Cancer Research, General Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Plant Science
21
Scopus Publications
Scopus Publications
Nanotechnology-enhanced Natural Products for Cancer Chemoprevention: Molecular Mechanisms and Clinical Translation Rajat Nath, Sibashish Kityania, Deepa Nath, Jayanta Kumar Patra, Emran Habibi, Satyajit D. Sarker, Anupam Das Talukdar, Lutfun Nahar AAPS Journal, 2026 Cancer remains a major global health challenge. Natural compounds, such as curcumin, resveratrol, genistein, thymoquinone, and paclitaxel, show chemopreventive activity by modulating signaling pathways, including PI3K/Akt, NF-κB, and p53. These agents also promote apoptosis, autophagy, and DNA repair. However, their clinical use is restricted by poor solubility, instability, and low bioavailability. Nanotechnology offers solutions by improving stability, enhancing pharmacokinetics, and enabling targeted delivery. Liposomes, polymeric nanoparticles, dendrimers, and albumin-bound systems amplify the anticancer effects of natural compounds. Preclinical studies confirm improved efficacy, while early clinical trials reveal both promise and barriers. The key translational challenges include immune clearance, large-scale reproducibility, and regulatory approval. This review highlights the synergy between nanotechnology and natural compounds in cancer chemoprevention and outlines opportunities for future research.
Concept of Metabolites Fingerprinting Rupshikha Nath, Sibashish Kityania, Rajat Nath, Deepa Nath, Anupam Das Talukdar Exploring Plant Stress Tolerance A Metabolomics Approach, 2026 Metabolite fingerprinting, a subfield of metabolomics, has become an effective tool for characterizing the dynamic metabolic profiles of biological systems. Metabolomics, the investigation of metabolites of very small molecules, plays a pivotal role in understanding cellular metabolism and its alterations in different physiological and pathological circumstances. Metabolite fingerprinting involves the qualitative and quantitative analysis of these metabolites to generate unique metabolic profiles, akin to fingerprints, which reflect the underlying biochemical processes within a biological system. The use of advanced analytical techniques, such as mass spectrometry, liquid chromatography, and nuclear magnetic resonance spectroscopy, has significantly enhanced the scope and accuracy of metabolite fingerprinting. By comparing metabolic profiles between healthy and diseased individuals or different disease stages, unique metabolite signatures associated with specific conditions can be uncovered. Metabolic signatures offer insights into disease pathogenesis, helping to find possible drug targets and making it easier to create cutting-edge treatment approaches. Metabolite fingerprinting faces challenges in standardization, data processing, interpretation, and combining methods from systems biology and multi-omics. Metabolite fingerprinting has the potential to revolutionize the identification of illness biomarkers, deepen our understanding of biological mechanisms, and enhance human health.
Computational Study on Antheraea assamensis Helfer Metabolites: Targeting FGFR, EGFR, mTOR, and VEGFR1 for Cancer Therapy Deepshikha Buragohain, Sibashish Kityania, Rajat Nath, Erom Romi Singha, Anupam Das Talukdar, Anirudha Giri Current Bioactive Compounds, 2026 Aim: Cancer, characterized by uncontrolled cell growth, poses global health challenges, while natural bioactive compounds offer a cost-effective and less toxic alternative by targeting cancer pathways. This current study aims to identify potential bioactive compounds from silk warm pupa and screen their bioactivity against various cancers through in-silico approaches. Background: Cancer, a disease with substantial worldwide health consequences, is driven by the uncontrolled division and spread of cells. A combination of genetics, environmental factors, and personal lifestyle choices influences its development. Cancer remains a significant global health challenge, driving the need for new therapeutic compounds. Antheraea assamensis Helfer, an edible insect, contains bioactive compounds that may provide a natural approach to reducing cancer progression through dietary intake. Rich in proteins, fatty acids, and bioactive compounds, this insect shows promise in its anti-inflammatory and antioxidant properties. Objective: Currently, available cancer medications are often associated with a range of side effects. Plant-derived compounds present a promising alternative for cancer treatment, offering the potential for fewer side effects. This research aims to identify the most effective bioactive lead molecule for future drug development in the fight against various types of cancer. Methods: To evaluate the therapeutic potential of metabolites from Antheraea assamensis Helfer, various in-silico techniques were used. Molecular docking analysis were conducted to assess the binding affinity and stability of the compounds with cancer-related targets such as EGFR, FGFR, VEGFR1, and mTOR, revealing their inhibitory potential. ADMET analysis predicted the pharmacokinetic properties, including absorption, toxicity, and drug-likeness. In contrast, QSAR analysis forecasted the biological activity of the compounds, helping to quantify their effectiveness in triggering specific biological responses. Results: The molecular docking studies showed promising results, with several bioactive compounds from Antheraea assamensis Helfer exhibiting strong binding affinities to EGFR, FGFR, VEGFR1, and mTOR, suggesting significant inhibitory potential against these cancer-related targets. ADMET analysis further supported these findings by indicating favorable pharmacokinetic properties, such as good absorption, low toxicity, and minimal risk of side effects. QSAR analysis predicted high biological activity for the compounds, reinforcing their potential as effective anticancer agents. Conclusion: The study identifies Antheraea assamensis Helfer as a significant source of bioactive agents like 2-(Dimethylamino) ethyl (9Z,12Z)-octadeca-9,12-dienoate, Echinulin, and Phorbol 12-tiglate 13-decanoate, with promising anticancer activity. In-silico analysis indicates these compounds could inhibit key cancer-related targets like EGFR, FGFR, VEGFR1, and mTOR. Further in-vitro and experimental studies are needed to validate their therapeutic efficacy and safety.
Plant Metabolome Databases Shabana Begum, Sibashish Kityania, Rajat Nath, Deepa Nath, Pranab Behari Mazumder, Anupam Das Talukdar Exploring Plant Stress Tolerance A Metabolomics Approach, 2026 Plant metabolomics has come to the forefront as a crucial methodology for comprehending plant metabolism, physiology, and molecular biology. Investigating plant metabolic pathways in response to diverse environmental conditions is facilitated through the utilization of plant metabolomics databases. These information repositories provide comprehensive insight into a plant’s metabolic processes, activities, and products, encompassing intricate details about the enzymes involved, metabolites generated, and the activated metabolic pathways that contribute to the plant’s metabolic functionality. Plant metabolomic datasets have greatly facilitated the study of plant metabolism and the development of various innovative technologies. Some of the well-known plant metabolomics databases are PlantGDB, PMDB (plant metabolome databases), Plant Metabolic Network (PMN), MeRy-B, RIKEN Plant Metabolome Meta Database (RIKEN PMN), AraCyc, etc. The databases enable researchers to analyze the metabolic pathways of plants in response to various environmental situations and recognize and quantify metabolites and associated pathways. These databases provide helpful information on plant metabolism’s activities, processes, and outcomes. The availability of these databases has helped develop a number of cutting-edge technologies, provided researchers with insight into plant evolution and can help researchers find new treatments and therapies and understand the mechanism underpinning plant adaptation.
Identification of RAGE Inhibitors from Curcuma caesia Roxb: Implications in Treatment against Diabetic Complications Priyakshi Nath, Anil K. Pasupulati, Rupshikha Nath, Rajat Nath, Mriganka Das, Deepa Nath, Jagajjit Sahu, Sibashish Kityania, Anupam Das Talukdar Current Diabetes Reviews, 2026 Introduction: Diabetic nephropathy (DN) is a progressive renal complication that significantly contributes to end-stage renal disease. Hyperglycaemia contributes to the formation of advanced glycation end-products (AGEs). The interaction between AGEs and their receptor (RAGE) plays a key role in the progression of DN. RAGE activation increases oxidative stress and promotes inflammation, thereby evoking cellular and molecular damage. Together, these events result in kidney injury and varying degrees of proteinuria. This study aims to evaluate the drug-like properties of potential natural compounds derived from Curcuma caesia and their potential effectiveness against DN. Methods: This study investigates the antioxidant properties of Curcuma caesia (CC) rhizome extracts, alongside in silico methodologies including molecular docking, QSAR, and ADMET analysis to identify potential metabolites. Results: In this study, we examined the potential of phytochemicals identified from the rhizome extracts of Curcuma caesia (CC) that may mimic AGEs and inhibit RAGE activation. We assessed whether these phytochemicals could prevent ROS accumulation and inflammation, thereby providing renoprotection in a diabetic milieu. Using molecular docking and ADMET analysis, we identified two compounds, Lappaol A and Piperaduncin B, in the methanolic extract of CC, which demonstrated a stronger affinity for interacting with RAGE than the AGE compound MODIC and the RAGE inhibitor Azeliragon. Discussion: Since the interaction between AGEs and RAGE contributes to major pathological events in the development of DN, inhibiting this interaction could be a valuable therapeutic strategy against DN and other AGE-mediated pathologies such as retinopathy and neuropathy. Virtual screening of the identified compounds revealed that Lappaol A and Piperaduncin B effectively bind to RAGE and may interrupt RAGE activation, thereby potentially slowing the progression of DN. Conclusion: These natural compounds exhibited promising drug-like characteristics against the target protein RAGE and may serve as lead compounds for the development of RAGE inhibitors. The study recommends further in vitro and in vivo investigations to assess the therapeutic potential of these identified compounds in the treatment of diabetic nephropathy.
Design and Applications of Bioplastics in the Industry Sibashish Kityania, Rupshikha Nath, Rajat Nath, Deepa Nath, Anupam Das Talukdar Bioplastics Synthesis Characterization and Applications, 2025 Bioplastics are a sustainable replacement to mitigate the harmful impact of conventional plastic on the environment. In the modern era, the craze for the usage of bioplastics is at another level, as they have less harmful effects and retention in nature. Bioplastics are mainly produced from renewable bioresources such as algae, starch, cellulose-based plant material, seaweeds, and sometimes from the waste of bioresources such as potato peels, and so on. Such resources are extracted from nature and then processed through a series of steps, such as pre-treatment mechanisms, addition, and removal of the required compounds through engineering. Afterward, the compounds are examined by analyzing their potential properties, such as mechanical strength, durability, degradability, thermal stability, solubility, absorption by plants, and many others. Bioplastics have different properties; they may be flexible, printable, transparent, and 66heat-resistant, which has made it possible to choose them as raw materials for the large-scale production of sustainable, durable, and non-toxic products. They are widely used for the preparation of medical devices, stitches, dental implants, and tablet containers. Moreover, they are used in the aerospace industry for the preparation of low-weight, thermostable, sustainable vehicles, and in the cosmetics industry for packaging products without degrading their quality. In the food industry, they are used for the packaging of various food products, and in many other industries such as sports, electronics, building and construction, and so on. Nowadays, the production of biomethane and biogas by anaerobic digestion of bioplastics is one of the research perspectives.
Market Value and Demand for Bioplastics Sharmistha Sharma, Rajat Nath, Sibashish Kityania, Deepa Nath, Anupam Das Talukdar Bioplastics Synthesis Characterization and Applications, 2025 Non-biodegradable petroleum plastics exacerbate the tremendous impacts, including global warming, accumulation of marine debris, harming flora, fauna, and habitats, and when they enter the food web, they cause biomagnification, and so on. To mitigate this and rely upon a sustainable solution, ‘bioplastics’ are introduced into the market. The global bioplastic market grows at a rate of 20% to 25% annually. The global market size for bioplastics was 11.2 billion USD in 2021 and is expected to reach 46.1 billion USD by 2023. The compound annual growth rate (CAGR) is about 17.02% between 2022 and 2023. The Asia Pacific market is growing by around 13.5% CAGR in the upcoming years. Key market players like Nestlé, Nike, and Coca-Cola are investing in the manufacture of bioplastics for a wide range of applications. Bioplastics are used in goods like POS terminals and LCD projectors by companies such as NEC Corporation. 248They also act as good materials for organic farming. Global market share states that about 60% of total bioplastic production is used in the packaging industry, the textile industry uses 10%, transport and consumer goods share an equal amount of 7%, while the electronic sector uses about 2%. Demand for bioplastics can be observed in the packaging sector, catering items, toys, textiles, agriculture, and horticulture. The packaging sector is the largest contributor to the bioplastic market, accounting for 48% of the entire bioplastic market in 2021. It has the power to mitigate the overburdened waste management system, but it has to overcome some hurdles to make this field accessible and economically feasible.
Endophytic Fungi Interactions with Plants Priyakshi Nath, Sibashish Kityania, Rajat Nath, Deepa Nath, Anupam Das Talukdar Fungal Endophytes Volume I Biodiversity and Bioactive Materials, 2025
Foliar Endophytic Fungi: Interactions and Importance Rupshikha Nath, Jayeeta Mitra, Sibashish Kityania, Rajat Nath, Deepa Nath, Anupam Das Talukdar Fungal Endophytes Volume I Biodiversity and Bioactive Materials, 2025
Bioactive Compounds from Bryophytes Kakoli Das, Sibashish Kityania, Rajat Nath, Subrata Das, Deepa Nath, Anupam Das Talukdar Reference Series in Phytochemistry, 2023
