Dr. Ajit Kumar Acharya

@ncpbalasore.org

Professor of Pharmaceutics in the Department of Pharmacy
Nityananda College of Pharmacy

Dr. Ajit Kumar Acharya


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https://researchid.co/ajit417

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, General Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Drug Discovery
3

Scopus Publications

76

Scholar Citations

4

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Preparation and characterization of phase-separated hydrogels based on gelatin and hydroxypropyl methylcellulose for vaginal drug delivery applications
    Rajeshree Panigrahi, Jajnadatta Panda, Ajit Kumar Acharya, Biswaranjan Mohanty, Iswori Prasad Padhy, Deepak Kumar Dash
    Research Journal of Pharmacy and Technology, 2025
    Objective: The objective of this work was to formulate and characterize a series of phase-separated hydrogel formulations based on gelatin and hydroxypropyl methylcellulose (HPMC) for controlled delivery applications. Methods: The hydrogel was evaluated for physicochemical properties such as swelling index, mechanical strength, and pH compatibility. Thermal stability was assessed using Thermo Gravimetric Analysis (TGA/DSC), while microscopy confirmed phase separation. Biocompatibility and stability were examined under different storage conditions. Drug release kinetics and mechanisms were analyzed, and FTIR was used to identify material interactions. Result: Gelatin/HPMC hydrogels were prepared via segregative phase separation and stabilized with glutaraldehyde to enhance structural integrity. The hydrogels exhibited hydrogen bonding, pH-responsive swelling, and mechanical properties influenced by HPMC viscosity. Moisture content was consistent across formulations (80-85%). Higher HPMC viscosity reduced swelling at acidic pH, altered mechanical strength, and slowed drug release by forming a robust gel network. Conclusion: Gelatin/HPMC-based phase-separated hydrogels demonstrate potential as pH-sensitive intravaginal drug delivery systems, offering sustained and controlled release of antibiotics. FTIR confirmed strong hydrogen bonding, while swelling, impedance, and mechanical studies highlighted the influence of HPMC content on hydrogel properties. These biodegradable hydrogels are flexible, user-friendly, and effective for localized therapeutic delivery. Discussion: This study develops pH-sensitive hydrogels made from gelatin and hydroxypropyl methylcellulose (HPMC) for controlled intravaginal drug delivery. These hydrogels, which degrade after use, exhibit enhanced water retention, controlled drug release, and pH-responsive swelling behaviour, indicating their potential as effective drug delivery systems.
  • SOLUBILITY ENHANCEMENT OF RIVAROXABAN BY SOLID DISPERSION WITH POLYETHYLENE GLYCOL 4000
    RUCHITA KUMARI PATRA, AJIT KUMAR ACHARYA, ANJAN KUMAR MAHAPATRA, PADALA NARASIMHA MURTHY
    International Journal of Applied Pharmaceutics, 2023
    Objective: The aim of the work was to enhance the dissolution rate of rivaroxaban by preparing its solid dispersions (SDs) using hydrophilic carrier PEG 4000. Methods: The SDs of rivaroxaban with PEG 4000 were prepared at 1:1, 1:2 and 1:3 w/w ratios by physical mixing, melting and solvent evaporation techniques. The prepared solid dispersions were characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Results: Both the solubility and dissolution rate of the drug in these formulations were increased. The used hydrophilic carriers showed a more than two-fold increase in dissolution rate in their prepared solid dispersions by melting or solvent evaporation techniques. The pure drug rivaroxaban as the pure drug shows a dissolution rate of nearly 39 % after 60 m, whereas the solid dispersions by melting or solvent evaporation showed 90% of dissolution after 60 m. The FTIR spectroscopic and DCS thermal studies showed the compatibility of rivaroxaban and the absence of well-defined drug polymer interactions, though the shift in peaks was observed due to the formation of new bonds. Conclusion: Formulation of solid dispersions of drug with hydrophilic carriers is a successful approach for solubility or dissolution rate enhancement of low soluble drug(s). In this work for solubility enhancement of rivaroxaban the hydrophilic carrier PEG 4000 showed significant solubility enhancement.
  • In vitro corneal permeation of etoricoxib from oil drops
    Asian Journal of Pharmaceutics, 2018

