I am presently working as Professor in division of Pediatric Nephrology, department of Pediatrics AIIMS, Bhopal. My special field of interest are Pediatric Nephrology/Urology, Pediatric hypertension, Ambulatory blood pressure monitoring in children , Childhood incontinence and evidence based medicine
Prevalence of elevated blood pressure and hypertension based on repeat measurements among school-going adolescents in Central India Revadi Gouroumourty, Amit Kumar, Smriti Bhaskar, Akhil Jaison, Girish C. Bhatt, Ankur Joshi, Abhijit P. Pakhare, Mahesh Maheshwari BMC Pediatrics, 2025 BACKGROUND: Scarcity of evidence regarding the need to obtain three separate Blood Pressure (BP) readings before diagnosing hypertension in adolescents exists in low middle income countries. Hence, this study aimed at determining the prevalence of elevated BP / hypertension in any two of the three visits among 10-18 years school-going adolescents. Secondly, to determine the trajectory of BP readings across age group, sex and over three visits. METHODS: A longitudinal study was conducted across five urban schools of Bhopal district (Madhya Pradesh) among children aged 10-18-years. Multistage cluster sampling was adopted to cover a sample size of 780 over a one-year period. Those adolescents who satisfied the study criteria were checked for height and weight, followed by measurement of auscultatory BP readings on three different occasions, one week apart in each student. Three BP readings were obtained in each of the three settings at f-minute interval. The R shiny app was used to classify hypertension and compute systolic and diastolic percentiles. RESULTS: The overall prevalence of elevated BP/hypertension in adolescents was 1.4% (N = 795), with 2.6% in boys and 0.2% in girls. There was a significant difference in the systolic and diastolic BP percentiles between boys and girls (N = 767) obtained during the second (P < 0.001) and third visit (P < 0.001). Also, significant changes in systolic and diastolic percentile across the three visits were observed (P < 0.001) (N = 767). CONCLUSION: The overall prevalence of elevated BP/HTN was one in hundred adolescents. Also, considering two out of three visits as a criteria for diagnosing HTN needs to be clarified and validated in a larger sample size and with further clinical follow-up to guide policymakers and suggest recommendations.
Diluted Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Pediatric Patients: A Systematic Review and Suggested Practice Points Sidharth Kumar Sethi, Ashita Tolwani, Omer S. Ashruf, Mihika Aggarwal, Girish Chandra Bhatt, Aishwarya Nair, Kritika Soni, Savita Savita, Shyam Bihari Bansal, Khalid Alhasan, Timothy Bunchman, Rupesh Raina Blood Purification, 2025 Introduction: Continuous renal replacement therapy (CRRT) is increasingly used in critical pediatric patients with acute kidney injury (AKI). The choice of anticoagulant is vital to minimize circuit clotting and bleeding complications. Regional citrate anticoagulation (RCA) is preferred for its safety profile, particularly in critically ill pediatric patients who are susceptible to bleeding. Methods: A comprehensive literature search was conducted using PubMed, Google Scholar, and Cochrane databases following PRISMA guidelines. Keywords included “diluted citrate,” “regional citrate anticoagulation,” “continuous renal replacement therapy,” “pediatrics,” and “adverse effects.” Studies were included if they involved neonates and pediatric patients, reported citrate concentration, and safety and efficacy outcomes of RCA in CRRT. Data were extracted on study characteristics, citrate concentration, circuit lifespan, metabolic and electrolyte disturbances, and other adverse effects. Results: A total of 16 studies met the inclusion criteria. RCA was associated with fewer clotting events and a longer median circuit life compared to heparin. However, complications such as metabolic alkalosis, hypocalcemia, and hypernatremia were noted. In our single-center experience, dilute citrate anticoagulation was used in 16 pediatric patients undergoing CRRT, showing promising results with reduced clotting and prolonged circuit life. The modified pediatric citrate protocol presented aims to address complications by using a diluted citrate solution. Conclusions: RCA is effective in prolonging circuit life and reducing clotting in pediatric CRRT. The modified pediatric citrate protocol presents a safer alternative by reducing the risk of metabolic and electrolyte disturbances. Ongoing monitoring of calcium and electrolyte levels is essential to mitigate potential complications. This protocol may standardize RCA use in pediatric CRRT, improving safety and outcomes for critically ill children with AKI.
