Symbiotic microbial interactions in fish gut Kumaran Subramanian, Mani Mahendrakumar, Kuppusamy Elumalai, S.R. Pugazhvendan, Panangal Mani, K. Balakrishnan Microbial Symbionts Functions and Molecular Interactions on Host, 2022
Intelligent pH Indicative Film from Plant-Based Extract for Active Biodegradable Smart Food Packing Kumaran Subramanian, Harinakshi Logaraj, V. Ramesh, Mahendrakumar Mani, K. Balakrishnan, Harshni Selvaraj, Sampath Renuga Pugazhvendan, S. Velmurugan, Wilson Aruni Journal of Nanomaterials, 2022 Background. Biodegradable biopolymers have been developed in response to the growing environmental concern over plastic packaging disposal. The emergence of active and intelligent packaging systems to monitor the quality of packed food is further necessitated by consumer demand and health concerns. Chemical dyes, on the other hand, are not ideal for use as an indicator in smart packaging for food due to their high toxicity and negative impacts on human health and the environment. As a result, the researchers are concentrating on natural pigments produced from plants and food waste as a signaling component in biodegradable packaging as well as the valorization of food waste. This review is focused on the advancement of active packaging from plant pigments.
An Introductory Assessment on Computational Algorithm in Initial Finding of COVID-19 Cases S. Jasmindebora, M Mahendrakumar, Archana S. Nanoty, V. Shanmugasundaram, Anurag Srivastava, Baba Vajrala Proceedings of International Conference on Technological Advancements and Innovations Ictai 2021, 2021 This research discusses how to detect coronavirus patients using various target optimization and deep learning methods. This research utilizes the J48 decision tree methodology to describe the extended attributes of X-ray coronagraphs to identify polluted ill persons rapidly and efficiently. The investigation has found eleven distinct releases of the converting neural network to categorize infected individuals utilizing coronavirus pneumonia employing X-ray imaging (CNN). An emperor penguin and its objectives also indicate the characteristics of the CNN model. In the classified x-ray photos, a comprehensive model analysis displays the proper percentages of the features such as accuracy, precision, recollections, specificities, and F1. Extensive testing has shown that the new strategy outperforms competitors using wellknown performance criteria. The proposed model is therefore suitable for the Covid-19 disease radiation thoroughbred image in real-time. The developed/projected design is unique and will aid in the COVID-19 screening process optimization.
Hypericin, an anthraquinone derivative of Hypericum hookerianum wight and Arn. (Hypericaceae) of Palni Hills, South India, exhibits anti-inflammatory property in lipopolysaccharide - Stimulated raw 264.7 macrophages K Perinbam, M Mahendrakumar, S Seeni Pharmacognosy Magazine, 2018 Background: Hypericin is an anthraquinone derivative of Hypericum hookerianum, a shrub from Palni hills of Southern India which possess various medicinal values. Aim: The present study was aimed to evaluate the anti-inflammatory activity of hypericin using RAW 264.7 macrophage cell line. Materials and Methods: The anti inflammatory property was determined by assessing the inhibitory action on lipopolysaccharide (LPS) stimulated nitric oxide (NO) production and pro inflammatory mediators/cytokines. RAW 264.7 macrophages cell line was used as in vitro inflammatory model. Cytotoxicity was evaluated using methylthiazolyldiphenyl tetrazolium bromide assay and NO estimation was carried out using Griess method. Gene expression of pro—inflammatory cytokines such as inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor α, interleukin—1 β (IL—1 β), and IL—6 was also evaluated. Results: The results exhibited that hypericin significantly suppressed LPS induced NO production with a concomitant decrease in the levels of pro—inflammatory cytokines. Conclusion: The study demonstrates the potential of hypericin as an effective anti—inflammatory agent. Abbreviations used: NSAID: Nonsteroidal anti-inflammatory drug; NO: Nitric oxide; IL — 6: Interleukin — 6; IL — 1β: Interleukin — 1β; TNF — α: Tumour necrosis factor — α; iNOS: inducible Nitric oxide synthase; COX — 2: Cyclooxygenase - 2; NF-κB: nuclear factor kappa B; PGE2: prostaglandin E2; LPS: Lipopolysaccharide; DMEM: Phenol free Dulbecco's modified Eagle medium; MTT: methyl thiazolyl diphenyl tetrazolium bromide; DMSO: Dimethyl sulfoxide; PBS: phosphate buffer saline; RNA: ribonucleic acid; q-PCR: quantitative polymerase chain reaction.
Biofertilizing efficiency of Sargassum polycystum extract on growth and biochemical composition of Vigna radiata and Vigna mungo B Bharath, K Perinbam, S Nirmalraj, M Mahendrakumar Asian Pacific Journal of Reproduction, 2018 Objective: To evaluate the effect of marine brown alga Sargassum polycystum extract on growth and biochemical parameters of Vigna radiata and Vigna mungo. Methods: Different concentrations of algal extracts (0.5%, 1.0%, 2.0%, 3.0%, 4.0%, and 5.0%) were prepared and applied to the crops at every 10-day intervals under natural conditions. After 30 d, the plants were harvested to evaluate the growth and biochemical parameters. Results: Seaweed liquid fertilizers treated seedlings showed maximum growth in 3.0% concentration when compared to the untreated seedlings. Similarly, biochemical parameters such as photosynthetic pigments, protein, reducing sugar, total sugar and amino acids exhibited increases in 3.0% concentration seaweed extract. Decreases in growth and biochemical parameters were noticed in concentrations higher than 3.0%. Conclusions: Presence of micronutrients and growth regulating substances in the liquid extract help healthier and faster productivity of the crop.
Whole cell protein profiling of human pathogenic bacteria isolated from clinical samples M. Mahendraku, M. Asrar Sheriff Asian Journal of Scientific Research, 2015 The present investigation deals with the protein profiling of clinical pathogens isolated from clinical samples. For the purpose, four different bacteria were isolated from the clinical samples and biochemically characterized. The 16S rRNA sequence analysis revealed the isolated bacteria were Escherichia coli, Staphylococcus epidermidis, Bacillus subtilis and Klebsiella pneumonia. The bacteria were cultured in liquid medium and the protein profile of the bacteria was investigated through ultra-sonication followed by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) analysis. The results revealed that the unique protein bands observed in the bacteria at defined size can act as biomarker for the identification and differentiation of the bacteria from the other species.
Antibacterial and anti-inflammatory activity of Justicia gendarussa Burm. F. Leaves S. Nirmalraj, M. Ravikumar, M. Mahendraku, B. Bharath, K. Perinbam Journal of Plant Sciences, 2015 The leaves of Justicia gendarussa are used in the folk medicine for the treatment of various ailments like rheumatic pain, jaundice, cephalgia, hemiplegia and eczema, etc. The leaves of the plant consists of important phytoconstituents including O-di-substituted aromatic amines, 2-aminobenzyl alcohol, O methyl ethers, friedelin, lupeol and β-sistosterol. In the present investigation, different solvent extracts of J. gendarussa leaves were screened and compared for membrane stability and antibacterial activities. Even at lower concentrations, methanolic extract of J. gendarussa shown good antibacterial and anti-inflammatory activity. At higher concentrations, methanolic extracts gave relatively more projecting antibacterial activity when compared with gentamycin. The anti-inflammatory effects of the crude drug were compared with Diclofenac as positive control. The methanolic extracts of J. gendarussa leaves possessed a broad spectrum antibacterial activity against both gram-negative and gram positive organisms like Staphylococcus aureus (MTCC 96), Staphylococcus mutans (MTCC 497), Bacillus subtilis (MTCC 441), Micrococcus luteus (MTCC 1538), gram negative organisms; Proteus vulgaris (MTCC 426), Klebsiella pneumoniae (MTCC 109), Escherichia coli (MTCC 443) and Shigella flexneri (MTCC 1457) with a zone of inhibition from 7-12 mm. The extract also showed good membrane stability to be considered to have significant anti-inflammatory action.
Pharmacognostic, phytochemical and physicochemical investigations of hypericum hookerianum wight & Arn. (Hypericaceae) of palni hills, India Mahendrakumar M, Nirmalraj S, Ravikumar M, Bharath B, Seeni S, Perinbam K Pharmacognosy Journal, 2014 Introduction: Hypericum hookerianum Wight and Arn. (Hooker’s wort) is a lesser known unfamiliar yet critically endangered native therapeutically active native medicinal plant. It is being characterized by the presence of various secretory glands. Methodology: In this present study, characterization of the plant in terms of morphology, anatomy and histochemistry of tissues and phytochemicals and antimicrobial potentials were made. Results: The epidermal layer contains oil cells while histochemistry showed the presence of the secondary metabolites. Qualitative analysis indicated presence of maximum phytocompounds in the high polar ethanolic extract; flavonoids, anthocyanin and phenol are prominently present and quantified. Conclusion: The results suggest that the less studied herb, H. hookerianum is a multifaceted high value species having a wide range of phytochemicals with abundant medicinal properties.
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Pharmacognostic, Phytochemical and Physicochemical Investigations of Hypericum hookerianum Wight & Arn.(Hypericaceae) of Palni Hills, India. M Mahendrakumar, S Nirmalraj, M Ravikumar, B Bharath, S Seeni, ... Pharmacognosy Journal 9 (6) , 2017 2017.0 Citations: 5
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002_Nirmalraj et al_2015. pdf M Mahendrakumar
MOST CITED SCHOLAR PUBLICATIONS
Biofertilizing efficiency of Sargassum polycystum extract on growth and biochemical composition of Vigna radiata and Vigna mungo B Bharath, S Nirmalraj, M Mahendrakumar, K Perinbam Asian Pacific Journal of Reproduction 7 (1), 27-32 , 2018 2018.0 Citations: 44
Biobutanol preparation through sugar-rich biomass by Clostridium saccharoperbutylacetonicum conversion using ZnO nanoparticle catalyst M Mani Biomass Conversion and Biorefinery , 2022 2022.0 Citations: 34
Intelligent pH Indicative Film from Plant‐Based Extract for Active Biodegradable Smart Food Packing K Subramanian, H Logaraj, V Ramesh, M Mani, K Balakrishnan, ... Journal of Nanomaterials 2022 (1), 4482114 , 2022 2022.0 Citations: 31
Phytobiome engineering and its impact on next-generation agriculture B Kumari, M Mani, AC Solanki, MK Solanki, A Hora, MA Mallick Phytobiomes: current insights and future vistas, 381-403 , 2020 2020.0 Citations: 28
Applying nanotechnology to bacteria: an emerging technology for sustainable agriculture B Kumari, MA Mallick, MK Solanki, A Hora, M Mani Role of plant growth promoting microorganisms in sustainable agriculture and … , 2019 2019.0 Citations: 19
Antibacterial and anti-inflammatory activity of Justicia gendarussa Burm. f. leaves S Nirmalraj, M Ravikumar, M Mahendrakumar, B Bharath, K Perinbam Journal of Plant Sciences 10 (2), 70 , 2015 2015.0 Citations: 19
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Green Preparation of Bract Extract (Musa acuminate) Doped Magnesium Oxide Nanoparticles and Their Bio Efficacy S Jayashree, SA Sharmili, S Roshitha, R Balaji, M Mahendrakumar, ... Applied Organometallic Chemistry, 1-15 , 2023 2023.0 Citations: 7
Symbiotic microbial interactions in fish gut K Subramanian, M Mahendrakumar, K Elumalai, SR Pugazhvendan, ... Microbial Symbionts, 521-531 , 2023 2023.0 Citations: 7
Hypericin, an anthraquinone derivative of Hypericum hookerianum wight and Arn.(Hypericaceae) of Palni Hills, South India, exhibits anti-inflammatory property in … Mahendrakumar, S M, Seeni, K Perinbam Pharmacognosy Magazine 14 (56), 378 , 2018 2018.0 Citations: 6
Whole cell protein profiling of human pathogenic bacteria isolated from clinical samples M Mahendrakumar, MA Sheriff Asian Journal of Scientific Research 8 (3), 374 - 380 , 2015 2015.0 Citations: 6
Pharmacognostic, Phytochemical and Physicochemical Investigations of Hypericum hookerianum Wight & Arn.(Hypericaceae) of Palni Hills, India. M Mahendrakumar, S Nirmalraj, M Ravikumar, B Bharath, S Seeni, ... Pharmacognosy Journal 9 (6) , 2017 2017.0 Citations: 5
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Eco-Friendly Control of Disease-Transmit Mosquito Vectors using the Mosquito Fish Gambusia Affinis and Low Dosages of Mukia Maderaspatana Extracts S Deepa Rani, R Abiramy Neveda, T, N Shettu, M Mahendrakumar, ... Journal of Chemical Health Risks 15 (1), 874-891 , 2025 2025.0
An Introductory Assessment on Computational Algorithm in Initial Finding of COVID-19 Cases M Mahendrakumar IEEE, 472-477 , 2022 2022.0
Controlling potential of Singapore Daisy (Sphagneticola trilobata) against Bruchid Weevil Callosobruchus maculatus (Fab.) (Coleoptera: Bruchidae) K Mahendrakumar M, Medona L and Elumalai Journal of the Maharaja Sayajirao University of Baroda 55 (1(VI)), 416-436 , 2021 2021.0
Role of Higher Education System for Promoting Sustainable Human Competence M M, S Paliwal Guru Nanak Journal of Multi-Disciplinary Research (GNJMDR) 1 (Special Issue … , 2020 2020.0
Hypericum hookerianum (Wight and Arn.) as a Potential Bio-Pesticide to Control Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) M M, E K Asian Journal of Agricultural Research 14 (2), 34-40 , 2020 2020.0
