ADRIANE REGINA TODESCHINI
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Scopus Publications
- Structural elucidation of a crystalline mannan from açaí (Euterpe oleracea Mart.) seeds
Ingrid Santos Miguez, Francisco Felipe Bezerra, Paulo Antônio de Souza Mourão, Jochen Junker, Sylwia Głazowska, Peter Ulvskov, Bodil Jørgensen, Adriane Regina Todeschini, Carmen Lucia de Oliveira Petkowicz, Ayla Sant'Ana da Silva
International Journal of Biological Macromolecules, 2026
Açaí is an Amazonian “superfruit” whose pulp production generates large amounts of seed waste. As nearly half of the dry mass of this residue is composed of mannan, this study investigated the structure and distribution of mannan in açaí seeds to support its bioconversion into value-added products such as mannose and mannan-oligosaccharides. To this end, the seeds were fractionated to obtain soluble and water-insoluble fractions, which were analyzed to assess their mannan content. In soluble fractions, glycomic profiling revealed the presence of an alkali-soluble mannan together with low amounts of pectin, (hetero)xylan, xyloglucan, and glucan. The water-insoluble fraction was further analyzed by solution-state NMR, where 1 H/ 13 C HSQC and HMBC spectra showed signals consistent with a backbone of 1,4-linked β-D-Man p , with chemical shifts similar to those reported for mannan from ivory nut, a material known to contain linear mannan. Gas chromatography analysis indicated a predominantly linear mannan with mannose-to-galactose ratio of 50:1, suggesting only minor galactose substitutions. Furthermore, due to the limited solubility of this fraction, 13 C CP/MAS solid-state NMR was employed to enable a comprehensive structural assessment. Solid-state NMR revealed the presence of a mannan I polymorph, with its crystalline nature further confirmed by X-ray diffraction. The identification of a highly crystalline linear mannan in açaí seeds provides structural insight relevant to the development of strategies aimed at reducing mannan crystallinity and designing specialized enzymatic cocktails for its efficient hydrolysis, thereby supporting the sustainable valorization of this abundant agro-industrial byproduct. • Glycome profiling identified epitopes of xyloglucan, xylan and an alkali-soluble mannan in seeds. • There is an insoluble linear β-(1 → 4)-D-mannan structure in açaí seeds endosperm. • Solid-state NMR and X-ray diffraction confirmed a crystalline mannan I polymorph. • Crystallinity is a structural feature that may contribute to mannan recalcitrance. - GlycoGenius: a streamlined high-throughput glycan composition identification tool
Hector F. Loponte, Jing Zheng, Yajie Ding, Isadora A. Oliveira, Kristoffer Basse, Adriane R. Todeschini, Peter L. Horvatovich, Guinevere S. M. Lageveen-Kammeijer
Nature Communications, 2025
Mass spectrometry is recognized as the gold standard for glycan analysis, yet the complexity of the generated data hampers progress in glycobiology, as existing tools lack full automation, requiring extensive manual effort. We introduce GlycoGenius, an open-source program offering an automated workflow for glycomics data analysis, featuring an intuitive graphical interface. With algorithms tailored to reduce manual workload, it allows for data visualization and automatically constructs search spaces, identifies, scores, and quantifies glycans, filters results, and annotates fragment spectra of N- and O-glycans, glycosaminoglycans and more. It seamlessly guides researchers of all expertise levels from raw data to publication-ready figures. Our findings demonstrate that GlycoGenius achieves results comparable to manual analysis or competing tools, identifying more glycans, including novel ones, while significantly reducing processing time. This groundbreaking tool represents a significant advancement in the study of glycoconjugates, empowering researchers to focus on insights rather than data processing. Researchers present GlycoGenius, an open-source tool that automates complex glycomics data analysis. It streamlines workflows, identifies known and previously unreported glycans, and enables faster, more accessible insights into glycobiology. - Chikungunya virus infection under high glucose environment reverts insulin unresponsiveness and promotes cellular metabolic shift to increase anaplerosis and virion production
