Oxana Klementieva
@lu.se
Lunds universitet
Scopus Publications
- ATR-FTIR analysis of temperature-dependent changes in extracellular vesicles and associated released components
Kar-Yan Su, Oxana Klementieva, Wai-Leng Lee, Siong Fong Sim, Laura-Madalina Lixandru, et al.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2026 - Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease
Violeta Chițu, Julia Alvarenga, Wenna Chen, David Reynolds, Yang Liu, et al.
Journal of Clinical Investigation, 2026
Dominant-inactivating mutations in the colony stimulating factor-1 receptor ( CSF1R ) cause CSF-1R–related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r +/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r +/– mice without pathological or behavioral alterations. Reduction of CSF-1R signaling caused metal ion accumulation in brain macrophages, with concomitant activation of cell death and stress response pathways in oligodendrocytes and neuronal subpopulations. Reduction of metallothionein 1 ( Mt1 ) and 3 ( Mt3 ) gene expression was a common feature in glial and neuronal cells of Csf1r +/– mice. Overexpression of Mt1 restored metal ion homeostasis, normalized ROS production in microglia, and prevented the development of behavioral deficits, while Mt3 deletion had disease-enhancing effects. These findings demonstrate CSF-1R regulation of metal ion homeostasis via metallothioneins in the brain. - Polystyrene nanoplastic exposure promotes amyloid misfolding and metabolic impairment at sublethal doses. A subcellular infrared imaging study
Iran Augusto Neves da Silva, Agnes Paulus, Valeriia Skoryk, Kar-Yan Su, Fátima Herranz-Trillo, et al.
Environmental Science Nano, 2026
Sub-diffraction O-PTIR imaging reveals that polystyrene nanoplastics penetrate cells and promote pathological amyloid-β misfolding at sublethal doses. - Mid-Infrared Photothermal Mesoscopy with Millimeter Field of View and Sub-micron Spatial Resolution
Rong Tang, Jiaze Yin, Bethany Weinberg, Haonan Lin, Jiahui Lu, et al.
Progress in Biomedical Optics and Imaging Proceedings of SPIE, 2026 - A distinct lineage pathway drives parvalbumin chandelier cell fate in human interneuron reprogramming
Christina A. Stamouli, Alexander Degener, Efrain Cepeda-Prado, Andreas Bruzelius, Emil Andersson, et al.
Science Advances, 2026
Direct lineage reprogramming of glial cells to induced neurons has the potential for restoring brain circuits and function in neuronal disorders and states. We introduce three-dimensional (3D) human glia reprogramming into neurons with a GABAergic interneuron phenotype using stem cell–derived human glia. Single-nucleus RNA sequencing of the converted cells demonstrates distinct neuronal clusters within 2 weeks, including a parvalbumin (PV) cluster with high neuronal maturity and features of chandelier interneurons. A lineage trajectory analysis of the glia-to-neuron conversion reveals a distinct lineage pathway to PV chandelier fate, including various neuronal developmental stages and the establishment of synaptic machinery. This analysis reveals PV fate-important genes that are previously unknown to neural reprogramming with promising functional importance for future derivations. Our data demonstrate successful human glia conversion into interneurons with features of bona fide PV subtype and highlight the reprogramming trajectory with key transitional genes. This advancement holds promise for future human brain cell engineering and repair. - Strain-Distinct α-Synuclein and Tau Cross-Seeding Uncovered by Correlative Approach with Optical Photothermal Infrared Sub-Micron Imaging
Xiaoni Zhan, Wen Li, Eric Hatterer, Jean-Philippe Courade, Kristin Piché, et al.
Journal of the American Chemical Society, 2025 - Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons[Figure presented]
Emma Nyberg, Sabine C. Konings, Nils Lindblom, Bodil Israelsson, Oxana Klementieva, et al.
Journal of Biological Chemistry, 2025 - Molecular architectures of glycosylated dendronized bottle brushes in action: Biocompatibility and anti-amyloidogenic activity of pseudo-glycodendrimers
Tom Kösterke, Radika Thakore, Silvia Moreno, Jan Skov Pedersen, Brigitte Voit, et al.
