Nguyen Manh Cuong

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Department of Bioactive Products
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology



Phytochemistry (isolation and structural elucidation of natural compounds), semisynthesis of natural compounds, pharmaceutical and medicinal chemistry


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Scopus Publications

  • Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
    Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Yoshiyasu Fukuyama, Amer Ahmed, Simona Saponara, Alfonso Trezza, Beatrice Gianibbi, Ginevra Vigni, Ottavia Spiga, and Fabio Fusi

    Molecules (Basel, Switzerland), eISSN: 14203049, Published: 14 July 2022 MDPI AG
    Hypertension is a risk factor for cardiovascular diseases, which are the main cause of morbidity and mortality in the world. In the search for new molecules capable of targeting KCa1.1 and CaV1.2 channels, the expression of which is altered in hypertension, the in vitro vascular effects of a series of flavonoids extracted from the heartwoods, roots, and leaves of Dalbergia tonkinensis Prain, widely used in traditional medicine, were assessed. Rat aorta rings, tail artery myocytes, and docking and molecular dynamics simulations were used to analyse their effect on these channels. Formononetin, orobol, pinocembrin, and biochanin A showed a marked myorelaxant activity, particularly in rings stimulated by moderate rather than high KCl concentrations. Ba2+ currents through CaV1.2 channels (IBa1.2) were blocked in a concentration-dependent manner by sativanone, 3′-O-methylviolanone, pinocembrin, and biochanin A, while it was stimulated by ambocin. Sativanone, dalsissooside, and eriodictyol inhibited, while tectorigenin 7-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside], ambocin, butin, and biochanin A increased IKCa1.1. In silico analyses showed that biochanin A, sativanone, and pinocembrin bound with high affinity in target-sensing regions of both channels, providing insight into their potential mechanism of action. In conclusion, Dalbergia tonkinensis is a valuable source of mono- and bifunctional, vasoactive scaffolds for the development of novel antihypertensive drugs.

  • Trace detection of ciprofloxacin antibiotic using surface-enhanced Raman scattering coupled with silver nanostars
    Vu Thi Thu, Nguyen Manh Cuong, Dao Tran Cao, Luu Tien Hung, and Luong Truc-Quynh Ngan

    Optik, ISSN: 00304026, Volume: 260, Published: June 2022 Elsevier BV

  • Bergera unifolia (Rutaceae), A New Species from Guangxi (China) Based on Morphological and Molecular Data
    Chong-Ling Deng, Chuan-Wu Chen, Xiao-Xiao Wu, Nguyen Manh Cuong, and Feng-Juan Mou

    Annales Botanici Fennici, ISSN: 00033847, Issue: 4-6, Pages: 363-376, Published: 1 November 2021 Finnish Zoological and Botanical Publishing Board
    A new species, Bergera unifolia C.L. Deng & F.J. Mou (Rutaceae, Aurantioideae, Clauseneae) is described and illustrated from Dahua County, Guangxi Province, China, based on morphological characters as well as on nrDNA (ITS) and cpDNA (trnL-F, atpB-rbcL, rbcL, matK, psbH-petB and psbA-trnH) sequences. It is characterised by unifoliate leaves similar to those of Murraya stenocarpa (Murraya sect. Bergera, or Chalcas sect. Bergera) but differs from it by having smaller and thinner subcoriaceous leaflets with irregularly toothed margins. The leaflets resemble those of M. kwangsiensis (Murraya sect. Bergera) in having hairs under the leaflets, oil glands and similar odour. Based on molecular data, B. unifolia is closely related to M. stenocarpa and M. kwangsiensis and thus it is important for resolving the classification of those species within Murraya sect. Bergera that should be formally transferred to Bergera.

  • Direct detection of melamine in liquid milk and infant formula using surface-enhanced Raman scattering combined with silver nanodendrites
    Nguyen Manh Cuong, Dao Tran Cao, Vu Thi Thu, and Luong Truc-Quynh Ngan

    Optik, ISSN: 00304026, Volume: 243, Published: October 2021 Elsevier BV
    Abstract In this report, we present the use of surface-enhanced Raman scattering (SERS) in combination with the silver nanodendrites (AgNDs) for direct detection of melamine at low concentrations in liquid milk and infant formula. The fern-like AgNDs were electrochemically deposited onto the surface of silicon. The results showed that the molecular fingerprints of melamine in liquid milk and infant formula could be directly detected with the limit of detection (LOD) as low as 0.1 mg/L in liquid milk and 0.02 mg/L in infant formula without the need for the extraction procedure. A good linear relationship between melamine SERS intensity (at 682 cm−1) and concentration of melamine in liquid milk and infant formula was obtained with the correlation coefficient (R2) reaches 0.9914 and 0.9952, respectively. These results suggest that SERS is a promising analytical method for application in food safety and environmental monitoring.

