Nesrine mohamed refaat mahmoud

@iau.edu.sa

Department of basic Sciences
Imam Abdulrahman Bin Faisal University

Nesrine mohamed refaat mahmoud


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https://researchid.co/nesrine

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Multidisciplinary, Catalysis, Environmental Chemistry
11

Scopus Publications

215

Scholar Citations

9

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • Beyond Conventional Heating: Unlocking the Synergy Between Microwave Irradiation and pH Control for High-Efficiency Fabrication of Phyto-Copper Oxide Nanoparticles
    Amal Alqahtani, Nesrine Mahmoud, Suriya Rehman, Somia Ahmed
    Nanotechnology Science and Applications, 2026
    Introduction: Sustainable nanotechnology requires synthesis approaches that are environmentally benign while maintaining high efficiency, yield, and functionality. Plant-mediated synthesis combined with advanced heating techniques offers a promising route to achieve these goals. Methods: Phyto-copper oxide nanoparticles (Phy-CuO-NPs) were synthesized using Psidium guajava leaf extract under different pH conditions via two approaches: conventional heating (Series A) and microwave-assisted synthesis (Series B). The influence of pH and heating mode on nanoparticle formation was systematically evaluated. The synthesized nanoparticles were characterized using physicochemical and morphological techniques, and their antibacterial activity was assessed against Staphylococcus aureus and Pseudomonas aeruginosa . Results: Microwave-assisted synthesis significantly altered pH-dependent nucleation pathways, resulting in nanoparticles with enhanced crystallinity, more uniform morphology, higher copper content, and improved colloidal stability, particularly under alkaline conditions. Series B nanoparticles showed a 34% increase in maximum yield (up to 80 mg/g) while achieving a 92% reduction in energy consumption compared to the conventional method. Antibacterial assays revealed strong inhibitory activity against both tested strains, with greater efficacy against Gram-negative bacteria. Discussion: The improved antibacterial performance is attributed to the bio-capped nature of the nanoparticles, which facilitates cellular entry and promotes intracellular copper ion release, leading predominantly to reactive oxygen species generation rather than direct ionic toxicity. This study highlights the synergistic role of microwave irradiation and pH control in enhancing both sustainability and functionality. Keywords: phyto, green fabrication, biomass, valorization, microwave synthesis, copper oxide nanoparticles, antibacterial mechanism, reactive oxygen species
  • Stability studies of titanium–carboxylate complexes: A multi-method computational approach
    Abdalazeem A. Omar, Yasser R. M. Elmarassi, M. Saadawy, Abdallah Bashir Musa, Nesrine M. R. Mahmoud
    Open Chemistry, 2025
    Understanding the stability of metal–ligand complexes is essential for advancing applications in environmental, industrial, and biomedical chemistry; however, titanium coordination systems remain underexplored, particularly with organic ligands of chelating properties. This study aims to evaluate and compare the stability constants of titanium ( iv ) complexes with propanoic acid and citric acid to better understand their coordination behavior. A multi-method computational approach was employed, integrating point-wise calculation, half-integral, linear plot, and least-squares methods to enhance the accuracy and reproducibility of proton–ligand dissociation constants (p K a ) and metal–ligand formation constants (log K ). The titanium–propanoate complexes showed moderate stability (log K 2 = 4.7564, log K 3 = 4.1015), influenced by steric and electronic factors, while the titanium–citrate complex exhibited a higher binding affinity (log K 1 = 7.8351), indicating strong chelation capacity. The consistency across all computational and graphical methods validates the reliability of the findings. These insights provide a dependable framework for evaluating titanium-based coordination compounds and may guide future research into their potential applications in environmental and biomedical fields.
