Rubens Gisbert Cury currently works at the Department of Neurology, University of São Paulo, Brazil. Rubens does research in Movement Disorders, focusing on Deep Brain Stimulation and Noninvasive Neuromodulation.
Choreiform Wilson's disease and a distinctive 7-Tesla magnetic resonance imaging finding Ana Rosa Santana, Igor Vilela Brum, Izaely Ramos Prates, Júlio Melão Cordeiro, Rubens Gisbert Cury, et al. Arquivos De Neuro Psiquiatria, 2026 Chorea is a rare manifestation of Wilson's disease (WD), resulting from copper-induced dysfunction of the basal ganglia. We herein report the case of a 22-year-old woman with progressive dysarthria and generalized chorea, later confirmed as WD. After 1 year of penicillamine therapy, she showed marked clinical improvement, with only residual chorea in the right upper limb. A 7-Tesla (7-T) magnetic resonance imaging (MRI) scan revealed predominant involvement of the left basal ganglia and corticospinal tract, including the hyperintense globus pallidus rim sign. This case highlights chorea as a potential initial manifestation of WD and reinforces its reversibility with the appropriate treatment.
Safety and Feasibility of Low-Intensity Transcranial Focused Ultrasound Targeting the Anterior Thalamus: A Pilot Study for Chronic Central Neuropathic Pain Glaucia Aline Nunes, Josimar Reis Ortiz, Claudia Mingrone, Debora Arnaut, Hélder Picarelli, et al. Journal of ECT, 2026 Low-intensity transcranial focused ultrasound (tFUS) is a novel noninvasive neuromodulation technique capable of reaching deep brain structures with high spatial precision. The anterior thalamus, a key relay in pain processing, is a promising target for modulating central pain networks. In this context, this study aims to assess the safety, feasibility, and preliminary effects of anterior thalamic low-intensity tFUS in patients with chronic Central Neuropathic Pain (CNP). In this prospective, open-label, single-arm pilot study, 5 adults with refractory central neuropathic pain underwent neuronavigated low-intensity transcranial focused ultrasound targeting the anterior thalamus contralateral to the pain-affected region. Each session consisted of two 10-minute stimulation blocks separated by 20 minutes. Pain intensity was assessed using the visual analog scale at baseline, immediately poststimulation, and also after 4 hours, 24 hours and 10 days after the intervention. Secondary outcomes included the Brief Pain Inventory, McGill Pain Questionnaire, Douleur Neuropatique 4, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Patient Global Impression of Change and Clinical Global Impression of Change scale. The procedure demonstrated feasible with no serious adverse events. One participant experienced mild transient neck discomfort. No statistically significant improvements were observed in pain intensity or secondary outcomes at any time point compared with baseline. Overall, anterior thalamic low-intensity tFUS presented safe and feasible for patients with CNP but did not yield significant short-term analgesic effects. These findings support further controlled clinical trials with larger samples, optimized stimulation parameters and repeated sessions to better evaluate the therapeutic potential of low-intensity tFUS for chronic CNP.
Choreiform Wilson's disease and a distinctive 7-Tesla magnetic resonance imaging finding AR Santana, IV Brum, IR Prates, JM Cordeiro, RG Cury, LT Lucato, ... Arquivos de Neuro-Psiquiatria 84 (04), 001-003 , 2026 2026
Exploring quantile graphs: A novel approach for classifying Parkinson’s disease-related events during the TUG test AM Pineda, ML Vicchietti, RB Carra, S Thome-Souza, D Salgado, ... Biomedical Signal Processing and Control 114, 109269 , 2026 2026
Evaluation of novel assays of non-ceruloplasmin copper to monitor chelation treatment in patients with Wilson disease: Monitoring chelation treatment in Wilson disease P Ott, T Sandahl, A Ala, D Cassiman, E Couchonnal-Bedoya, RG Cury, ... JHEP Reports, 101822 , 2026 2026
