In 2019-2020, she was a postdoctoral fellow at the Centre of Magnetic Resonance (CERM) from the University of Florence (Italy), working with scientific programming to facilitate the analysis of integrative structural biology and NMR-metabolomics. In between 2020-2021, she was a postdoctoral researcher at Fundación MEDINA (Spain), where her research focuses on the discovery of new potential antibiotics by high throughput screening of microbial species. Currently, she is a Metabolomics Specialist in the Zimmermann Group (Metabolic host-microbiome interactions) from the European Laboratory of Molecular Biology (EMBL) in Heidelberg.
EDUCATION
Denise M. Selegato has a Bachelor's degree in Pharmacy and Biochemistry from São Paulo State University, UNESP (2008-2013), and a Ph.D. in Chemistry from the same University (2014-2019). Her main work was to investigate the chemical profile of plants and microbes for the purposes of drug discovery and the understanding of metabolic variation affected by different genetic and environmental perturbations. This includes the development and application of computational tools (mainly molecular networking and multivariate data analysis) to overcome analytical challenges in LC-MS and NMR-based metabolomics. During that period, she was also a guest researcher at the Natural Products Laboratory from Leiden University (Netherlands), under the supervision of Prof. Dr. Young H. Choi, in which she continued to explore metabolomics for drug discovery purposes, with a particular interest in overcoming microbial resistance to current antimicrobial therapy.
RESEARCH INTERESTS
Currently, she is a research staff in the Zimmermann Group (Metabolic host-microbiome interactions) from the European Laboratory of Molecular Biology (EMBL) in Heidelberg.
513
Scholar Citations
12
Scholar h-index
15
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
Personalized microbiotas (counter-) select for antibiotic resistant pathogens M Knopp, S Garcia-Santamarina, L Michel, D Papagiannidis, S David, ... bioRxiv, 2026.03. 29.715108 , 2026 2026
Multi-omics and biophysical phosphoproteomics upon BRAF inhibition uncover functional networks of BRAFV600E-driven signaling ML Burtscher, M Garrido-Rodriguez, PA Rivera Mejias, D Papagiannidis, ... bioRxiv, 2026.02. 09.704793 , 2026 2026
Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites N Denisov, F Springer, A Brauer-Nikonow, G Maftei, G Zeller, ... Analytical and Bioanalytical Chemistry 418 (4), 1035-1054 , 2026 2026 Citations: 2
Vitamin B 2 Production by Vaginal Lactobacilli Promotes Symbiosis CEMK Dricot, DM Selegato, T Van Rillaer, E Cauwenberghs, I Erreygers, ... bioRxiv, 2025.10. 28.684342 , 2025 2025 Citations: 2
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation OI Coleman, A Sorbie, A Riva, M von Stern, S Kuhls, DM Selegato, ... Nature Metabolism 7 (9), 1830-1850 , 2025 2025 Citations: 8
O-081 Serum metabolic profiling in endometriosis reveals a strong metabolic signature for peritoneal endometriosis R Kollarics, DM Selegato, A Marshall, J Jauckus, T Strowitzki, ... Human Reproduction 40 (Supplement_1), deaf097. 081 , 2025 2025
Application of feature-based molecular networking and MassQL for the MS/MS fragmentation study of depsipeptides DM Selegato, AC Zanatta, AC Pilon, J Veloso, I Castro-Gamboa Frontiers in Molecular Bioscience 10, XX , 2023 2023 Citations: 22
Enhancing Chemical and Biological Diversity by Co-cultivation DM Selegato, I Castro-Gamboa Frontiers in Microbiology 14, 67 , 2023 2023 Citations: 123
Enhancing chemical and biological diversity by co-cultivation. Front Microbiol 14: 1117559 DM Selegato, I Castro-Gamboa 2023 Citations: 10
Acknowledgment to the Reviewers of Molecules in 2022 AKMM Islam, AM Nafchi, ANM Mamun-Or-Rashid, A Boucekkine, ... Molecules 28, 1072 , 2023 2023
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant DS Chacon, MDM Santos, B Bonilauri, J Vilasboa, CT Da Costa, ... Frontiers in plant science 13, 947558 , 2022 2022 Citations: 12
Time-related multivariate strategy for the comprehensive evaluation of microbial chemical data DM Selegato, TR Freitas, M Pivatto, AD Pivatto, AC Pilon, ... Metabolomics 18 (6), 33 , 2022 2022 Citations: 8
Erythrina velutina Willd. alkaloids: Piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves D Sotero Chacon, T Melo Torres, I Bezerra da Silva, T Ferreira de Araújo, ... Journal of Advanced Research, 2021, vol. 34, p. 123-136 , 2021 2021
Erythrina velutina Willd. alkaloids: piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves Journal of Advanced Research, 00 , 2021 2021 Citations: 14