Materials Today Bio, 2025 - Erratum: Correction: Apolipoprotein E intersects with amyloid-β within neurons (Life science alliance (2023) 6 8 PII: e202402875 DOI: 10.26508/lsa.202201887)
Sabine C Konings, Emma Nyberg, Isak Martinsson, Laura Torres-Garcia, Oxana Klementieva, et al.
Life Science Alliance, 2024
Apolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes-autophagosomes of neurites and modulate intraneuronal amyloid-β-42. - Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
Ana M. Espinosa‐Oliva, Rocío Ruiz, Manuel Sarmiento Soto, Antonio Boza‐Serrano, Ana I. Rodriguez‐Perez, et al.
Neuropathology and Applied Neurobiology, 2024
AimsAccording to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α‐synuclein (α‐syn) in the gastrointestinal tract and midbrain dopaminergic neurons.MethodsWe have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS‐based rat model of gut inflammation in terms of α‐syn pathology.ResultsOur data support the existence of pathogenic α‐syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS‐based rat model of gut inflammation to demonstrate (i) the appearance of P‐α‐syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α‐syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD.ConclusionThese results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut‐brain axis in initiating α‐syn aggregation and transport to the substantia nigra, resulting in neurodegeneration. - Bioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation
Manoj Puthia, Jitka Petrlova, Ganna Petruk, Marta Butrym, Firdaus Samsudin, et al.
Advanced Healthcare Materials, 2023 - Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, et al.
Acta Neuropathologica Communications, 2023 - Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer's disease-transgenic mice
M.G. Garcia, A. Paulus, S. Vázquez-Reyes, O. Klementieva, G.K. Gouras, et al.
Brain Behavior and Immunity Health, 2023 - Apolipoprotein E intersects with amyloid-β within neurons
Sabine C Konings, Emma Nyberg, Isak Martinsson, Laura Torres-Garcia, Oxana Klementieva, et al.
Life Science Alliance, 2023 - Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
Juan García-Revilla, Antonio Boza-Serrano, Yiyun Jin, Devkee M. Vadukul, Jesús Soldán-Hidalgo, et al.
Acta Neuropathologica, 2023 - Erratum: Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, et al.
Stem Cell Reports, 2023 - Fluorescently Guided Optical Photothermal Infrared Microspectroscopy for Protein-Specific Bioimaging at Subcellular Level
Craig Prater, Yeran Bai, Sabine C. Konings, Isak Martinsson, Vinay S. Swaminathan, et al.
Journal of Medicinal Chemistry, 2023 - Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos
Nika Gvazava, Sabine C. Konings, Efrain Cepeda-Prado, Valeriia Skoryk, Chimezie H. Umeano, et al.
Journal of the American Chemical Society, 2023 - Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases
Miriam Solomon, Vito Foderà, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, et al.
Journal of Translational Medicine, 2022 - Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, et al.
Journal of Neuroinflammation, 2022 - Correlative imaging to resolve molecular structures in individual cells: Substrate validation study for super-resolution infrared microspectroscopy
Agnes Paulus, Sahana Yogarasa, Mustafa Kansiz, Isak Martinsson, Gunnar K. Gouras, et al.
Nanomedicine Nanotechnology Biology and Medicine, 2022 - Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein–induced changes in maturation and immune reactive properties
Carla Azevedo, Gabriel Teku, Yuriy Pomeshchik, Juan F. Reyes, Margarita Chumarina, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022 - The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
Nadja Gustavsson, Ekaterina Savchenko, Oxana Klementieva, Laurent Roybon
Acta Neuropathologica Communications, 2021 - Correlative optical photothermal infrared and X-ray fluorescence for chemical imaging of trace elements and relevant molecular structures directly in neurons
Nadja Gustavsson, Agnes Paulus, Isak Martinsson, Anders Engdahl, Kadda Medjoubi, et al.
Light Science and Applications, 2021 - Erratum: Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, et al.
Stem Cell Reports, 2021
