ELLEN CORDEIRO BENTO DA SILVA

@ufrpe.br

Area of ​​physiology and pharmacology, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco
Federal Rural University of Pernambuco

ELLEN CORDEIRO BENTO DA SILVA


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https://researchid.co/ellensilva
Graduated in Veterinary Medicine from the Federal Rural University of Pernambuco, Master in Veterinary Science from the Federal Rural University of Pernambuco, PhD in Biotechnology from the Northeast Biotechnology Network. She is a professor of Physiology at the Federal Rural University of Pernambuco, having taught in undergraduate courses in Animal Science, Veterinary Medicine, Physical Education, Biology, and Gastronomy. She works as a research professor in the Postgraduate Program in Veterinary Medicine at the Federal Rural University of Pernambuco, where she teaches the subject of Male Reproduction Clinic and supervises in the research lines of Physiopathology and Biotechnology of Reproduction and Biotechnologies applied to the food and health industries.

EDUCATION

Graduated in Veterinary Medicine from the Federal Rural University of Pernambuco, Master in Veterinary Science from the Federal Rural University of Pernambuco, PhD in Biotechnology from the Northeast Biotechnology Network.

RESEARCH, TEACHING, or OTHER INTERESTS

Veterinary, Physiology, Reproductive Medicine, Applied Microbiology and Biotechnology
8

