Marina Bellido

@icho.edu.pl

Postdoctoral researcher
Institute of Organic Chemistry, Polish Academy of Science

Marina Bellido


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https://researchid.co/marinabellido
7

Scopus Publications

75

Scholar Citations

4

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • MAdPHOS, a P-Stereogenic Aminodiphosphane Ligand with Adamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodium and Nickel Complexes
    Marina Bellido, Helena Solé-Àvila, Martí Sidro, Arnald Grabulosa, Xavier Verdaguer, Antoni Riera
    Journal of Organic Chemistry, 2025
    A novel chiral ligand, named MAdPHOS, bearing a P-stereogenic phosphane and a diadamantyl phosphane linked by a NH bridge has been synthesized. This bulky, C1-symmetric, PNP ligand has been prepared from enantiopure tert-butylmethyl aminophosphane and was obtained as a crystalline solid. The NH/PH tautomerism, air-stability, and σ-donor capacity of MAdPHOS have been assessed herein. The free ligand has been prepared, showing much higher stability, in the solid form, than its tert-butyl analogue MaxPHOS. Both rhodium and nickel COD complexes have been prepared. The Rh-MAdPHOS complex has shown outstanding enantioselectivities in the asymmetric hydrogenation of enamides.
  • Three-Component Palladium-Catalyzed Tandem Suzuki-Miyaura/Allylic Substitution: A Regioselective Synthesis of (2-Arylallyl) Aryl Sulfones
    Marina Bellido, Martí Garçon, Xavier Verdaguer, Antoni Riera
    Advanced Synthesis and Catalysis, 2024
    A one‐pot Pd‐catalyzed tandem process to prepare (2‐arylallyl) aryl sulfones has been developed. This strategy is based on the modular assembly of a boronic acid, a sodium sulfinate and 2‐bromoallyl acetate. The reaction is completely regioselective towards the terminal alkene, yielding (2‐arylallyl) aryl (or alkyl) sulfones with yields ranging from 56 to 93%. Control experiments together with DFT calculations allowed to propose a plausible reaction mechanism of the tandem reaction. The usefulness of this methodology has been demonstrated with the formal synthesis of the marketed drug Apremilast and of several natural products by asymmetric hydrogenation. Using the commercially available UbaPHOX iridium complex, chiral β‐methyl sulfones with up to 98% ee were obtained
  • Regioselective Ring-Opening of Oxetanes Catalyzed by Lewis Superacid Al(C6F5)3
    Marina Bellido, Carlos Riego‐Mejías, Giuseppe Sciortino, Xavier Verdaguer, Agustí Lledós, Antoni Riera
    Advanced Synthesis and Catalysis, 2024
    This study details an aluminum‐catalyzed regioselective isomerization of 2,2‐disubstituted oxetanes to yield homoallylic alcohols. The reaction takes place in toluene at 40 °C, employing 1 mol % of Al(C6F5)3 as catalyst. This catalytic system shows a wide substrate scope (12 examples). The optimized conditions are especially useful for electron‐rich aryl oxetanes, completely suppressing the formation of allyl isomers and reducing the amount of the dimer by‐product. The synthetic applicability of the reported methodology is demonstrated by the enantioselective formal synthesis of curcuquinone and the σ1 receptor agonist RC‐33.
  • Enantioselective Ir-Catalyzed Hydrogenation of Terminal Homoallyl Sulfones: Total Synthesis of (−)-Curcumene
    Marina Bellido, Carlos Riego-Mejías, Alejandro Diaz-Moreno, Xavier Verdaguer, Antoni Riera
    Organic Letters, 2023
    A novel methodology for the preparation of chiral methyl benzylic compounds is reported. Terminal homoallyl sulfones were prepared from homoallyl alcohols, which are easily accessible through the recently reported Lewis acid isomerization of oxetanes. The iridium-catalyzed asymmetric hydrogenation of homoallylic sulfones afforded γ-chiral sulfones with excellent enantioselectivities (up to 98% ee). The synthetic potential of this novel methodology was demonstrated by the total synthesis of ( R )-(−)-curcumene.
  • Amino acids with fluorescent tetrazine ethers as bioorthogonal handles for peptide modification
    Enric Ros, Marina Bellido, Joan A. Matarin, Albert Gallen, Manuel Martínez, Laura Rodríguez, Xavier Verdaguer, Lluís Ribas de Pouplana, Antoni Riera
    Rsc Advances, 2022
    Octreotide derivatized with the fluorogenic amino acid 6-methyltetratrazinyl tryosine. Emission spectra before and after the iEDDA cycloaddition.
  • Direct and Enantioselective Aldol Reactions Catalyzed by Chiral Nickel(II) Complexes
    Stuart C. D. Kennington, Saul F. Teloxa, Miguel Mellado‐Hidalgo, Oriol Galeote, Sabrina Puddu, Marina Bellido, Pedro Romea, Fèlix Urpí, Gabriel Aullón, Mercè Font‐Bardia
    Angewandte Chemie International Edition, 2021
    A direct and asymmetric aldol reaction of N‐acyl thiazinanethiones with aromatic aldehydes catalyzed by chiral nickel(II) complexes is reported. The reaction gives the corresponding O‐TIPS‐protected anti‐aldol adducts in high yields and with remarkable stereocontrol and atom economy. Furthermore, the straightforward removal of the achiral scaffold provides enantiomerically pure intermediates of synthetic interest, which involve precursors for anti‐α‐amino‐β‐hydroxy and α,β‐dihydroxy carboxylic derivatives. Theoretical calculations explain the observed high stereocontrol.
  • Synthesis and Application of 3-Bromo-1,2,4,5-Tetrazine for Protein Labeling to Trigger Click-to-Release Biorthogonal Reactions
    Enric Ros, Marina Bellido, Xavier Verdaguer, Lluís Ribas de Pouplana, Antoni Riera
    Bioconjugate Chemistry, 2020
    3-Bromo-1,2,4,5-tetrazine has been synthesized in an oxidant- and metal-free method. The synthesis is scalable and relies on inexpensive starting materials. 3-Bromo-1,2,4,5-tetrazine can undergo nucleophilic aromatic substitutions with differently substituted heteroatoms under mild conditions. In particular, its excellent reactivity has been used to attain chemoselective protein labeling. The resulting labeled lysines can react with strained dienophiles to trigger fast click-to-release (CtR) biorthogonal reactions. The characterization of the CtR reaction in physiological conditions and a therapeutically relevant example with the monoclonal antibody Trastuzumab to showcase its application is presented. Finally, 3-bromo-1,2,4,5-tetrazine has been used to achieve site-selective protein labeling through the genetic incorporation of the first unnatural amino acid bearing an unsubstituted 1,2,4,5-tetrazin-3-yl functionality, which can also undergo CtR reactions.