Pesticide Levels and Other Etiopathogenetic Factors in Patients with Chronic Kidney Disease of Unknown Cause in Central India – A Case–Control Study Mahendra Atlani, Ashok Kumar, Anshuman Srivastava, Ashutosh Shrivastava, Sudhir K Goel, Abhijit Pakhare, Girish Bhatt, M N Meenu, Athira Anirudhan, Sailesh Mullaguri, Sai Dheeraj Gowtham Pereddy Indian Journal of Nephrology, 2025 Background The etiology of chronic kidney disease of unknown cause (CKDu) remains unexplained, with environmental toxins, i.e., heavy metals and pesticides. being explored for their causal role. We measured pesticide levels in blood and urine in patients with CKDu in central India. We compared them with healthy and chronic kidney disease (CKD) controls. Materials and Methods This case–control study compared patients with CKDu (n = 55), CKD (n = 53) and healthy controls (n = 50). Levels of 6 organophosphates (OPs) and 16 organochlorines were measured by GC-MS. Drinking water sources and pesticide use, and hours spent in sunlight were also evaluated. Results CKDu and CKD subjects were age and sex matched. CKDu and CKD subjects had higher median chlorpyrifos (CP) 3.69 (2.36–5.65) and 3.79 (1.9–5.53) µg/L; pesticide use 19.6% and 12.5%; and heat spent hours 3.0 (2.0, 5.0) compared to healthy subjects 1.49 (0.97–2.20) µg/L; 0%; and 1.0 (1.0, 3.0) hours, respectively (p ≤ 0.001 for all). Surface water use was higher in CKDu (49%) compared to CKD (20.7%) and healthy subjects (20%) (p<0.01). The CP (ρ −0.0532, p<0.01), and ethion (ET) (ρ 0.221, p<0.01) had inverse correlation with GFR. Urine CP and ET were significantly higher in healthy controls. On multinomial regression, CP was independently associated with CKDu (OR, 95%CI) (3.5, 2.1–5.9) and CKD (3.7, 2.2–6.1). ET was also associated with CKDu (2.2, 1.2–3.9) and CKD (1.9, 1.1–3.4). Spending 4 hours or more in sunlight was associated with CKDu (6.1, 1.7–22.3) and CKD (6.0,1.7–21.3) (P<0.01 for all) in reference to healthy subjects. Surface water was associated with CKDu (4.0, 1.3–12.7) (p<.01). Conclusion Environmental factors such as spending 4 hours or more in sunlight and higher levels of OP pesticides, namely, CP and ET, are associated with both CKDu and CKD. As higher levels of pesticides were seen in both groups of CKDu and CKD, the association of pesticides with CKDu could not be established. The higher levels could be due to low eGFR. Surface water use is independently associated with CKDu; however, larger studies are required to establish the causation.
Decoding Monogenic Hypertension: A Review of Rare Hypertension Disorders Flora R Gallegos, Meaghan P Delahunty, Jieji Hu, Shivani B Yerigeri, Vishnu Dev, Girish Bhatt, Rupesh Raina American Journal of Hypertension, 2025 BACKGROUND Hypertension is a growing concern worldwide, with increasing prevalence rates in both children and adults. Most cases of hypertension are multifactorial, with various genetic, environmental, socioeconomic, and lifestyle influences. However, monogenic hypertension, a blanket term for a group of rare hypertensive disorders, is caused by single-gene mutations that are typically inherited in an autosomal dominant fashion, and ultimately disrupt normal blood pressure regulation in the kidney or adrenal gland. Being able to recognize and understand the pathophysiology of these rare disorders is critical for properly diagnosing hypertension, particularly in children and young adults, as treating each form of monogenic hypertension requires specific and targeted treatment approaches. METHODS A scoping literature review was conducted on the available knowledge regarding each of the disorders currently categorized as forms of monogenic hypertension. RESULTS This narrative review serves to highlight the epidemiology, pathophysiology, clinical presentation, recent case reports, and most current methods of evaluation and treatment for familial hyperaldosteronism types 1–4, Gordon syndrome. Liddle syndrome, syndrome of apparent mineralocorticoid excess, congenital adrenal hyperplasia, Geller syndrome, hereditary syndromes related to pheochromocytomas and paragangliomas, and brachydactyly type E. CONCLUSIONS Recent and future advances in genetic analysis techniques will further enhance the diagnosis and early management of these disorders, preventing the consequences of uncontrolled hypertension.
