Chinedum Uche Emelike

Scopus Publications

Effect of Green Tea Extract on Renal Function Biomarkers in Rats: A Study of N-acetylglucosaminidase Levels, Electrolyte Imbalances, and Renal Health
Konyefom, Chukwu, Okorocha, Ekakitie, Emelike, et al.
Tropical Journal of Natural Product Research, 2025
Modulation of oxidative stress markers, antioxidant status and inflammatory mediator levels in alloxan-induced diabetic male wistar rats by (Ipomoea batatas) sweet potatoes
Ojichukwuka Ebere Chijioke-Agu, Chinedum Uche Emelike
Pharmacological Research Natural Products, 2025
Moringa oleifera Lam. is a potential mitigator of neurodevelopmental defects caused by prenatal stress in Wistar rats
Journal of Medicinal Plants, 2025
Impact of Gestational Stress and Administration of Moringa oleifera Leaveson Post-Natal Reproductive Development of Male Offspring of Wistar Rats
Tropical Journal of Natural Product Research, 2025
Anti-hyperlipidemic and Biochemical Effect of Aqueous Extract of Combretum dolichopetalum in High Cholesterol Diet Fed Rats
Chinedum Uche Emelike, Chiemeziem Adanma Obike, Ofovwe Obruche Ekakitie, Eze Frank Ahuekwe
Majalah Obat Tradisional, 2025
It is commonly known that atherosclerosis and coronary heart disease (CAD) are associated with hyperlipidemia, which is brought on by abnormalities in the transportation, production, or catabolism of cholesterol. Hence, preventing hyperlipidemia can positively impact managing and treating cardiovascular diseases. This present study aimed to examine the possible aqueous extract's effects of Combretum dolichopetalum (AECD) on liver indices and lipid status in rats on a diet rich in cholesterol. Five groups of twenty-five male albino Wistar rats, weighing between 130 and 160 grams, were assembled. Group A (Standard control group), Group B (Hyperlipidemic control), Group C (treatment): which received high cholesterol diet (HCD) + AECD (200 mg/kg bwt.), Group D: HCD + AECD (400 mg/kg bwt), Group E: HCD + atorvastatin (standard drug) (30 mg/kg bwt). The rats were sacrificed on day 28th of the experiment, and samples were obtained for liver indices and lipid profile using standard protocols. The findings show that the treatment groups' lipid profile was significantly lower (p < 0.05) than those of the hyperlipidemic controls. The liver enzymes; alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and total bilirubin (TB), direct bilirubin (DB), remain unchanged across all groups. These findings suggest that AECD is beneficial in lowering cholesterol levels and does not have a toxic effect on the liver.
GC–MS analysis of Moringa oleifera leaf extract and effects of administration on histology of reproductive organs and liver of female rats exposed to chronic unpredictable stress
Odochi O. Chukwu, Cordilia O. Iyare, Chinedum U. Emelike, Anthony C.U. Ezimah, Nnaemeka T Asogwa, et al.
Food Chemistry Advances, 2024
Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity
Chinedu Godwin Uzomba, Uchenna Kenneth Ezemagu, Mary-Sonia Ofoegbu, Njoku Lydia, Essien Goodness, et al.
Anatomy and Cell Biology, 2024
Chitosan-based nanoformulation of metal and metal oxide nanoparticles
E.F. Ahuekwe, O.S. Aworunse, S.O. Akinpelu, B.T. Adekeye, S. Abimbola, et al.
Chitosan Based Nanoparticles for Biomedical Applications, 2024
Modulation of antioxidant activities, markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by Combretum dolichopetalum
Chinedum U. EMELIKE, Ojichukwuka E. CHIJIOKE-AGU, Favour-Ann K. NWOKE, Romanus OYIBE, Chinwendu G. ENWEREUZO, et al.
