Adejuwon Adewale Adeneye

Scopus Publications

Safeguarding Spermatogenesis: Garcinia kola Extract and Kolaviron Effectively Ameliorate Testicular Toxicity in Rats Treated With Bleomycin, Etoposide, and Cisplatin Combination Therapy
O. A. Ayedogba, O. E. Olorundare, A. A. Adeneye, A. M. Ajayi, Y. C. F. Teles, A. A. Fatokun
Andrologia, 2026
Background Emerging evidence indicates that certain chemotherapeutic agents, particularly the bleomycin, etoposide, and cisplatin (BEP) regimen, exert deleterious effects on male reproductive function, including impaired spermatogenesis. Previous studies have demonstrated that Garcinia kola (GK) seed extract and its bioactive biflavonoid constituent, kolaviron (KV), exhibit beneficial properties in reproductive physiology. However, their potential protective effects against BEP‐induced testicular toxicity remain underexplored. This study evaluated the chemopreventive efficacy of GK extract (GKE) and KV in attenuating BEP‐mediated testicular damage in a preclinical rodent model. Methods Adult male Wistar rats ( n = 8 per group) were subjected to three 21‐day cycles of BEP chemotherapy (0.5 mg/kg bleomycin, 5 mg/kg etoposide, and 1 mg/kg cisplatin, administered intraperitoneally). Concurrently, treatment groups received oral supplementation with GKE (100 mg/kg), KV (100 mg/kg), silymarin (SLM; 10 mg/kg), or prednisolone (PRED; 5 mg/kg), with dosages determined via prior dose–response optimization. Post‐treatment assessments included: sperm functional analysis (count, motility, morphology), serum reproductive hormone profiling [testosterone (TST), luteinizing hormone (LH), follicle stimulating hormone (FSH)], oxidative stress markers [glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione‐S‐transferase (GST)], lipid peroxidation indicators [malondialdehyde (MDA), nitric oxide (NO)], inflammatory cytokines (TNF‐α, IL‐6), and apoptotic markers [caspase‐3 (CAS‐3) and caspase‐9 (CAS‐9)]. Results BEP administration significantly impaired spermatogenic output, which was ameliorated by GKE, KV, SLM, and PRED co‐treatment. Notably, TST levels remained stable in GKE‐ and KV‐supplemented groups. All test compounds enhanced antioxidant capacity, suppressing lipid peroxidation (reduced MDA and NO). Furthermore, GKE and KV significantly attenuated BEP‐induced elevations in pro‐inflammatory cytokines (TNF‐α, IL‐6) and apoptotic mediators (CAS‐3, CAS‐9). Conclusion GKE and KV conferred substantial protection against BEP‐induced testicular toxicity, primarily through mechanisms involving oxidative stress mitigation, anti‐inflammatory action, and apoptosis suppression. Their efficacy paralleled that of established agents (SLM, PRED), suggesting potential utility as adjunctive therapies to preserve male fertility during chemotherapy. These findings warrant further clinical investigation to assess translational applicability.
In Silico and In Vitro Studies Unveil the Protective Potential of Diosmin-Hesperidin Conjugate in Doxorubicin Toxicity
, Adejuwon A. Adeneye, Taiwo M. Abdulrafiu, and
Al Nahrain Journal of Science, 2025
Doxorubicin (DOX), a potent anthracycline antibiotic widely used in cancer therapy, is notorious for inducing off-target multi-organ toxicities. These toxicities arise through mechanisms such as DNA intercalation, topoisomerase II poisoning, oxidative stress via free radical generation, and membrane disruption caused by altered sphingolipid metabolism. Mitigating these adverse effects is essential to improving the therapeutic index of DOX. This study investigates the protective potential of a diosmin-hesperidin conjugate using in silico and in vitro methods. The diosmin-hesperidin conjugate, derived from natural flavonoids, was assessed for its anti-apoptosis and antioxidant potential to alleviate DOX-induced toxicities. In silico analyses, including molecular docking and dynamic simulations, revealed high binding affinities of the conjugate to key oxidative stress-related targets, such as catalase, glutathione reductase, and apoptosis-related proteins (e.g., caspase-3, Hsp70, and Hsp90β). In vitro assays, including DPPH, NO scavenging, FRAP, H₂O₂ scavenging, lipid peroxidation inhibition, and total antioxidant capacity, validated the conjugate’s robust antioxidant activity. The computational and in vitro studies showed that the conjugate stabilized antioxidant enzymes and inhibited apoptotic pathways. Overall, by leveraging the synergistic effects of this flavonoid conjugate, this study highlighted the diosmin-hesperidin conjugate as a promising natural adjunct therapy to mitigate DOX’s off-target oxidative stress-and apoptosis-mediated toxicities. Thus, providing a foundation for further preclinical and clinical evaluations, and contributing to the advancement of natural product-based cancer therapy.