Comparison of different reweighting approaches for the calculation of conformational variability of macromolecules from molecular simulations DM Selegato, C Bracco, C Giannelli, G Parigi, C Luchinat, L Sgheri, ... ChemPhysChem , 2020 2020 Citations: 24
Plant metabolomics: Methods and challenges AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... Soc Brasileira Quimica , 2020 2020 Citations: 9
METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... Química Nova 43 (3), 329-354 , 2020 2020 Citations: 70
Quim. Nova AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... 2020 Citations: 12
Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1 HNMR quantification DM Selegato, RT Freire, AC Pilon, CR Biasetto, HC de Oliveira, ... Magnetic Resonance in Chemistry 57 (8), 458-471 , 2019 2019 Citations: 19
Estudos metabolômicos de fungos associados a plantas: desenvolvimento de métodos para o aumento da produção e identificação de metabólitos secundários bioativos microbianos DM Selegato Universidade Estadual Paulista (Unesp) , 2019 2019
MOST CITED SCHOLAR PUBLICATIONS
Enhancing Chemical and Biological Diversity by Co-cultivation DM Selegato, I Castro-Gamboa Frontiers in Microbiology 14, 67 , 2023 2023 Citations: 123
METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... Química Nova 43 (3), 329-354 , 2020 2020 Citations: 70
Dereplication of natural products using GC-TOF mass spectrometry: improved metabolite identification by spectral deconvolution ratio analysis F Carnevale Neto, AC Pilon, DM Selegato, RT Freire, H Gu, D Raftery, ... Frontiers in Molecular Biosciences 3, 59 , 2016 2016 Citations: 40
Update: Biological and chemical aspects of Senna spectabilis DM Selegato, AF Monteiro, NC Vieira, P Cardoso, VD Pavani, VS Bolzani, ... Journal of the Brazilian Chemical Society 28 (3), 415-426 , 2017 2017 Citations: 37
NMR-based metabolomics: Methods and protocols GA Gowda, D Raftery (No Title) , 2019 2019 Citations: 33
Plant Metabolomics Using NMR Spectroscopy DM Selegato, AC Pilon, FC Neto NMR-Based Metabolomics, 345-362 , 2019 2019 Citations: 30
Comparison of different reweighting approaches for the calculation of conformational variability of macromolecules from molecular simulations DM Selegato, C Bracco, C Giannelli, G Parigi, C Luchinat, L Sgheri, ... ChemPhysChem , 2020 2020 Citations: 24
Application of feature-based molecular networking and MassQL for the MS/MS fragmentation study of depsipeptides DM Selegato, AC Zanatta, AC Pilon, J Veloso, I Castro-Gamboa Frontiers in Molecular Bioscience 10, XX , 2023 2023 Citations: 22
Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1 HNMR quantification DM Selegato, RT Freire, AC Pilon, CR Biasetto, HC de Oliveira, ... Magnetic Resonance in Chemistry 57 (8), 458-471 , 2019 2019 Citations: 19
Identification of antiplasmodial triterpenes from Keetia species using NMR-based metabolic profiling RT Freire, J Bero, C Beaufay, DM Selegato, A Coqueiro, YH Choi, ... Metabolomics 15 (3), 27 , 2019 2019 Citations: 18
New dereplication method applied to NMR-based metabolomics on different Fusarium species isolated from rhizosphere of Senna spectabilis DM Selegato, RT Freire, A Tannús, I Castro-Gamboa Journal of the Brazilian Chemical Society 27 (8), 1421-1431 , 2016 2016 Citations: 18
Erythrina velutina Willd. alkaloids: piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves Journal of Advanced Research, 00 , 2021 2021 Citations: 14
Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant DS Chacon, MDM Santos, B Bonilauri, J Vilasboa, CT Da Costa, ... Frontiers in plant science 13, 947558 , 2022 2022 Citations: 12
Quim. Nova AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... 2020 Citations: 12
Enhancing chemical and biological diversity by co-cultivation. Front Microbiol 14: 1117559 DM Selegato, I Castro-Gamboa 2023 Citations: 10
Plant metabolomics: Methods and challenges AC Pilon, DM Selegato, RP Fernandes, PCP Bueno, DR Pinho, ... Soc Brasileira Quimica , 2020 2020 Citations: 9
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation OI Coleman, A Sorbie, A Riva, M von Stern, S Kuhls, DM Selegato, ... Nature Metabolism 7 (9), 1830-1850 , 2025 2025 Citations: 8
Time-related multivariate strategy for the comprehensive evaluation of microbial chemical data DM Selegato, TR Freitas, M Pivatto, AD Pivatto, AC Pilon, ... Metabolomics 18 (6), 33 , 2022 2022 Citations: 8
Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites N Denisov, F Springer, A Brauer-Nikonow, G Maftei, G Zeller, ... Analytical and Bioanalytical Chemistry 418 (4), 1035-1054 , 2026 2026 Citations: 2
Vitamin B 2 Production by Vaginal Lactobacilli Promotes Symbiosis CEMK Dricot, DM Selegato, T Van Rillaer, E Cauwenberghs, I Erreygers, ... bioRxiv, 2025.10. 28.684342 , 2025 2025 Citations: 2