  • Chemical Composition of Essential Oils from the Leaves, Stems and Roots of Aristolochia petelotii O.C. Schmidt Growing in Vietnam
    Nguyen Quoc Binh, Nguyen Thanh Tung, Nguyen Phuong Hanh, Luu Hong Truong, Nguyen Hieu Cuong, Kieu Thi Hoai, Nguyen Viet Than, and Ain Raal

    Journal of Essential Oil-Bearing Plants, ISSN: 0972060X, Pages: 983-989, Published: 2021 Informa UK Limited

  • Soluble epoxide hydrolase inhibitors from Docynia indica (Wall.) Decne.
    Le Xuan Duy, Vinh Le Ba, Dan Gao, Vu Dinh Hoang, Tran Quoc Toan, Seo Young Yang, Dao Duy Quang, Young Ho Kim, and Nguyen Manh Cuong

    Natural Product Research, ISSN: 14786419, eISSN: 14786427, Pages: 5403-5408, Published: 2021 Informa UK Limited
    Nine bioactive compounds, including one new dihydroisocoumarin glycoside, 3S-thunberginol C 6-O-β-D-glucopyranoside (1a/1b), were isolated by chromatographic separation from the fruits of the Vietnamese medicinal plant Docynia indica (Wall.) Decne. 3S-thunberginol C 6-O-β-D-glucopyranoside was determined as a mixture of boat-like conformers based on NMR evidence and density functional theory (DFT) calculations. The in vitro inhibition of soluble epoxide hydrolase (sEH) by the isolated compounds was comparable to that of AUDA (positive control), yielding IC50 values ranging from 10.0 ± 0.6 to 88.4 ± 0.2 µM. Among isolated compounds, 3-methoxy-4-hydroxy-benzoic acid (7) and 2',6'-dihydroxy 3',4'-dimethoxychalcone (9) were identified as a potent inhibitor of sEH, with IC50 values of 19.3 ± 2.2 and 10.0 ± 0.6 mM, respectively. These results suggest that the fruits of D. indica may be useful as daily supplements for the prevention of cardiovascular and other sEH-related diseases.[Formula: see text].

  • Cytotoxic constituents from Isotrema tadungense
    Luu Hong Truong, Nguyen Hieu Cuong, Tran Huu Dang, Nguyen Thi My Hanh, Vien Le Thi, Hanh Tran Thi Hong, Tran Hong Quang, Hai Dang Nguyen, Cuong Nguyen Xuan, Nam Nguyen Hoai, and Chau Van Minh

    Journal of Asian Natural Products Research, ISSN: 10286020, eISSN: 14772213, Pages: 491-497, Published: 2021 Informa UK Limited
    Abstract In our search for cytotoxic constituents from Vietnamese plants, the methanolic extract of Isotrema tadungense was found to exhibit significant cytotoxic effect. Subsequent phytochemical investigation of ethyl acetate fractions of this plant led to isolation of 11 compounds including one new arylbenzofuran rhamnoside namely aristolochiaside (1), two aristololactams (2 and 3), three lignanamides (4–6) and five phenolic amides (7–11). Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among the isolated compounds, aristolochiaside (1), aristolactam AIIIa (2) and N-trans-sinapoyltyramine (10) exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 7.59 ± 1.03, 8.51 ± 1.73 and 9.77 ± 1.25 μM, respectively.

  • Sulphated flavones and pregnane-type steroids from Helicteres viscida
    Luu Hong Truong, Nguyen Hieu Cuong, Tran Huu Dang, Trinh Thi My Dung, Pham Thi Cham, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, and Chau Van Minh

    Natural Product Research, ISSN: 14786419, eISSN: 14786427, Pages: 3390-3395, Published: 2021 Informa UK Limited
    Abstract In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of Helicteres viscida was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (1–4), including one new compound 5,3′,4′-trihydroxy-7-methoxy-8-O-sulphate flavone (1), and two pregnane-type steroids (5 and 6), including one new compound 7-epi-heligenin B (5). Their structures were elucidated by 1D and 2D NMR as well as HR-QTOF-MS experiments. Among isolated compounds, heligenin B (6) exhibited potent inhibitory effect on LPS-induced NO production in RAW264.7 cells with IC50 of 1.23 ± 0.05 µM. The activity of 6 was comparable to that of the positive control cardamonin. Graphical Abstract

  • Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives
    Nguyen Trong Dan, Hoang Duc Quang, Vuong Van Truong, Do Huu Nghi, Nguyen Manh Cuong, To Dao Cuong, Tran Quoc Toan, Long Giang Bach, Nguyen Huu Thuan Anh, Nguyen Thi Mai, Ngo Thi Lan, Luu Van Chinh, and Pham Minh Quan

    Scientific Reports, eISSN: 20452322, Published: 1 December 2020 Springer Science and Business Media LLC
    The addition of chalcone and amine components into indirubin-3′-oxime resulted in 15 new derivatives with high yields. Structures of new derivatives were also elucidated through 1D, 2D-NMR and HR-MS(ESI) spectra and X-ray crystallography. All designed compounds were screened for cytotoxic activity against four human cancer cell lines (HepG2, LU-1, SW480 and HL-60) and one human normal kidney cell line (HEK-293). Compound 6f exhibited the most marked cytotoxicity meanwhile cytotoxicity of compounds 6e , 6h and 6l was more profound toward cancer cell lines than toward normal cell. These new derivatives were further analyzed via molecular docking studies on GSK-3β enzyme. Docking analysis shows that most of the derivatives exhibited potential inhibition activity against GSK-3β with characteristic interacting residues in the binding site. The fast pulling of ligand scheme was then employed to refine the binding affinity and mechanism between ligands and GSK-3β enzyme. The computational results are expected to contribute to predicting enzyme target of the trial inhibitors and their possible interaction, from which the design of new cytotoxic agents could be created in the future.

  • Vasorelaxing Activity of R -(-)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle Ca <inf>V</inf> 12 Channels
    Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Pham Ngoc Khanh, Tran Thu Huong, Nguyen Thi Thu Tram, Giampietro Sgaragli, Amer Ahmed, Alfonso Trezza, Ottavia Spiga, and Fabio Fusi

    Planta Medica, ISSN: 00320943, eISSN: 14390221, Pages: 284-293, Published: 1 March 2020 Georg Thieme Verlag KG
    Abstract Dalbergia species heartwood, widely used in traditional medicine to treat various cardiovascular diseases, might represent a rich source of vasoactive agents. In Vietnam, Dalbergia tonkinensis is an endemic tree. Therefore, the aim of the present work was to investigate the vascular activity of R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol isolated from the heartwood of D. tonkinensis and to provide circular dichroism features of its R absolute configuration. The vascular effects of R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol were assessed on the in vitro mechanical activity of rat aorta rings, under isometric conditions, and on whole-cell Ba2+ currents through CaV1.2 channels (IBa1.2) recorded in single, rat tail main artery myocytes by means of the patch-clamp technique. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol showed concentration-dependent, vasorelaxant activity on both endothelium-deprived and endothelium intact rings precontracted with the α 1 receptor agonist phenylephrine. Neither the NO (nitric oxide) synthase inhibitor Nω-nitro-L-arginine methyl ester nor the cyclooxygenase inhibitor indomethacin affected its spasmolytic activity. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol-induced vasorelaxation was antagonized by (S)-(−)-Bay K 8644 and unaffected by tetraethylammonium plus glibenclamide. In patch-clamp experiments, R-(−)-3′-hydroxy-2,4,5-trimethoxydalbergiquinol inhibited IBa1.2 in a concentration-dependent manner and significantly decreased the time constant of current inactivation. R-(−)-3′-Hydroxy-2,4,5-trimethoxydalbergiquinol likely stabilized the channel in its closed state, as suggested by molecular modelling and docking simulation to the CaV1.2 channel α 1c subunit. In conclusion, D. tonkinensis species may represent a source of agents potentially useful for the development of novel antihypertensive drugs.

  • Serine protease inhibitors and activators from Dalbergia tonkinensis species
    Ninh The Son, Midori Suenaga, Yoiichi Matsunaga, Luu Van Chinh, Miwa Kubo, Kenichi Harada, Nguyen Manh Cuong, and Yoshiyasu Fukuyama

    Journal of Natural Medicines, ISSN: 13403443, eISSN: 18610293, Pages: 257-263, Published: 1 January 2020 Springer Science and Business Media LLC
    The vulnerable plant Dalbergia tonkinensis Prain is a rare species in Vietnam. In the course of our studies on biologically active plants, we performed serine protease enzyme screenings. The results suggest that at concentrations of 25–250 ng/mL, methanol extracts of leaf and root, root ethanol extract and its dichloromethane fraction, and heartwood water decoction extract can serve as useful sources to stimulate trypsin enzyme activity. In addition, water decoction extracts of leaf and stem bark may explain unknown ethno-pharmacology due to the high inhibitory effects in enzyme assays using trypsin, chymotrypsin, and elastase. Among 23 isolated compounds and two semi-synthetic derivatives tested, quercetin (17) inhibits the activities of trypsin and chymotrypsin with IC50 9.7 µM. Flavonoids categorized as flavanone, isoflavanone, flavone, isoflavone, pretocarpan, aurone, and neoflavanone demonstrated variable activities. Several substitutions are closely correlated with protease actions, including hydroxylation at C-3 and C-3′ in flavone and C-5 and C-3′ in isoflavone, hydroxylation at C-3, C-5 and C-3′, carboxylation at C-6 and C-8, and 7-substitution in flavanone; 7-substitution and methoxylation at C-3′ in isoflavanone; and lactone ring opening in neoflavanone. In the assessment of casein cleavage, at a dose of 25 ng/mL, leaf water decoction extract demonstrates an inhibitory effect on casein cleavage by trypsin, whereas ethanol and methanol extracts of the root caused activation.

  • Chemical Constituents of the Heartwood of Dalbergia tonkinensis
    Ninh The Son, Yoshiyasu Fukuyama, and Nguyen Manh Cuong

    Chemistry of Natural Compounds, ISSN: 00093130, eISSN: 15738388, Pages: 854-856, Published: 1 September 2019 Springer Science and Business Media LLC
    A new sesquiterpene, rel-(3R,6S,7S)-6α-hydroxycyclonerolidol (1), along with three known compounds, including neroplomacrol (2), naringin (3), and p-formylphenol (4), was isolated from the heartwood of Dalbergia tonkinensis. Their chemical structures were elucidated based on spectroscopic analysis.

  • Chemical constituents of the Vietnamese plants Dalbergia tonkinensis Prain and Cratoxylum formosum (Jack) Dyer in Hook and their DPPH radical scavenging activities
    Ninh The Son, Mari Kamiji, Tran Thu Huong, Miwa Kubo, Nguyen Manh Cuong, and Yoshiyasu Fukuyama

    Medicinal Chemistry Research, ISSN: 10542523, eISSN: 15548120, Pages: 1441-1447, Published: 1 September 2019 Springer Science and Business Media LLC
    Phytochemical investigations of the leaves and roots of Dalbergia tonkinensis led to the isolation of a new isoflavone glycoside derivative, isocaviunin 7-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (1), and a new scalemic sesquiterpene lactone, 3,7-dimethyl-3-vinylhexahydro-6,7-bifuran-3(2H)-one (2), along with the previously known compounds 3-16, and nine other known compounds 17-25 were isolated from the leaves of Cratoxylum formosum. The chemical structures of the isolated compounds were elucidated by 1D- and 2D-NMR analyses as well as MS spectroscopic data. The results suggest that flavonoids are characteristic of both plants. In the DPPH radical scavenging assay, (3 R)-vestitol (5) and isoquercetin (24) possessed the strongest antioxidative IC50 values of 42.20 µg/mL and 45.63 µg/mL, respectively, and their values were comparable to that of the positive control catechin (IC50 42.98 µg/mL).

  • Identification of soluble epoxide hydrolase inhibitors from the seeds of passiflora edulis cultivated in Vietnam
    To Dao Cuong, Hoang Thi Ngoc Anh, Tran Thu Huong, Pham Ngoc Khanh, Vu Thi Ha, Tran Manh Hung, Young Ho Kim, and Nguyen Manh Cuong

    Natural Product Sciences, ISSN: 12263907, eISSN: 22889027, Pages: 348-353, Published: 2019 The Korean Society of Pharmacognosy (KAMJE)
    − Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 μM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.

  • New Constituents from the Roots and Stems of Paramignya trimera
    Tran Thu Huong, Vu Thi Ha, To Dao Cuong, Ninh The Son, Tran Quoc Toan, Hoang Thi Ngoc Anh, Nguyen Thi Thu Tram, Sun Hee Woo, Young Ho Kim, and Nguyen Manh Cuong

    Natural Product Communications, ISSN: 1934578X, eISSN: 15559475, Pages: 1-5, Published: 2019 SAGE Publications
    Paramignya trimera (Oliv.) Guill. (Rutaceae), mostly distributed in the southern regions of Vietnam, has been used as a medicinal plant for treatment of liver diseases and cancer. From the methanol extract of the roots and stems of P. trimera, 3 new compounds (1-3) were isolated, including ninhvanin B (1), paramitrimerol (2), and parabacunoic acid (3), and a known alkaloid, citrusinine-I (4). The structures of these compounds were elucidated by electrospray ionization mass spectrometry and nuclear magnetic resonance spectral analysis, as well as by comparison with literature data.

  • In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is)
    Pham Ngoc Khanh, Tran Thu Huong, Ottavia Spiga, Alfonso Trezza, Ninh The Son, To Dao Cuong, Vu Thi Ha, and Nguyen Manh Cuong

    Revista Internacional de Andrologia, ISSN: 1698031X, eISSN: 16980409, Pages: 147-158, Published: October - December 2018 Elsevier BV
    OBJECTIVE Prismatomeris memecyloides Craib (Rubiaceae) is a medicinal plant traditionally used by ethnic minorities in Vietnam for the treatment of erectile dysfunction (ED). The aim of this study was to investigate the chemical compositions and screen in silico its possible inhibitory effect against PDE-5 which reduced cyclic guanosine-3',5'-monophosphate (cGMP) levels and indirectly caused the male ED. METHODS Separation of natural compounds were carried out on chromatographic column with silica gel or reversed phase materials, eluting with different solvent gradients. The structures of all isolated compounds were elucidated on the basis of spectroscopic data (HR-MS, 1D/2D-NMR). Docking simulation study of compound (1-7) was performed by using flexible side chains protocol based on Iterated Local Search Global Optimizer Algorithm of AutoDock/Vina v.1.1.2. Pharmacokinetic parameters and toxicity prediction were also calculated by appropriate softwares. RESULTS From the methanol extract of roots of P. memecyloides collected in Vietnam, seven compounds including four anthraquinone/one anthraquinone glycoside namely damnacanthal (1), lucidin-ω-methyl ether (2), 3-methylalizarin (3), rubiadin-3-methyl ether (4), and 1-O-methylrubiadin 3-O-primeveroside (5) along with two iridoid glucosides, asperulosidic acid (6) and aitchisonide A (7) were isolated. The molecular modeling results showed that 5 anthraquinone compounds possess the lowest binding energies to PDE-5. The anthraquinone glucoside 1-O-methylrubiadin 3-O-primeveroside (5) potentially inhibited PDE-5 similarly to commercial PDE-5Is sildenafil (SLD) and tadalafil (TLD). Calculated pharmacokinetic results like pIC50,pred; miLogP, TPSA, enzyme inhibitory of anthraquinone glucoside (5) were similar and even higher to those of the commercial PDE-5 inhibitors. Especially the predictive toxicity of 1-O-methylrubiadin 3-O-primeveroside (5) was even lower than those of SLD and TLD. CONCLUSION This is the first study to find a scientific-based evidence for the ethnic use of P. memecyloides as medicinal plant for the treatment of ED. The result indicates that the anthraquinones (damnacanthal (1), lucidin-ω-methyl ether (2), 3-methylalizarin (3) and rubiadin-3-methyl ether (4)), especially anthraquinone glycoside (1-O-methylrubiadin 3-O-primeveroside (5)) are compounds of potential novel drug class for the ED treatment.

  • Antimicrobial activity of the constituents of dalbergia tonkinensis and structural-bioactive highlights
    Ninh The Son, Masataka Oda, Naoki Hayashi, Daiki Yamaguchi, Yu Kawagishi, Fumi Takahashi, Kenichi Harada, Nguyen Manh Cuong, and Yoshiyasu Fukuyama

    Natural Product Communications, ISSN: 1934578X, eISSN: 15559475, Pages: 157-161, Published: February 2018 SAGE Publications
    The vulnerable plant Dalbergia tonkinensis Prain, is a rare species, native to Vietnam. Phytochemical investigations and biological evaluations of this species are quite limited. Antimicrobial screening has suggested that, at the low dose of 1.0 mg/mL, the methanol extracts of the leaf, stem bark, and root, as well as chloroform fraction of heartwood can serve as useful sources against seven gram-positive skin microbacteria, Bacillus cereus (ATCC27522), Escherichia coli (JM109), Staphylococcus aureus (ATCC25923), Staphylococcus epidermidis (ATCC14990), Streptococcus pneumonia (ATCC49619), Streptococcus pyogenes (ATCC12344), and Vibrio parahaemolyticus (RIMD2210010), and four oral gram-positive microbacteria Streptococcus mutans (ATCC 25175), Streptococcus mitis (ATCC903), Streptococcus sobrinus (ATCC 33478), and Porphyromonas gingivalis (ATCC33277), with an inhibitory percentage of 60-80% growth for several strains Bacillus cereus, Escherichia coli, and Streptococcus pneumonia. We further assessed antimicrobial activities of the enriched diverse flavonoids from chloroform fraction of its heartwood. Extensive structural activity relationship studies showed structure function closely related to the antimicrobial activity, in which methoxylation at C-2’, and 4’ in isoflavanones, hydroxylation at C-3’ in flavones, substitution at C-5 in isoflavones, and lactone opened ring in neoflavonoids were found to increase the effective inhibitions. In the second antimicrobial assessment, the isolated flavonoid liquiritigenin showed the MIC values of 50, and 100 μg/mL against the microbacterial strains Staphylococcus aureus subsp. aureus (ATCC 11632), and Aspergillus niger (439), respectively, whereas the MIC value of 100 μg/mL was assignable to biochanin A against microbacterium Staphylococcus aureus subsp. aureus.

  • New records of potent in-vitro antidiabetic properties of dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds
    Van Nguyen, San-Lang Wang, Ngu Nhan, Thi Nguyen, Nguyen Nguyen, Do Nghi, and Nguyen Cuong

    Molecules, eISSN: 14203049, Published: 2018 MDPI AG
    Alpha-glucosidase inhibitory activity has been commonly used for the evaluation of antidiabetic property in vitro. The aim of this study is to investigate and characterize Dalbergia tonkinensis as a potential source of antidiabetic compounds. The screening of the active parts used, such as trunk bark, heartwood, and the leaves of Dalbergia tonkinensis indicated that all these extracted parts used with methanol demonstrated potent α-glucosidase inhibitory activity. The in vitro antidiabetic property of Dalbergia tonkinensis was notably recorded for the first time and showed activity (EC50 = 0.17–0.78 mg/mL) comparable to those of reported potent herbal extracts (EC50 = 0.25–4.0 mg/mL) and higher activity than that of acarbose, a commercial antidiabetic drug (EC50 = 1.21 mg/mL). The stability tests revealed that the heartwood of Dalbergia tonkinensis extract (HDT) possesses high pH stability with relative activity in the range of 80–98%. Further bioassay-guided purification led to the isolation of 2 active compounds identified as sativanone and formononetin from the ethyl acetate fraction and water fraction of HDT, respectively. These α-glucosidase inhibitors (aGIs) show promising inhibition against various types of α-glucosidases. Remarkably, these inhibitors were determined as new mammalian aGIs, showing good effect on rat α-glucosidase. The results suggest that Dalbergia tonkinensis is a potent source of aGIs and suggest promise in being developed as functional food with antidiabetic efficacy. The results of this study also enrich our knowledge concerning current biological activity and constituents of Dalbergia tonkinensis species.

  • Daltonkins A and B, Two New Carboxyethylflavanones from the Heartwood of Dalbergia tonkinensis
    Nguyen Manh Cuong, Ngu Truong Nhan, Ninh The Son, Do Huu Nghi, and To Dao Cuong

    Bulletin of the Korean Chemical Society, ISSN: 02532964, eISSN: 12295949, Pages: 1511-1514, Published: December 2017 Wiley

  • Two new carboxyethylflavanones from the heartwood of Dalbergia tonkinensis and their antimicrobial activities
    Ninh The Son, Kenichi Harada, Nguyen Manh Cuong, and Yoshiyasu Fukuyama

    Natural Product Communications, ISSN: 1934578X, eISSN: 15559475, Pages: 1721-1723, Published: November 2017 SAGE Publications
    Two new carboxyethylflavanone derivatives, (2 S)-8-carboxyethylnarigenin (2) and (2 S)-6,8-dicarboxyethylpinocembrin (3) were isolated from the heartwood of Dalbergia tonkinensis Prain, along with four known compounds 1, and 4-6. The chemical structures of two new compounds 2 and 3 were elucidated based on analyses of the spectroscopic data, including 1D and 2D NMR, HR-ESI-MS, IR, UV, and CD spectroscopies. By carrying out antimicrobial assay, CH3OH and CHCl3 fractions exhibited weak MIC value at 200 μg/mL against filamentous fungus A. niger (439), whereas the known flavanone 1 and the new carboxyethylflavanone 2 had MIC at 100 μg/mL.

  • Synthesis and in vitro cytotoxic evaluation of novel murrayafoline a derived β-amino alcohols
    Luu Van Chinh, Le Duc Anh, Nguyen Thi Nga, Nguyen Thi Ha Ly, Vu Thi Ha, Tran Quoc Toan, Nguyen Manh Cuong, and Tran Khac Vu

    Letters in Organic Chemistry, ISSN: 15701786, Pages: 603-611, Published: 1 October 2017 Bentham Science Publishers Ltd.

  • The hepatoprotective activity of a new derivative kaempferol glycoside from the leaves of Vietnamese Phyllanthus acidus (L.) Skeels
    Nguyen Cong Thuy Tram, Ninh The Son, Nguyen Thi Nga, Vu Thi Thu Phuong, Nguyen Thi Cuc, Do Thi Phuong, Gilles Truan, Nguyen Manh Cuong, and Do Thi Thao

    Medicinal Chemistry Research, ISSN: 10542523, eISSN: 15548120, Pages: 2057-2064, Published: 1 September 2017 Springer Science and Business Media LLC
    A new derivative kaempferol glycoside, kaempferol-3-O-(2-α-l-rhamnopyranosyl)-β-d-glucuronopyranosyl methyl ester (3), together with six other known kaempferol glycosides, kaempferol-3-O-[α-l-rhamnopyranosyl (1→2)]-β-d-galactopyranoside (1), kaempferol-3-O-(2-α-l-rhamnopyranosyl)-β-d-glucuronopyranoside (2), rutin (4), isoquercitrin (5), quercitrin (6), and myricitrin (7) were isolated from the leaves of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Here, is the first report described the isolation of compound (1) and (2) from the genus Phyllanthus. Compound (1) presents antioxidant activity in 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay. Compound (2) and (3) performed no antioxidant activity in 2,2-diphenyl-1-picryl-hydrazyl-hydrate and thiobarbituric acid reactive substances assays (IC50 > 100 µM). However, compound (2) showed anti-inflammation activity through inhibiting interleukin 6 and tumor necrosis factor alpha production (P < 0.05). Compound (3) also exhibited cytokine modulating activities such as inhibiting tumor necrosis factor alpha, activating interleukin 10 at concentration of 10 µM (P < 0.05). The interleukin 6 cytokine level was also up or down-regulated by compound (3) at two time points; 24 and 48 h. This activeness of compound (3) might induce hepatoprotection in the acute-phase response by activating the signal transducer and activator of transcription 3(STAT3) through cytokine modulation. Together with other kaempferol glycosides, this new derivative compound may mediate the liver-protective activity of the Vietnamese medicinal plant Phyllanthus acidus.

  • Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa
    Hong-Jie Zhang, Emily Rumschlag-Booms, Yi-Fu Guan, Dong-Ying Wang, Kang-Lun Liu, Wan-Fei Li, Van H. Nguyen, Nguyen M. Cuong, Djaja D. Soejarto, Harry H. S. Fong, and Lijun Rong

    Journal of Natural Products, ISSN: 01633864, eISSN: 15206025, Pages: 1798-1807, Published: 23 June 2017 American Chemical Society (ACS)
    Justicia gendarussa, a medicinal plant collected in Vietnam, was identified as a potent anti-HIV-1 active lead from the evaluation of over 4500 plant extracts. Bioassay-guided separation of the extracts of the stems and roots of this plant led to the isolation of an anti-HIV arylnaphthalene lignan (ANL) glycoside, patentiflorin A (1). Evaluation of the compound against both the M- and T-tropic HIV-1 isolates showed it to possess a significantly higher inhibition effect than the clinically used anti-HIV drug AZT. Patentiflorin A and two congeners were synthesized, de novo, as an efficient strategy for resupply as well as for further structural modification of the anti-HIV ANL glycosides in the search for drug leads. Subsequently, it was determined that the presence of a quinovopyranosyloxy group in the structure is likely essential to retain the high degree of anti-HIV activity of this type of compounds. Patentiflorin A was further investigated against the HIV-1 gene expression of the R/U5 and U5/gag transcripts, and the data showed that the compound acts as a potential inhibitor of HIV-1 reverse transcription. Importantly, the compound displayed potent inhibitory activity against drug-resistant HIV-1 isolates of both the nucleotide analogue (AZT) and non-nucleotide analogue (nevaripine). Thus, the ANL glycosides have the potential to be developed as novel anti-HIV drugs.

  • Inhibitory effects of novel diarylheptanoids and other constituents of the rhizomes of Curcuma singularis on the catalytic activity of soluble epoxide hydrolase
    Nguyen Manh Cuong, Doan Thi Van, Ninh The Son, To Dao Cuong, Pham Ngoc Khanh, Nguyen Quoc Binh, Tran Thi Viet Thanh, Ji Sun Lee, Ah Reum Jo, and Young Ho Kim

    Bulletin of the Korean Chemical Society, eISSN: 12295949, Pages: 112-115, Published: 1 January 2017 Wiley

  • Inhibitory components from Glycosmis stenocarpa on pepper mild mottle virus
    Jang Hoon Kim, Ju-Yeon Yoon, Sun Jung Kwon, In Sook Cho, Nguyen Manh Cuong, Seung-Kook Choi, Young Ho Kim, and Gug Seoun Choi

    Journal of Microbiology and Biotechnology, ISSN: 10177825, eISSN: 17388872, Pages: 2138-2140, Published: December 2016 Korean Society for Microbiology and Biotechnology
    The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.


  • Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
    NM Cuong, NT Son, NT Nhan, Y Fukuyama, A Ahmed, S Saponara, ...
    Molecules 27 (14), 4505 2022

  • In vitro and in silico cytotoxic activities of triterpenoids from the leaves of Aralia dasyphylla Miq. and the assessment of their ADMET properties
    H Nguyen Thi Thu, D Nguyen Huu Huong, T Nguyen Thi Dieu, ...
    Journal of Biomolecular Structure and Dynamics, 1-9 2022

    NM Cuong, PN Khanh, TT Huong, VT Ha, HTN Anh, TD Cuong
    Vietnam Journal of Science and Technology 60 (3), 410-423 2022

    DD Quang, NT Thuy, HTN Anh, TD Hieu, PM Quan, PQ Long, NM Cuong, ...
    Vietnam Journal of Science and Technology 60 (1) 2022

  • Chrysosplenol-C increases contraction by augmentation of sarcoplasmic reticulum Ca2+ loading and release via protein kinase C in rat ventricular myocytes
    J Wang, TN Trinh, ATV Vu, JC Kim, HTN Anh, CJ Ohk, YH Zhang, ...
    Molecular Pharmacology 101 (1), 13-23 2022

    DH Nghi, TTN Hang, DN Quynh, NM Cuong
    Vietnam Journal of Science and Technology 59 (6) 2021

  • Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation
    NK Pham, HT Bui, TH Tran, TNA Hoang, TH Vu, DT Do, YH Kim, SB Song, ...
    Steroids 175, 108902 2021

  • Bergera unifolia (Rutaceae), a new species from Guangxi (China) based on morphological and molecular data
    CL Deng, CW Chen, XX Wu, NM Cuong, FJ Mou
    Annales Botanici Fennici 58 (4-6), 363-376 2021

  • Optimization and purification of α-glucosidase inhibitor from Bacillus subtilis YT20
    TTD Tien Cuong Nguyen, Thanh Hoang Le, Van Hien Mai, Thi Yen Hoang, Thi ...
    Vietnam Journal of Science and Technology 59 (2), 179-188 2021

  • Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells
    TNPDTNP Quoc Toan Tran, The Dan Pham, Thanh Duong Nguyen, Van Huyen Luu, Huu ...
    Open Chemistry 19 (1), 830-842 2021

  • Vasorelaxing Activity of R-(−)-3′-Hydroxy-2, 4, 5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle CaV1. 2 Channels
    FF Nguyen Manh Cuong, Ninh The Son, Ngu Truong Nhan, Pham Ngoc Khanh, Tran ...
    Planta Medica 86 (04), 284-293 2020

  • Gp phần nghin cứu về thnh phần ha học của cy Sưa đỏ (dalbergia tonkinesis) ở Ty Nguyn
    CN Manh

  • Investigation of anti-Helicobacter pylori activity and chemical constituents of Ludwigia hyssopifolia aerial parts
    Nguyen Thi Thu Tram, Huynh Thi Thanh Thuy, Pham Thanh Trong, Phan Hoang Duy ...
    Vietnam Journal of Science and Technology 58 (6A), 35-40 2020

  • Antimicrobial, antioxidant and cytotoxic activity on human breast cancer cells of essential oil from Pinus sylvestris. var mongolica needle
    Javzmaa Namshir, Altantsetseg Shatar, Oyukhan Khandaa, Rentsenkhand ...
    Mong. J. Chem. 21 (47), 19-26 2020

  • Initial study on SARS-COV-2 main protease inhibition mechanism of some potential drugs using molecular docking simulation
    PQL Pham Minh Quan, Le Thi Thuy Huong, Tran Quoc Toan, Ngo Son Tung, Nguyen ...
    Vietnam Journal of Science and Technology 58 (6), 665-675 2020

  • Constituents of essential oils from the leaves and rhizomes of Ophiopogon fruticulosus Aver., N.Tanaka & K.S. Nguyen from Vietnam
    Pham Ngoc Khanh, Hoang Thi Ngoc Anh, Tran Thu Huong, Vu Thi Ha, DinhThi Thu ...
    American Journal of Essential Oils and Natural Products 8 (4), 19-23 2020

  • New method for preparing purity β-D-glucans (beta-Glucan) from baker’s yeast (Saccharomyces cerevisiae)
    Pham Ngoc Khanh, Nguyen Duy Nhut, Nguyen Manh Cuong
    Science & Technology Development Journal 23 (3), 673-678 2020

  • Ha thực vật v tc dụng dược l cc loi trong chi Trắc
    PTHT Ngũ Trường Nhn, Nguyễn Mạnh Cường, Đỗ Hữu Nghị, Nguyễn Thị Thảo ...
    Nh Xuất bản Đại học Sư phạm TP Hồ Ch Minh 2020

  • Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK‑3β of new indirubin‑3ʹ‑oxime derivatives
    NT Dan, HD Quang, VV Truong, DH Nghi, NM Cuong, TD Cuong, ...
    Scientific Reports 10 (11429) 2020

  • Soluble epoxide hydrolase inhibitors from Docynia indica (Wall.) Decne
    NMC Le Xuan Duy, Le Ba Vinh, Gao Dan, Vu Dinh Hoang, Tran Quoc Toan, Seo ...
    Natural Products Research 2020


  • Antioxidative and anti-inflammatory effect of quercetin and its glycosides isolated from mampat (Cratoxylum formosum)
    SJ Choi, BH Tai, NM Cuong, YH Kim, HD Jang
    Food Science and biotechnology 21 (2), 587-595 2012
    Citations: 76

  • Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities
    C Liang, Y Ding, NH Tung, JA Kim, HJ Boo, HK Kang, NM Cuong, YH Kim
    Bioorganic & Medicinal Chemistry Letters 20 (23), 7110-7115 2010
    Citations: 67

  • A new dimeric carbazole alkaloid from Glycosmis stenocarpa roots
    NM Cuong, TQ Hung, T Van Sung, WC Taylor
    Chemical and pharmaceutical bulletin 52 (10), 1175-1178 2004
    Citations: 54

  • Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins
    H Choi, J Gwak, M Cho, MJ Ryu, JH Lee, SK Kim, YH Kim, GW Lee, ...
    Biochemical and biophysical research communications 391 (1), 915-920 2010
    Citations: 46

  • Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis
    BH Tai, BY Jung, NM Cuong, PT Linh, NH Tung, NX Nhiem, TT Huong, ...
    Biological and Pharmaceutical Bulletin 32 (12), 1952-1956 2009
    Citations: 44

  • Mechanism of osthole inhibition of vascular Cav1. 2 current
    F Fusi, G Sgaragli, LM Ha, NM Cuong, S Saponara
    European journal of pharmacology 680 (1-3), 22-27 2012
    Citations: 41

  • A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity
    BTT Luyen, BH Tai, NP Thao, SY Yang, NM Cuong, YI Kwon, HD Jang, ...
    Bioorganic & medicinal chemistry letters 24 (17), 4120-4124 2014
    Citations: 38

  • Antimicrobial Activity of the Constituents of Dalbergia tonkinensis and Structural-Bioactive Highlights
    YF Ninh The Son, Masataka Oda, Naoki Hayashi, Daiki Yamaguchi, Yu Kawagishi ...
    Natural Product Communications 13 (2), 157-161 2018
    Citations: 34

  • 1-O-Substituted derivatives of murrayafoline A and their antifungal properties
    NM Cuong, H Wilhelm, A Porzel, N Arnold, L Wessjohann
    Natural product research 22 (16), 1428-1432 2008
    Citations: 32

  • New pyrano-pyrone from Goniothalamus tamirensis enhances the proliferation and differentiation of osteoblastic MC3T3-E1 cells
    BH Tai, VT Huyen, TT Huong, NX Nhiem, EM Choi, JA Kim, PQ Long, ...
    Chemical and Pharmaceutical Bulletin 58 (4), 521-525 2010
    Citations: 30

  • Paratrimerins A and B, two new dimeric monoterpene-linked coumarin glycosides from the roots and stems of Paramignya trimera
    NM Cuong, TT Huong, PN Khanh, N Van Tai, VT Ha, BH Tai, YH Kim
    Chemical and Pharmaceutical Bulletin 63 (11), 945-949 2015
    Citations: 29

  • A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis
    BH Tai, NX Nhiem, TH Quang, NTT Ngan, NH Tung, Y Kim, JJ Lee, ...
    Bioorganic & medicinal chemistry letters 21 (11), 3462-3466 2011
    Citations: 29

  • New Records of Potent In-Vitro Antidiabetic Properties of Dalbergia tonkinensis Heartwood and the Bioactivity-Guided Isolation of Active Compounds
    NMC Van Bon Nguyen, San-Lang Wang, Ngu Truong Nhan, Thi Hanh Nguyen, Nguyen ...
    Molecules 23, 1589 2018
    Citations: 25

  • Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa
    JH Kim, AMA Morgan, BH Tai, DT Van, NM Cuong, YH Kim
    Journal of enzyme inhibition and medicinal chemistry 31 (4), 640-644 2016
    Citations: 25

  • Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells
    BH Tai, NM Cuong, TT Huong, EM Choi, JA Kim, YH Kim
    Journal of Asian natural products research 11 (9), 817-823 2009
    Citations: 25

  • Flavanoids from Carya tonkinensis
    NM Cuong, TV Sung, C Kamperdick, G Adam
    Pharmazie 51 (2), 127-128 1996
    Citations: 23

  • Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB
    C Liang, Y Ding, SB Song, JA Kim, NM Cuong, JY Ma, YH Kim
    Journal of Ginseng Research 37 (1), 74 2013
    Citations: 22

  • Glypetelotine, a sulphur-containing indole alkaloid from Glycosmis petelotii
    NM Cuong, WC Taylor, T Van Sung
    Phytochemistry 52 (8), 1711-1714 1999
    Citations: 22

  • Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus
    PN Khanh, HV Duc, TT Huong, NT Son, VT Ha, DT Van, BH Tai, JE Kim, ...
    Fitoterapia 109, 39-44 2015
    Citations: 21

  • Two New Carboxyethylflavanones from the Heartwood of Dalbergia tonkinensis and Their Antimicrobial Activities
    Ninh The Son, Kenichi Harada, Nguyen Manh Cuong, and Yoshiyasu Fukuyama
    Natural Product communications 12 (11), 1721-1723 2017
    Citations: 20