Diosmin-Hesperidin fixed-dose combination ameliorates cisplatin-induced hepotorenal toxicities in wistar rats: Involvements of antioxidant and anti-inflammatory mechanisms
Adejuwon A. Adeneye, Favor O. Ogunole, Quadri Remi-Lawal, Abdulfatai Ojewale, Ikechuckwu I. Okoye
Phytomedicine Plus, 2025
The chemotherapeutic agent, cisplatin (CIS), is limited by significant hepatorenal toxicity. This study evaluated the protective efficacy of a micronized diosmin (90 %) and hesperidin (10 %) combination (DH) against this toxicity in young adult male Wistar rats. In a dose-response study, rats were orally pre-treated with DH (50, 100, and 200 mg/kg/day) for 10 days before receiving CIS. Control groups received distilled water, CIS alone, DH alone, or silymarin (SIL) as a positive control. Following euthanasia and sacrifice, serum and tissue samples were analyzed for biochemical markers of liver and kidney function, oxidative stress (SOD, CAT, MDA, GSH), and inflammation (TNF-α, IL-10), along with histopathological assessments.Results showed that cisplatin administration induced significant hepatorenal dysfunction, oxidative imbalance, and inflammatory responses (p < 0.05, p < 0.0001 versus control). However, DH pre-treatment provided a dose-dependent protective effect, significantly attenuating these adverse changes, preserving tissue integrity, and improving biochemical indices of oxidative stress and inflammation (p < 0.05, p < 0.0001 versus CIS alone). These results provide compelling preclinical evidence for the capacity of a diosmin-hesperidin combination to mitigate CIS-induced hepatotoxicity and nephrotoxicity. The primary mechanism of this protection appears to involve the synergistic modulation of oxidative stress and inflammatory pathways. As this specific micronized flavonoid formulation is already an approved clinical agent with a well-established safety profile for its venotonic and vasoprotective effects, these findings support its potential for drug repositioning. It represents a promising candidate for off-label use as an adjunctive therapy to ameliorate debilitating side effects, potentially improving therapeutic outcomes and patient quality of life during cisplatin-based chemotherapy.
Tadalafil pretreatment attenuates doxorubicin-induced hepatorenal toxicity by modulating oxidative stress and inflammation in Wistar rats
Adejuwon Adewale Adeneye, Fidaraoluwa Esther Babatope, Ademilayo Eunice Adesiji-Adelekan, Olufunke Esan Olorundare, Ikechukwu Innocent Okoye
Toxicology Reports, 2024
Doxorubicin (DOX) is a widely used anticancer agent, but its clinical application is limited by significant off-target hepatorenal toxicity. Tadalafil (TAD), a selective phosphodiesterase-5 inhibitor used mainly for erectile dysfunction and pulmonary arterial hypertension, has shown potential in reducing oxidative stress. This study investigated TAD's chemoprotective effects and underlying mechanisms in DOX-induced hepatorenal toxicity in rats over 12 days. Eight groups of six rats each were orally pretreated with sterile water, silymarin (SIL), or TAD one hour before receiving intraperitoneal injections of 2.5 mg/kg DOX. On the 13th day, the rats were humanely sacrificed under inhaled halothane anesthesia, and serum was collected for hepatic and renal function tests, while liver and kidney tissues were analyzed for antioxidant enzyme activity, pro-inflammatory cytokines assay, and histopathological evaluation. DOX successfully induced hepatorenal toxicity, evidenced by significant increases (p<0.001, p<0.0001) in serum K + , urea, and creatinine levels, along with decreases in HCO 3 - , TCa 2+ , and Cl - . Tissue analysis showed reduced SOD, CAT, GST, and GPx activities, with elevated MDA and GSH levels. TAD pretreatment significantly ameliorated these biochemical alterations (p<0.05, p<0.001, p<0.0001), suggesting its potential as an effective chemoprophylactic adjuvant in the development of DOX-induced hepatorenal toxicity. • Doxorubicin (DOX) is notorious for causing hepatorenal toxicity as its off-target side effect. • Intraperitoneal injections of 2.5 mg/kg DOX for 12 days resulted in hepatorenal toxicities in the treated rats. • Tadalafil (TAD) pretreatments effectively attenuated and reversed these toxicities via antioxidant and anti-inflammatory mechanisms.