Bia Francis Rajsfus, José Xavier Nascimento-Júnior, Marina Santos Chichierchio, Adriane Regina Todeschini, Isadora de Araujo Oliveira, Fernando de Souza Borges, Shana Priscila Barroso, Ronaldo Mohana-Borges, Juliana Camacho-Pereira, Patrícia Zancan, Diego Allonso
Life Sciences, 2025 - Dietary intake of the red meat-derived glycan Neu5Gc fuels colorectal cancer through up-regulation of Wnt signaling pathway
Ana Luiza Lopes, Amanda Carlos Paulino, Mariana A.S. Thaumaturgo, Wallace Martins Araújo, Philippe Caloba, Kunio Kawanishi, Karl Willert, Rodrigo P. De Oliveira, João C. Machado, Felipe Lemos, Nissi Varki, Jose Andres Morgado-Diaz, Heinz Läubli, Adriane Regina Todeschini, Ajit Varki, Frederico Alisson-Silva
Cancer Letters, 2025 - O-GlcNAcylation regulates tyrosine hydroxylase serine 40 phosphorylation and L-DOPA levels
Bruno da Costa Rodrigues, Miguel Clodomiro dos Santos Lucena, Anna Carolina Rego Costa, Isadora de Araújo Oliveira, Mariana Thaumaturgo, Yolanda Paes-Colli, Danielle Beckman, Sergio T. Ferreira, Fernando Garcia de Mello, Ricardo Augusto de Melo Reis, Adriane Regina Todeschini, Wagner Barbosa Dias
American Journal of Physiology Cell Physiology, 2025
This study shows how β- O-linked- N-acetylglucosamine ( O-GlcNAcylation) modulates tyrosine hydroxylase (TH) activity, revealing a negative feedback loop with Ser40 phosphorylation both in vitro and ex vivo, which directly influences on l-3,4-dihydroxyphenylalanine (l-DOPA) production. These findings offer insights into neurotransmitter homeostasis regulation, with implications for understanding and potentially treating disorders linked to aberrant catecholamine signaling. - Sex-specific effect of antenatal Zika virus infection on murine fetal growth, placental nutrient transporters, and nutrient sensor signaling pathways
Daniela Pereira‐Carvalho, Alessandra Cristina Chagas Valim, Cherley Borba Vieira Andrade, Enrrico Bloise, Ariane Fontes Dias, Veronica Muller Oliveira Nascimento, Rakel Kelly Silva Alves, Ronan Christian dos Santos, Felipe Lopes Brum, Inácio Gomes Medeiros, Sharton Vinicius Antunes Coelho, Luciana Barros Arruda, Adriane Regina Todeschini, Wagner Barbosa Dias, Tania Maria Ortiga‐Carvalho
FASEB Journal, 2024
Maternal Zika virus (ZIKV) infection during pregnancy has been associated with severe intrauterine growth restriction (IUGR), placental damage, metabolism disturbances, and newborn neurological abnormalities. Here, we investigated the impact of maternal ZIKV infection on placental nutrient transporters and nutrient‐sensitive pathways. Immunocompetent (C57BL/6) mice were injected with Low (103 PFU‐ZIKVPE243) or High (5 × 107 PFU‐ZIKVPE243) ZIKV titers at gestational day (GD) 12.5, and tissue was collected at GD18.5 (term). Fetal–placental growth was impaired in male fetuses, which exhibited higher placental expression of the ZIKV infective marker, eukaryotic translation initiation factor 2 (eIF2α), but lower levels of phospho‐eIF2α. There were no differences in fetal–placental growth in female fetuses, which exhibited no significant alterations in placental ZIKV infective markers. Furthermore, ZIKV promoted increased expression of glucose transporter type 1 (Slc2a1/Glut1) and decreased levels of glucose‐6‐phosphate in female placentae, with no differences in amino acid transport potential. In contrast, ZIKV did not impact glucose transporters in male placentae but downregulated sodium‐coupled neutral amino acid 2 (Snat2) transporter expression. We also observed sex‐dependent differences in the hexosamine biosynthesis pathway (HBP) and O‐GlcNAcylation in ZIKV‐infected pregnancies, showing that ZIKV can disturb placental nutrient sensing. Our findings highlight molecular alterations in the placenta caused by maternal ZIKV infection, shedding light on nutrient transport, sensing, and availability. Our results also suggest that female and male placentae employ distinct coping mechanisms in response to ZIKV‐induced metabolic changes, providing insights into therapeutic approaches for congenital Zika syndrome. - Cuts to postgraduate funding threaten Brazilian science — again
Marcus F. Oliveira, Adriane R. Todeschini
Nature, 2024 - Interfacing manganese-based carbonaceous nanocomposites with plasma components: insights on protein interaction, structure and opsonization
Yarima Sanchez Garcia, Thais Meira Menezes, Marcela Rodrigues Barros, Elizabeth Martins da Silva, Gustavo Tavares Ventura, Susana Frases, Adriane Regina Todeschini, Jorge Luiz Neves
Journal of Biomolecular Structure and Dynamics, 2024
Metal encapsulation delivers a straightforward strategy to improve miscellaneous nanoparticle properties and qualifies the resulting nanocomposite for exceptional application, including bioimaging, drug release, and theranostic development. Besides crucial applications, investigations associated with the nanocomposite impact on the biological media are highly relevant from a pharmacological viewpoint. Such studies can be conducted by exploring nanocomposite attributes and all aspects of their interaction with proteins existing in biofluids. Based on these aspects, the present work examines manganese-encapsulated carbonaceous nanocomposite (MnCQD) and their interaction with plasma proteins. On one side, the obtained nanocomposite has almost spherical shapes (≈12 nm in size), an appropriate composition and interesting optical properties for bioimaging applications. On another side, MnCQD quenches the fluorescence of two plasma proteins (BSA and HTF) following a static mechanism, confirming the formation of the MnCQD-BSA and MnCQD-HTF complexes. Although hydrophobic forces guide the stability of both formed complexes, MnCQD binds preferentially to BSA compared to HTF, with affinity constants differing by almost an order of magnitude. Furthermore, HTF and BSA underwent modifications in their secondary structure provoked due to contact with the nanocomposite, which also presented neglectable opsonization levels when exposed to appropriate biological media. These results highlight the MnCQD outstanding potential to be employed in diverse bioapplications.Communicated by Ramaswamy H. Sarma - Inhibition of O-GlcNAcylation Reduces Cell Viability and Autophagy and Increases Sensitivity to Chemotherapeutic Temozolomide in Glioblastoma
Amanda V. Leonel, Frederico Alisson-Silva, Ronan C. M. Santos, Rodrigo P. Silva-Aguiar, Julia C. Gomes, Gabriel M. C. Longo, Bruna M. Faria, Mariana S. Siqueira, Miria G. Pereira, Andreia Vasconcelos-dos-Santos, Luciana B. Chiarini, Chad Slawson, Celso Caruso-Neves, Luciana Romão, Leonardo H. Travassos, Katia Carneiro, Adriane R. Todeschini, Wagner B. Dias
Cancers, 2023
Glioblastoma (GB) is the most aggressive primary malignant brain tumor and is associated with short survival. O-GlcNAcylation is an intracellular glycosylation that regulates protein function, enzymatic activity, protein stability, and subcellular localization. Aberrant O-GlcNAcylation is related to the tumorigenesis of different tumors, and mounting evidence supports O-GlcNAc transferase (OGT) as a potential therapeutic target. Here, we used two human GB cell lines alongside primary human astrocytes as a non-tumoral control to investigate the role of O-GlcNAcylation in cell proliferation, cell cycle, autophagy, and cell death. We observed that hyper O-GlcNAcylation promoted increased cellular proliferation, independent of alterations in the cell cycle, through the activation of autophagy. On the other hand, hypo O-GlcNAcylation inhibited autophagy, promoted cell death by apoptosis, and reduced cell proliferation. In addition, the decrease in O-GlcNAcylation sensitized GB cells to the chemotherapeutic temozolomide (TMZ) without affecting human astrocytes. Combined, these results indicated a role for O-GlcNAcylation in governing cell proliferation, autophagy, cell death, and TMZ response, thereby indicating possible therapeutic implications for treating GB. These findings pave the way for further research and the development of novel treatment approaches which may contribute to improved outcomes and increased survival rates for patients facing this challenging disease. - From metabolism to disease: The biological roles of glutamine:fructose-6-phosphate amidotransferase (GFAT)
Isadora de Araújo Oliveira, Daniela Maria dos Santos Lucena, Bruno da Costa Rodrigues, Victória Trindade Maller, Rodrigo Nunes da Fonseca, Diego Allonso, Adriane Regina Todeschini
Pure and Applied Chemistry, 2023
Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP), an important route for de novo synthesis of amino sugars, which are key components of prokaryotic cell walls, chitin, and complex eukaryotic glycoconjugates. GFAT also plays a major role in several pathological processes, including cancer and diabetes. It has been 60 years since GFAT was first characterized. During this time, the knowledge about the enzyme’s mechanisms and biological relevance has increased considerably. We take the anniversary of GFAT’s discovery as an opportunity to discuss the role of GFAT in both health and disease and explore its biotechnological potential as a target for antimicrobial and anticancer chemotherapy. - Protein glycosylation in cancer
Wagner B. Dias, Andréia Vasconcelos-dos-Santos, Hector F.B.R. Loponte, Felipe C.O.B. Teixeira, Ronan C. Santos, Julio C.M. de-Freitas-Junior, Mauro S.G. Pavão, Frederico Alisson-Silva, Adriane R. Todeschini
Translational Glycobiology in Human Health and Disease, 2023 - Development and clinical application of hydrogel formulations containing papain and urea for wound healing
Thais Menezes dos Santos, Danieli Silva Feijó de Sousa, Karina Chamma Di Piero, Adriane Regina Todeschini, Wagner Barbosa Dias, Catarina Amorim Oliveira, Elisabete Pereira dos Santos, Mariana Sato de Souza Bustamante Monteiro, Maria Kátia Gomes, Cristiano dos Reis Moura, Pedro Antônio Castelo Teixeira, Eduardo Ricci-Junior, Zaida Maria Faria de Freitas
Brazilian Journal of Pharmaceutical Sciences, 2023 - BDE-209 and TCDD enhance metastatic characteristics of melanoma cells after chronic exposure
Benisio Ferreira Silva Filho, Francisco Filipak Neto, Micheli de Marchi, Erick Laurent Moggio, Izadora Volpato Rossi, Bruna Sabatke, Marcel Ivan Ramirez, Miguel Clodomiro dos Santos Lucena, Adriane Regina Todeschini, Ciro Alberto de Oliveira Ribeiro
Environmental Pollution, 2022 - GM2/GM3 controls the organizational status of CD82/Met microdomains: further studies in GM2/GM3 complexation
Ronan C. M. Santos, Daniela M. S. Lucena, Hector F. B. R. Loponte, Frederico Alisson-Silva, Wagner B. Dias, Roberto D. Lins, Adriane R. Todeschini
Glycoconjugate Journal, 2022 - Hyperglycemia alters N-glycans on colon cancer cells through increased production of activated monosaccharides
H. F. Loponte, I. A. Oliveira, B. C. Rodrigues, R. Nunes-da-Fonseca, R. Mohana-Borges, F. Alisson-Silva, W. B. Dias, A. R. Todeschini
Glycoconjugate Journal, 2022 - Evaluation of europium-based carbon nanocomposites as bioimaging probes: Preparation, NMR relaxivities, binding effects over plasma proteins and cytotoxic aspects
Thais Meira Menezes, Yarima Sanchez Garcia, Caio Rodrigo Dias de Assis, Gustavo Tavares Ventura, Rafaela Muniz de Queiroz, Wagner Barbosa Dias, Adriane Regina Todeschini, Jorge Luiz Neves
Colloids and Surfaces A Physicochemical and Engineering Aspects, 2021 - Enzymatic and structural properties of human glutamine:fructose-6-phosphate amidotransferase 2 (hGFAT2)
Isadora A. Oliveira, Diego Allonso, Tácio V.A. Fernandes, Daniela M.S. Lucena, Gustavo T. Ventura, Wagner Barbosa Dias, Ronaldo S. Mohana-Borges, Pedro G. Pascutti, Adriane R. Todeschini
Journal of Biological Chemistry, 2021 - The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)
Angélica Arcanjo, Jorgete Logullo, Camilla Cristie Barreto Menezes, Thais Chrispim de Souza Carvalho Giangiarulo, Mirella Carneiro dos Reis, Gabriellen Menezes Migliani de Castro, Yasmin da Silva Fontes, Adriane Regina Todeschini, Leonardo Freire-de-Lima, Debora Decoté-Ricardo, Antônio Ferreira-Pereira, Celio Geraldo Freire-de-Lima, Shana Priscila Coutinho Barroso, Christina Takiya, Fátima Conceição-Silva, Wilson Savino, Alexandre Morrot
Scientific Reports, 2020 - Insights on the interaction of furfural derivatives with BSA and HTF by applying multi-spectroscopic and molecular docking approaches
Thaıs Meira Menezes, Marcela Rodrigues Barros, Gustavo Tavares Ventura, Dartagnan de Sa Pires Ferreira, Adriane Regina Todeschini, Ronaldo Mohana Borges, Jefferson Luiz Princival, Gustavo Seabra, Jorge Luiz Neves
Journal of Molecular Liquids, 2020 - Biological evaluation and molecular modeling of peptidomimetic compounds as inhibitors for O-GlcNAc transferase (OGT)
Suraby O. Albuquerque, Thalita G. Barros, Luiza R.S. Dias, Camilo H. da S. Lima, Pedro H.R. de A. Azevedo, Luiz A.P. Flores-Junior, Eldio G. dos Santos, Hector F. Loponte, Sergio Pinheiro, Wagner B. Dias, Estela M.F. Muri, Adriane R. Todeschini
European Journal of Pharmaceutical Sciences, 2020 - Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation
Natália Rodrigues Mantuano, Michal A. Stanczak, Isadora de Araújo Oliveira, Nicole Kirchhammer, Alessandra A. Filardy, Gianni Monaco, Ronan Christian Santos, Agatha Carlos Fonseca, Miguel Fontes, César de Souza Bastos, Wagner B. Dias, Alfred Zippelius, Adriane R. Todeschini, Heinz Läubli
Cancer Immunology Research, 2020 - Trends in nanomedicines for cancer treatment
Tatielle do Nascimento, Adriane R. Todeschini, Ralph Santos-Oliveira, Mariana S. de Souza de Bustamante Monteiro, Vilênia T. de Souza, Eduardo Ricci-Júnior
Current Pharmaceutical Design, 2020 - Trends in nanotechnology for in vivo cancer diagnosis: Products and patents
Tatielle do Nascimento, Melanie Tavares, Mariana S.S.B. Monteiro, Ralph Santos-Oliveira, Adriane R. Todeschini, Vilênia T. de Souza, Eduardo Ricci-Júnior
Current Pharmaceutical Design, 2020 - CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection
Frederico Alisson-Silva, Natália Rodrigues Mantuano, Ana Luiza Lopes, Andréia Vasconcelos-dos-Santos, André Macedo Vale, Miriam Maria Costa, Judy L. Cannon, Ana Carolina Oliveira, Adriane R. Todeschini
Scientific Reports, 2019 - Probing the interaction of carbonaceous dots with transferrin and albumin: Impact on the protein structure and non-synergetic metal release
Yarima Sanchez Garcia, Marcela Rodrigues Barros, Gustavo Tavares Ventura, Rafaela Muniz de Queiroz, Adriane Regina Todeschini, Jorge Luiz Neves
Journal of Molecular Liquids, 2019 - Emerging role of glycosylation in the polarization of tumor-associated macrophages
Natalia Rodrigues Mantuano, Maria Cecilia Oliveira-Nunes, Frederico Alisson-Silva, Wagner Barbosa Dias, Adriane Regina Todeschini
Pharmacological Research, 2019 - Duffy binding-like 1α adhesin from Plasmodium falciparum recognizes ABH histo-blood group saccharide in a type specific manner
Isadora A. Oliveira, Laércio Pol-Fachin, Sebastião T. de Carvalho, Roberto D. Lins, Thereza A. Soares, Ronaldo Mohana-Borges, Jorge L. Neves, Adriane R. Todeschini
Carbohydrate Polymers, 2019 - Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells
Rafaela Muniz de Queiroz, Isadora Araújo Oliveira, Bruno Piva, Felipe Bouchuid Catão, Bruno da Costa Rodrigues, Adriana da Costa Pascoal, Bruno Lourenço Diaz, Adriane Regina Todeschini, Michelle Botelho Caarls, Wagner Barbosa Dias
Frontiers in Oncology, 2019 - Targeting the hexosamine biosynthetic pathway prevents plasmodium developmental cycle and disease pathology in vertebrate host
Pollyanna Stephanie Gomes, Scott Tanghe, Julio Gallego-Delgado, Luciana Conde, Leonardo Freire-de-Lima, Ana Carolina Lima, Célio Geraldo Freire-de-Lima, Josué da Costa Lima Junior, Otacílio Moreira, Paulo Totino, Ana Rodriguez, Adriane Regina Todeschini, Alexandre Morrot
Frontiers in Microbiology, 2019 - N-linked glycosylation restricts the function of short gastrulation to bind and shuttle BMPs
E. Negreiros, S. Herszterg, K. Hwa, A. Câmara, W. B. Dias, K. Carneiro, E. Bier, A. Todeschini, H. Araujo
Development Cambridge, 2018 - Hyperglycemia and aberrant O-GlcNAcylation: contributions to tumor progression
Andréia Vasconcelos-dos-Santos, Rafaela Muniz de Queiroz, Bruno da Costa Rodrigues, Adriane R. Todeschini, Wagner B. Dias
Journal of Bioenergetics and Biomembranes, 2018 - Cellular glycosylation senses metabolic changes and modulates cell plasticity during epithelial to mesenchymal transition
Patricia Carvalho‐cruz, Frederico Alisson‐Silva, Adriane R. Todeschini, Wagner B. Dias
Developmental Dynamics, 2018 - Prevalence of IgG autoantibodies against GD3 ganglioside in acute Zika virus infection
Dirlei Nico, Luciana Conde, Juan L. Rivera-Correa, Andréia Vasconcelos-dos-Santos, Louise Mesentier-Louro, Leonardo Freire-de-Lima, Mônica Barcellos Arruda, Celio Geraldo Freire-de-Lima, Orlando da Costa Ferreira, Maria Elisabeth Lopes Moreira, Andrea Araújo Zin, Zilton Farias Meira Vasconcelos, Rosalia Mendez Otero, Clarisa Beatriz Palatnik-de-Sousa, Amilcar Tanuri, Adriane Regina Todeschini, Wilson Savino, Ana Rodriguez, Alexandre Morrot
Frontiers in Medicine, 2018 - Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway
A Vasconcelos-dos-Santos, H F B R Loponte, N R Mantuano, I A Oliveira, I F de Paula, L K Teixeira, J C M de-Freitas-Junior, K C Gondim, N Heise, R Mohana-Borges, J A Morgado-Díaz, W B Dias, A R Todeschini
Oncogenesis, 2017 - Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation
Miguel C. Lucena, Patricia Carvalho-Cruz, Joana L. Donadio, Isadora A. Oliveira, Rafaela M. de Queiroz, Monica M. Marinho-Carvalho, Mauro Sola-Penna, Iron F. de Paula, Katia C. Gondim, Mark E. McComb, Catherine E. Costello, Stephen A. Whelan, Adriane R. Todeschini, Wagner B. Dias
Journal of Biological Chemistry, 2016 - Calcium-induced lipid peroxidation is mediated by rhodnius heme-binding protein (RHBP) and prevented by vitellin
Marcia C. Paes, Alan B. Silveira, Guilherme Ventura‐Martins, Monalisa Luciano, Marsen G. P. Coelho, Adriane R. Todeschini, M. Lucia Bianconi, Georgia C. Atella, Mário A. C. Silva‐Neto
Archives of Insect Biochemistry and Physiology, 2015 - Sperm and egg jelly coat from sea urchin Lytechinus variegatus collected in Rio de Janeiro contain distinct sialic acid-rich polysaccharides
Gabrielle M. Valle, Leonardo P. Cinelli, Adriane R. Todeschini, Lycia de Brito-Gitirana, Ana-Cristina E.S. Vilela-Silva, Paulo A.S. Mourão
Brazilian Archives of Biology and Technology, 2015 - Biosynthetic machinery involved in aberrant glycosylation: Promising targets for developing of drugs against cancer
Andréia Vasconcelos-dos-Santos, Isadora A. Oliveira, Miguel Clodomiro Lucena, Natalia Rodrigues Mantuano, Stephen A. Whelan, Wagner Barbosa Dias, Adriane Regina Todeschini
Frontiers in Oncology, 2015 - Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis
Dirlei Nico, Naiara Maran, Leonardo Santos, Erivan Schnaider Ramos-Junior, Natália Rodrigues Mantuano, Joseane Lima Prado Coutinho, Andre Macedo Vale, Celio Geraldo Freire-de-Lima, Adriane Todeschini, Juliany Cola Fernandes Rodrigues, Clarisa Beatriz Palatnik-de-Sousa, Alexandre Morrot
Parasites and Vectors, 2015 - Evidence of ternary complex formation in Trypanosoma cruzi trans-sialidase catalysis
Isadora A. Oliveira, Arlan S. Gonçalves, Jorge L. Neves, Mark von Itzstein, Adriane R. Todeschini
Journal of Biological Chemistry, 2014 - Trypanosoma Cruzi trans-sialidase: Structural features and biological implications
Isadora A. Oliveira, Leonardo Freire-de-Lima, Luciana L. Penha, Wagner B. Dias, Adriane R. Todeschini
Sub Cellular Biochemistry, 2014 - Evidences for the involvement of cell surface glycans in stem cell pluripotency and differentiation
F. Alisson-Silva, D. de Carvalho Rodrigues, L. Vairo, K. D. Asensi, A. Vasconcelos-dos-Santos, N. R. Mantuano, W. B. Dias, E. Rondinelli, R. C. d. S. Goldenberg, T. P. Urmenyi, A. R. Todeschini
Glycobiology, 2014 - Inhibitory Effects of Trypanosoma cruzi Sialoglycoproteins on CD4+ T Cells Are Associated with Increased Susceptibility to Infection
Marise Pinheiro Nunes, Bárbara Fortes, João Luiz Silva-Filho, Eugênia Terra-Granado, Leonardo Santos, Luciana Conde, Isadora de Araújo Oliveira, Leonardo Freire-de-Lima, Marina Vieira Martins, Ana Acacia Sá Pinheiro, Christina Maeda Takyia, Célio Geraldo Freire-de-Lima, Adriane Regina Todeschini, George Alexandre DosReis, Alexandre Morrot
Plos One, 2013 - Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes
Ana Flávia F.R. Nardy, João Luiz da Silva Filho, Ana Rosa Pérez, Juliana de Meis, Désio Aurélio Farias-de-Oliveira, Luciana Penha, Isadora de Araújo Oliveira, Wagner B. Dias, Adriane R. Todeschini, Célio Geraldo Freire-de-Lima, Maria Bellio, Celso Caruso-Neves, Ana Acácia Pinheiro, Christina Maeda Takiya, Oscar Bottasso, Wilson Savino, Alexandre Morrot
Microbes and Infection, 2013 - Increase of O-Glycosylated Oncofetal Fibronectin in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Epithelial Cells
Frederico Alisson-Silva, Leonardo Freire-de-Lima, Joana L. Donadio, Miguel C. Lucena, Luciana Penha, Julliana N. Sá-Diniz, Wagner B. Dias, Adriane R. Todeschini
Plos One, 2013 - Further structural characterization of the Echinococcus granulosus laminated layer carbohydrates: The blood-antigen P1-motif gives rise to branches at different points of the O-glycan chains
Gerardo Lin, Adriane R Todeschini, Akihiko Koizumi, Jorge L Neves, Humberto González, Sylvia Dematteis, Noriyasu Hada, Jose O Previato, Fernando Ferreira, Lucia Mendonça-Previato, Alvaro Díaz
Glycobiology, 2013 - Sialic acid: A sweet swing between mammalian host and Trypanosoma cruzi
Leonardo Freire-de-Lima, Isadora A. Oliveira, Jorge L. Neves, Luciana L. Penha, Frederico Alisson-Silva, Wagner B. Dias, Adriane R. Todeschini
Frontiers in Immunology, 2012 - Role of the 9-O-acetyl GD3 in subventricular zone neuroblast migration
L.M. Miyakoshi, A.R. Todeschini, R. Mendez-Otero, C. Hedin-Pereira
Molecular and Cellular Neuroscience, 2012 - The trans-sialidase from Trypanosoma cruzi a putative target for Trypanocidal agents
Lucia Mendonça-Previato, Adriane Regina Todeschini, Leonardo Freire de Lima, Jose Osvaldo Previato
Open Parasitology Journal, 2010 - Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses
Leonardo Freire-de-Lima, Frederico Alisson-Silva, Sebastião T. Carvalho, Christina M. Takiya, Maurício M. Rodrigues, George A. DosReis, Lucia Mendonça-Previato, José O. Previato, Adriane R. Todeschini
Journal of Biological Chemistry, 2010 - A new class of mechanism-based inhibitors for trypanosoma cruzi transsialidase and their influence on parasite virulence
S. T. Carvalho, M. Sola-Penna, I. A. Oliveira, S. Pita, A. S. Goncalves, B. C. Neves, F. R. Sousa, L. Freire-de-Lima, M. Kurogochi, H. Hinou, S.-I. Nishimura, L. Mendonca-Previato, J. O. Previato, A. R. Todeschini
Glycobiology, 2010 - Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A review
Cristiana S de Macedo, Ralph T Schwarz, Adriane R Todeschini, Jose O Previato, Lucia Mendonça-Previato
Memorias do Instituto Oswaldo Cruz, 2010 - The major surface carbohydrates of the Echinococcus granulosus cyst: Mucin-type O-glycans decorated by novel galactose-based structures
Alvaro Díaz, E. Carolina Fontana, Adriane R. Todeschini, Silvia Soulé, Humberto González, Cecilia Casaravilla, Magdalena Portela, Ronaldo Mohana-Borges, Lucia Mendonça-Previato, Jose O. Previato, Fernando Ferreira
Biochemistry, 2009 - Structural elucidation of the repeat unit in highly branched acidic exopolysaccharides produced by nitrogen fixing Burkholderia
L. F Hallack, D. S Passos, K. A Mattos, O. A Agrellos, C. Jones, L. Mendonca-Previato, J. O Previato, A. R Todeschini
Glycobiology, 2009 - Inclusion of the sunscreen octyl methoxycinnamate in the β-cyclodextrin and inclusion complex purification assessment by NMR 1H
Latin American Journal of Pharmacy, 2009 - α-N-acetylglucosamine-linked O-glycans of sialoglycoproteins (Tc-mucins) from Trypanosoma cruzi Colombiana strain
Adriane R Todeschini, Eliane G de Almeida, Orlando A Agrellos, Christopher Jones, José O Previato, Lucia Mendonça-Previato
Memorias do Instituto Oswaldo Cruz, 2009 - Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp
Michelle I Portugal, Adriane R Todeschini, Cristiana S de Lima, Carlos AM Silva, Ronaldo Mohana-Borges, Tom HM Ottenhoff, Lucia Mendonça-Previato, Jose O Previato, Maria CV Pessolani
BMC Microbiology, 2008 - Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains
Adriane Regina Todeschini, Sen-itiroh Hakomori
Biochimica Et Biophysica Acta General Subjects, 2008 - Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway
Adriane Regina Todeschini, Jose Nilson Dos Santos, Kazuko Handa, Sen-itiroh Hakomori
Proceedings of the National Academy of Sciences of the United States of America, 2008 - Chemical structure of major glycoconjugates from parasites
Lucia Mendonca-Previato, Adriane Todeschini, Norton Heise, Orlando Agrellos, Wagner Dias, Jose Previato
Current Organic Chemistry, 2008 - Endophytic colonization of rice (Oryza sativa L.) by the diazotrophic bacterium Burkholderia kururiensis and its ability to enhance plant growth
Katherine A. Mattos, Vania L.M. Pádua, Alexandre Romeiro, Leticia F. Hallack, Bianca C. Neves, Tecia M.U. Ulisses, Claudia F. Barros, Adriane R. Todeschini, José O. Previato, Lucia Mendonça-Previato
Anais Da Academia Brasileira De Ciencias, 2008 - Endothelial cell signalling induced by trans-sialidase from Trypanosoma cruzi
Wagner B. Dias, Fernanda D. Fajardo, Aurelio V. Graça-Souza, Leonardo Freire-de-Lima, Fabiana Vieira, Murielle F. Girard, Bernard Bouteille, José O. Previato, Lucia Mendonça-Previato, Adriane R. Todeschini
Cellular Microbiology, 2008 - Antiplatelet activity of geranylgeraniol isolated from Pterodon pubescens fruit oil is mediated by inhibition of cyclooxygenase-1
Nivea Calixto, Maria da Costa e Silva, Carlos Gayer, Marsen Coelho, Márcia Paes, Adriane Todeschini
Planta Medica, 2007 - Ganglioside GM2-tetraspanin CD82 complex inhibits Met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
Adriane Regina Todeschini, Jose Nilson Dos Santos, Kazuko Handa, Sen-itiroh Hakomori
Journal of Biological Chemistry, 2007 - Protozoan parasite-specific carbohydrate structures
Lucia Mendonça-Previato, Adriane Regina Todeschini, Norton Heise, Jose Osvaldo Previato
Current Opinion in Structural Biology, 2005 - Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds
Luciana Pontes Coelho, Patrícia Alves Reis, Fernanda Lima de Castro, Carlos Roberto Machado Gayer, Carlos da Silva Lopes, Maria Cristina da Costa e Silva, Kátia Costa de Carvalho Sabino, Adriane Regina Todeschini, Marsen Garcia Pinto Coelho
Journal of Ethnopharmacology, 2005 - Nitrogen-fixing bacterium Burkholderia brasiliensis produces a novel yersiniose A - Containing O-polysaccharide
K. A. Mattos
Glycobiology, 2005 - Heterogeneity in the biosynthesis of mucin O-glycans from Trypanosoma cruzi Tulahuen strain with the expression of novel galactofuranosyl-containing oligosaccharides
Christopher Jones, Adriane R. Todeschini, Orlando A. Agrellos, José O. Previato, Lucia Mendonça-Previato
Biochemistry, 2004 - Enzymatically Inactive trans-Sialidase from Trypanosoma cruzi Binds Sialyl and β-Galactopyranosyl Residues in a Sequential Ordered Mechanism
Adriane R. Todeschini, Wagner B. Dias, Murielle F. Girard, Jean-Michel Wieruszeski, Lucia Mendonça-Previato, Jose O. Previato
Journal of Biological Chemistry, 2004 - Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens
M C C Silva, C R M Gayer, C S Lopes, N O Calixto, P A Reis, C P B Passaes, M C Paes, S R Dalmau, K C C Sabino, A R Todeschini, M G P Coelho
Journal of Pharmacy and Pharmacology, 2004 - A novel sialylated and galactofuranose-containing O-linked glycan, Neu5Acα2→3Galpβ1→6(Galfβ1→4)GlcNAc, is expressed on the sialoglycoprotein of Trypanosoma cruzi Dm28c
Orlando A. Agrellos, Christopher Jones, Adriane R. Todeschini, José O. Previato, Lúcia Mendonça-Previato
Molecular and Biochemical Parasitology, 2003 - Glycoinositolphospholipid from Trypanosoma cruzi: Structure, Biosynthesis and Immunobiology
J PREVIATO, R WAIT, C JONES, G DOSREIS, A TODESCHINI, N HEISE, L MENDONCAPREVIATO
Advances in Parasitology, 2003 - Trans-sialidase from Trypanosoma cruzi binds host T-lymphocytes in a lectin manner
Adriane R. Todeschini, Murielle F. Girard, Jean-Michel Wieruszeski, Marise P. Nunes, George A. DosReis, Lúcia Mendonça-Previato, José O. Previato
Journal of Biological Chemistry, 2002 - Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: Involvement of CD43 signaling
Adriane R Todeschini, Marise P Nunes, Rachel S Pires, Marcela F Lopes, José O Previato, Lúcia Mendonça-Previato, George A DosReis
Journal of Immunology, 2002 - Characterization of novel structures of mannosylinositolphosphoryl-ceramides from the yeast forms of sporothrix schenckii
Carla V. Loureiro y Penha, Adriane R. Todeschini, Leila M. Lopes‐Bezerra, Robin Wait, Christopher Jones, Katherine A. Mattos, Norton Heise, Lucia Mendonça‐Previato, Jose O. Previato
European Journal of Biochemistry, 2001 - Structure of O-glycosidically linked oligosaccharides from glycoproteins of Trypanosoma cruzi CL-Brener strain: Evidence for the presence of O-linked sialyl-oligosaccharides
A. R. Todeschini, E. X. da Silveira, C. Jones, R. Wait, J. O. Previato, L. Mendonca-Previato
Glycobiology, 2001 - Trans-sialidase from Trypanosoma cruzi catalyzes sialoside hydrolysis with retention of configuration
A. R. Todeschini
Glycobiology, 2000 - Synthesis and evaluation of analgesic, antiinflammatory and antiplatelet properties of new 2-pyridylarylhydrazone derivatives
Adriane R. Todeschini, Ana Luisa P. de Miranda, Kelly Christine M. da Silva, Sergio C. Parrini, Eliezer J. Barreiro
European Journal of Medicinal Chemistry, 1998 - 2-Pyridylarylhydrazone derivatives, a new class of platelet aggregation inhibitors
Brazilian Journal of Medical and Biological Research, 1996 - Improvements chemical processes to obtain Fenitoin
Revista Brasileira De Farmacia, 1992