Notulae Scientia Biologicae, 2023
Diabetes mellitus is a metabolic dysfunction of insulin secretion exhibiting hyperglycemia with abnormalities in protein, fat and carbohydrate metabolism. The present study aimed to investigate the effect of Combretum dolichopetalum (CD) on hepatic parameters, renal indices and antioxidant markers of alloxan-induced diabetic rats. Twenty (20) male rats were used, and they were divided into four groups of five rats each. Group 1- Normal control received distilled water (non-diabetic control); Group 2- Diabetic control received distilled water; Group 3 and Group 4 are Diabetic rats treated with 200 mg/kg and 400 mg/kg of CD extract. There were significant decreases in the final body weights of Group 2 compared with Group 1 and an elevation of the body weights of Groups 3 and 4 compared with Group 2. There were significant increases in the blood glucose concentration of Group 2 compared with Group 1 and a reduction in blood glucose concentration of Groups 3 and 4 compared with Group 2. There were increases in the alanine amino transaminase (ALT), alkaline phosphatase (ALP) activities and serum total and conjugated bilirubin levels of Groups 2 and 3 compared with Group 1, but a reduction in the ALP, ALT activities and total bilirubin in Group 4. There was an elevation in the superoxide dismutase (SOD) the activity of Group 4. There were reductions in catalase activities and no change in the renal indices. The study showed ameliorating potentials on hyperglycemia, hepatoprotective activity and antioxidation effects.
Combating Lassa Fever in West African Sub-Region: Progress, Challenges, and Future Perspectives
Chinyere Aloke, Nwogo Ajuka Obasi, Patrick Maduabuchi Aja, Chinedum Uche Emelike, Chinedu Ogbonnia Egwu, et al.
Viruses, 2023
Lassa fever (LF) is a rodent-borne disease that threatens human health in the sub-region of West Africa where the zoonotic host of Lassa virus (LASV) is predominant. Currently, treatment options for LF are limited and since no preventive vaccine is approved for its infectivity, there is a high mortality rate in endemic areas. This narrative review explores the transmission, pathogenicity of LASV, advances, and challenges of different treatment options. Our findings indicate that genetic diversity among the different strains of LASV and their ability to circumvent the immune system poses a critical challenge to the development of LASV vaccines/therapeutics. Thus, understanding the biochemistry, physiology and genetic polymorphism of LASV, mechanism of evading host immunity are essential for development of effective LASV vaccines/therapeutics to combat this lethal viral disease. The LASV nucleoprotein (NP) is a novel target for therapeutics as it functions significantly in several aspects of the viral life cycle. Consequently, LASV NP inhibitors could be employed as effective therapeutics as they will potentially inhibit LASV replication. Effective preventive control measures, vaccine development, target validation, and repurposing of existing drugs, such as ribavirin, using activity or in silico-based and computational bioinformatics, would aid in the development of novel drugs for LF management.
Histological Studies of the Heart and Biochemical Changes Due to the Perinatal Consumption of Hibiscus sabdariffa (Flavonoid-rich Extract) to Feed-restricted Rats on Offspring
Odochi O. Chukwu, Chinedum Uche Emelike, Nwaeze G. Konyefom, Sylvester N. Ibekailo, Ofovwe O. Ekakitie, et al.
Iranian Journal of Veterinary Medicine, 2023
Effect of prenatal consumption of Combretum dolichopetalum by pregnant rats on haematological and biochemical parameters as well as pregnancy outcome
Chinedum Emelike, Ugochukwu Anyaehie, Eghosa Iyare, Chiemeziem Obike, Chinyere Aloke, et al.
Physiology and Pharmacology Iran, 2022
Cleistopholis patens Extracts Attenuate Inflammatory Cytokine and Oxidative Stress Status in Complete Freund's Adjuvant-induced Rheumatoid Arthritis in Wistar Albino Rats
Chinyere Aloke, Udu A. Ibiam, Orji U. Obasi, Nwogo A. Obasi, Chuks O. Edeogu, et al.