  • Novel Biological-Based Strategy for Synthesis of Green Nanochitosan and Copper-Chitosan Nanocomposites: Promising Antibacterial and Hematological Agents
    Hadeer I. Mohamed, Nesrine M. R. Mahmoud, Abeer Ramadan, Abeer M. Al-Subaie, Somia B. Ahmed
    Nanomaterials, 2024
    Two novel samples of nanoparticles based on chitosan were greenly synthesized using pomegranate peel extract. The extract served as a nanoparticle precursor, facilitating the precipitation of nanosized chitosan through the ionic gelation method. Additionally, by mixing the green chitosan nanoparticles with copper ions, a nanoscale composite of chitosan and copper oxide was also produced. Structural and morphological investigations (FTIR, XRD, SEM, EDX, and TGA analyses) were performed for greenly synthesized chitosan nanoparticles and their copper oxide composite to determine all the significant characteristics of those nanoparticles. In addition, both samples were tested using some biological investigations, such as antimicrobial activity and hematological effects. The antimicrobial tests yielded promising results for both the green chitosan nanoparticles and the CuO composite when tested using two bacterial strains and two fungal strains. Moreover, the results showed that using a similar concentration of both green-based chitosan samples resulted in a slightly larger inhibition zone and a lower minimum inhibition concentration (MIC) for the copper oxide chitosan composite compared to the chitosan nanoparticles for all microorganisms included in the test. The mean count of blood components (RBCs and platelets), clotting time, and cholesterol levels in three different blood samples were used to indicate the hematological activity of both greenly synthesized nanoparticles. The results verified a slight reduction in blood component count after the addition of green chitosan nanoparticles, but the chitosan copper oxide composite did not have a noticeable effect on the three blood samples. The chitosan nanoparticles were able to cause a considerable reduction in clotting time and cholesterol levels for all blood samples, thus acting as procoagulants. However, the mixing of CuO with chitosan nanoparticles prolonged the rate of clotting in blood samples from hypercholesteremic individuals, and thus, the mixture acted as an anticoagulant agent.
  • Study the effect of simple extraction techniques to synthesizing promising antimicrobial bio-capped copper oxide nanoparticles
    Nesrine M.R. Mahmoud, Amal L. Al-Otaibi, Sultan Akhtar, Mohammad Azam Ansari, Abeer Ramadan, Somia B. Ahmed
    Green Chemistry Letters and Reviews, 2023
    ABSTRACTSix samples of bio-capped copper oxide nanoparticles were made from two bio-waste extracts: Punica granatum L. peels and Psidium guajava Linn. leaves. Extraction methods included soaking in water or hydroethanol and boiling in water. The samples were characterized using FT-IR, XRD, SEM, and TGA. Results showed organic residue capping on CuO nanoparticles varied based on the extract and capping medium used. The thermal stability of all CuO samples was observed to be high, as recorded from TGA patterns and confirmed by EDX analysis, which showed a high content of copper ranging from 10.1 to 36.1%. TEM analysis revealed an average particle size of less than 20 nm for all six samples, suggesting a similarity in size. The soaking technique produced the most stable bio-capped CuO nanoparticles with a high negative zeta potential value. According to the study, the CuO samples synthesized from aqueous extracts obtained through soaking showed the highest antibacterial activity. This could be attributed to the high oxygen ratio, which was confirmed via EDX analysis. The bio-capped CuO was effective against multidrug- resistant gram-positive bacteria MRSA, and C. albicans. A mechanism was proposed to explain how the capping media affected the antimicrobial activity of the bio-capped CuO nanoparticles.