From Motor Effectors to Action Networks: SCAN Reshapes Parkinson's Disease Pathophysiology RG Cury, N Pavese Movement Disorders , 2026 2026
The electric brain: approach to suboptimal DBS parameters ACM de Falcone, C França, TG Guimarães, RG Cury Clinical Parkinsonism & Related Disorders, 100418 , 2025 2025
Target the Circuit, Not the Brain: Rethinking Essential Tremor Therapy ACM de Falcone, RGM Barbosa, RG Cury Movement Disorders Clinical Practice 12 (12), 2386-2387 , 2025 2025 Citations: 1
Surgical Treatment of Holmes Tremor: Case Report, Systematic Review, and Meta-Analysis: WSSFN 2025 Interim Meeting. Abstract 0042 J Rodrigues, KC Laube, MM Correia, EPC Dos Santos, R Cury, ... NeuroTarget 19 (2), 20-1 , 2025 2025
Deep brain stimulation for dystonia: outcomes from a Brazilian cohort C Listik, E Listik, FPS Rolim, MC Soares, RMG Barbosa, BA de Monaco, ... Arquivos de Neuro-psiquiatria 83 (11), 001-007 , 2025 2025
Evaluating the neuroprotective effect of GLP-1 receptor agonists in parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials YM Pessoa-Gonçalves, VHP Flávio-Reis, CS Desidério, MA Dias-Sousa, ... Neurological Sciences, 1-10 , 2025 2025
Differences and contributors to global cognitive performance in the underrepresented Latinx Parkinson’s disease population S Anis, HM Chaparro-Solano, T Peixoto Leal, SA Sperling, C Sonneborn, ... The Clinical Neuropsychologist 39 (7), 1905-1925 , 2025 2025 Citations: 1
Correlation of 7T MRI Susceptibility and Retinal Nerve Fiber Thickness with Neurological Severity in Wilson's Disease I Brum, I Prates, J Cordeiro, F Otsuka, R Guidi, P Barbosa, R Cury, ... MOVEMENT DISORDERS 40 , 2025 2025
Trans-Spinal Theta Burst Magnetic Stimulation Enhances Treadmill Training Effects on Gait in Parkinson's Disease L Lopes, J Oliveira, A Costa-Ribeiro, K Monte-Silva, C Souza, M De Melo, ... MOVEMENT DISORDERS 40 , 2025 2025
Comparative Analysis of MoCA Scores Between Latin American Latinos and White Patients with Parkinson's Disease S Sperling, S Anis, HM Chaparro-Solano, TP Leal, C Sonneborn, ... MOVEMENT DISORDERS 40 , 2025 2025
Transcutaneous Spinal Magnetic Stimulation Affects Subthalamic Activity in Parkinson's Disease AL de Moraes Alves, J da Silva Simões, LRT da Silva, AF Neto, ... Movement Disorders 40 (11), 2543 , 2025 2025
CLINICAL ASSESSMENT OF UPPER LIMB IMPAIRMENTS AND FUNCTIONAL CAPACITY IN PARKINSON'S DISEASE: A SYSTEMATIC REVIEW. RR Magalhães, TTC Capato, RG Cury, MJ Teixeira, ER Barbosa Revista Movimenta 18 (3) , 2025 2025
EFFECTS OF A SPECIALIZED PHYSIOTHERAPY PROGRAM TO IMPROVE BALANCE COMBINED WITH CEREBELLAR TRANSCRANIAL DIRECT CURRENT STIMULATION TDCS IN CANVAS: A CASE REPORT. M León Barrera, E Verdi, S De Almozara, R Cury, ER Barbosa, T Capato Revista Movimenta 18 (3) , 2025 2025
The best of both worlds: deep brain stimulation or high-frequency focused ultrasound for tremor refractory syndromes C França, RG Cury Arquivos de Neuro-psiquiatria 83 (07), 001-003 , 2025 2025 Citations: 1
Spinal Cord Stimulation Failed to Improve Parkinson's Disease Symptoms in Randomized Crossover Double‐Blinded Evaluation RB Carra, LÁL Garcia, JR Menezes, T Capato, F Santos, ER Barbosa, ... Movement Disorders 40 (7), 1279-1290 , 2025 2025 Citations: 5
Magnetic resonance-guided focused ultrasound for essential tremor patients with low skull density ratio: a systematic review and meta-analysis J dos Santos Monteiro, RR de Oliveira, OR Gonçalves, BB e Silva, ... Parkinsonism & Related Disorders, 107936 , 2025 2025 Citations: 3
Comparison of Two Methods of Deep Brain Stimulation Lead Reconstruction and Their Prediction Capacities RMG Barbosa, JYS Yamamoto, MC Soares, IBB Paraguay, ... Neuromodulation: Technology at the Neural Interface , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Thalamic deep brain stimulation for tremor in Parkinson disease, essential tremor, and dystonia RG Cury, V Fraix, A Castrioto, MA Pérez Fernández, P Krack, ... Neurology 89 (13), 1416-1423 , 2017 2017 Citations: 287
Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease RG Cury, R Galhardoni, ET Fonoff, MG dos Santos Ghilardi, F Fonoff, ... Neurology 83 (16), 1403-1409 , 2014 2014 Citations: 198
Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms RG Cury, R Galhardoni, ET Fonoff, S Pérez Lloret, ... European journal of pain 20 (2), 151-165 , 2016 2016 Citations: 136
The Parkinson disease pain classification system: results from an international mechanism-based classification approach V Mylius, SP Lloret, RG Cury, MJ Teixeira, VR Barbosa, ER Barbosa, ... Pain 162 (4), 1201-1210 , 2021 2021 Citations: 129
Spinal cord stimulation improves gait in patients with Parkinson's disease previously treated with deep brain stimulation C Pinto de Souza, C Hamani, C Oliveira Souza, WO Lopez Contreras, ... Movement disorders 32 (2), 278-282 , 2017 2017 Citations: 122
Effects of cerebellar neuromodulation in movement disorders: a systematic review C França, DC de Andrade, MJ Teixeira, R Galhardoni, V Silva, ... Brain stimulation 11 (2), 249-260 , 2018 2018 Citations: 120
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial ML Schilsky, A Czlonkowska, M Zuin, D Cassiman, C Twardowschy, ... The Lancet Gastroenterology & Hepatology 7 (12), 1092-1102 , 2022 2022 Citations: 92
Pregabalin for the prevention of oxaliplatin‐induced painful neuropathy: a randomized, double‐blind trial DC De Andrade, M Jacobsen Teixeira, R Galhardoni, KSL Ferreira, ... The oncologist 22 (10), 1154-e105 , 2017 2017 Citations: 87
Spinal cord stimulation for Parkinson’s disease: a systematic review EM de Andrade, MG Ghilardi, RG Cury, ER Barbosa, R Fuentes, ... Neurosurgical review 39 (1), 27-35 , 2016 2016 Citations: 86
Deep brain stimulation of the dentate nucleus improves cerebellar ataxia after cerebellar stroke MJ Teixeira, RG Cury, R Galhardoni, VR Barboza, AR Brunoni, E Alho, ... Neurology 85 (23), 2075-2076 , 2015 2015 Citations: 83
Normative data of cortical excitability measurements obtained by transcranial magnetic stimulation in healthy subjects AS Cueva, R Galhardoni, RG Cury, DC Parravano, G Correa, H Araujo, ... Neurophysiologie Clinique/Clinical Neurophysiology 46 (1), 43-51 , 2016 2016 Citations: 79
Pain in Parkinson's disease: current concepts and a new diagnostic algorithm V Mylius, D Ciampi de Andrade, RG Cury, M Teepker, U Ehrt, KM Eggert, ... Movement disorders clinical practice 2 (4), 357-364 , 2015 2015 Citations: 78
Sleep disorder, chorea, and dementia associated with IgLON5 antibodies MM Simabukuro, L Sabater, T Adoni, RG Cury, MS Haddad, CH Moreira, ... Neuroimmunology & Neuroinflammation 2 (4), e136 , 2015 2015 Citations: 75
Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease HS Dafsari, MG dos Santos Ghilardi, V Visser-Vandewalle, A Rizos, ... Brain stimulation 13 (6), 1697-1705 , 2020 2020 Citations: 73
Surgical treatment of dystonia RG Cury, SK Kalia, BB Shah, J Jimenez-Shahed, LK Prashanth, E Moro Expert review of neurotherapeutics 18 (6), 477-492 , 2018 2018 Citations: 68
Deep brain stimulation in Tourette’s syndrome: evidence to date SCB Casagrande, RG Cury, EJL Alho, ET Fonoff Neuropsychiatric disease and treatment, 1061-1075 , 2019 2019 Citations: 64
Deep brain stimulation in patients with mutations in Parkinson's disease–related genes: a systematic review LM de Oliveira, ER Barbosa, CC Aquino, RP Munhoz, A Fasano, RG Cury Movement disorders clinical practice 6 (5), 359-368 , 2019 2019 Citations: 58
Effects of cerebellar transcranial magnetic stimulation on ataxias: a randomized trial C Franca, DC de Andrade, V Silva, R Galhardoni, ER Barbosa, ... Parkinsonism & Related Disorders 80, 1-6 , 2020 2020 Citations: 53
Deep brain stimulation in Parkinson’s disease: state of the art and future perspectives C França, RB Carra, JM Diniz, RP Munhoz, RG Cury Arquivos de Neuro-psiquiatria 80 (S 05), 105-115 , 2022 2022 Citations: 49
Subthalamic deep brain stimulation modulates conscious perception of sensory function in Parkinson's disease RG Cury, R Galhardoni, MJ Teixeira, MG dos Santos Ghilardi, V Silva, ... Pain 157 (12), 2758-2765 , 2016 2016 Citations: 48