Ocimum Gratissimum Linn. Leaf Extract and Fractions Pre-Treatments are not Associated With Deleterious Electrocardiogram Changes in Trastuzumab-Intoxicated Wistar Rats
Adejuwon A.Adeneye, , Olufunke E. Olorundare, Olumuyiwa A. Adejumobi, Temidayo O. Omobowale, Akinyele O. Akinsola, Abayomi M. Ajayi, , , , , and
Al Nahrain Journal of Science, 2024
Trastuzumab (TZM) treatment is known to be associated with arrhythmogenic potentialwhich primarily is the basis for its cardiotoxicity. The purpose of this study was to investigate the acute influence of oral pretreatments with 100 mg/kg/day of Ocimun gratissimumethanolic leaf extract (OG) and its fractions (petroleum ether,PEOG; ethyl acetate,EAOG; and ethanolic extract, EOG) as well as valsartan-lisinopril fixed dose combination (VAL-LSP) on electrocardiogram (ECG) of Wistar rats intaperitoneally treated with 2.25 mg/kg/day TZMfor 7 days. Young adult male Wistar rats were randomly allotted into 12groups of 6 rats per group. Therats were subjected to electrocardiograms (ECG) measurement using non-invasive procedures on days 1 and 7 of the experiment. Results showed that oral pretreatment with OGand its fractions (except EOG) as well as VAL-LSP fixed dose combination did not cause any remarkable changes in the ECG patterns of TZM-treated rats indicating that their relative oral safety in TZMchemotherapy. On the other hand, EOGpretreatment caused significant shortening of the OT/QTc interval in the TZM-treated rats highlighting the arrhthymogenic potential of this fraction. Overall, the study highlighted the arrhythmogenic potential of EOG in TZM chemotherapy while OG and its other solvent fractions as well as VAL-LSP could be considered relatively safe for use as adjuvants in TZM chemotherapy
Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential of Ocimum gratissimum Linn. Leaf extract and fractions against trastuzumab-induced cardiotoxicity in Wistar rats
Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Abayomi Mayowa Ajayi, Olubunmi Atolani, Sunday Sokunle Soyemi, Alban Ikenna Mgbehoma, Ralph Muehl Albrecht
Toxicology Reports, 2024
Clinical use of trastuzumab (TZM), has been widely associated with increased incidence of cardiotoxicity. Ocimum gratissimum Linn. is a household medicinal plant popularly used for treating inflammatory conditions. In this study, we investigated the abrogative potential of 100 mg/kg/day of the ethanol leaf extract of Ocimum gratissimum Linn. (OG) and its petroleum ether (PEOG), ethyl acetate (EAOG) and ethanol (EOG) fractions in TZM intoxicated Wistar rats for 7 days using anthropometric, biochemical, histopathological and immunohistochemical endpoints. In addition, secondary metabolite constituents in OG and its fractions were determined through Gas Chromatography-Mass Spectrometry (GC-MS). The study results showed that oral pretreatments with OG and OG fractions as well as the fixed dose valsartan-lisinopril (VAL-LSP) combination effectively ameliorated and restore nearly normal levels the TZM-altered plasma cardiac troponin I and antioxidant profile which were corroborated by histopathological and immunohistochemical findings as indicated by the inhibition of TZM-induced activation of caspases-3 and -9 and profound upregulation of BCL-2 expression. Phytoscan of OG and its fractions showed the presence of thymol and in high amount. Overall, our findings revealed the cardioprotective potentials of OG, OG fractions and fixed dose VAL-LSP combination against TZM-induced cardiotoxicity which probably was mediated via abrogation of cardiomyocyte apoptosis and antioxidant mechanisms.
