

  • Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection
    DP Pavarini, DM Selegato, I Castro-Gamboa, LVS Do Sacramento, ...
    Molecules 24 (6), 1160 2019

  • Identification of antiplasmodial triterpenes from Keetia species using NMR-based metabolic profiling
    RT Freire, J Bero, C Beaufay, DM Selegato, A Coqueiro, YH Choi, ...
    Metabolomics 15, 1-11 2019

  • Activity of fractions obtained from extract of Fusarium oxysporum isolated from Senna spectabilis against Staphylococcus epidermidis in biofilm and planktonic forms
    GM Righetto, DM Selegato, IC Gamboa, ILBC Camargo
    Abstracts 2019

  • NMR-based metabolomics: Methods and protocols
    GAN Gowda, D Raftery
    Humana Press 2019

  • Plant Metabolomics Using NMR Spectroscopy
    DM Selegato, AC Pilon, FC Neto
    NMR-Based Metabolomics, 345-362 2019

  • Update: Biological and chemical aspects of Senna spectabilis
    DM Selegato, AF Monteiro, NC Vieira, P Cardoso, VD Pavani, VS Bolzani, ...
    Journal of the Brazilian Chemical Society 28 (3), 415-426 2017

  • Dereplication of natural products using GC-TOF mass spectrometry: improved metabolite identification by spectral deconvolution ratio analysis
    F Carnevale Neto, AC Pilon, DM Selegato, RT Freire, H Gu, D Raftery, ...
    Frontiers in Molecular Biosciences 3, 59 2016

MOST CITED SCHOLAR PUBLICATIONS

  • METABOLMICA DE PLANTAS: MTODOS E DESAFIOS
    AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ...
    Qumica Nova 43 (3), 329-354 2020
    Citations: 36

  • Dereplication of natural products using GC-TOF mass spectrometry: improved metabolite identification by spectral deconvolution ratio analysis
    F Carnevale Neto, AC Pilon, DM Selegato, RT Freire, H Gu, D Raftery, ...
    Frontiers in Molecular Biosciences 3, 59 2016
    Citations: 33

  • NMR-based metabolomics: Methods and protocols
    GAN Gowda, D Raftery
    Humana Press 2019
    Citations: 31

  • Update: Biological and chemical aspects of Senna spectabilis
    DM Selegato, AF Monteiro, NC Vieira, P Cardoso, VD Pavani, VS Bolzani, ...
    Journal of the Brazilian Chemical Society 28 (3), 415-426 2017
    Citations: 26

  • New dereplication method applied to NMR-based metabolomics on different Fusarium species isolated from rhizosphere of Senna spectabilis
    DM Selegato, RT Freire, A Tanns, I Castro-Gamboa
    Journal of the Brazilian Chemical Society 27 (8), 1421-1431 2016
    Citations: 18

  • Comparison of different reweighting approaches for the calculation of conformational variability of macromolecules from molecular simulations
    DM Selegato, C Bracco, C Giannelli, G Parigi, C Luchinat, L Sgheri, ...
    ChemPhysChem 2020
    Citations: 17

  • Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification
    DM Selegato, RT Freire, AC Pilon, CR Biasetto, HC de Oliveira, ...
    Magnetic Resonance in Chemistry 57 (8), 458-471 2019
    Citations: 14

  • Plant Metabolomics Using NMR Spectroscopy
    DM Selegato, AC Pilon, FC Neto
    NMR-Based Metabolomics, 345-362 2019
    Citations: 14

  • Identification of antiplasmodial triterpenes from Keetia species using NMR-based metabolic profiling
    RT Freire, J Bero, C Beaufay, DM Selegato, A Coqueiro, YH Choi, ...
    Metabolomics 15, 1-11 2019
    Citations: 13

  • Enhancing Chemical and Biological Diversity by Co-cultivation
    DM Selegato, I Castro-Gamboa
    Frontiers in Microbiology 14, 67 2023
    Citations: 10

  • Quim. Nova
    AC Pilon, D Selegato, R Fernandes, P Bueno, D Pinho, F Carnevale Neto, ...
    2020
    Citations: 8

  • Erythrina velutina Willd. alkaloids: piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves

    Journal of Advanced Research, 00 2021
    Citations: 6

  • Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant
    DS Chacon, MDM Santos, B Bonilauri, J Vilasboa, CT Da Costa, ...
    Frontiers in Plant Science 13, 947558 2022
    Citations: 3

  • Plant metabolomics: Methods and challenges
    AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ...
    Soc Brasileira Quimica 2020
    Citations: 3

  • Application of feature-based molecular networking and MassQL for the MS/MS fragmentation study of depsipeptides
    DM Selegato, AC Zanatta, AC Pilon, J Veloso, I Castro-Gamboa
    Frontiers in Molecular Bioscience 10, XX 2023
    Citations: 2

  • Time-related multivariate strategy for the comprehensive evaluation of microbial chemical data
    DM Selegato, TR Freitas, M Pivatto, AD Pivatto, AC Pilon, ...
    Metabolomics 18 (6), 33 2022
    Citations: 2

  • Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection
    DP Pavarini, DM Selegato, I Castro-Gamboa, LVS Do Sacramento, ...
    Molecules 24 (6), 1160 2019
    Citations: 2