RECENT SCHOLAR PUBLICATIONS

  • Preparation and characterization of phase-separated hydrogels based on gelatin and hydroxypropyl methylcellulose for vaginal drug delivery applications
    R Panigrahi, J Panda, AK Acharya, B Mohanty, IP Padhy, DK Dash
    Research Journal of Pharmacy and Technology 18 (11), 5377-5384 , 2025
    2025
  • Preparation and characterization of phase-separated hydrogels based on gelatin and hydroxypropyl methylcellulose for vaginal drug delivery applications.
    DDK Panigrahi R, Panda J, Acharya AK, Mohanty B, Padhy I
    Research Journal of Pharmacy and Technology 18 (11), 5 , 2025
    2025
  • EXTRACTION, FORMULATION AND EVALUATION OF THERMO-REVERSIBLE ORAL GEL OF CURCUMIN FOR MOUTH ULCERS
    A Sahu, AK Mahapatra, AK Acharya
    Research Journal of Pharmacy and Life Sciences: Volume 5 (2), 90-102 , 2024
    2024
  • Capsule Filling Machine
    PDNGRRDRSSMLSRDDDBDJKDAK Acharya
    IN Patent 386817-001 , 2023
    2023
  • Capsule Filling Machine
    DAKA Prof.(Dr.) Nidagurthi Guggulla Raghavendra Rao, Dr. Rahul Shivajirao ...
    IN Patent 206,424 , 2023
    2023
  • A METHOD OF MAKING A THREE-DIMENSIONAL HYDROGEL-CONDUCTING POLYMER ELECTRODE FOR AN IMPLANTABLE MEDICAL DEVICE
    DAKA Dr. Badrud Duza Mohammad, Mr Darla Raju, Dr.Y.Ganesh Kumar, Mr ...
    IN Patent 202,341,008,637 , 2023
    2023
  • A METHOD OF MAKING A THREE-DIMENSIONAL HYDROGEL-CONDUCTING POLYMER ELECTRODE FOR AN IMPLANTABLE MEDICAL DEVICE
    DAKA Dr. Badrud Duza Mohammad, Mr Darla Raju, Dr.Y.Ganesh Kumar, Mr ...
    IN Patent 07/2,023 , 2023
    2023
  • Solubility enhancement of rivaroxaban by solid dispersion with polyethylene glycol 4000
    RK PATRA, AK ACHARYA, AK MAHAPATRA, S MALLICK
    Int. J. App. Pharm 15 (2), 78-85 , 2023
    2023
    Citations: 3
  • Research Article Solubility Enhancement of Apixaban and Formulation of its Fast-Disintegrating Tablets
    RK Patra, S Mallick, RK Rautray, AK Acharya, AK Mahapatra
    Research Journal of Pharmacy and Life Sciences: Volume 4 (1), 58-66 , 2023
    2023
    Citations: 1
  • DISSOLUTION RATE ENHANCEMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF RIVAROXABAN SOLID DISPERSIONS WITH POLOXAMER 188.
    RK Patra, AK Acharya, AK Mahapatra, S Mallick, PN Murthy
    Journal of Pharmaceutical Negative Results 13 , 2022
    2022
    Citations: 3
  • Formulation and Evaluation of Celecoxib In-Situ Ophthalmic Gel
    ABM Asish Kumar Sahu, Ajit Kumar Acharya
    Research Journal of Pharmacy and Life Sciences 3 (1), 71-78 , 2022
    2022
    Citations: 1
  • COVID-19: Preventive Measures and Alternative Remedies
    AK Acharya
    College of Health Sciences, Ayder Comprehensive Specialized Hospital … , 2020
    2020
  • Development and Characterization of Etoricoxib Nanoparticles
    AK Acharya
    Maharajah’s College of Pharmacy, a two day National Seminar on “Advances in … , 2018
    2018
  • In vitro corneal permeation of etoricoxib from oil drops
    AK Acharya
    Asian Journal of Pharmaceutics (AJP) 12 (04) , 2018
    2018
    Citations: 3
  • Development and Characterization of Celecoxib Nanoparticles
    AK Acharya
    International Conference on “Recent Trends of Chemical & Biological Science … , 2017
    2017
  • In vitro and in vivo evaluation of celecoxib ocular and oil formulations
    AK Acharya
    XXVI annual conference, Indian Pharmacological Society, Odisha State Branch … , 2016
    2016
  • Formulation and Evaluation of Fast Dissolving Films of Lisinopril
    GM Rajeshree Panigrahi, A. K. Acharya, K. A. Chowdary
    International Journal of Institutional Pharmacy and Life Sciences 6 (6), 75-89 , 2016
    2016
  • In Vitro Corneal Permeation Of Celecoxib From Oil Drops
    GMDKM Ajit Kumar Acharya
    International Journal of Research and Development in Pharmacy and Life … , 2016
    2016
    Citations: 2
  • Solubility Enhancement of Poorly Water Soluble Drug Celecoxib
    AKA Pranab Prakash Panigrahi
    PharmaTutor 1 (1), 53-64 , 2013
    2013
    Citations: 1
  • Investigation of possible Hypoglycemic and Hypolipidemic effect of Methanolic extract of Sesbania Grandiflora
    AAK Panigrahi Ghanshyam, Panda Chhayakanta, Mishra Uma Shankar, Mahapatra ...
    International Research Journal of Pharmacy 5 (3), 275-280 , 2012
    2012