RECENT SCHOLAR PUBLICATIONS

  • MAdPHOS, a P‑Stereogenic Aminodiphosphane Ligand withAdamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodiumand Nickel Complexes.
    M Bellido, H Solé Àvila, M Sidro Inglés, A Grabulosa, ...
    American Chemical Society , 2025
    2025
  • MAdPHOS, a P-Stereogenic Aminodiphosphane Ligand with Adamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodium and Nickel Complexes
    M Bellido, H Solé-Àvila, M Sidro, A Grabulosa, X Verdaguer, A Riera
    The Journal of Organic Chemistry 90 (5), 1794-1800 , 2025
    2025
    Citations: 1
  • Three‐Component Palladium‐Catalyzed Tandem Suzuki‐Miyaura/Allylic Substitution: A Regioselective Synthesis of (2‐Arylallyl) Aryl Sulfones
    M Bellido, M Garçon, X Verdaguer, A Riera
    Advanced Synthesis & Catalysis 366 (12), 2791-2800 , 2024
    2024
    Citations: 4
  • Regioselective Ring‐Opening of Oxetanes Catalyzed by Lewis Superacid Al(C 6 F 5 ) 3
    M Bellido, C Riego‐Mejías, G Sciortino, X Verdaguer, A Lledós, A Riera
    Advanced Synthesis & Catalysis 366 (4), 925-933 , 2024
    2024
    Citations: 4
  • Regioselective Ring-Opening of Oxetanes Catalyzed by Lewis Superacid
    M Bellido, C Riego Mejías, G Sciortino, X Verdaguer i Espaulella, ...
    Wiley-VCH , 2024
    2024
  • Enantioselective Ir-catalyzed hydrogenation of terminal homoallyl Sulfones: total synthesis of (−)-curcumene
    M Bellido, C Riego-Mejías, A Diaz-Moreno, X Verdaguer, A Riera
    Organic Letters 25 (9), 1453-1457 , 2023
    2023
    Citations: 10
  • Heuristics and serendipity in synthetic methodologies
    M Bellido, X Verdaguer, A Riera
    of Pre-doctoral Researchers , 2023
    2023
  • Amino acids with fluorescent tetrazine ethers as bioorthogonal handles for peptide modification
    E Ros, M Bellido, JA Matarin, A Gallen, M Martínez, L Rodríguez, ...
    RSC advances 12 (23), 14321-14327 , 2022
    2022
    Citations: 3
  • Direct and enantioselective aldol reactions catalyzed by chiral Nickel (II) complexes
    SCD Kennington, SF Teloxa, M Mellado‐Hidalgo, O Galeote, S Puddu, ...
    Angewandte Chemie 133 (28), 15435-15440 , 2021
    2021
    Citations: 17
  • Chiral Bidentate Heterodonor PN-Other-Ligands
    P Rojo, M Bellido, X Verdaguer, A Riera
    Chiral Ligands, 33-80 , 2021
    2021
  • Synthesis and application of 3-bromo-1, 2, 4, 5-tetrazine for protein labeling to trigger click-to-release biorthogonal reactions
    E Ros, M Bellido, X Verdaguer, L Ribas de Pouplana, A Riera
    Bioconjugate Chemistry 31 (3), 933-938 , 2020
    2020
    Citations: 36

MOST CITED SCHOLAR PUBLICATIONS

  • Synthesis and application of 3-bromo-1, 2, 4, 5-tetrazine for protein labeling to trigger click-to-release biorthogonal reactions
    E Ros, M Bellido, X Verdaguer, L Ribas de Pouplana, A Riera
    Bioconjugate Chemistry 31 (3), 933-938 , 2020
    2020
    Citations: 36
  • Direct and enantioselective aldol reactions catalyzed by chiral Nickel (II) complexes
    SCD Kennington, SF Teloxa, M Mellado‐Hidalgo, O Galeote, S Puddu, ...
    Angewandte Chemie 133 (28), 15435-15440 , 2021
    2021
    Citations: 17
  • Enantioselective Ir-catalyzed hydrogenation of terminal homoallyl Sulfones: total synthesis of (−)-curcumene
    M Bellido, C Riego-Mejías, A Diaz-Moreno, X Verdaguer, A Riera
    Organic Letters 25 (9), 1453-1457 , 2023
    2023
    Citations: 10
  • Three‐Component Palladium‐Catalyzed Tandem Suzuki‐Miyaura/Allylic Substitution: A Regioselective Synthesis of (2‐Arylallyl) Aryl Sulfones
    M Bellido, M Garçon, X Verdaguer, A Riera
    Advanced Synthesis & Catalysis 366 (12), 2791-2800 , 2024
    2024
    Citations: 4
  • Regioselective Ring‐Opening of Oxetanes Catalyzed by Lewis Superacid Al(C 6 F 5 ) 3
    M Bellido, C Riego‐Mejías, G Sciortino, X Verdaguer, A Lledós, A Riera
    Advanced Synthesis & Catalysis 366 (4), 925-933 , 2024
    2024
    Citations: 4
  • Amino acids with fluorescent tetrazine ethers as bioorthogonal handles for peptide modification
    E Ros, M Bellido, JA Matarin, A Gallen, M Martínez, L Rodríguez, ...
    RSC advances 12 (23), 14321-14327 , 2022
    2022
    Citations: 3
  • MAdPHOS, a P-Stereogenic Aminodiphosphane Ligand with Adamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodium and Nickel Complexes
    M Bellido, H Solé-Àvila, M Sidro, A Grabulosa, X Verdaguer, A Riera
    The Journal of Organic Chemistry 90 (5), 1794-1800 , 2025
    2025
    Citations: 1
  • MAdPHOS, a P‑Stereogenic Aminodiphosphane Ligand withAdamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodiumand Nickel Complexes.
    M Bellido, H Solé Àvila, M Sidro Inglés, A Grabulosa, ...
    American Chemical Society , 2025
    2025
  • Regioselective Ring-Opening of Oxetanes Catalyzed by Lewis Superacid
    M Bellido, C Riego Mejías, G Sciortino, X Verdaguer i Espaulella, ...
    Wiley-VCH , 2024
    2024
  • Heuristics and serendipity in synthetic methodologies
    M Bellido, X Verdaguer, A Riera
    of Pre-doctoral Researchers , 2023
    2023
  • Chiral Bidentate Heterodonor PN-Other-Ligands
    P Rojo, M Bellido, X Verdaguer, A Riera
    Chiral Ligands, 33-80 , 2021
    2021