Scopus Publications

Scopus Publications

  • Neutering is not associated with early-onset urethral obstruction in cats
    Keytyanne de Oliveira Sampaio, Valdemiro Amaro da Silva-Junior, Reginaldo Pereira de Sousa-Filho, Grazielle Anahy de Sousa Aleixo, Marina Gabriela Monteiro Carvalho Mori da Cunha, et al.
    Journal of Feline Medicine and Surgery, 2022
    Objectives The purpose of this study was to evaluate the correlation between clinical aspects and urethral lesions with reproductive status and age at neutering in obstructed male cats. Methods All cats with compatible signs of urethral obstruction (UO) treated at the Veterinary Hospital of the Federal Rural University of Pernambuco from 2019 to 2021 were divided into three groups according to their reproductive status: intact; prepubertal neutered; and post-pubertal neutered. Cats with compatible signs of UO were selected for further analysis. Age, clinical signs, age at neutering and age of the first obstructive event were documented. Cats with recurrent obstructive urinary signs or urethral trauma that made catheterization impossible were referred for perineal urethrostomy. The morphology of the excised penises was assessed by histopathological analysis. Results Of 84 cats with signs of UO included in this study, 28.6% were classified as intact, 28.6% as prepubertal neutered and 42.8% as post-pubertal neutered. Intact cats had a significantly earlier onset of UO compared with prepubertal and post-pubertal neutered cats, as seen by the age at obstruction (3.6 vs 5.7 and 5.5 years, respectively). Similar clinical signs and histopathological lesions were observed in all groups. The main clinical signs observed were stranguria, hematuria and pollakiuria. All cats had some degree of injury in the penile urethra. The most common lesions were hemorrhage, fibrosis and congestion. Conclusions and relevance It appears that intact cats had an earlier onset of UO than neutered cats, regardless of age at neutering. Urethral histopathological lesions and clinical signs were similar in both groups. Pediatric neutering represents a useful tool in the control of abandoned and stray animals and the consequent dissemination of zoonoses, thus having a positive impact on public health.
  • Mandibulectomy in Feline with Bacterial Fibrosing Osteomyelitis
    Keytyanne de Oliveira Sampaio, Jéssica Mara da Costa Silva, Alexandre Tavares Camelo Oliveira, Ellen Cordeiro Bento Da Silva, Diana Célia Sousa Nunes-Pinheiro, et al.
    Acta Scientiae Veterinariae, 2021
    Background: Fibrosing osteomyelitis is a chronic inflammatory process caused by infectious agents that lead to the destruction and replacement of bone tissue by fibroblasts. The diagnosis is based especially on histopathological and bacterial culture. In cases where extensive and irreversible injuries are observed, surgical treatment may be indicated. The objective of this work is to report the clinical, radiographic, histopathological, and microbiological aspects of a cat presenting fibrosing osteomyelitis.Case: A 10-year-old male feline, no defined breed, weighing 3.9 kg was referred to one Private Veterinary Clinic of Fortaleza, CE, Brazil with a history of left mandibular enlargement, presenting dysphagia, sialorrhea, an increase in firm consistency along of the left mandibular body, temporomandibular arthralgia and decreased joint motion range. On cranium radiograph, signs of proliferative osteopathy of irregular contours were observed in the branch and body of the left mandible and extending to the rostral region of the right mandible, suggesting a neoplastic process. After anesthesia, for better assessment of the oral cavity, a sample was collected by incisional biopsy, however, the histopathological result was nonspecific. In view of the inconclusive condition, it was decided to perform left hemimandibulectomy combined with right partial mandibulectomy. Tissue samples were obtained and sent for microbiological and histopathological analyses. The last test revealed an inflammatory reaction consisting of neutrophils and plasma cells, associated with a large amount of fibrous connective tissue, multifocal bacterial aggregates, necrosis and bone resorption. Based on the findings, the diagnosis of chronic bacterial osteomyelitis was concluded. The microbiological culture demonstrated the growth of the bacterium Pseudomonas aeruginosa, with sensitivity to cefovecin, which was administered to the treatment in doses of 8 mg/kg/SC, every 15 days, for 60 days. After 10 days of the surgery, the patient was able to start the process of swallowing and seizing pasty food.Discussion: Although radiography is a diagnostic method of choice to assess the extent of bone involvement, it hardly allows the distinction between neoplastic processes and osteomyelitis. Thus, in addition to the cranium radiographic examination, that revealed signs of proliferative osteopathy with irregular contours in branch and body topography of the left mandible were required biopsy and bacterial culture. After mandibulectomy, difficulty in retracting the tongue and anorexia were observed in the first days. Despite that, from the 12th day on, there was an improvement in food seizure, with the return to voluntary feeding. Mandibulectomy is indicated in cases where extensive and irreversible lesions are observed, although excision of the caudal mandible to the third or fourth premolar tooth is not recommended, because it compromises the sublingual musculature, with fall of the tongue and loss of function apprehension. In the present case, the caudal portion of the right mandibular branch was maintained, which facilitated the return of spontaneous feeding. The tissue removed was necessary to perform a microbiological culture with antibiogram, essential to determine the possible etiologic agent and choosing antimicrobial drugs. For the treatment of P. aeruginosa infection, cefovecin was prescribed due to the dosage and route of administration that collaborate with the mandibular surgery, once that the oral treatment is more difficult. Post-surgical complications related to mandibular resection, such as anorexia and difficulty in grasping food, are common. However, in the present case, the patient had an adequate reestablish after 15 days. Therefore, hemimandibulectomy is effective in treating fibrosing osteomyelitis, with maintenance of the patient's ingestive function.