MOST CITED SCHOLAR PUBLICATIONS

  • Investigation of comparative antimicrobial activity of Aloe vera gel and juice
    G Kaithwas, A Kumar, H Pandey, AK Acharya, M Singh, D Bhatia, ...
    Pharmacologyonline 1, 239-243 , 2008
    2008
    Citations: 38
  • Formulation and evaluation of spherical crystal of etoricoxib
    R Dash, AK Acharya, S Swain, M Barg, HK Choudhary, K Meher
    International Journal of Pharmaceutical & Biological Archive 2 (4), 1123-1129 , 2011
    2011
    Citations: 8
  • Antidiabetic Activity of Glibenclamide Loaded Liposomes in Alloxan Induced Diabetic Rats
    GA Singh M, Acharya A, Balamurugan M
    Ars Pharm 1 (48), 31-36 , 2007
    2007
    Citations: 6
  • Free convection of conducting viscous fluid between two vertical walls filled with a porous material
    JP Panda, AB Patnaik, A Acharya
    AMSE, Mod., Meas. Cont., B 75 (3), 31-44 , 2006
    2006
    Citations: 6
  • Effect of formulation factors on in vitro transcorneal permeation of olopatadine hydrochloride aqueous eye drops
    R Mohanty, AK Acharya, G Mishra
    International journal of pharmtech research 4, 742-749 , 2012
    2012
    Citations: 4
  • Solubility enhancement of rivaroxaban by solid dispersion with polyethylene glycol 4000
    RK PATRA, AK ACHARYA, AK MAHAPATRA, S MALLICK
    Int. J. App. Pharm 15 (2), 78-85 , 2023
    2023
    Citations: 3
  • DISSOLUTION RATE ENHANCEMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF RIVAROXABAN SOLID DISPERSIONS WITH POLOXAMER 188.
    RK Patra, AK Acharya, AK Mahapatra, S Mallick, PN Murthy
    Journal of Pharmaceutical Negative Results 13 , 2022
    2022
    Citations: 3
  • In vitro corneal permeation of etoricoxib from oil drops
    AK Acharya
    Asian Journal of Pharmaceutics (AJP) 12 (04) , 2018
    2018
    Citations: 3
  • In Vitro Corneal Permeation Of Celecoxib From Oil Drops
    GMDKM Ajit Kumar Acharya
    International Journal of Research and Development in Pharmacy and Life … , 2016
    2016
    Citations: 2
  • Research Article Solubility Enhancement of Apixaban and Formulation of its Fast-Disintegrating Tablets
    RK Patra, S Mallick, RK Rautray, AK Acharya, AK Mahapatra
    Research Journal of Pharmacy and Life Sciences: Volume 4 (1), 58-66 , 2023
    2023
    Citations: 1
  • Formulation and Evaluation of Celecoxib In-Situ Ophthalmic Gel
    ABM Asish Kumar Sahu, Ajit Kumar Acharya
    Research Journal of Pharmacy and Life Sciences 3 (1), 71-78 , 2022
    2022
    Citations: 1
  • Solubility Enhancement of Poorly Water Soluble Drug Celecoxib
    AKA Pranab Prakash Panigrahi
    PharmaTutor 1 (1), 53-64 , 2013
    2013
    Citations: 1
  • Preparation and characterization of phase-separated hydrogels based on gelatin and hydroxypropyl methylcellulose for vaginal drug delivery applications
    R Panigrahi, J Panda, AK Acharya, B Mohanty, IP Padhy, DK Dash
    Research Journal of Pharmacy and Technology 18 (11), 5377-5384 , 2025
    2025
  • Preparation and characterization of phase-separated hydrogels based on gelatin and hydroxypropyl methylcellulose for vaginal drug delivery applications.
    DDK Panigrahi R, Panda J, Acharya AK, Mohanty B, Padhy I
    Research Journal of Pharmacy and Technology 18 (11), 5 , 2025
    2025
  • EXTRACTION, FORMULATION AND EVALUATION OF THERMO-REVERSIBLE ORAL GEL OF CURCUMIN FOR MOUTH ULCERS
    A Sahu, AK Mahapatra, AK Acharya
    Research Journal of Pharmacy and Life Sciences: Volume 5 (2), 90-102 , 2024
    2024
  • Capsule Filling Machine
    PDNGRRDRSSMLSRDDDBDJKDAK Acharya
    IN Patent 386817-001 , 2023
    2023
  • Capsule Filling Machine
    DAKA Prof.(Dr.) Nidagurthi Guggulla Raghavendra Rao, Dr. Rahul Shivajirao ...
    IN Patent 206,424 , 2023
    2023
  • A METHOD OF MAKING A THREE-DIMENSIONAL HYDROGEL-CONDUCTING POLYMER ELECTRODE FOR AN IMPLANTABLE MEDICAL DEVICE
    DAKA Dr. Badrud Duza Mohammad, Mr Darla Raju, Dr.Y.Ganesh Kumar, Mr ...
    IN Patent 202,341,008,637 , 2023
    2023
  • A METHOD OF MAKING A THREE-DIMENSIONAL HYDROGEL-CONDUCTING POLYMER ELECTRODE FOR AN IMPLANTABLE MEDICAL DEVICE
    DAKA Dr. Badrud Duza Mohammad, Mr Darla Raju, Dr.Y.Ganesh Kumar, Mr ...
    IN Patent 07/2,023 , 2023
    2023
  • COVID-19: Preventive Measures and Alternative Remedies
    AK Acharya
    College of Health Sciences, Ayder Comprehensive Specialized Hospital … , 2020
    2020