  • Study of the optimization and mechanism for the remediation process of Malachite green dye via hybrid-based Magnetite-date's stones: Study of the optimization and mechanism for the remediation process
    Somia B. Ahmed, Nesrine M.R. Mahmoud, Abdullah A Manda, Heba M. Refaat
    Alexandria Engineering Journal, 2022
    Dates' stones, a natural, abundant biowaste in Saudi Arabia, was hybridized with magnetite nanoparticles to produce hybrid-based magnetite dates' stones nanoparticles (D-Fe3O4-NPS). The synthesized sorbent was utilized for remediation of dye pollutants. A set of techniques were used to characterize D-Fe3O4-NPS. Scanning electron microscopy (SEM) showed masses of spherical magnetite nanoparticles dispersed uniformly among the dates' stones bed. The average diameter of the nanoparticles was found to be 8 nm, while BET surface area was 44.174 m2/g. The adsorption capability of the synthesized D-Fe3O4-NPS towards the malachite green (MG) dye was evaluated via optimization factors, isotherm, and kinetics studies. The optimization factors investigated included pH, temperature, contact time, and sorbent mass. It was found that the extent of MG adsorption by D-Fe3O4-NPS increased with initial dye concentration, contact time, the dosage of the sorbent, and pH of solution while temperature effect was not pronounced. Overall, the sorption kinetics of MG was best described by the pseudo-second-order model. Finally, a mechanism for the adsorption behavior of (MG) was suggested to obtain a deeper understanding of the sorption procedure. The results showed that D-Fe3O4-NPS could be very promising as a low-cost sorbent, which easily hooks MG from an aqueous environment.
  • Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
    Somia B. Ahmed, Hadeer I. Mohamed, Abeer M. Al-Subaie, Ahoud I. Al-Ohali, Nesrine M. R. Mahmoud
    Scientific Reports, 2021
    Novel synthesized Chitosan–Copper oxide nanocomposite (Cs–CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method. The characterization of biogenic nanoparticles Cs-NP's and Cs–CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles. Antimicrobial activity was tested for both Cs-NP's and Cs–CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative. The antimicrobial test results showed high sensitivity of Cs–CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000–40,000 mg/L except for the C. albicans species. The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples. The measurement showed a decrease in RBCs and platelet count by adding Cs-NP’s or Cs–CuO-NP's to the three blood samples. Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP’s to Cs-NP’s increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
  • An efficient green protocol for photo-degradation of bromophenol blue dye
    Nesrine M.R. Mahmoud, Hemmat A. Elbadawy, Heba M. Refaat
    Desalination and Water Treatment, 2021
  • Efficient biosynthesis of CuO nanoparticles with potential cytotoxic activity
    Nesrine M. R. Mahmoud, Hadeer I. Mohamed, Somia B. Ahmed, Sultan Akhtar
    Chemical Papers, 2020
  • Remediation of methyl green dye from aqueous solution via adsorption and degradation using silica gel modified with hydrated zinc oxide catalyst
    Nesrine M.R. Mahmoud, Medhat Mohamed El-Moselhy, Mishael.A. Alkhaldi
    Desalination and Water Treatment, 2019
  • Removal of fluoride from aqueous solution using amberlite-IRA-aluminum sorbent nanoexchanger
    Mostafa M. Emara, Aida A. Salman, Nesrine M.R. Mahmoud, Samah A. Fattah
    Desalination and Water Treatment, 2017
  • Copper modified exchanger for the photodegradation of methyl orange dye
    Medhat Mohamed El-Moselhy, Nesrine M.R. Mahmoud, Mostafa M. Emara
    Desalination and Water Treatment, 2014

