Weekly assessment of volumetric and dosimetric changes during volumetric modulated arc therapy of locally advanced head and neck carcinoma: Implications for adaptive radiation therapy—A prospective study Aathira T. Sreejeev, Deepa Joseph, Ajay S. Krishnan, Rajesh Pasricha, Sweety Gupta, Rachit Ahuja, Nidhi Sharma, Debanjan Sikdar, Sagar Raut, Abhijith Sasi, Manoj Gupta Head and Neck, 2024 BackgroundChemoradiation in head and neck carcinoma (HNC) shows significant anatomical resulting in erroneous dose deposition in the target or the organ at risk (OAR). Adaptive radiotherapy (ART) can overcome this. Timing of significant target and OAR changes with dosimetric impact; thus, most suitable time and frequency of ART is unclear.MethodsThis dosimetric study used prospective weekly non‐contrast CT scans in 12 HNC patients (78 scans). OARs and TVs were manually contoured after registration with simulation scan. Dose overlay done on each scan without reoptimization. Dosimetric and volumetric variations assessed.ResultsCommonest site was oropharynx. Gross Tumor Volume (GTV) reduced from 47.5 ± 19.2 to 17.8 ± 10.7 cc. Nodal GTV reduced from 15.7 ± 18.8 to 4.7 ± 7.1 cc. Parotid showed mean volume loss of 35%. T stage moderately correlated with GTV regression.ConclusionMaximum GTV changes occurred after 3 weeks. Best time to do single fixed interval ART would be by the end of 3 weeks.
Hypercalcemia of malignancy: An incidental finding in carcinoma cervix Sweety Gupta, Ajas Ibrahim, SagarNilkanthrao Raut, Debanjan Sikdar, Nidhi Sharma, Shreeya Pabi, Rachit Ahuja, Deepa Joseph, Manoj Gupta Indian Journal of Palliative Care, 2020 Hypercalcemia occurs in 30% of patients of cancer at either as apart of paraneoplastic process or due to bone metastases. It is an uncommon finding in gynecological cancers. Most common in ovarian cancers and till date very few cancer cervix with hypercalcemia have been reported. We, hereby, report patient of carcinoma cervix who was found to have incidental hypercalcemia without any associated clinical symptoms.
RECENT SCHOLAR PUBLICATIONS
The Changing Landscape of Liver Cancer in India: A Comprehensive Analysis of the Global Burden of Disease Study 2023 HA Jindal, S Raut, TK Santhosh, Nancy International Journal of Science and Healthcare Research 11 (1), 316-327 , 2026 2026.0
A prospective randomized study of sequential boost versus simultaneous integrated boost intensity-modulated radiation therapy with concurrent chemotherapy in locally advanced … D Sikdar, DM Joseph, N Sharma, SN Rout, AT Sreejeev, A Rastogi, ... Journal of Cancer Research and Therapeutics 22 (1), 128-135 , 2026 2026.0 Citations: 1
Dual Fronts: The Psychological and Logistical Burden of War on Oncology Patients S Raut JCO Global Oncology 11, 1-4 , 2025 2025.0 Citations: 1
A Dosimetric Comparison of Coplanar Versus Noncoplanar Volumetric Modulated Arc Therapy (VMAT) for High Grade Glioma S Raut, R Pasricha, M Gupta, D Joseph, S Gupta, R Ahuja, L Pandey, ... Cureus 17 (10) , 2025 2025.0
Relevance of ORATOR Trial Results in a Developing Country Like India S Raut, SK Samala Practical Radiation Oncology 15 (1), e88-e89 , 2025 2025.0
Treating endometrial hyperplasia (EH) post-tamoxifen treatment in breast cancer survivors: what are our options? S Raut, N Bakshi, B Sharma Medical Oncology 41 (11), 282 , 2024 2024.0 Citations: 3
Weekly assessment of volumetric and dosimetric changes during volumetric modulated Arc therapy of locally advanced head and neck carcinoma: implications for adaptive radiation … AT Sreejeev, D Joseph, AS Krishnan, R Pasricha, S Gupta, R Ahuja, ... Head & Neck 46 (7), 1547-1556 , 2024 2024.0 Citations: 4
Hippocampal Avoidance Whole BRAIN Radiotherapy (HA-WBRT) with Simultaneous Integrated BOOST (SIB) vs. HA-WBRT in Multiple Brain Metastases: A Dosimetric Comparison SK Samala, S Gupta, S Sharma, J Pattanaik, S Pandey, S Sushant, ... International Journal of Radiation Oncology, Biology, Physics 117 (2), e147-e148 , 2023 2023.0
Varied clinical presentation and management of calvarial metastases S Gupta, G Sharma, S Sajeevan, SN Raut, R Ahuja, D Joseph, A Gupta, ... Asian Journal of Neurosurgery 17 (04), 631-634 , 2022 2022.0 Citations: 10
PO43 Presentation Time: 4: 45 PM: Reduced Duration Intracavitary Brachytherapy in Cervix Malignancies: A Comparative Analysis from Single Institute S Chaudhary, V Goel, V Pareek, V Abiramasundari, S Raut, A Amritt, ... Brachytherapy 21 (6), S93-S94 , 2022 2022.0
A prospective randomized study of intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent chemotherapy in locally advanced … N Sharma Sr, M Gupta, D Joseph, S Gupta, R Pasricha, R Ahuja, ... Cureus 14 (1) , 2022 2022.0 Citations: 10
Stage Migration in Head-and-Neck Cancers due to Extranodal Extension: Clinical Experience from a Tertiary Care Centre D Joseph, L Pandey, R Pasricha, S Raut, Y Yanpothung, A Ibrahim, ... Journal of Medical Evidence 3 (1), 24-27 , 2022 2022.0
Hypercalcemia of malignancy: An incidental finding in carcinoma cervix S Gupta, A Ibrahim, SN Raut, D Sikdar, N Sharma, S Pabi, R Ahuja, ... Indian Journal of Palliative Care 26 (4), 548 , 2020 2020.0 Citations: 1
278P Serial assessment of parotid volume changes during radical chemoradiation of locally advanced head and neck cancer: its implications in practice of adaptive radiotherapy AT Sreejeev, D Joseph, AS Krishnan, R Ahuja, D Sikdar, S Raut, ... Annals of Oncology 31, S1351 , 2020 2020.0 Citations: 6
Inguinal Lymphadenopathy in Carcinoma Gall Bladder: An Unusual Site of Metastasis A Ibrahim, D Sikdar, SN Raut, J Jain, S Gupta, A Gupta, P Joshi, M Gupta International Research Journal of Oncology 2 (2), 159-162 , 2020 2020.0
Upstaging of head and neck cancers due to extranodal extension: An Indian study. DM Joseph, S Raut, R Pasricha, S Gupta Journal of Clinical Oncology 37 (15_suppl), e17553-e17553 , 2019 2019.0 Citations: 2
Blood Parameters as Surrogate Markers to Predict Treatment Response after Radiation Therapy in Head and Neck Malignancies TS Aathira, S Gupta, AS Krishnan, D Sikdar, S Raut, N Sharma, ... Alcoholism 88, 12 , 0
MOST CITED SCHOLAR PUBLICATIONS
Varied clinical presentation and management of calvarial metastases S Gupta, G Sharma, S Sajeevan, SN Raut, R Ahuja, D Joseph, A Gupta, ... Asian Journal of Neurosurgery 17 (04), 631-634 , 2022 2022.0 Citations: 10
A prospective randomized study of intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent chemotherapy in locally advanced … N Sharma Sr, M Gupta, D Joseph, S Gupta, R Pasricha, R Ahuja, ... Cureus 14 (1) , 2022 2022.0 Citations: 10
278P Serial assessment of parotid volume changes during radical chemoradiation of locally advanced head and neck cancer: its implications in practice of adaptive radiotherapy AT Sreejeev, D Joseph, AS Krishnan, R Ahuja, D Sikdar, S Raut, ... Annals of Oncology 31, S1351 , 2020 2020.0 Citations: 6
Weekly assessment of volumetric and dosimetric changes during volumetric modulated Arc therapy of locally advanced head and neck carcinoma: implications for adaptive radiation … AT Sreejeev, D Joseph, AS Krishnan, R Pasricha, S Gupta, R Ahuja, ... Head & Neck 46 (7), 1547-1556 , 2024 2024.0 Citations: 4
Treating endometrial hyperplasia (EH) post-tamoxifen treatment in breast cancer survivors: what are our options? S Raut, N Bakshi, B Sharma Medical Oncology 41 (11), 282 , 2024 2024.0 Citations: 3
Upstaging of head and neck cancers due to extranodal extension: An Indian study. DM Joseph, S Raut, R Pasricha, S Gupta Journal of Clinical Oncology 37 (15_suppl), e17553-e17553 , 2019 2019.0 Citations: 2
A prospective randomized study of sequential boost versus simultaneous integrated boost intensity-modulated radiation therapy with concurrent chemotherapy in locally advanced … D Sikdar, DM Joseph, N Sharma, SN Rout, AT Sreejeev, A Rastogi, ... Journal of Cancer Research and Therapeutics 22 (1), 128-135 , 2026 2026.0 Citations: 1
Dual Fronts: The Psychological and Logistical Burden of War on Oncology Patients S Raut JCO Global Oncology 11, 1-4 , 2025 2025.0 Citations: 1
Hypercalcemia of malignancy: An incidental finding in carcinoma cervix S Gupta, A Ibrahim, SN Raut, D Sikdar, N Sharma, S Pabi, R Ahuja, ... Indian Journal of Palliative Care 26 (4), 548 , 2020 2020.0 Citations: 1
The Changing Landscape of Liver Cancer in India: A Comprehensive Analysis of the Global Burden of Disease Study 2023 HA Jindal, S Raut, TK Santhosh, Nancy International Journal of Science and Healthcare Research 11 (1), 316-327 , 2026 2026.0
A Dosimetric Comparison of Coplanar Versus Noncoplanar Volumetric Modulated Arc Therapy (VMAT) for High Grade Glioma S Raut, R Pasricha, M Gupta, D Joseph, S Gupta, R Ahuja, L Pandey, ... Cureus 17 (10) , 2025 2025.0
Relevance of ORATOR Trial Results in a Developing Country Like India S Raut, SK Samala Practical Radiation Oncology 15 (1), e88-e89 , 2025 2025.0
Hippocampal Avoidance Whole BRAIN Radiotherapy (HA-WBRT) with Simultaneous Integrated BOOST (SIB) vs. HA-WBRT in Multiple Brain Metastases: A Dosimetric Comparison SK Samala, S Gupta, S Sharma, J Pattanaik, S Pandey, S Sushant, ... International Journal of Radiation Oncology, Biology, Physics 117 (2), e147-e148 , 2023 2023.0
PO43 Presentation Time: 4: 45 PM: Reduced Duration Intracavitary Brachytherapy in Cervix Malignancies: A Comparative Analysis from Single Institute S Chaudhary, V Goel, V Pareek, V Abiramasundari, S Raut, A Amritt, ... Brachytherapy 21 (6), S93-S94 , 2022 2022.0
Stage Migration in Head-and-Neck Cancers due to Extranodal Extension: Clinical Experience from a Tertiary Care Centre D Joseph, L Pandey, R Pasricha, S Raut, Y Yanpothung, A Ibrahim, ... Journal of Medical Evidence 3 (1), 24-27 , 2022 2022.0
Inguinal Lymphadenopathy in Carcinoma Gall Bladder: An Unusual Site of Metastasis A Ibrahim, D Sikdar, SN Raut, J Jain, S Gupta, A Gupta, P Joshi, M Gupta International Research Journal of Oncology 2 (2), 159-162 , 2020 2020.0
Blood Parameters as Surrogate Markers to Predict Treatment Response after Radiation Therapy in Head and Neck Malignancies TS Aathira, S Gupta, AS Krishnan, D Sikdar, S Raut, N Sharma, ... Alcoholism 88, 12 , 0