Oral Safety Evaluation of the Aqueous Fruit Extract of Annona Muricata in Wistar Rats
, Adedoyin T. Agbabiaka, Adejuwon Adewale Adeneye, , Joseph A. Olagunju, , Ikechukwu I. Okoye, and
Al Nahrain Journal of Science, 2024
Annona muricata fruit (i.e. Soursoup or custard apple a tropical plant species known for its edible fruit)has been attributed with numerous medicinal benefits (including antimicrobial, anti-inflammatory, anti-protozoan, antioxidant, anxiolytic, anti-stress, anti-ulcerogenic, wound healing, hepato-protective, anti-icteric, hepatoprotective, anticancer and antihyperglycemic activities) as well as some toxicological effects (neurotoxicity and neurodegeneration). Despite its ancestral use and wide applications in human health, scientific information on its oral safety remains scanty. In this study, the oral safety of 100 mg/kd/day, 200 mg/kg/day and 400 mg/kg/day of the aqueous fruit extract of Annona Muricata (AFAM) was evaluated in young adult, male and female white albino Wistar rats using standard acute and 42-days sub-chronic oral toxicity testing guidelines on anthropometric, biochemical, hematological and histo-pathological endpoints. In addition, preliminary qualitative and quantitative analyses of AFAM were undertaken using standard procedures. Results of the study showed that the estimated LD50 value for the acute oral toxicity study of AFAM calculated to be greater than 5 g/kg body weight/oral route although the testing was associated with transient but reversible behavioral toxicities. For its sub-chronic oral toxicity testing, AFAM treatment resulted in profound %weight gain, decreases in the serum triglycerides and very low density lipoprotein cholesterol and liver enzymes. Similarly, prolonged oral AFAM treatments caused significant decrease and increase in the differential neutrophils and platelet counts, respectively while the hist-opathological features of hepatic steatos is and renal tubule collapse in the AFAM-treated livers and kidneys, respectively suggested possible increased intrahepatic lipids biosynthesis and nephrotoxicity. The preliminary phytochemical analyses of AFAM showed the presence and relative amount of flavonoids, alkaloids, tannin, glycosides, saponin, and reducing sugars while the Gas Chromatography-Mass spectroscopy showed the relative abundance of thirteen compounds. Composite analyses conducted on the extract showed the presence of carbohydrate (64.65%), protein (2.14%), moisture content (8.07%), ash value (6.73%), lipid (14.22%) and fiber (4.19%). Overall, the study suggested that the prolonged AFAM oral treatments could predispose to the development of fatty liver disease from de novo intrahepatic biosynthesis of triglycerides, nephrotoxicity and hematotoxicity. In conclusion, the results of this study showed that prolonged consumption of AFAM should be with a great caution as it could pose serious health concerns.
Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
Joy Temiloluwa Folahan, Olufunke Esan Olorundare, Abayomi Mayowa Ajayi, Adeoye Oyetunji Oyewopo, Sunday Sokunle Soyemi, Adejuwon Adewale Adeneye, Ikechukwu Innocent Okoye, Saheed Olanrewaju Afolabi, Anoka Ayembe Njan
Lipids in Health and Disease, 2023
Background Thermoxidation of edible oil through deep fat frying results in the generation of several oxidized products that promote lipid peroxidation and ROS production when eaten. Consumption of thermoxidized oil in post-menopausal conditions where the estrogen level is low contributes to cardiovascular disease. This study evaluates the role of estradiol and antihyperlipidemic agents (AHD) in restoring the vascular health of ovariectomized (OVX) rats fed with thermoxidized palm oil (TPO) and thermoxidized soya oil (TSO) diets. Method A total of 10 groups of rats (n = 6) were set up for the experiment. Group I (normal control) rats were sham handled while other groups were OVX to bring about estrogen deficient post-menopausal state. Group II (OVX only) was not treated and received normal rat chow. Groups III-X were fed with either TPO or TSO diet for 12 weeks and treated with estradiol (ETD) 0.2 mg/kg/day, atorvastatin (ATV) 10 mg/kg/day, and a fixed-dose combination of ezetimibe and ATV (EZE 3 mg/kg/day + ATV 10 mg/kg/day). Results Pro-atherogenic lipids levels were significantly elevated in untreated TSO and TPO groups compared to OVX and sham, resulting in increased atherogenic and Coronary-risk indices. Treatment with Estradiol and AHDs significantly reduced the total cholesterol, triglycerides, low-density lipoprotein cholesterol as well as AI and CRI compared to untreated TSO and TPO groups, whereas TSO and TPO groups showed significant elevation in these parameters compared to Group I values. Moreover, aortic TNF-α levels were extremely elevated in the untreated TSO and TPO compared to Group I. TNF-α levels were significantly reduced in rats treated with AHDs and ETD. Localized oxidative stress was indicated in the aortic tissues of TSO and TPO-fed OVX rats by increased malondialdehyde and decreased glutathione, catalase, and superoxide dismutase levels. This contributed to a depletion in aortic nitric oxide. AHDs and ETD replenished the nitric oxide levels significantly. Histological evaluation of the aorta of TSO and TPO rats revealed increased peri-adventitia fat, aortic medial hypertrophy, and aortic recanalization. These pathologic changes were less seen in AHDs and ETD rats. Conclusion This study suggests that ETD and AHDs profoundly attenuate oxidized lipid-induced vascular inflammation and atherogenesis through oxidative-stress reduction and inhibition of TNF-α signaling.