Descriptive Epidemiology of Unintentional Childhood Injuries in India: An ICMR Taskforce Multisite Study Shalini C. Nooyi, K. N. Sonaliya, Bhavna Dhingra, Rabindra Nath Roy, P. Indumathy, R. K. Soni, Nithin Kumar, Rajesh K. Chudasama, Ch. Satish Kumar, Amit Kumar Singh, Venkata Raghava Mohan, Nanda Kumar BS, ICMR Taskforce on Childhood Injuries, Devendra Mishra, G. Gururaj, Kiran Aggarwal, Piyush Gupta, Rakesh Lodha, Y. K. Sarin Indian Pediatrics, 2021
Obstructive Sleep Apnea in Children with Nocturnal Enuresis Indian Pediatrics, 2018
Research Letters Shikha Jain, Girish Chandra Bhatt, Abhishek Goya, Vikas Gupta, Bhavna Dhingra, T. M. Ananda Kesavan, Nithya Thuruthiyath, Elizabeth Preethi Thomas Indian Pediatrics, 2018
Emphysematous pyelonephritis in children: Lessons from a case report and systematic review KV Aparna, M Darshan, A Kulkarni, P Athira, A Kumar, M Maheshwari, ... Journal of Pediatric Urology, 106040 , 2026 2026
Ambulatory blood pressure abnormalities, obstructive sleep apnea, and end-organ damage in children with sickle cell disease A Puthukara, A Kumar, A Goyal, T Sharma, B Dhingra, N Chaudhary, ... Pediatric Nephrology, 1-11 , 2026 2026
WCN26-7974 MAPPING GLOBAL GENETIC & PHENOTYPIC VARIATIONS IN DISTAL RENAL TUBULAR ACIDOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS A Kulkarni, S Pathak, KV Aparna, G Dubey, P Athira, M Kumar, A Mittal, ... Kidney International Reports 11 (4) , 2026 2026
WCN26-7514 ANTIGENIC AND CLINICOPATHOLOGICAL PROFILE OF MEMBRANOUS NEPHROPATHY: AN EXPERIENCE FROM CENTRAL INDIA T Sharma, M Atlani, GC Bhatt, E Jayashankar, S Mukhopadhyay, V Ingle, ... Kidney International Reports 11 (4) , 2026 2026
Efficacy of mycophenolate mofetil versus cyclophosphamide in the management of childhood-onset lupus nephritis: a systematic review and meta-analysis S Sarkar, K Mukhopadhyay, A Das, M Mandal, R Bhowmick, NS Bhunia, ... Pediatric Nephrology, 1-10 , 2026 2026
Exploring bamboo resources as a viable option for sustainable livelihoods of mountain communities in the Himalayan region P Baduni, PC Phondani, GC Bhatt, HS Rawat, RK Maikhuri Discover Agriculture 3 (1), 1-15 , 2025 2025
Is guided growth a viable treatment option for angular deformity correction in distal renal tubular acidosis patients? S Jain, P Behera, GC Bhatt, SK Sinha, V Gupta, A Singh Journal of Clinical Orthopaedics and Trauma 71, 103260 , 2025 2025
Prevalence of elevated blood pressure and hypertension based on repeat measurements among school-going adolescents in Central India R Gouroumourty, A Kumar, S Bhaskar, A Jaison, GC Bhatt, A Joshi, ... BMC pediatrics 25 (1), 716 , 2025 2025 Citations: 1
A Silent Heart in a Febrile Storm: Sequential Leptospirosis and Scrub Typhus Unmasking Pediatric Bradycardia. MM Darshan, R Kundavaram, D Pandya, A Kumar, GC Bhatt, S Malik European Journal of Cardiovascular Medicine 15 (9) , 2025 2025
Linkage of Obstructive Sleep Apnea and Hypertension A Puthukara, A Kumar, GC Bhatt Handbook of the Biology and Pathology of Mental Disorders, 2707-2716 , 2025 2025
Diluted regional citrate anticoagulation for continuous renal replacement therapy in pediatric patients: a systematic review and suggested practice points SK Sethi, A Tolwani, OS Ashruf, M Aggarwal, GC Bhatt, A Nair, K Soni, ... Blood Purification 54 (8), 455-473 , 2025 2025 Citations: 4