RECENT SCHOLAR PUBLICATIONS

  • Beyond Conventional Heating: Unlocking the Synergy Between Microwave Irradiation and pH Control for High-Efficiency Fabrication of Phyto-Copper Oxide Nanoparticles
    A Alqahtani, NMR Mahmoud, S Rehman, SB Ahmed
    Nanotechnology, Science and Applications, 576435 , 2026
    2026
  • Stability studies of titanium–carboxylate complexes: A multi-method computational approach
    AA Omar, YRM Elmarassi, M Saadawy, AB Musa, NMR Mahmoud
    Open Chemistry 23 (1), 20250180 , 2025
    2025
  • Novel Biological-Based Strategy for Synthesis of Green Nanochitosan and Copper-Chitosan Nanocomposites: Promising Antibacterial and Hematological Agents
    HI Mohamed, NMR Mahmoud, A Ramadan, AM Al-Subaie, SB Ahmed
    Nanomaterials 14 (13), 1111 , 2024
    2024
    Citations: 10
  • Study the effect of simple extraction techniques to synthesizing promising antimicrobial bio-capped copper oxide nanoparticles
    NMR Mahmoud, AL Al-Otaibi, S Akhtar, MA Ansari, A Ramadan, ...
    Green Chemistry Letters and Reviews 16 (1), 2260417 , 2023
    2023
    Citations: 7
  • Study of the optimization and mechanism for the remediation process of Malachite green dye via hybrid-based Magnetite-date’s stones
    SB Ahmed, NMR Mahmoud, AA Manda, HM Refaat
    Alexandria Engineering Journal 61 (12), 9879-9889 , 2022
    2022
    Citations: 9
  • An efficient green protocol for photo-degradation of bromophenol blue dye
    NMR Mahmoud, HA Elbadawy, HM Refaat
    Desalination and Water Treatment 229, 403-412 , 2021
    2021
    Citations: 9
  • Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
    SB Ahmed, HI Mohamed, AM Al-Subaie, AI Al-Ohali, NMR Mahmoud
    Scientific Reports 11 (1), 9540 , 2021
    2021
    Citations: 65
  • Efficient biosynthesis of CuO nanoparticles with potential cytotoxic activity
    NMR Mahmoud, HI Mohamed, SB Ahmed, S Akhtar
    Chemical Papers 74 (9), 2825-2835 , 2020
    2020
    Citations: 47
  • Remediation of methyl green dye from aqueous solution via adsorption and degradation using silica gel modified with hydrated zinc oxide catalyst
    NMR Mahmoud, MM El-Moselhy, MA Alkhaldi
    Desalination and Water Treatment 158, 385-397 , 2019
    2019
    Citations: 9
  • Removal of fluoride from aqueous solution using Amberlite-IRA-aluminum sorbent nanoexchanger
    MM Emara, AA Salman, NMR Mahmoud, SA Fattah
    Desalination and Water Treatment 81, 152-161 , 2017
    2017
    Citations: 2
  • Cadmium Removal from Aqueous Solution Using Superparamagnetic Iron Oxide Nanosorbents on Amberlite IR 120 H Support
    AMASASES Mohamed Goher,MostafaM. Emara, Mohamed Hassan Abdo, Nesrine Mohamed ...
    Journal of Applied Sciences 17 (Issue: 6), | Page No.: 296-305 , 2017
    2017
    Citations: 13
  • Application of a newly developed super paramagnetic magnetite Fe3O4 nanowafers nanoparticle in the removal of heavy metals from industrial wastewater submerging in the River Nile
    MM Emara1, ME Goher2, MH Abdo2, NMMAS El-Shamy2
    Egypt. J. Aquat. Biol. & Fish 20 (No. 3), 53 – 66 , 2016
    2016
  • SYNTHESIS AND CHARACTERIZATION OF Fe, Mn AND SUPER PARAMAGNETIC MAGNETITE Fe3O4 NANOPARTICLES.
    NMMASES Mostafa M. Emara1, Mohamed E Goher2, Mohamed H Abdo2
    Int. J. Adv. Res., 447-461 , 2016
    2016
    Citations: 9
  • Copper modified exchanger for the photodegradation of methyl orange dye
    MM El-Moselhy, NMR Mahmoud, MM Emara
    Desalination and Water Treatment 52 (37-39), 7225-7234 , 2014
    2014
    Citations: 6
  • Solvation and Temperature Effects on the Proton Transfer Equilibria between 2,5-dihydroxy- p -benzoquinone and amines
    MM Habeeb, HA Al-Wakil, A El-Dissouky, NM Refat
    Journal of Chemical Research 2001 (5), 200-205 , 2001
    2001
    Citations: 13
  • Vibrational spectroscopic studies of hydrogen‒bonded complexes between 2, 5‐dihydroxy‐P‐benzoquinone and amines
    MM Habeeb, HA Al-Wakil, A El-Dissouky, NM Refat
    Journal of Spectroscopy 15 (1), 33-44 , 2001
    2001
    Citations: 16