Awareness and preparedness of healthcare workers against the first wave of the COVID- 19 pandemic: A cross-sectional survey across 57 countries
Nguyen Tien Huy, R. Matthew Chico, Vuong Thanh Huan, Hosam Waleed Shaikhkhalil, Vuong Ngoc Thao Uyen, Ahmad Taysir Atieh Qarawi, Shamael Thabit Mohammed Alhady, Nguyen Lam Vuong, Le Van Truong, Mai Ngoc Luu, Shyam Prakash Dumre, Atsuko Imoto, Peter N. Lee, Dao Ngoc Hien Tam, Sze Jia Ng, Mohammad Rashidul Hashan, Mitsuaki Matsui, Nguyen Tran Minh Duc, Sedighe Karimzadeh, Nut Koonrungsesomboon, Chris Smith, Sharon Cox, Kazuhiko Moji, Kenji Hirayama, Le Khac Linh, Kirellos Said Abbas, Tran Nu Thuy Dung, Tareq Mohammed Ali AL-Ahdal, Emmanuel Oluwadare Balogun, Nguyen The Duy, Mennatullah Mohamed Eltaras, Trang Huynh, Nguyen Thi Linh Hue, Bui Diem Khue, Abdelrahman Gad, Gehad Mohamed Tawfik, Kazumi Kubota, Hoang-Minh Nguyen, Dmytro Pavlenko, Vu Thi Thu Trang, Le Thuong Vu, Tran Hai Yen, Nguyen Thi Yen-Xuan, Luong Thi Trang, Vinh Dong, Akash Sharma, Vu Quoc Dat, Mohammed Soliman, Jeza Abdul Aziz, Jaffer Shah, Pham Dinh Long Hung, Yap Siang Jee, Dang Thuy Ha Phuong, Tran Thuy Huong Quynh, Hoang Thi Nam Giang, Vy Thi Nhat Huynh, Nguyen Anh Thi, Nacir Dhouibi, Truc Phan, Vincent Duru, Nguyen Hai Nam, Sherief Ghozy, and
Plos One, 2021
Background Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. Methods This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. Results We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0–14.0) and the median awareness score was 29.6 (IQR = 26.6–32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a ’great-extent-of-confidence’ in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. Interpretation There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type.
Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity
Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Abayomi Mayowa Ajayi, Olalekan Ayodele Agede, Sunday Sokunle Soyemi, Alban Ikenna Mgbehoma, Ikechukwu Innocent Okoye, Ralph M. Albrecht, James Mukasa Ntambi, Peter Anthony Crooks
Frontiers in Pharmacology, 2021
Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day valsartan, and their fixed-dose combinations in TZM-intoxicated Wistar rats that were randomly allotted into 10 groups of 6 rats for each group. Group I rats were treated with 10 ml/kg/day sterile water orally and 1 ml/kg/day sterile water intraperitoneally; Groups II, III, and IV rats were orally gavaged with 5 mg/kg/day valsartan and 1 ml/kg/day sterile water intraperitoneally, 0.25 mg/kg/day amlodipine and 1 ml/kg/day sterile water via the intraperitoneal route, 0.035 mg/kg/day lisinopril and 1 ml/kg/day sterile water administered intraperitoneally, respectively. Group V rats were orally treated with 10 ml/kg/day of sterile water prior to intraperitoneal administration of 2.25 mg/kg/day of TZM. Groups VI–VIII rats were equally pretreated with 5 mg/kg/day valsartan, 0.25 mg/kg/day amlodipine, and 0.035 mg/kg/day lisinopril before intraperitoneal 2.25 mg/kg/day TZM treatment, respectively; Groups IX and X rats were orally pretreated with the fixed-dose combinations of 0.25 mg/kg/day amlodipine +0.035 mg/kg/day lisinopril and 5 mg/kg/day valsartan +0.035 mg/kg/day lisinopril, respectively, before TZM treatment. Cardiac injury and tissue oxidative stress markers, complete lipids profile, histopathological, and immunohistochemical assays were the evaluating endpoints. Results showed that repeated TZM treatments caused profound increases in the serum TG and VLDL-c levels, serum cTnI and LDH levels, and cardiac tissue caspase-3 and -9 levels but decreased BCL-2 expression. TZM also profoundly attenuated CAT, SOD, GST and GPx activities, and increased MDA levels in the treated tissues. In addition, TZM cardiotoxicity was characterized by marked vascular and cardiomyocyte congestion and coronary artery microthrombi formation. However, the altered biochemical, histopathological, and immunohistochemical changes were reversed with amlodipine, lisinopril, valsartan, and fixed-dose combinations, although fixed-dose valsartan/lisinopril combination was further associated with hyperlipidemia and increased AI and CRI values and coronary artery cartilaginous metaplasia. Thus, the promising therapeutic potentials of amlodipine, lisinopril, valsartan and their fixed-dose combinations in the management of TZM cardiotoxicity, majorly mediated via antiapoptotic and oxidative stress inhibition mechanisms were unveiled through this study.
