Corrado Cali

@unito.it

Associate Professor, Department of Neuroscience, University of Turin
University of Turin

Corrado Cali
I trained an electronic engineer at Politecnico di Torino, Italy. After my MSc in 2006, in the lab of Henry Markram at EPFL (Lausanne, Switzerland), I became interested in neuroscience. In the same year I joined the lab of Paola Bezzi at UNIL (University of Lausanne, Lausanne, Switzerland), where I got a PhD in 2012. My research was focused in elucidating the physiological role of astroglial cells in the modulation of synaptic transmission. After one year as postdoctoral fellow in Graham Knott’s lab, where I enriched my skills in volume electron microscopy, I joined Pierre Magistretti’s lab in KAUST (King Abdullah University of Science and Technology, Thuwal, Saudi Arabia). Here, I investigated the mechanisms of astrocyte-neuron metabolic coupling using morphological and 3D imaging particular, pioneered the use of VR in basic neuroscience. In 2020 I joined the University of Turin (Italy), where I am associate professor of Human Anatomy.

EDUCATION

I graduated in Biomedical Engineering in 2006 from Politecnico di Torino, following a undergraduate internship at EPFL. In 2012 I obtained a PhD in Neuroscience from the Lemanic Neuroscience School (University of Lausanne and University of Geneva). During this period, I was a visiting scholar in the laboratory of Vidar Gundersen in Oslo (Norway).

