Dr. Sanjay Kumar Gupta is a Professor and Head of the Department of Pharmacology at Rungta College of Pharmaceutical Sciences and Research (RCPSR), Bhilai, Chhattisgarh, and serves as Dean (Research & Development). He earned his Ph.D. in Pharmacology from Guru Ghasidas Vishwavidyalaya, Bilaspur, under the UGC-BSR fellowship, and completed his M.Pharm from the University of Pune. With over 16 years of teaching and research experience and prior industry exposure in regulatory affairs, his expertise spans experimental pharmacology, antihypertensive research, and nanotechnology-based drug delivery systems. He has published more than 30 research papers, along with books, book chapters, and patents. Dr. Gupta has guided numerous postgraduate and doctoral scholars and actively contributes as a reviewer, examiner, and resource person. His work reflects a strong commitment to advancing pharmaceutical research, education, and innovation.
EDUCATION
PhD in Pharmacy
M.Pharm in Pharmacology
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Pharmaceutical Science
30
Scopus Publications
466
Scholar Citations
8
Scholar h-index
7
Scholar i10-index
Scopus Publications
Glucose-Responsive and Sustained Insulin-Releasing G-quartet/Protein Hydrogel Promotes Week-Long Normoglycemia in DiabeticRats Sunita Saha, Dharmesh Jinagal, Saroj Saroj, Akbar Ali, Debashish Paul, Sanjay Kumar Gupta, Tatini Rakshit, Suchetan Pal ACS Applied Bio Materials, 2026 Diabetes remains a major global health burden, necessitating advanced therapies beyond insulin injections, such as closed-loop systems mimicking pancreatic beta-cell function. To address the limitations of current glucose-responsive insulin delivery platforms, particularly limited injectability and suboptimal biocompatibility, we developed injectable, glucose-responsive G-quartet/protein hydrogels (GPHGs) via supramolecular self-assembly and iminoboronate chemistry. GPHGs exhibit tunable viscoelasticity, with storage moduli ranging from 17 to 50 kPa across three formyl-phenylboronic acid (FPBA)-based crosslinkers (2FPBA, 3FPBA, and 4FPBA), thereby imparting structural integrity and stimulus responsiveness to the network. Under high glucose conditions (100 mM glucose), GPHG derived using 2FPBA exhibited a 0.28-fold decrease in storage modulus (G′) and a 0.21-fold reduction in loss modulus (G″), indicating glucose-mediated softening of the network. This mechanical response corresponds with accelerated insulin release, yielding ∼85% insulin release in 24 h under 100 mM glucose compared to ∼45% insulin release under 0 mM glucose. GPHG1 exhibits remarkable self-healing and negligible cytotoxicity at a concentration of 10 mg/mL in HaCaT, MCF7, and HCT116 cells. In type 1 diabetic rats, insulin-loaded GPHG1 sustained normoglycemia (120−150 mg/dL or 6.6−8.3 mM) for up to seven days, outperforming subcutaneous insulin. These findings highlight GPHG as a minimally invasive strategy for innovative insulin delivery systems, harnessing macromolecular and supramolecular design to advance blood glucose control.
Homovanillic acid inhibits Candida albicans-Staphylococcus aureus polymicrobial biofilm: in vitro and in vivo evaluation Anmol Kulshrestha, Pratima Gupta, Sumit Sahu, Priya Komre, Sanjay Kumar Gupta, Avani Tiwari Journal of Applied Microbiology, 2026 Aims Candida albicans and Staphylococcus aureus polymicrobial biofilms cause chronic wound infections and tolerate standard antimicrobials poorly. Their endurance is driven by fungal hyphal morphogenesis, interkingdom co-aggregation, and virulence proteins, including SAP5, which create a strong polymicrobial biofilm. Homovanillic acid, a plant-derived phenolic molecule, was tested for its antibiofilm effects on hyphal growth, bacterial–fungal interactions, and SAP5-associated pathogenicity. Methods and Results Integrated in vitro, real-time dynamic, and in vivo methods were used to assess antibiofilm activity. Microtiter plate experiments evaluated the minimum biofilm inhibitory concentration (MBIC), whereas a real-time Biofilm Infection Simulator System examined biofilm formation under flow circumstances. SAP5 proteinase activity was measured spectrophotometrically, and microbiological and histological investigations confirmed in vivo efficacy in a catheter-associated rat wound model. HVA significantly inhibited polymicrobial biofilm initiation at sub-inhibitory concentrations, with an MBIC of 128 µg mL−1 corresponding to an 82.18% reduction in biofilm formation. Real-time analysis confirmed substantial suppression of biofilm development. Inhibition of C. albicans hyphal morphogenesis impaired S. aureus adhesion and destabilized biofilm architecture, while SAP5 activity was reduced by 53.37%. In vivo treatment promoted effective wound healing, marked by reduced inflammation, near-complete epithelial regeneration, and organized collagen deposition by day 14. Conclusions HVA demonstrates potent multitarget antibiofilm activity and represents a promising plant-derived therapeutic candidate for managing polymicrobial biofilm-associated wound infections.
Fluorescent-Tagged, pH- and Redox-Responsive Polymeric Nanocarrier for Site-Specific Gastrointestinal Delivery Swarup Maity, Sudipta Paul, Sandipan Ghosh, Sanjay Kumar Gupta, Sanjib Banerjee ACS Applied Materials and Interfaces, 2026 Stimuli-responsive polymeric nanocarriers have emerged as a promising strategy for targeted and controlled drug delivery, addressing limitations such as premature drug release and low bioavailability. Developing systems that respond to multiple physiological triggers is crucial for improving therapeutic precision and reducing side effects. The present study introduces the development of a unique amphiphilic random copolymeric nanocarrier with pH- and redox-responsiveness for advanced drug delivery applications. The copolymer incorporates hydrophilic carboxylic acid groups, hydrophobic coumarin moieties, and disulfide linkages, enabling self-assembly into spherical aggregates with a coumarin-rich core and a hydrophilic surface. These aggregates exhibit a low critical micelle concentration (0.006 mg mL–1), ensuring stability in dilute environments. Spherical nanocarriers remain stable under acidic conditions (∼pH 2.0) and disassemble at neutral to basic pH (∼pH 7.4), mimicking gastrointestinal conditions. This property allows site-specific, stimulus-triggered drug release, with high drug-loading efficiency. The stimuli-responsiveness of the nanocarrier not only enhances oral drug delivery but also offers a versatile platform for encapsulating a wide range of therapeutics and diagnostics. This multifunctional nanocarrier system opens new avenues for personalized medicine and advanced material technologies, highlighting its potential for broader translational and industrial applications.
Emerging Formulation Strategies and Nanotechnology in Psoriasis Management: Synergizing for Improved Outcomes Akash Gupta, Sanjay Kumar Gupta Drug Delivery Letters, 2026 Psoriasis is a long-term inflammatory skin condition that is immune-mediated and involves hyperproliferation of the keratinocyte, leading to an uncontrolled immune response. Firstline treatments for psoriasis may include systemic conventional therapies, phototherapy, or topical therapies. Often with traditional therapies, limitations can arise, which include restricted penetration of the agent into the skin, systemic side effects and low patient adherence. New drug delivery systems are being researched and formulated using novel formulation strategies and nanotechnology to address existing limitations and enhance therapeutic efficacy. Advanced drug delivery formulations such as liposomes, nano emulsions, solid lipid nanoparticles, or ethosomes can enhance the solubility of drugs, facilitate targeted delivery, and allow for extended release. These nanocarriers enhance skin penetration, reduce systemic toxicity, and enable co-delivery of synthetic drugs and natural bioactives with increased therapeutic flexibility. The complementarity of nanotechnology with current formulation methods has the possibility of addressing both the pathophysiological complexities of psoriasis and the implementation of individualized treatment plans. This review has presented the innovations, mechanisms of action, and clinical implications of nanotechnology-based formulations with respect to the treatment of psoriasis. The implications of the evidence presented indicate that several innovative systems could vastly improve dermatologic care and quality of life for patients.
Transferosome as Nanocarrier for Drug Penetration Enhancement Across Skin: A Comparison with Liposome and Ethosome Dhanesh Kumar, Sanjay Kumar Gupta, Astha Verma, Ajazuddin Current Nanomedicine, 2026 Transdermal drug delivery systems have greatly attracted investigators because of their advantages over parenteral and oral delivery methods. The skin's structure usually limits drug penetration, prompting the development of vesicular transdermal drug delivery systems like ethosomes, liposomes, niosomes, transferosomes, etc., to increase drug delivery. This review aims to explore the concept of transferosome and to compare its composition and functionality with other vesicular systems. The recent applications of transferosomes in transdermal drug delivery were also discussed. An extensive literature review was conducted to gather information on the composition of transferosomes, their mechanism of action, and their comparative advantages over other vesicular systems. Transferosomes are composed of phosphatidylcholine and an edge activator, which provide an ultra-deformable characteristic, allowing them to penetrate the skin’s inner layers via paracellular and intercellular pathways. The primary mechanism guiding transferosomes into the epidermis layer of skin is the osmotic gradient. Transferosomes overcome the limitations of liposomes and ethosomes, such as low encapsulation potential for hydrophilic molecules, leaky behaviour due to an uneven membrane, a short shelf-life, and other issues. Transferosomes have shown significant potential in transdermal drug delivery, with extensive research supporting their use in various drug categories, including anti-inflammatory, anti-cancer, antidiabetics, etc. The ability of transferosomes to penetrate the skin layers effectively makes them a promising carrier for further research in the delivery of different classes of drugs.
Agave sisalana Sanjay Kumar Gupta, Akash Gupta, Sumit Sahu, Avinash Kumar Jha, Pooja Mahey, Durgesh Nandini Chauhan, Nagendra Singh Chauhan Underutilized Tuber Crops of the Himalayan Region Nutraceutical Potential Processing and Applications, 2026
Maranta arundinacea Sanjay Kumar Gupta, Akash Gupta, Sumit Sahu, Priya Komre, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pratiksha, Birinchi Bora Underutilized Tuber Crops of the Himalayan Region Nutraceutical Potential Processing and Applications, 2026
Next-generation CRISPR gene editing tools in the precision treatment of Alzheimer's and Parkinson's disease Harsh Kumar Meshram, Sanjay Kumar Gupta, Akash Gupta, Kushagra Nagori, Ajazuddin Ageing Research Reviews, 2025 Emerging gene-editing technologies, such as the CRISPR system, represent a potential pathway for precision medicine targeting the genetic and molecular causes of diseases. Second-generation CRISPR technologies, including base editing, prime editing, and engineered Cas variants, have improved fidelity and offer alternative strategies for precise gene correction, transcriptional repression or activation, and modulation of pathological pathways in neurodegeneration. These tools can correct single-nucleotide mutations, reduce pathological protein accumulation, and modulate neuroinflammatory responses, all integral to the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD), both chronic, progressive neurodegenerative disorders. Unfortunately, currently available treatments are limited and primarily palliative. Preclinical studies have shown promising results, with improvements in cognitive and motor deficits in animal models. However, significant challenges must be addressed to ensure safe and effective delivery to the CNS, minimize off-target effects, and address ethical concerns. Current clinical investigations aim to translate these findings into available therapeutic options. This review also identifies the biological mechanisms, therapeutic use cases, and current limitations of next-generation CRISPR systems as tools in the context of AD and PD, providing both therapeutic and research capabilities through their unique strengths. Ultimately, the future of transactional neurogenomics will determine the clinical possibilities of CRISPR-based strategies for advancing neurodegenerative disease management beyond palliative and symptomatic treatment, toward a feasible mechanistic form of disease modification.
Improved Diabetic Wound Healing via Flower Extracellular Vesicles and Carbon-Dot-Infused Alginate-Polyethylenimine Antibacterial Hydrogel Safoora Zaffar, Sunita Saha, Tanya Agrawal, Sanjay Kumar Gupta, Parth Gulati, Debashish Paul, Anuj Verma, Suchetan Pal, Tatini Rakshit ACS Biomaterials Science and Engineering, 2025 Diabetic wounds lead to substantial challenges in healthcare systems due to prolonged healing and susceptibility to debilitating bacterial infections. Traditional wound dressings, designed to regenerate wound voids and aid healing, often lack antibacterial properties. In this study, we present a syringe-injectable hydrogel (HG) infused with rose-petal-derived extracellular vesicles (REVs) and fluorescent carbon dots (CDs), which exhibit intrinsic antibacterial activity. The HG matrix was created by combining oxidized sodium alginate (OA) with branched polyethylenimine (PEI). This formulation selectively targets Gram-negative bacteria through strong physical and mechanical interactions while preserving human erythrocytes, as confirmed by hemolytic assays. Using a Wistar rat type 1 diabetic model, we demonstrated that the HG effectively eradicates E. coli at the application site, ensuring slow release and retention of REVs and CDs at the wound site, causing minimal inflammation. REV-CD-HG represents a scalable, cost-efficient, and innovative wound dressing with promising clinical applications.
Animal models of erectile dysfunction Mandeep Singh Kapoor, Samsroz Ahmad Khan, Sanjay Kumar Gupta, Rajesh Choudhary, Surendra H. Bodakhe Journal of Pharmacological and Toxicological Methods, 2015
Diagnostic methods for non-alcoholic fatty liver diseases alternative to liver biopsy: A review Asian Journal of Pharmaceutical and Clinical Research, 2015
An elevated pulse pressure: A major risk factor for cardiovascular diseases Asian Journal of Pharmaceutical and Clinical Research, 2013
Assessment of antihypertensive activity of novel synthetic hybrid compound on 2K1C induced hypertensive rats Pharmacologyonline, 2009
RECENT SCHOLAR PUBLICATIONS
Homovanillic acid inhibits Candida albicans-Staphylococcus aureus polymicrobial biofilm: in vitro and in vivo evaluation A Kulshrestha, P Gupta, S Sahu, P Komre, SK Gupta, A Tiwari Journal of Applied Microbiology, lxag111 , 2026 2026
Novel Drug Delivery Systems to Combat Antimicrobial Resistance MAR Sanjay Kumar Gupta, Astha Verma, Akash Gupta, Sumit Sahu, Nousheen ... Diagnosis and Treatment of Bacterial Infection 1, 178-217 , 2026 2026
Glucose-Responsive and Sustained Insulin-Releasing G-quartet/Protein Hydrogel Promotes Week-Long Normoglycemia in Diabetic Rats S Sunita Saha, Dharmesh Jinagal, Saroj Saroj, Akbar Ali, Debashish Paul ... ACS Applied Bio Materials , 2026 2026
Fluorescent-Tagged, pH- and Redox-Responsive Polymeric Nanocarrier for Site-Specific Gastrointestinal Delivery BS Maity S, Paul S, Ghosh S, Gupta SK ACS Applied Materials and Interfaces , 2026 2026
Transferosome as Nanocarrier for Drug Penetration Enhancement Across Skin: A Comparison with Liposome and Ethosome VA Kumar D, Gupta SK Current Nanomedicine 16 (1), 1-11 , 2026 2026 Citations: 3
Next Generation Green-Synthesized Nanoparticles Targeting HER2, ER, PR, EGFR, Folate Receptors, and CD44: A Review on Emerging Therapeutic Approaches for Breast Cancer GSK Joshi M, Gupta A, Sharma M, Ajazuddin Next Research, 101649 , 2026 2026
Synergistic Silver Nanoparticle–Graphene Quantum Dot Composites in Silk Fibroin/Lathyrus Protein–Oxidized Alginate Hydrogels for Accelerated Diabetic Wound Healing P Gulati, A Verma, S Zaffar, A Ali, SK Gupta, T Rakshit, S Banerjee, S Pal Journal of Materials Chemistry B , 2026 2026
Agave sisalana SK Gupta, A Gupta, S Sahu, AK Jha, P Mahey, DN Chauhan, ... Underutilized Tuber Crops of the Himalayan Region, 19-35 , 2026 2026
Maranta arundinacea BB Gupta SK, Gupta A, Sahu S, Komre P, Chauhan DN, Chauhan NS, Pratiksha Underutilized Tuber Crops of the Himalayan Region Nutraceutical Potential … , 2026 2026 Citations: 1
Emerging Formulation Strategies and Nanotechnology in Psoriasis Management: Synergizing for Improved Outcomes GSK Gupta A Drug Delivery Letters , 2026 2026
Techniques for characterising micro/nanoemulsions in pharmaceutical formulations A Raza M, Firdous A, Patil TB, Khatoon N, Roy A, Ghosh V, Gupta SK Micro and Nano Emulsion Technologies: Pharmaceutical Design, Pharmaceutical … , 2025 2025
Accelerating recovery through advanced wound healing applications of micro/nanoemulsions YS Sanjay Kumar Gupta, Akash Gupta, Debarshi Kar Mahapatra, Alka Sahu, Sumit ... Micro and Nano Emulsion Technologies: Pharmaceutical Design, Pharmaceutical … , 2025 2025
Next-generation CRISPR gene editing tools in the precision treatment of Alzheimer’s and Parkinson’s disease HK Meshram, SK Gupta, A Gupta, K Nagori Ageing Research Reviews 111, 102851 , 2025 2025 Citations: 9
Micro-and Nano-emulsion Technologies: Pharmaceutical Design, Pharmaceutical Development, and Drug Delivery G Jeswani, A Khichariya De Gruyter , 2025 2025
Acorus calamus in Neurodegenerative Disorders SK Gupta, A Verma, N Verma, K Shah, DN Chauhan, NS Chauhan Natural Scaffolds for Prevention and Treatment of Neurodegenerative … , 2025 2025 Citations: 1
Advances in Green Synthesis of Zinc Oxide Nanoparticles: A Promising Nanotechnology Approach for Diabetes Mellitus Management R Banchhor, A Patel, MK Sharma, Ajazuddin 3, P Jain, SK Gupta, ... Drug Delivery Letters , 2025 2025 Citations: 2
Emerging Trends in Hydrogel for Treatment of Vaginal Candidiasis: A Comprehensive Review G SK Recent Advances in Anti-Infective Drug Discovery , 2025 2025 Citations: 3
Toxicity and Safety Aspects of Inulin VA Gupta SK Inulin for Pharmaceutical Applications: A Versatile Biopolymer, 169-187 , 2025 2025 Citations: 3
Eosinophilic Granulomatosis with Polyangiitis: Overcoming Diagnostic Obstacles and Exploring Pharmacotherapeutic Approaches MDK Komre P, Gupta A, Gupta SK, Joseph TM Exploration of Immunology 5 (1), 1003219 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Assessment of the Antiulcer Potential of< i> Moringa oleifera</i> Root-Bark Extract in Rats MK Choudhary, SH Bodakhe, SK Gupta Journal of acupuncture and meridian studies 6 (4), 214-220 , 2013 2013.0 Citations: 223
Glucose-Responsive Chitosan Nanoparticle/Poly(vinyl alcohol) Hydrogels for Sustained Insulin Release In Vivo SP Akbar Ali Akbar Ali Department of Chemistry, Indian Institute of ... ACS Applied Materials & Interfaces , 2023 2023.0 Citations: 55
Animal Models of Erectile Dysfunction SHB Mandeep Singh Kapoor, Samsroz Khan, Sanjay Kumar Gupta, Rajesh Choudhary Journal of Pharmacological and Toxicological Methods 76, 43-54 , 2015 2015.0 Citations: 32
Antifertility studies of curcumin and andrographolide combination in female rats Shinde N, Chauhan AS, GUPTA SK, Bodakhe SH, Pandey DP asian pacific journal of reproduction 4 (3), 188-194 , 2015 2015.0 Citations: 29
Plant extracellular nanovesicle-loaded hydrogel for topical antibacterial wound healing in vivo RT Gupta SK, Saroj S, Saha S, Ali A, Bhardwaj A, Agrawal T, Pal S ACS Applied Bio Materials , 2024 2024.0 Citations: 23
Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. J Acupunct Meridian Stud 2013; 6 (4): 214-20 MK Choudhary, SH Bodakhe, SK Gupta Citations: 10
Next-generation CRISPR gene editing tools in the precision treatment of Alzheimer’s and Parkinson’s disease HK Meshram, SK Gupta, A Gupta, K Nagori Ageing Research Reviews 111, 102851 , 2025 2025.0 Citations: 9
DIAGNOSTIC METHODS FOR NON-ALCOHOLIC FATTY LIVER DISEASES ALTERNATIVE TO LIVER BIOPSY: A REVIEW SH Bodakhe, SK Gupta Asian Journal of Pharmaceutical and Clinical Research 8 (2), 54-59 , 2015 2015.0 Citations: 8
AN ELEVATED PULSE PRESSURE: A MAJOR RISK FACTOR FOR CARDIOVASCULAR DISEASES SK Gupta, SH Bodakhe Asian Journal of Pharmaceutical and Clinical Research 6 (5) , 2013 2013.0 Citations: 8
Recent Advancement in Nanoparticle Drug Delivery Systems to Cure Neurological Disorders Via the Nasal Route MA Sharma MK, Gupta SK Neurologia Argentina , 2025 2025.0 Citations: 7
History and Techniques of Bioimaging SKG Astha Verma Magnetic Quantum Dots for Bioimaging 1, 111-132 , 2023 2023.0 Citations: 5
Hepatoprotective activity of carissa carandas linn. fruit etahnolic extract in carbon tetrachloride intoxicated rats Surendra H. Bodakhe, Nirmala Devi, Sanjay K. Gupta, K.P. Namdeo Advances in Pharmacology and Toxicology 15 (3), 51-58 , 2014 2014.0 Citations: 5
A Panoptic Review on Improvement in Chemothera-peutic Properties of Cytotoxic Drugs through Calixarene B Gidwani, SK Gupta, J Sahu International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2023 2023.0 Citations: 4
Correlation between diabetic cataract, HBA1C and Gurakhu: A clinical study in Chhattisgarh State A Bhattacharya, S Gupta, SH Bodakhe Clinical Therapeutics 37 (8), e45 , 2015 2015.0 Citations: 4
Assessment of antihypertensive activity of novel synthetic hybrid compound on 2K1C induced hypertensive rats SK Gupta, NS Vyawahare, VG Kagathara, MN Patil, RR Pujari Pharmacologyonline 2, 273-280 , 2009 2009.0 Citations: 4
Transferosome as Nanocarrier for Drug Penetration Enhancement Across Skin: A Comparison with Liposome and Ethosome VA Kumar D, Gupta SK Current Nanomedicine 16 (1), 1-11 , 2026 2026.0 Citations: 3
Emerging Trends in Hydrogel for Treatment of Vaginal Candidiasis: A Comprehensive Review G SK Recent Advances in Anti-Infective Drug Discovery , 2025 2025.0 Citations: 3
Toxicity and Safety Aspects of Inulin VA Gupta SK Inulin for Pharmaceutical Applications: A Versatile Biopolymer, 169-187 , 2025 2025.0 Citations: 3
Development of pharmacological screening method for evaluation of effect of drug on elevated pulse pressure and arterial stiffness SK Gupta, SH Bodakhe Journal of Pharmacological and Toxicological Methods 91, 59-65 , 2018 2018.0 Citations: 3