Toxicology International, 2022
HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats
Chinyere Aloke, Chinedum Uche Emelike, Nwogo Ajuka Obasi, Patience Nkemjika Ogbu, Chuks Oswald Edeogu, et al.
Arabian Journal of Chemistry, 2021
Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
Avicenna Journal of Phytomedicine, 2021
Effect of perinatal administration of flavonoid-rich extract from Hibiscus sabdariffa to feed-restricted rats, on offspring postnatal growth and reproductive development
Odochi O. Chukwu, Chinedum U. Emelike, Nwaeze G. Konyefom, Sylvester N. Ibekailo, Sharon O. Azubuike-Osu, et al.
Current Issues in Pharmacy and Medical Sciences, 2021
Protective effect of copaifera salikounda heckel against paracetamol-induced hepatorenal injury in rat
Chinyere Aloke, Nwogo Ajuka Obasi, Chinedum Uche Emelike, Patience Nkemjika Ogbu, Godswill Odumero Ufebe, et al.
Sains Malaysiana, 2021
Chemical composition and evaluation of methanol leaf extract of combretum dolichopetalum on body weights and haematological indices of phenylhydrazine induced-anaemic rats
Chinedum U. Emelike, Ugochukwu S. B. Anyaehie, Eghosa E. Iyare, Chiemeziem A. Obike, Chinyere Aloke, et al.
Toxicology International, 2021
Methanolic extract of Citrullus lanatus Seeds Abates Testicular Degeneration and Dose-Dependently Modulates Testicular Function in Hyperlipidemic Male Wistar Rats
Nigerian Journal of Physiological Sciences, 2021
Studies on ethanol extracts of olax subscorpioidea against carbon tetrachloride-induced hepatotoxicity in rats
Chukwuemeka Ogbonna Ok, Chinyere Aloke, Udu Ama Ibiam, Nwogo Ajuka Obasi, Obasi Uche Orji, et al.
Pakistan Journal of Biological Sciences, 2021
Acute and sub-acute toxicity studies on combretum dolichopetalum engl. & diels leaves
Chinedum U. Emelike, Ugochukwu S.B. Anyaehie, Eghosa E. Iyare, Chiemeziem A. Obike, Chinedum Eleazu, et al.
Slovenian Veterinary Research, 2020
Modulation of the lipid profile, hepatic and renal antioxidant activities, and markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by virgin coconut oil
Chinedum Eleazu, Chima E. Ekeleme, Ademola Famurewa, Mahaneem Mohamed, Gabriel Akunna, et al.
Endocrine Metabolic and Immune Disorders Drug Targets, 2019
Effect of livingstonepotato (Plectranthus esculenthus N.E.Br) on hyperglycemia, antioxidant activity and lipid metabolism of streptozotocin induced diabetic rats
C.O. Eleazu, K.C. Eleazu, S.C. Chukwuma, J. Okoronkwo, C.U. Emelike
Toxicology Reports, 2014

RECENT SCHOLAR PUBLICATIONS

In vivo protein quality, biochemical and histopathological responses of velvet bean ( Mucuna pruriens ) and African yam bean ( Sphenostylis stenocarpa ) proteins
CA Obike, PN Anyiam, CU Emelike, EN Uhuo, PN Anyadiegwu
Discover Chemistry 3 (1), 103 , 2026
2026
Composition, Techno‐Functional Properties, and Biological Potential of Velvet and African Yam Beans as Plant Protein Sources
CA Obike, PN Anyiam, CU Emelike, EN Uhuo, SF Igbazenda
Sustainable Food Proteins 4 (1), e70050 , 2026
2026
Citations: 1
Ameliorative Effects of Methanol Extract of Citrullus lanatus Seed in Hyperlipidaemic Wistar Rats
OO Ekakitie, OC Okeke, OO Chukwu, CU Emelike, AR Nwaji, ...