Posterior Reversible Encephalopathy Syndrome in a Pediatric Burn Patient: A Case Report S Shouri, J Sharma, A KUMAR, G Bhatt, A VT Cureus 17 (8), e90792 , 2025 2025
Etiology and outcomes of primary renal tubular acidosis S Priyadarshini, A Sinha, M Jana, R Tandon, K Sikka, VP Mathur, ... Pediatric Nephrology 40 (8), 2515-2527 , 2025 2025 Citations: 4
Pesticide Levels and Other Etiopathogenetic Factors in Patients with Chronic Kidney Disease of Unknown Cause in Central India–A Case–Control Study M Atlani, A Kumar, A Srivastava, A Shrivastava, SK Goel, A Pakhare, ... Indian Journal of Nephrology 35 (4), 497 , 2025 2025 Citations: 1
Etiology, clinical characteristics, genetic profile, and outcomes of children with refractory rickets at a referral center in India: a cohort study V Mathew, B Deepthi, S Krishnasamy, P Yadav, M Sravani, ... Pediatric Nephrology 40 (6), 1915-1927 , 2025 2025 Citations: 6
Decoding monogenic hypertension: a review of rare hypertension disorders FR Gallegos, MP Delahunty, J Hu, SB Yerigeri, V Dev, G Bhatt, R Raina American Journal of Hypertension 38 (6), 333-351 , 2025 2025 Citations: 7
Effectiveness of yoga on depression and anxiety in people with chronic primary pain: a meta-analysis of randomized controlled trials J Rai, A Pathak, R Singh, GC Bhatt, NK Rai International Journal of Yoga Therapy 35 (2025) , 2025 2025 Citations: 2
1488 Evaluation of New Antigens in Membranous Nephropathy: A Single-Center Experience from India T Sharma, M Atlani, S Mukhopadhyay, E Jayashankar, G Bhatt, A Kumar, ... Laboratory Investigation 105 (3) , 2025 2025
WCN25-1097 Impact of New AHA statement of ABPM in diagnosis of hypertension in Obese children A Puthukara, G BHATT, A KUMAR, M MAHESHWARI, S MALIK, ... Kidney International Reports 10 (2), S342-S343 , 2025 2025
WCN25-2578 CLINICAL CHARACTERISTICS, GENETIC PROFILE AND OUTCOMES OF CHILDREN WITH NON-AZOTEMIC REFRACTORY RICKETS: A COHORT STUDY B Deepthi, V Mathew, S Krishnasamy, P Yadav, M Sravani, ... Kidney International Reports 10 (2), S356-S357 , 2025 2025
Effect of peer counselling by mother support groups on infant and young child feeding practices: the Lalitpur experience KP Kushwaha, J Sankar, MJ Sankar, A Gupta, JP Dadhich, YP Gupta, ... PloS one 9 (11), e109181 , 2014 2014 Citations: 96
Early versus late initiation of renal replacement therapy in patients with acute kidney injury-a systematic review & meta-analysis of randomized controlled trials GC Bhatt, RR Das BMC nephrology 18 (1), 78 , 2017 2017 Citations: 92
Hemolytic uremic syndrome in a developing country: Consensus guidelines DDMA Bagga A, Khandelwal P, Mishra , Thergaonkar R, Vasudevan A, Sharma J ... Pediatric Nephrology 34 (8), 1465-1482 , 2019 2019 Citations: 90
Enteroviral encephalitis in children: clinical features, pathophysiology, and treatment advances S Jain, B Patel, GC Bhatt Pathogens and global health 108 (5), 216-222 , 2014 2014 Citations: 80
Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review GC Bhatt, P Gogia, M Bitzan, RR Das Archives of disease in childhood 104 (7), 670-679 , 2019 2019 Citations: 70