RESEARCH, TEACHING, or OTHER INTERESTS

Neuroscience, Computer Science, Anatomy, Multidisciplinary
64

Scopus Publications

2777

Scholar Citations

26

Scholar h-index

42

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Optimized Focused-Beam Microwave Fixation Preserves Brain Integrity and Uncovers Sex-Specific Anesthetic Effects on Glycogen
    MF Veloz-Castillo, GH López, H Fiumelli, PJ Magistretti, C Calì
    Elsevier BV , 2026
    2026
  • GraPHFormer: A Multimodal Graph Persistent Homology Transformer for the Analysis of Neuroscience Morphologies
    U Shah, M Agus, M Gamal, M Alzubaidi, C Cali, PJ Magistretti, ...
    arXiv preprint arXiv:2603.20970 , 2026
    2026
  • PBM illumination across the range: from single cells to human heads
    T Cantat-Moltrecht, JH Kam, M Billères, C Calì, J Mitrofanis
    Mechanisms of Photobiomodulation Therapy XX, PC1382808 , 2026
    2026
  • Custom Surgical Phantom Workflow with Radiographic Compatibility and Haptic Fidelity
    G Riberi, R Spagnulo, F Riberi, V Monasterolo, E Vezzetti, L Ulrich, ...
    2026
  • The ultrastructural properties of the endoplasmic reticulum govern microdomain signaling in perisynaptic astrocytic processes
    A Denizot, MFV Castillo, P Puchenkov, C Calì, E De Schutter
    Glia 74 (2), e70091 , 2026
    2026
    Citations: 2
  • Ultrastructure of astrocytes using volume electron microscopy: A scoping review
    V Chiappini, MFV Castillo, F Biancardi, F Di Cunto, PJ Magistretti, ...
    The Journal of Physiology 604 (4), 1498-1517 , 2026
    2026
    Citations: 8
  • Advancements in Forensic Odontology: Anatomage Table and Metaverse Innovations
    C Cali, C Viteritti, E Nuzzolese
    Proceedings of the 78th Annual Scientific Meeting of the American Academy of … , 2026
    2026
  • Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases
    NJ Diederich, M Brüne, JS Allen, N Bender, E Bruner, JP Changeux, ...
    Annals of Neurology 98 (6), 1178-1195 , 2025
    2025
    Citations: 1
  • Deep learning for brain electron microscopy segmentation: Advances, challenges, and future directions in connectomics and ultrastructure analysis
    U Shah, M Alzubaidi, M Agus, C Calí, PJ Magistretti, M Househ
    Computers & Graphics, 104391 , 2025
    2025
    Citations: 3
  • Advancing open-source visual analytics in digital pathology: A systematic review of tools, trends, and clinical applications
    Z Ahmad, M Alzubaidi, K Al-Thelaya, C Calí, S Boughorbel, J Schneider, ...
    Journal of Pathology Informatics 18, 100454 , 2025
    2025
    Citations: 8
  • Tight spaces, tighter signals: Spatial constraints as drivers of peripheral myelination
    L Bartesaghi, B Giangreco, V Chiappini, MF Veloz Castillo, M Monaco, ...
    Cells 14 (12), 926 , 2025
    2025
    Citations: 2
  • AI-guided immersive exploration of brain ultrastructure for collaborative analysis and education
    U Shah, M Agus, D Boges, H Aldous, V Chiappini, M Alzubaidi, ...
    Computers & Graphics 129, 104239 , 2025
    2025
    Citations: 5
  • Validation study on iatrogenic nerve damage reduction using augmented reality on elbow phantom
    G Riberi, A Cangelosi, P Titolo, E Dutto, M Salvi, F Molinari, L Ulrich, ...
    Mayo Clinic Proceedings: Digital Health 3 (2), 100221 , 2025
    2025
    Citations: 1
  • Augmented reality simulation framework for minimally invasive orthopedic surgery
    A Cangelosi, G Riberi, P Titolo, M Salvi, F Molinari, L Ulrich, E Vezzetti, ...
    Computers in Biology and Medicine 189, 109943 , 2025
    2025
    Citations: 14
  • Advances in volume electron microscopy for brain imaging: methods, applications, and affordability
    C Calì, X Wang
    Frontiers in Neuroscience 19, 1561852 , 2025
    2025
    Citations: 1
  • NeuroShape: exploiting neural architectures for shape analysis of ultrastructural 3D neuroscience morphologies
    H Shaffique, U Shah, M Alzubaidi, J Schneider, PJ Magistretti, C Calí, ...
    The Eurographics Association , 2025
    2025
  • Enhancing Forensic Dental Identification with Anatomge Table: a novel approach
    E Nuzzolese, C Calì, G Di Vella
    Balkan Academy of Forensic Sciences 16th Annual Scientific Meeting Abstract … , 2025
    2025
  • SAM4EM: Efficient memory-based two stage prompt-free segment anything model adapter for complex 3D neuroscience electron microscopy stacks
    U Shah, M Agus, D Boges, V Chiappini, M Alzubaidi, J Schneider, ...
    Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern … , 2025
    2025
    Citations: 4
  • Exploring current and future technologies to make sense of the biophoton phenomenon: a narrative review
    JH Kam, M Billeres, L Herault, C Cali, B Sarmiento, P Cassano, ...
    Advanced Technology in Neuroscience 1 (2), 201-210 , 2024
    2024
    Citations: 10
  • NeuroVerse: Immersive exploration of 3D ultrastructural brain reconstructions for education and collaborative analysis
    C Calì, M Agus
    Proceedings of the 29th international ACM conference on 3D web technology, 1-10 , 2024
    2024
    Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

  • Gliotransmission and the tripartite synapse
    M Santello, C Calì, P Bezzi
    Synaptic plasticity: Dynamics, development and disease, 307-331 , 2012
    2012
    Citations: 315
  • Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments
    F Petrelli, G Dallérac, L Pucci, C Calì, T Zehnder, S Sultan, S Lecca, ...
    Molecular psychiatry 25 (4), 732-749 , 2020
    2020
    Citations: 139
  • Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes
    J Marchaland, C Calì, SM Voglmaier, H Li, R Regazzi, RH Edwards, ...
    Journal of Neuroscience 28 (37), 9122-9132 , 2008
    2008
    Citations: 138
  • Three‐dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues
    C Calì, J Baghabra, DJ Boges, GR Holst, A Kreshuk, FA Hamprecht, ...
    Journal of Comparative Neurology 524 (1), 23-38 , 2016
    2016
    Citations: 132
  • The strategic location of glycogen and lactate: from body energy reserve to brain plasticity
    C Calì, A Tauffenberger, P Magistretti
    Frontiers in cellular neuroscience 13, 82 , 2019
    2019
    Citations: 130
  • Method, apparatus, and system for utilizing augmented reality to improve surgery
    C Calì, J Besuchet
    US Patent App. 15/564,347 , 2018
    2018
    Citations: 125
  • 3D cellular reconstruction of cortical glia and parenchymal morphometric analysis from Serial Block-Face Electron Microscopy of juvenile rat
    C Calì, M Agus, K Kare, DJ Boges, H Lehväslaiho, M Hadwiger, ...
    Progress in neurobiology 183, 101696 , 2019
    2019
    Citations: 117
  • Augmented reality in medical practice: from spine surgery to remote assistance
    F Cofano, G Di Perna, M Bozzaro, A Longo, N Marengo, F Zenga, N Zullo, ...
    Frontiers in Surgery 8, 657901 , 2021
    2021
    Citations: 101
  • The effects of aging on neuropil structure in mouse somatosensory cortex—A 3D electron microscopy analysis of layer 1
    C Calì, M Wawrzyniak, C Becker, B Maco, M Cantoni, A Jorstad, B Nigro, ...
    Plos One , 2018
    2018
    Citations: 100
  • Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel
    L Fortunato, S Bucs, RV Linares, C Cali, JS Vrouwenvelder, TO Leiknes
    Journal of Membrane Science 524, 673-681 , 2017
    2017
    Citations: 96
  • Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate
    JS Coggan, D Keller, C Calì, H Lehväslaiho, H Markram, F Schürmann, ...
    PLoS computational biology 14 (8), e1006392 , 2018
    2018
    Citations: 95
  • Emerging evidence for astrocyte dysfunction in schizophrenia
    EC de Oliveira Figueiredo, C Calì, F Petrelli, P Bezzi
    Glia 70 (9), 1585-1604 , 2022
    2022
    Citations: 94
  • NeuroMorph: a toolset for the morphometric analysis and visualization of 3D models derived from electron microscopy image stacks
    A Jorstad, B Nigro, C Cali, M Wawrzyniak, P Fua, G Knott
    Neuroinformatics 13 (1), 83-92 , 2015
    2015
    Citations: 92
  • Ultrastructural evidence for a role of astrocytes and glycogen-derived lactate in learning-dependent synaptic stabilization
    E Vezzoli, C Cali, M De Roo, L Ponzoni, E Sogne, N Gagnon, ...
    Cerebral Cortex 30 (4), 2114-2127 , 2020
    2020
    Citations: 91
  • SDF 1-alpha (CXCL12) triggers glutamate exocytosis from astrocytes on a millisecond time scale: imaging analysis at the single-vesicle level with TIRF microscopy
    C Calì, J Marchaland, R Regazzi, P Bezzi
    Journal of neuroimmunology 198 (1-2), 82-91 , 2008
    2008
    Citations: 88
  • Astrocyte structural heterogeneity in the mouse hippocampus
    JF Viana, JL Machado, DS Abreu, A Veiga, S Barsanti, G Tavares, ...
    Glia 71 (7), 1667-1682 , 2023
    2023
    Citations: 70
  • Abstractocyte: A visual tool for exploring nanoscale astroglial cells
    H Mohammed, AK Al-Awami, J Beyer, C Cali, P Magistretti, H Pfister, ...
    IEEE transactions on visualization and computer graphics 24 (1), 853-861 , 2017
    2017
    Citations: 65
  • CXCR4-mediated glutamate exocytosis from astrocytes
    C Calì, P Bezzi
    Journal of neuroimmunology 224 (1-2), 13-21 , 2010
    2010
    Citations: 63
  • Digital reconstruction of the neuro-glia-vascular architecture
    E Zisis, D Keller, L Kanari, A Arnaudon, M Gevaert, T Delemontex, ...
    Cerebral Cortex 31 (12), 5686-5703 , 2021
    2021
    Citations: 61
  • Metabolic reprogramming of astrocytes in pathological conditions: implications for neurodegenerative diseases
    C Calì, I Cantando, MF Veloz Castillo, L Gonzalez, P Bezzi
    International Journal of Molecular Sciences 25 (16), 8922 , 2024
    2024
    Citations: 56

INDUSTRY EXPERIENCE

I serve as Scientific Officer at the Clinatec Endowment Fund (Fonds Clinatec), one of the four members of Clinatec (Grenoble, France). Here, I lead a team of researchers working of Photobiomodulation (PBM), an innovative non-invasive approach based on the use of red and near-infrared light as a method for prevention of neuroinflammation. We cover all aspects, from basic science (in vitro) to preclinical (animal models), to clinical trials on human patients, on several neurodegenerative disaseases.

STARTUP

I am founder and president of Intravides SRL, a startup that develops Mixed Reality solutions for surgical simulation, planning and practise.