Niger. J. Physiol. Sci 40, 167-170 , 2025
2025
Effect of Green Tea Extract on Renal Function Biomarkers in Rats: A Study of N-acetylglucosaminidase Levels, Electrolyte Imbalances, and Renal Health.
NG Konyefom, OO Chukwu, AE Okorocha, OO Ekakitie, CU Emelike, ...
Tropical Journal of Natural Product Research 9 (6) , 2025
2025
Modulation of oxidative stress markers, antioxidant status and inflammatory mediator levels in alloxan-induced diabetic male wistar rats by (Ipomoea batatas) sweet potatoes
OE Chijioke-Agu, CU Emelike
Pharmacological Research-Natural Products 7, 100205 , 2025
2025
Citations: 2
Moringa oleifera Lam. is a potential mitigator of neurodevelopmental defects caused by prenatal stress in Wistar rats
OO Chukwu, CO Iyare, AE Okorocha, NG Konyefom, CU Emelike, ...
فصلنامه علمی پژوهشی گیاهان دارویی 24 (93), 79-101 , 2025 ‎
2025
Citations: 2
Bioactive and Hepatotoxicity Evaluation of Selected Herbal Remedies Commonly used in Abakaliki, Ebonyi State Nigeria using Albino Wistar Rats
CJ Chukwu, O Oje, AB Alieze, M Ineke, IE Atiaetuk, J Isiugo, NO Omaka, ...
International Journal Of Research And Technopreneurial Innovations 2 (1), 25-38 , 2025
2025
Anti-hyperlipidemic and Biochemical Effect of Aqueous Extract of Combretum dolichopetalum in High Cholesterol Diet Fed Rats
CU Emelike, CA Obike, OO Ekakitie, EF Ahuekwe
Majalah Obat Tradisional 30 (1), 61-66 , 2025
2025
Impact of Gestational Stress and Administration of Moringa oleifera Leaveson Post-Natal Reproductive Development of Male Offspring of Wistar Rats.
OO Chukwu, CO Iyare, CU Emelike, NG Konyefom, AE Okorocha, ...
Tropical Journal of Natural Product Research 9 (1) , 2025
2025
Citations: 5
Chapter 5 - Chitosan-based nanoformulation of metal and metal oxide nanoparticles
EF Ahuekwe, OS Aworunse, SO Akinpelu, BT Adekeye, S Abimbola, ...
Chitosan-Based Nanoparticles for Biomedical Applications, 89-135 , 2025
2025
Citations: 3
Edible mushroom (Pleurotus cornucopiae) extract vs. glibenclamide on alloxan induced diabetes: sub-acute in vivo study of Nrf2 expression and renal toxicity
CG Uzomba, UK Ezemagu, MS Ofoegbu, N Lydia, E Goodness, ...
Anatomy & cell biology 57 (3), 446-458 , 2024
2024
Citations: 2
GC–MS analysis of Moringa oleifera leaf extract and effects of administration on histology of reproductive organs and liver of female rats exposed to chronic unpredictable stress
OO Chukwu, CO Iyare, CU Emelike, ACU Ezimah, NT Asogwa, ...
Food Chemistry Advances 4, 100661 , 2024
2024
Citations: 8
Histological studies of the heart and biochemical changes due to the perinatal consumption of Hibiscus sabdariffa (flavonoid-rich extract) to feed-restricted rats on offspring.
OO Chukwu, CU Emelike, NG Konyefom, SN Ibekailo, OO Ekakitie, ...
Iranian Journal of Veterinary Medicine 17 (1), 37-46 , 2023
2023
Citations: 14
Modulation of antioxidant activities, markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by Combretum dolichopetalum
CU Emelike, E Ojichukwuka, FAK Nwoke, R Oyibe, CG Enwereuzo, ...
Notulae Scientia Biologicae 15 (3), 11315-11315 , 2023
2023
Citations: 2
Combating Lassa fever in West African sub-region: Progress, challenges, and future perspectives
C Aloke, NA Obasi, PM Aja, CU Emelike, CO Egwu, O Jeje, CO Edeogu, ...