Association of pediatric obstructive sleep apnea with poor academic performance: a school-based study from India A Goyal, AP Pakhare, GC Bhatt, B Choudhary, R Patil Lung India 35 (2), 132-136 , 2018 2018 Citations: 68
Consensus Guidelines on Management of Steroid-Resistant Nephrotic Syndrome BA Vasudevan A, Thergaonkar R, Mantan M,Sharma J, Khandelwal P, Hari P, Sinha A Indian Pediatrics 58 (7), 650-666 , 2021 2021 Citations: 59
Use of intravenous immunoglobulin compared with standard therapy is associated with improved clinical outcomes in children with acute encephalitis syndrome complicated by … GC Bhatt, J Sankar, KP Kushwaha Pediatric cardiology 33 (8), 1370-1376 , 2012 2012 Citations: 55
Advances in the management of primary monosymptomatic nocturnal enuresis in children S Jain, GC Bhatt Paediatrics and international child health 36 (1), 7-14 , 2016 2016 Citations: 45
Acute kidney injury following multisystem inflammatory syndrome associated with SARS-CoV-2 infection in children: a systematic review and meta-analysis AK Tripathi, RK Pilania, GC Bhatt, M Atlani, A Kumar, S Malik Pediatric Nephrology 38 (2), 357-370 , 2023 2023 Citations: 37
Association of sleep disordered breathing with mono-symptomatic nocturnal enuresis: a study among school children of Central India B Choudhary, R Patil, GC Bhatt, AP Pakhare, A Goyal, A P, B Dhingra, ... PLoS One 11 (5), e0155808 , 2016 2016 Citations: 32
Changing clinico-laboratory profile of encephalitis patients in the eastern Uttar Pradesh region of India GC Bhatt, VP Bondre, GN Sapkal, T Sharma, S Kumar, MM Gore, ... Tropical Doctor 42 (2), 106-108 , 2012 2012 Citations: 32
Central osteoma of maxilla associated with an impacted tooth: report of a rare case with literature review G Bhatt, S Gupta, S Ghosh, S Mohanty, P Kumar Head and Neck Pathology 13 (4), 554-561 , 2019 2019 Citations: 29
Complementary feeding practices and their determinants among children 6–23 months of age in an outpatient hospital setting in Central India: A cross-sectional study S Jain, BD Bhan, GC Bhatt Journal of Family Medicine and Primary Care 9 (2), 1187-1190 , 2020 2020 Citations: 27
Enterobius vermicularis : An unusual cause of recurrent urinary tract infestation in a 7-year-old girl: case report and review of the literature B Patel, T Sharma, GC Bhatt, B Dhingra Bhan Tropical Doctor 45 (2), 132-134 , 2015 2015 Citations: 25
Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome-a systematic review GC Bhatt, S Jain, RR Das World journal of clinical pediatrics 5 (4), 383 , 2016 2016 Citations: 23
Profile of deferral of blood donors in regional blood transfusion center in North India T Sharma, B Singh, GC Bhatt Asian journal of transfusion science 7 (2), 163-164 , 2013 2013 Citations: 21
Complete right lung agenesis with dextrocardia: an unusual cause of respiratory distress D Nandan, GC Bhatt, V Dewan, I Pongener Journal of clinical imaging science 2, 81 , 2012 2012 Citations: 21
Early versus late initiation of renal replacement therapy: have we reached the consensus? An updated meta-analysis GC Bhatt, RR Das, A Satapathy Nephron 145 (4), 371-385 , 2021 2021 Citations: 20