MOST CITED SCHOLAR PUBLICATIONS

  • Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite
    SB Ahmed, HI Mohamed, AM Al-Subaie, AI Al-Ohali, NMR Mahmoud
    Scientific Reports 11 (1), 9540 , 2021
    2021
    Citations: 65
  • Efficient biosynthesis of CuO nanoparticles with potential cytotoxic activity
    NMR Mahmoud, HI Mohamed, SB Ahmed, S Akhtar
    Chemical Papers 74 (9), 2825-2835 , 2020
    2020
    Citations: 47
  • Vibrational spectroscopic studies of hydrogen‒bonded complexes between 2, 5‐dihydroxy‐P‐benzoquinone and amines
    MM Habeeb, HA Al-Wakil, A El-Dissouky, NM Refat
    Journal of Spectroscopy 15 (1), 33-44 , 2001
    2001
    Citations: 16
  • Cadmium Removal from Aqueous Solution Using Superparamagnetic Iron Oxide Nanosorbents on Amberlite IR 120 H Support
    AMASASES Mohamed Goher,MostafaM. Emara, Mohamed Hassan Abdo, Nesrine Mohamed ...
    Journal of Applied Sciences 17 (Issue: 6), | Page No.: 296-305 , 2017
    2017
    Citations: 13
  • Solvation and Temperature Effects on the Proton Transfer Equilibria between 2,5-dihydroxy- p -benzoquinone and amines
    MM Habeeb, HA Al-Wakil, A El-Dissouky, NM Refat
    Journal of Chemical Research 2001 (5), 200-205 , 2001
    2001
    Citations: 13
  • Novel Biological-Based Strategy for Synthesis of Green Nanochitosan and Copper-Chitosan Nanocomposites: Promising Antibacterial and Hematological Agents
    HI Mohamed, NMR Mahmoud, A Ramadan, AM Al-Subaie, SB Ahmed
    Nanomaterials 14 (13), 1111 , 2024
    2024
    Citations: 10
  • Study of the optimization and mechanism for the remediation process of Malachite green dye via hybrid-based Magnetite-date’s stones
    SB Ahmed, NMR Mahmoud, AA Manda, HM Refaat
    Alexandria Engineering Journal 61 (12), 9879-9889 , 2022
    2022
    Citations: 9
  • An efficient green protocol for photo-degradation of bromophenol blue dye
    NMR Mahmoud, HA Elbadawy, HM Refaat
    Desalination and Water Treatment 229, 403-412 , 2021
    2021
    Citations: 9
  • Remediation of methyl green dye from aqueous solution via adsorption and degradation using silica gel modified with hydrated zinc oxide catalyst
    NMR Mahmoud, MM El-Moselhy, MA Alkhaldi
    Desalination and Water Treatment 158, 385-397 , 2019
    2019
    Citations: 9
  • SYNTHESIS AND CHARACTERIZATION OF Fe, Mn AND SUPER PARAMAGNETIC MAGNETITE Fe3O4 NANOPARTICLES.
    NMMASES Mostafa M. Emara1, Mohamed E Goher2, Mohamed H Abdo2
    Int. J. Adv. Res., 447-461 , 2016
    2016
    Citations: 9
  • Study the effect of simple extraction techniques to synthesizing promising antimicrobial bio-capped copper oxide nanoparticles
    NMR Mahmoud, AL Al-Otaibi, S Akhtar, MA Ansari, A Ramadan, ...
    Green Chemistry Letters and Reviews 16 (1), 2260417 , 2023
    2023
    Citations: 7
  • Copper modified exchanger for the photodegradation of methyl orange dye
    MM El-Moselhy, NMR Mahmoud, MM Emara
    Desalination and Water Treatment 52 (37-39), 7225-7234 , 2014
    2014
    Citations: 6
  • Removal of fluoride from aqueous solution using Amberlite-IRA-aluminum sorbent nanoexchanger
    MM Emara, AA Salman, NMR Mahmoud, SA Fattah
    Desalination and Water Treatment 81, 152-161 , 2017
    2017
    Citations: 2
  • Beyond Conventional Heating: Unlocking the Synergy Between Microwave Irradiation and pH Control for High-Efficiency Fabrication of Phyto-Copper Oxide Nanoparticles
    A Alqahtani, NMR Mahmoud, S Rehman, SB Ahmed
    Nanotechnology, Science and Applications, 576435 , 2026
    2026
  • Stability studies of titanium–carboxylate complexes: A multi-method computational approach
    AA Omar, YRM Elmarassi, M Saadawy, AB Musa, NMR Mahmoud
    Open Chemistry 23 (1), 20250180 , 2025
    2025
  • Application of a newly developed super paramagnetic magnetite Fe3O4 nanowafers nanoparticle in the removal of heavy metals from industrial wastewater submerging in the River Nile
    MM Emara1, ME Goher2, MH Abdo2, NMMAS El-Shamy2
    Egypt. J. Aquat. Biol. & Fish 20 (No. 3), 53 – 66 , 2016
    2016