Viruses 15 (1), 146 , 2023
2023
Citations: 67
Effect of prenatal consumption of Combretum dolichopetalum by pregnant rats on haematological and biochemical parameters as well as pregnancy outcome
CU Emelike, USB Anyaehie, EE Iyare, CA Obike, C Aloke, OO Ekakitie, ...
Physiology and Pharmacology 26 (4), 459-467 , 2022
2022
Citations: 1
Cleistopholis patensextracts attenuate inflammatory cytokine and oxidative stress status in complete Freund’s adjuvant-induced rheumatoid arthritis in Wistar albino rats
C Aloke, UA Ibiam, OU Obasi, NA Obasi, CO Edeogu, PM Aja, ...
Toxicology International 29, 95-103 , 2022
2022
Citations: 1
HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats
C Aloke, CU Emelike, NA Obasi, PN Ogbu, CO Edeogu, CG Uzomba, ...
Arabian Journal of Chemistry 14 (12), 103428 , 2021
2021
Citations: 16
Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats
C Aloke, N Nwachukwu, NA Obasi, CU Emelike, PA Amu, PN Ogbu, ...
Avicenna Journal of Phytomedicine 11 (5), 428 , 2021
2021
Citations: 5
Effect of perinatal administration of flavonoid-rich extract from Hibiscus sabdariffa to feed-restricted rats, on offspring postnatal growth and reproductive development
OO Chukwu, CU Emelike, NG Konyefom, SN Ibekailo, SO Azubuike-Osu, ...
Current Issues in Pharmacy and Medical Sciences 34 (2), 61-69 , 2021
2021
Citations: 11

MOST CITED SCHOLAR PUBLICATIONS

Combating Lassa fever in West African sub-region: Progress, challenges, and future perspectives
C Aloke, NA Obasi, PM Aja, CU Emelike, CO Egwu, O Jeje, CO Edeogu, ...
Viruses 15 (1), 146 , 2023
2023
Citations: 67
Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M’diq-Fnideq provinces)
S Bakrim, Y Motiaa, A Ouarour, A Masrar
The Pan African Medical Journal 29, 205 , 2018
2018
Citations: 58
Haematological profile of pregnant women in Umuahia, Abia State, Nigeria
OE Ifeanyi, OT Ndubuisi, EOB Leticia, EC Uche
Int J Curr Microbiol App Sci 3 (1), 713-718 , 2014
2014
Citations: 58
Effect of livingstonepotato (Plectranthus esculenthus NE Br) on hyperglycemia, antioxidant activity and lipid metabolism of streptozotocin induced diabetic rats
CO Eleazu, KC Eleazu, SC Chukwuma, J Okoronkwo, CU Emelike
Toxicology reports 1, 674-681 , 2014
2014
Citations: 36
Effect of Euphorbia hirta on haematological and biochemical indices in albino rats
SC Akomas, SN Ijioma, CU Emelike
Applied Journal of Hygiene 4 (1), 1-5 , 2015
2015
Citations: 28
Antinociceptive property of Costus afer Ker stem juice and ethanol leaf extract in albino rats
SN Ijioma, CO Nwosu, CU Emelike, AI Okafor, AA Nwankwo
Comprehensive Journal of Medical Sciences 2 (2), 14-19 , 2014
2014
Citations: 25
Biochemical effects of oral administration of aqueous extract of Hibiscus sabdariffa on Wistar albino rats
CU Emelike, DV Dapper
IOSR Journal of Dental and Medical Sciences 9 (1), 35-39 , 2013
2013
Citations: 20
Modulation of the lipid profile, hepatic and renal antioxidant activities, and markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by virgin coconut oil.
UE C Eleazu, C Egedigwe-Ekeleme, A Famurewa, M Mohamed, G Akunna, E David, B ...