Race to Finding Covid-19 Cure: Could Traditional Herbal Medicine Hold the “Silver Bullet”? an Appraisal of Research Evidence
Al Nahrain Journal of Science, 2020
Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats
Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar
Journal of Toxicology, 2020
African Vegetables (Clerodendrum volibile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats
Olufunke Olorundare, Adejuwon Adeneye, Akinyele Akinsola, Sunday Soyemi, Alban Mgbehoma, Ikechukwu Okoye, James M. Ntambi, Hasan Mukhtar
Oxidative Medicine and Cellular Longevity, 2020
Irvingia gabonensis Seed Extract: An Effective Attenuator of Doxorubicin-Mediated Cardiotoxicity in Wistar Rats
Olufunke Olorundare, Adejuwon Adeneye, Akinyele Akinsola, Phillip Kolo, Olalekan Agede, Sunday Soyemi, Alban Mgbehoma, Ikechukwu Okoye, Ralph Albrecht, Hasan Mukhtar
Oxidative Medicine and Cellular Longevity, 2020
Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats
Adejuwon Adewale Adeneye, Joseph Abayomi Olagunju, Babatunde Adekunle Murtala
Evidence Based Complementary and Alternative Medicine, 2019
In vivo Safety Evaluation of a Nigerian Polyherbal Mixture in Female Wistar Rats
Nigerian Journal of Physiological Sciences, 2019
Morinda lucida aqueous stem bark extract ameliorates hepato-renal dysfunctions in experimental diabetes model
Nigerian Journal of Physiological Sciences, 2019
Modulatory effect of Morinda lucida aqueous stem bark extract on blood glucose and lipid profile in alloxan-induced diabetic rats
African Journal of Biomedical Research, 2017
Chemopreventive Effect of Tadalafil in Cisplatin-Induced Nephrotoxicity in Rats
Nigerian Journal of Physiological Sciences Official Publication of the Physiological Society of Nigeria, 2016
Modulatory effect of Mangifera indica against carbon tetrachloride induced kidney damage in rats
Olufunsho Awodele, Adejuwon Adewale Adeneye, Sheriff Aboyade Aiyeola, Adokiye Senibo Benebo
Interdisciplinary Toxicology, 2015
Modulatory potentials of the aqueous stem bark extract of Mangifera indica on carbon tetrachloride-induced hepatotoxicity in rats
Adejuwon Adewale Adeneye, Olufunsho Awodele, Sheriff Aboyade Aiyeola, Adokiye Senibo Benebo
Journal of Traditional and Complementary Medicine, 2015
Weight losing, antihyperlipidemic and cardioprotective effects of the alkaloid fraction of Hunteria umbellata seed extract on normal and triton-induced hyperlipidemic rats
Adejuwon Adewale Adeneye, Peter Anthony Crooks
Asian Pacific Journal of Tropical Biomedicine, 2015
Ethnopharmacological survey of herbal treatment of malaria in Lagos, Southwest Nigeria
I.O. Ishola, I.A. Oreagba, A.A. Adeneye, C. Adirije, K.A. Oshikoya, O.O. Ogunleye
Journal of Herbal Medicine, 2014
Subchronic and Chronic Toxicities of African Medicinal Plants
Adejuwon Adewale Adeneye
Toxicological Survey of African Medicinal Plants, 2014
EVALUATION OF THE ANTI-ARTHRITIC ACTIVITY OF THE HYDROETHANOLIC LEAF EXTRACT OF ALCHORNEA CORDIFOLIA IN RATS
AA Adeneye, AI Oreagba, IO Ishola, HA Kalejaiye
African Journal of Traditional Complementary and Alternative Medicines, 2014
Protective effect of selected calcium channel blockers and prednisolone, a phospholipase-A2 inhibitor, against gentamicin and carbon tetrachloride-induced nephrotoxicity
AJ Akindele, AA Adeneye, F Olatoye, AS Benebo
Human and Experimental Toxicology, 2014
Glucose utilization and anti-oxidative mechanisms of the aqueous hunteria umbellata seed extract in alloxan induced diabetic rats
Nigerian Journal of Physiological Sciences, 2014
Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav. (Malpighiaceae) in rodents
Abidemi J. Akindele, Adejuwon A. Adeneye, Oluwole S. Salau, Margaret O. Sofidiya, Adokiye S. Benebo
Frontiers in Pharmacology, 2014
EVALUATION OF THE TOXICOLOGICAL PROFILE OF THE LEAVES AND YOUNG TWIGS OF CAESALPINIA BONDUC (LINN) ROXB
OO Ogunlana, OE Ogunlana, AA Adeneye, OAC Udo-Chijioke, TI Dare-Olipede, JA Olagunju, AA Akindahunsi
African Journal of Traditional Complementary and Alternative Medicines, 2013
Survey of Hypertension, Diabetes and Obesity in three Nigerian Urban Slums
Iranian Journal of Public Health, 2013
The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies
Adejuwon Adewale Adeneye
Journal of Ethnopharmacology, 2012
The novel antihyperglycaemic action of Hunteria umbellata seed fractions mediated via intestinal glucose uptake inhibition
AA Adeneye, OO Adeyemi, EO Agbaje, MO Sofidiya
African Journal of Traditional Complementary and Alternative Medicines, 2012
Analgesic activity of the aqueous seed extract of hunteria umbellata (K. Schum.) hallier F. in rodents
Indian Journal of Experimental Biology, 2011
Metformin: An effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats
Indian Journal of Experimental Biology, 2011
Evaluation of the toxicity and reversibility profile of the aqueous seed extract of hunteria umbellata (k. schum.) hallier f. in rodents
African Journal of Traditional Complementary and Alternative Medicines, 2010
Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia
Adejuwon Adewale Adeneye, Olufunmilayo Olaide Adeyemi, Esther Oluwatoyin Agbaje
Journal of Ethnopharmacology, 2010
Haematopoietic activity of the seed aqueous extract of Hunteria umbellata (K. Schum) Hallier f. in experimental anaemia
Journal of Natural Remedies, 2010
Hypoglycaemic effects of the aqueous seed extract of Hunteria umbellata in normoglycaemic and glucoseand nicotine-induced hyperglycaemic rats
International Journal of Applied Research in Natural Products, 2009
Ethanolic seed extract of grapefruit (Citrus paradisi macfad) as an effective attenuator of doxorubicin-induced oxidative stress in the rat heart
L.C. Saalu, G.O. Ajayi, A.A. Adeneye, I.O. Imosemi, A.A. Osinubi
International Journal of Cancer Research, 2009
The aqueous seed extract of Carica papaya Linn. Prevents carbon tetrachloride induced hepatotoxicity in rats
International Journal of Applied Research in Natural Products, 2009
Further evaluation of antihyperglycaemic activity of Hunteria umbellata (K. Schum) Hallier f. seed extract in experimental diabetes
Adejuwon Adewale Adeneye, Olufunmilayo Olaide Adeyemi
Journal of Ethnopharmacology, 2009
Biochemical and toxicological studies of aqueous extract of Syzigium aromaticum (L.) Merr. & Perry (Myrtaceae) in rodents
African Journal of Traditional Complementary and Alternative Medicines, 2009
Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats
African Journal of Traditional Complementary and Alternative Medicines, 2009
Preliminary hypoglycemic and hypolipidemic activities of the aqueous seed extract of Carica papaya Linn. In wistar rats
Biology and Medicine, 2009
Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. In carbon tetrachloride induced renal injured wistar rats: A dose- and time-dependent study
Biology and Medicine, 2009
Protective effect of oral ascorbic acid (vitamin C) against acetaminophen-induced hepatic injury in rats
African Journal Biomedical Research, 2008
Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of Morinda Lucida benth. in normal and alloxan-induced diabetic rats
African Journal Biomedical Research, 2008
Protective activities of the aqueous root extract of Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats
International Journal of Applied Research in Natural Products, 2008
Nephroprotective effects of the aqueous root extract of Harungana madagascariensis (L.) In acute and repeated dose acetaminophen renal injured rats
International Journal of Applied Research in Natural Products, 2008
Hypoglycemic and hypolipidemic effects of methanol seed extract of Citrus paradisi Macfad (Rutaceae) in alloxan-induced diabetic Wistar rats.
Nigerian Quarterly Journal of Hospital Medicine, 2008
Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats
Adejuwon Adewale Adeneye, Adokiye Senebo Benebo
Journal of Ethnopharmacology, 2008
Hypoglycemic and hypolipidemic effects of the aqueous fresh leaves extract of Clerodendrum capitatum in Wistar rats
A.A. Adeneye, T.I. Adeleke, A.K. Adeneye
Journal of Ethnopharmacology, 2008
Haematopoetic effect of methanol seed extract of Citrus paradisi Macfad (grape fruit) in Wistar rats
Biomedical Research, 2008
Methanol seed extract of Citrus paradisi Macfad lowers blood glucose, lipids and cardiovascular disease risk indices in normal Wistar rats.
Nigerian Quarterly Journal of Hospital Medicine, 2008
Oral toxicity studies of a Nigerian polyherbal health tonic tea extract in rats.
African Journal of Medicine and Medical Sciences, 2008
Hypoglycemic and antidiabetic activities on the stem bark aqueous and ethanol extracts of Musanga cecropioides in normal and alloxan-induced diabetic rats
A.A. Adeneye, O.P. Ajagbonna, O.W. Ayodele
Fitoterapia, 2007
Oral metformin-ascorbic acid co-administration ameliorates alcohol-induced hepatotoxicity in rats.
Nigerian Quarterly Journal of Hospital Medicine, 2007
Hypoglycemic and hypolipidemic effects of fresh leaf aqueous extract of Cymbopogon citratus Stapf. in rats
Adejuwon Adewale Adeneye, Esther Oluwatoyin Agbaje
Journal of Ethnopharmacology, 2007
Effect of chronic co-administration of metformin and vitamin C on plasma glucose and lipid concentrations in normal rats.
African Journal of Medicine and Medical Sciences, 2007
Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice
A.A. Adeneye, O.O. Amole, A.K. Adeneye
Fitoterapia, 2006
Willingness to seek HIV testing and counseling among pregnant women attending antenatal clinics in Ogun State, Nigeria
A. K. Adeneye, W. R. Brieger, M. A. Mafe, A. A. Adeneye, K. K. Salami, M. A. Titiloye, T. A. Adewole, P. U. Agomo
International Quarterly of Community Health Education, 2006
The hypotensive mechanisms for the aqueous stem bark extract of Musanga cecropioides in Sprague-Dawley rats
A.A. Adeneye, O.P. Ajagbonna, F.B.O. Mojiminiyi, I.P. Odigie, P.D. Ojobor, R.R. Etarrh, A.K. Adeneye
Journal of Ethnopharmacology, 2006
Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats
A.A. Adeneye, O.P. Ajagbonna, T.I. Adeleke, S.O. Bello
Journal of Ethnopharmacology, 2006
Knowledge and perception of HIV/AIDS among pregnant women attending antenatal clinics in Ogun State, Nigeria
Adeniyi K Adeneye, Margaret A Mafe, Adejuwon A Adeneye, Kabiru K Salami, William R Brieger, Musbau A Titiloye, Taiwo A Adewole, Philip U Agomo
African Journal of AIDS Research, 2006
The pattern of infection and in vivo response to Chloroquine by uncomplicated Plasmodium falciparum malaria in northwestern Nigeria
African Journal of Biotechnology, 2005
Antidiarrhoeal activities of ocimum gratissimum (Lamiaceae)
Journal of Diarrhoeal Diseases Research, 1996

Adejuwon Adewale Adeneye

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