  • Virtual screening and assessment of anticancer potential of selenium-based compounds against HL-60 and MCF7 cells
    Ericka Fernanda Ferreira de Queiroz, José Alixandre de Sousa Luis, Diego de Sousa Dantas, Lúcia Cristina Pereira Arruda, Ellen Cordeiro Bento da Silva, et al.
    Future Medicinal Chemistry, 2020
  • Clinical outcomes of 28 cats 12–24 months after urethrostomy
    Reginaldo P Sousa-Filho, Diana CS Nunes-Pinheiro, Keytyanne O Sampaio, Ellen CB da Silva, Grazielle ASA Cavalcanti, et al.
    Journal of Feline Medicine and Surgery, 2020
    Objectives The aim of this study was to evaluate and compare the long-term clinical outcomes and quality of life of cats having undergone perineal urethrostomy (PU) or prepubic urethrostomy (PPU). Methods This clinical study followed 28 cats (PU, n = 22; PPU, n = 6) that underwent a urethrostomy, with a minimum of 1 year postoperative follow-up. Medical records, pet owner surveys and urologic laboratory tests were used for assessment. Urologic laboratory tests included serum symmetric dimethylarginine (SDMA), serum creatinine, urinalysis, urine specific gravity (USG), urine protein:creatinine (UPC) ratio and urine culture. Results The main indications for urethrostomy were multiple catheterizations and PU stricture. The overall complication rates of PU and PPU were 31.8% and 83.3%, respectively. Recurrent urinary tract infection (UTI) and urine scald dermatitis were less frequent in PU than in PPU cats (UTI 22.7% vs 66.6%; dermatitis 4.5% vs 83.3%). Bacteriuria was present in 77.2% and 100% of PU and PPU cats, respectively. Owner satisfaction rates were excellent in 81.8% of PU and 33.3% of PPU cases. Conclusions and relevance A proportion of cats that underwent urethrostomy showed bacteriuria, recurrent UTIs and increased levels of SDMA. PPU is important as a salvage procedure; however, it should be limited to cases in which standard techniques for PU cannot be performed, owing to the potential for recurrent complications and lower owner satisfaction.
  • Effect of green tea extract (Camellia sinensis) on the spermatic parameters of Wistar rats submitted or not to testicular heat shock
    Joane Isis Travassos Vieira, Taylane Alves da Silva, Williane Maria Pereira Barbosa, Gabriela Lima de Azevêdo, Lúcia Cristina Pereira Arruda, et al.
    Animal Reproduction, 2020
  • Influence of temperature on testicular function
    Joane Isis Travassos Vieira, Taylane Alves da Silva, Williane Maria Pereira Barbosa, Filipe Cássio Silva de Lima, Ellen Cordeiro Bento da Silva
    Medicina Veterinaria Brazil, 2018
    As células da linhagem germinativa são sensíveis a ação do calor, sendo a termorregulação um fator determinante para o sucesso reprodutivo. O aumento da temperatura testicular pode ocorrer devido a fatores internos ou externos e contribui para o aumento da produção de espécies reativas de oxigênio e nitrogênio, induzindo, assim, a degeneração testicular e perda de células germinativas. Em adição, mudanças nos níveis de testosterona e de corticosteroides em animais submetidos ao estresse térmico podem ser observadas e interferem na capacidade reprodutiva dos mesmos. Por outro lado, em resposta ao calor e com finalidade protetora, há o aumento da síntese de proteínas de choque térmico (HSP). Desta forma, a quantidade e qualidade do sêmen e, consequentemente, a fertilidade são comprometidas pelo estresse térmico testicular, o que torna a realização de estudos que aprofundem o conhecimento sobre as alterações causadas indispensáveis, inclusive para a busca de terapias que preservem e reparem as funções testiculares.
  • Soybean lecithin-based extender as an alternative for goat sperm cryopreservation
    Andréa Helena Vidal, André Mariano Batista, Ellen Cordeiro Bento da Silva, Wilton Arruda Gomes, Marina Arruda Pelinca, et al.
    Small Ruminant Research, 2013
  • Ethylene glycol and acetamide cryoprotectants on in vitro viability of thawed ram spermatozoa
    Ellen Cordeiro Bento da Silva, Jobson Filipe de Paula Cajueiro, Sildivane Valcácia Silva, Maria Madalena Pessoa Guerra
    Ciencia Rural, 2012
    Objetivando-se avaliar o efeito de diferentes concentrações dos crioprotetores etileno glicol ou acetamida na viabilidade in vitro de espermatozoides congelados de ovinos, foram utilizados seis pools de sêmen de quatro reprodutores mestiços da raça Santa Inês. Após aprovação, o pool dos ejaculados foi diluído em Tris-gema, acrescido de glicerol (G1=5%; controle), etileno glicol (G2=3%; G3=5%) ou acetamida (G4=2%; G5=7%), envasado em palhetas (0,25mL; 100x106 espermatozoides) e congelado. As amostras descongeladas (37oC/30 segundos) foram avaliadas quanto a motilidade progressiva (MP), vigor, integridade da membrana plasmática (iMP), potencial de membrana mitocondrial (PMM) e integridade do acrossoma (iAC). Constatou-se que a MP do G1 foi superior (P<0,05) à dos G3, G4 e G5, e que o vigor dos G1, G2 e G3 foi maior (P<0,05) do que o dos G4 e G5. A iMP do G1 foi superior (P<0,05) à dos G2, G3, G4 e G5, assim como os G2 e G3 foram superiores (P<0,05) a G4 e G5. O PMM e a iAC não diferiram (P>0,05) entre os grupos. Conclui-se que o etileno glicol (3 e 5%) e a acetamida (2 e 7%) não são eficazes para a proteção dos espermatozoides ovinos submetidos à congelação.