Endocrine, metabolic & immune disorders drug targets , 2019
2019
Citations: 17
HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats
C Aloke, CU Emelike, NA Obasi, PN Ogbu, CO Edeogu, CG Uzomba, ...
Arabian Journal of Chemistry 14 (12), 103428 , 2021
2021
Citations: 16
Acute and sub-acute toxicity studies on Combretum dolichopetalum Engl. & Diels leaves
CU Emelike, USB Anyaehie, EE Iyare, CA Obike, C Eleazu, C Chukwu
Slovenian Veterinary Research 57 (3) , 2020
2020
Citations: 16
Effects of oral administration of aqueous extract of Hibiscus sabdariffa on some haematological parameters of Wistar albino rats
CU Emelike, DV Dapper
IOSR J. Dental Med. Sci 9, 31-34 , 2013
2013
Citations: 15
Histological studies of the heart and biochemical changes due to the perinatal consumption of Hibiscus sabdariffa (flavonoid-rich extract) to feed-restricted rats on offspring.
OO Chukwu, CU Emelike, NG Konyefom, SN Ibekailo, OO Ekakitie, ...
Iranian Journal of Veterinary Medicine 17 (1), 37-46 , 2023
2023
Citations: 14
Frequency distribution of ABO, Rh blood groups and blood genotypes among the students and staff of Michael Okpara University of Agriculture, Umudike Abia State, Nigeria
EI Obeagu, OR Ogbodo, F Onyenweaku, CU Emelike, AI Udochukwu
Int J Res Rev Pharm Appl Sci 3 (4), 561-5 , 2013
2013
Citations: 14
Changes in some coagulation parameters among diabetic patients in Michael Okpara university of agriculture, Umudike, Abia state, Nigeria
OE Ifeanyi, OH Chukwuemeka, AG Sunday, EC Uche
World J Pharma Pharma Sci 3 (4), 52-61 , 2014
2014
Citations: 12
Effect of perinatal administration of flavonoid-rich extract from Hibiscus sabdariffa to feed-restricted rats, on offspring postnatal growth and reproductive development
OO Chukwu, CU Emelike, NG Konyefom, SN Ibekailo, SO Azubuike-Osu, ...
Current Issues in Pharmacy and Medical Sciences 34 (2), 61-69 , 2021
2021
Citations: 11
Impact of Plasmodium falciparum malaria and hookworm infection on anaemia among pregnant women of ikwuano local government area, Abia state, Nigeria
OE Ifeanyi, OM Chibunna, NAQ Braxton, EC Uche
Int J Curr Microbiol Appl Sci 3 (1), 104-11 , 2014
2014
Citations: 10
Studies on Ethanol Extracts of Olax subscorpioidea Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats.
C Aloke, UA Ibiam, NA Obasi, OU Orji, EC Ogbonnia, PN Ogbu, ...
Pakistan Journal of Biological Sciences: PJBS 24 (6), 724-732 , 2021
2021
Citations: 9
GC–MS analysis of Moringa oleifera leaf extract and effects of administration on histology of reproductive organs and liver of female rats exposed to chronic unpredictable stress
OO Chukwu, CO Iyare, CU Emelike, ACU Ezimah, NT Asogwa, ...
Food Chemistry Advances 4, 100661 , 2024
2024
Citations: 8
Chemical composition and evaluation of methanol leaf extract of Combretum dolichopetalum on body weights and haematological indices of phenylhydrazine induced-anaemic rats
CU Emelike, USB Anyaehie, EE Iyare, CA Obike, C Aloke, DF Chukwu, ...
Toxicology International 28 (2), 8-14 , 2021
2021
Citations: 8
Effects of oral administration of Cnidoscolus aconitifolius leaf extract (Chaya Tea) on biomarkers of cardiovascular system of Wistar albino Rats
CU Emelike, GO Unegbu
Adv Biol Res 9 (3), 182-188 , 2015
2015
Citations: 8

Chinedum Uche Emelike

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS