AWAL PRASETYO

Scopus Publications

A Qualitative Study of Strength, Hope, and Meaning: Multi-Stakeholder Perspectives on Spiritual Care for Breast Cancer
Hansen Su, Suhartini Ismail, Awal Prasetyo
Asian Pacific Journal of Cancer Prevention, 2026
OBJECTIVE: To explore the multi-stakeholder experiences of spiritual care for breast cancer patients from the perspectives of patients, families, medical personnel, and religious leaders. METHODS: This qualitative descriptive study employed Braun and Clarke's reflexive thematic analysis. A purposive sample of 20 participants (five patients, five family members, five medical personnel, and five religious leaders) was recruited in Semarang, Indonesia. Data were collected through semi-structured interviews and field notes between January and April 2025, and analyzed using NVivo 12. Credibility was ensured through source triangulation, member checking, peer debriefing, and audit trail procedures. RESULTS: Four themes emerged. First, spirituality was identified as a source of strength and hope, reflected in practices such as repeated prayer recitations that helped patients cope with treatment-related fear. Second, the family served as a pillar of spiritual support, illustrated by joint family prayers that reduced chemotherapy-related distress and motivated treatment adherence. Third, spiritual care was integrated by medical personnel, including simple practices such as offering space for prayer or initiating brief spiritual discussions despite time constraints. Fourth, religious leaders played a role in reinforcing meaning, shown through personalized guidance that helped patients reinterpret illness as a meaningful life test. CONCLUSION: Effective spiritual care requires the coordinated engagement from families, medical personnel, and religious leaders. Practical implications include the need for training in spiritual care for healthcare providers and the structured collaboration among families and religious leaders. This study is limited by its single-region setting and relatively homogeneous religious background. Future studies should evaluate structured spiritual care interventions longitudinally.
Implementation of the “Health-triangle Concept” for a “Biosmart and Safe Bus” as a Solution in the Pandemic Era: An Observational and Randomized Clinical Trial
Awal Prasetyo, Liftia Layyinatus Syifa, Saras Pujowati, Ai Devi Nuraeni, Udadi Sadhana, Agus Subagio, Susilo Adi Widyanto, Arlita Leniseptaria Antari, Stefan Arman, Anthony Steven Hambali, Soerjanto Tjahjono
Malaysian Journal of Medicine and Health Sciences, 2025
Introduction: The “Health Triangle Concept”, implemented in “Biosmart and Safe Bus”, balances interactions between the host, agent, and environment. This concept results in a safe eco-biological environment in the bus cabin, enhances immune system function, and maintains oxidative stress homeostasis. This study aimed to prove the effectiveness and efficacy of implementing the “Health Triangle Concept” in bus transportation through the development of a bus called the “Biosmart and Safe Bus.” Materials and methods: The “Challenge tests” were conducted at Laboratory for Development of Agro-industrial and Biomedical Technology (LAPTIAB). The pre- and post-test samples were taken from seventy passengers (19-23 years old), divided randomly to control group (n = 35) in a regular bus, and intervention group rode the “Biosmart and Safe Bus” (n = 35). Results: The delta levels of IgA improved (17.89±30.19 mg/mL) in buses adopting the concept, as well as delta levels of IL-6 (13.38±0.96 pg/mL). A significant difference (p = 0.016) and a strong negative correlation (r = -0.611) in delta levels of SOD3 (54.69±163.91 U/ml) and ROS (24.17±45.62 (U/ml) in intervention group. Conclusion: The “Health-Triangle Concept” for the “Biosmart and Safe Bus” resulted in an eco-biological safe bus cabin environment, improved passenger’s airway immune systems, and enhanced oxidative stress homeostasis.
Muntingia calabura Modulates Alveolar Matrix Metalloproteinase-9 (MMP-9) and Decreases The Alveolar Diameter in Sprague-Dawley Rats Exposed to Cigarette Smoke
Ika D. Kurniati, Kusmiyati Tjahjono, Awal Prasetyo, Ika P. Miranti
Tropical Journal of Natural Product Research, 2025
Exposure to cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), characterized by oxidative stress and inflammation. The fruit of Muntingia calabura demonstrates significant antioxidant and anti-inflammatory properties. This study investigates the effects of Muntingia calabura fruit extract on matrix metalloproteinase-9 (MMP-9) expression and changes in alveolar diameter in Sprague-Dawley rats subjected to cigarette smoke exposure. Eighteen male Sprague-Dawley rats were randomly assigned to three groups: control (K), treatment 1 (P1) receiving 100 mg/kg body weight/day of M. calabura extract, and treatment 2 (P2) receiving 200 mg/kg body weight/day of the extract. All groups were exposed to cigarette smoke from burning seven cigarettes daily for four weeks. MMP-9 expression was assessed via immunohistochemistry, and alveolar diameter was measured using Optilab software. Both treatment groups exhibited a significant increase in MMP-9 expression compared to the control group (p < 0.0001). Alveolar diameter was significantly reduced in the P2 group compared to P1 and K (p < 0.0001). A negative correlation was observed between MMP-9 expression and alveolar diameter (r = -0.384, p < 0.0001). Administration of Muntingia calabura fruit extract enhances MMP-9 expression and decreases alveolar diameter in rats exposed to cigarette smoke, suggesting its potential protective role against smoke-induced pulmonary damage.
Combination of Mangosteen (Garcinia mangostana L.) Pericarp Extract and Physical Exercise Decreases Atherosclerotic Lesions in Atherogenic Diet-Fed Rats
Andreas Arie Setiawan, . Sugiri, Awal Prasetyo, Eirin Yovita Kurniawan, Dominikus Evano Putra
Traditional and Integrative Medicine, 2024
The mangosteen pericarp (MP) has xanthone compounds, particularly alpha-mangostin (α-MG), which have been shown to exhibit potent antioxidant and anti-inflammatory activities. Physical exercise (PE) has also been shown to have atheroprotective effects. To date, their combined effect on atherosclerosis has not been studied histologically. This study aimed to investigate the effect of MP extract combined with PE on atherosclerotic changes in rats fed an atherogenic diet. Twenty-five male Wistar rats (Rattus norvegicus) aged 6-8 weeks were randomly divided into five groups of five rats each: C (control, normal diet), CH (atherogenic diet), T1 (atherogenic diet plus MP extract 800 mg/kg/day in three divided doses with PE), T2 (atherogenic diet plus MP extract-loaded nanoemulsion 50 mg/kg/day with PE), and T3 (atherogenic diet plus atorvastatin 1.44 mg/day with PE). The PE protocol involved daily treadmill running for 60 min at 12 m/min, 5 days/week. All rats were treated for eight weeks. Following eight weeks of treatment, the animals were sacrificed and the aortic tissues were taken for histological study. The histological features in groups CH, T1, T2, and T3 were consistent with type Vc atherosclerotic lesion (fibrotic lesion) with intimal thicknesses of 11.99 ± 0.88 μm, 3.61 ± 0.53 μm, 3.48 ± 0.47 μm, and 2.96 ± 0.20 μm, respectively. A comparative analysis revealed a significant reduction in intimal thickness in groups T1, T2, and T3 compared to the CH group (p <0.001). Group T2 exhibited a non-significant decrease compared to group T1 (p = 0.691). Moreover, neither the T1 nor T2 groups significantly differed from the T3 group (p = 0.052 and 0.128, respectively). In conclusion, the combination of MP extract (and its nanoemulsion) and PE decreases atherosclerotic lesions and provides comparable results to the atorvastatin-treated group, indicating their potential as alternative options for preventing atherosclerosis.
Malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in ischemic stroke: a systematic review
Dodik Tugasworo, Awal Prasetyo, Aditya Kurnianto, Retnaningsih Retnaningsih, Yovita Andhitara, Rahmi Ardhini, Jethro Budiman
Egyptian Journal of Neurology Psychiatry and Neurosurgery, 2023
Introduction The low blood flow in ischemic stroke reduces oxygen and glucose and induces a series of reactions that produce free radicals. Free radicals can destroy cell membranes (lipid peroxidation) marked by the elevation of malondialdehyde (MDA), and the damage of deoxyribonucleic acid (DNA) showed by the elevation of 8-hydroxy-2’-deoxyguanosine (8-OHdG). This review aimed to assess and conclude the research-based study systematically to analyze the relationship of MDA/8-OHdG and ischemic stroke. Method Cochrane handbook for systematic reviews, the guideline of preferred reporting items for systematic review and meta-analysis (PRISMA), and synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline was used as guideline in this systematic review. Inclusion criteria in this review were primary studies of every design, articles published in English around January 2000–December 2021, and the study used human as subject. A systematic literature search was applied in 15 electronic medical journals. The authors assessed the study quality and risk of bias of each included study. Results The authors evaluated 374 studies found in literature searching, 30 studies met the criteria for this review, and then underwent the assessment of study quality and risk of bias. Conclusion MDA has the role as oxidative stress biomarker, outcome predictor, mortality predictor, post-stroke cognitive impairment predictor, post-stroke depression predictor, and hand grip strength predictor of ischemic stroke; while 8-OHdG has the role as oxidative stress biomarker, outcome predictor, mortality predictor, post-stroke cognitive impairment predictor, post-stroke depression predictor of ischemic stroke.
Which are the best in protecting the upper respiratory tract, KN95® or Acchadana®-herbal masks on IL-6 perspective?
Resti Ariani, Awal Prasetyo, Rina Puspita, Fathur Nur Kholis, Udadi Sadhana, Ika Pawitra M, Hermawan Istiadi
Bali Medical Journal, 2023
Background: In the new normal era, face masks are very important for everyday use. Masks began to be developed involving herbal plants with anti-inflammatory and antibacterial potential. This study aims to prove the potential of KN95 masks and Acchadana® Herbal Masks. Methods: This randomized control trial has 50 laboratory workers as subjects. Subjects were divided into two groups. The control group wore KN95® masks (n=25), and the treatment group wore Acchadana® herbal masks (n=25, 1 dropout). Each group wore a mask for 60 days. Then a nasal wash sample was taken for a laboratory test for IL-6 levels using the ELISA method. Result: There was no significant comparison of IL-6 levels between the KN95® mask group and the herbal mask group in the Mann Whitney test (p=0.242). When viewed from the high and low levels of IL-6 in the respiratory tract of laboratory workers after 60 days of wearing masks, IL-6 levels in the Acchadana® mask group experienced a greater decrease compared to the KN95 mask group. However, the protection of the two masks was not significantly different (KN95®= -0.604 pg/ml and Herbal= -1.026 pg/ml; p>0.05). Conclusion: KN95® masks and Acchadana® herbal masks have equal ability to protect the respiratory tract.
BLOOD SUPPLY ANALYSIS DURING PANDEMIC IN INDONESIAN RED CROSS OF SEMARANG CITY
Southeast Asian Journal of Tropical Medicine and Public Health, 2022
The Superior Outcome of Collagen Nanosilver in Increasing Macrophage and Collagen on Deep Dermal Burn Wound Healing
Anggun Ari Mukti, Awal Prasetyo, Yan Wisnu Prajoko, Najatullah Najatullah, Neni Susilaningsih
Open Access Macedonian Journal of Medical Sciences, 2022
AIM: This study aims to prove the superior outcome of collagen nanosilver in increasing macrophage and collagen on deep dermal burn wound healing. METHODS: This study was a randomized control trial design. All animals used were male Sprague Dawley rats aged 12–14 weeks old and weighed about 200–250 g. Each rat gets four site injuries and is given treatments. The treatment group includes: I (negative control using NaCl 0.9%), II (positive control using silver sulfadiazine cream), III (treatment with nanosilver collagen cream 1%), and IV (treatment with collagen nanosilver cream 2%). Macrophages counts were assessed using IHC F40/80 and collagen density was assessed using Masson’s trichrome staining. RESULTS: Macrophage on day 6 showed a significant difference as seen in group III and group IV. A significant difference was also obtained between macrophage on day 3 and day 6 from group IV, likewise between collagen between day 3 and day 6 from group III and IV. Collagen nanosilver acts as an antimicrobial and anti-inflammatory agent by increasing the mechanism of activation and migration of macrophages to the site of injury. Moreover, this formula modulated the collagen deposition, which forms the tissue fibers which ultimately provide a conducive environment for wound healing. CONCLUSION: Collagen nanosilver has a superior outcome in the increasing macrophage cell count and collagen density of deep dermal burn wound healing.
The effect of hypnotherapy on anticipatory nausea in head and neck cancer patients undergoing chemotherapy
Dadi Hamdani, Awal Prasetyo, Anggorowati Anggorowati
Nurse Media Journal of Nursing, 2021
Background: One of the chemotherapy side effects on head and neck cancer patients is anticipatory nausea. However, the anticipatory nausea problem has not been properly resolved. Nausea might be psychologically reduced by hypnotherapy. There only have been very few studies conducted to examine the effects of hypnotherapy in alleviating anticipatory nausea.Purpose: This study aimed to determine the effect of hypnotherapy using Hanung induction technique on anticipatory nausea in head and neck cancer patients undergoing chemotherapy.Methods: This research employed a pre-post test of quasi-experiment with control group design. Consecutive sampling technique was used to obtain 64 subjects who met inclusion and exclusion criteria and were equally divided into the intervention and control groups. Hypnotherapy as the intervention was carried out in two sessions, each of which lasted for 20 minutes, with a week distance between sessions. The data were collected using a visual analog scale (VAS), which was used twice to measure anticipatory nausea and analyzed using the paired and independent-sample t-test.Result: The results showed that the mean score of anticipatory nausea in the intervention group reduced from 7.6±1.4 to 2.3 ±1.2 after hypnotherapy, while the mean in the control group increased from 6.4±1.6 to 6.7±1.4. There was a significant difference in the score of anticipatory nausea after the implementation of hypnotherapy between the intervention and the control group (p<0.001).Conclusion: The study concluded that hypnotherapy is effective in reducing the intensity of anticipatory nausea in head and neck cancer patients undergoing chemotherapy. Therefore, hypnotherapy can be applied by oncology nurses as an intervention in treating anticipatory nausea.
Effects of Caffeine Consumption on Autologous Full-Thickness Skin Graft Healing in an Animal Model
Tommy Supit, Neni Susilaningsih, Awal Prasetyo, and
Indian Journal of Plastic Surgery, 2021
Background There exists contradictory evidence that states both the beneficial and deleterious effects of caffeine on wound healing. The general population might unknowingly consume caffeine that negatively affects wound healing. The main objective of this study is to investigate the effect of daily caffeine consumption on wound healing, specifically full-thickness skin graft (FTSG). Methods Forty Sprague–Dawley rats were randomized into four groups of equal size: control-dose (CD), low-dose (LD), medium-dose (MD), and high-dose (HD) caffeine groups. After autologous FTSG, all subjects in the intervention group were given daily pure caffeine gavage. The FTSG was explanted 7 days posttransplant. The graft viability, secondary contraction, and adherence were evaluated macroscopically, while fibroblast and collagen deposition was analyzed microscopically with hematoxylin eosin stain. Results The least graft viability (72.8 ± 20.7%, clinical wound assessment scale [CWAS] 2.4), highest secondary contraction (11.4 ± 10.5%), and fibroblast count (331.8 ± 88.6 cells/5 high power fields) were observed in the MD group. More collagen synthesis was observed in subjects who consumed caffeine. The level of secondary contraction, fibroblast count as well as graft viability and collagen synthesis were positively correlated. Conclusions Daily consumption of caffeine impairs graft viability when given in medium dose and increases collagen synthesis, irrespective of dosage. This study was in experimental rats; the results are not directly translatable to humans.
Effectiveness of nanosilver collagen cream for healing deep dermal burns in sprague dawley rats: An overview of neutrophil counts and angiogenesis
Krisna Muhammad, Awal Prasetyo, Yan Wisnu Prajoko, Najatullah Najatullah, Neni Susilaningsih
Bali Medical Journal, 2021
The relationship between tumor-infiltrating lymphocytes (TILs) and nasopharyngeal carcinoma (NPC): A systematic review
Awal Prasetyo, Jethro Budiman, Udadi Sadhana
Iranian Journal of Otorhinolaryngology, 2021
Does a higher degree of education affect the performance of healthcare leaders? A systematic review
Awal Prasetyo, Jethro Budiman, Muzakar Isa
Bali Medical Journal, 2021
Prognostic significance of double expressor lymphoma subtype in patient with diffuse large b-cell lymphoma
Hermawan Istiadi, Udadi Sadhana, Dik Puspasari, Ika Pawitra Miranti, Vega Karlowee, Devia Eka Listiana, Awal Prasetyo
Bali Medical Journal, 2021
Nasal mucociliary clearance in smokers: A systematic review
Awal Prasetyo, Udadi Sadhana, Jethro Budiman
International Archives of Otorhinolaryngology, 2021
The role of interleukin in ectopic pregnancy: A systematic review
Cahyono Hadi, Jethro Budiman, Awal Prasetyo, Cipta Pramana
Open Access Macedonian Journal of Medical Sciences, 2021
The effectiveness of multiflora honey to prevent hepatotoxicity in invasive ductal breast cancer patients with fac chemotherapy
Dwi Feris Martua Sidabutar, Selamet Budijitno, Awal Prasetyo
Bali Medical Journal, 2021
Role of cell-origin profiling using immunohistochemistry to predict the survival of patients with diffuse large b-cell lymphoma in indonesia
Hermawan Istiadi, Udadi Sadhana, Dik Puspasari, Ika Pawitra Miranti, Vega Karlowee, Devia Eka Listiana, Awal Prasetyo
Yonago Acta Medica, 2021
Artemisia annua leaf extract increases GLUT-4 expression in type 2 diabetes mellitus rat
Arum Kartikadewi, Awal Prasetyo, Lisyani Budipradigdo, Heri Nugroho, Kusmiyati Tjahjono, Arthur Lelono
Indonesian Biomedical Journal, 2019
Effect of mindfulness intervention on the intensity of pain and anxiety in nasopharyngeal cancer patients
Pakistan Journal of Medical and Health Sciences, 2018
Effects of physical-cognitive therapy (PCT) on criticaly ill patients in intensive care unit
Hiroshima Journal of Medical Sciences, 2018
Effect of mindfulness intervention on the intensity of pain in nasopharyngeal cancer patients undergoing radiation treatment
Anna Jumatul Laely, Awal Prasetyo, Chandra Bagus Ropyanto
Belitung Nursing Journal, 2018
Annona muricata modulate brain-CXCL10 expression during cerebral malaria phase
Kis Djamiatun, Sumia M A Matug, Awal Prasetyo, Noor Wijayahadi, Djoko Nugroho
Iop Conference Series Earth and Environmental Science, 2017
Occupational exposure on gasoline station workers not affect the nasal mucociliary clearance time and pulmonary function test
Awal Prasetyo, Salim Darry, . Samuel, Drestanta Redyaksa, Udadi Sadhana, Armunanto Sigit
Advanced Science Letters, 2017

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Scopus Publications